DE3586640D1 - Einstufiger test fuer proteasehemstoffe. - Google Patents

Einstufiger test fuer proteasehemstoffe.

Info

Publication number
DE3586640D1
DE3586640D1 DE8585108422T DE3586640T DE3586640D1 DE 3586640 D1 DE3586640 D1 DE 3586640D1 DE 8585108422 T DE8585108422 T DE 8585108422T DE 3586640 T DE3586640 T DE 3586640T DE 3586640 D1 DE3586640 D1 DE 3586640D1
Authority
DE
Germany
Prior art keywords
detergents
protease
stage test
stage
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585108422T
Other languages
English (en)
Other versions
DE3586640T2 (de
Inventor
Lloyd A Schick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Publication of DE3586640D1 publication Critical patent/DE3586640D1/de
Application granted granted Critical
Publication of DE3586640T2 publication Critical patent/DE3586640T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19853586640 1984-07-20 1985-07-08 Einstufiger test fuer proteasehemstoffe. Expired - Fee Related DE3586640T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63271584A 1984-07-20 1984-07-20

Publications (2)

Publication Number Publication Date
DE3586640D1 true DE3586640D1 (de) 1992-10-22
DE3586640T2 DE3586640T2 (de) 1993-01-07

Family

ID=24536636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853586640 Expired - Fee Related DE3586640T2 (de) 1984-07-20 1985-07-08 Einstufiger test fuer proteasehemstoffe.

Country Status (4)

Country Link
EP (1) EP0168738B1 (de)
JP (1) JPS6137100A (de)
CA (1) CA1254119A (de)
DE (1) DE3586640T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531778A1 (de) * 1985-09-06 1987-03-12 Behringwerke Ag Verfahren zur bestimmung von proteaseinhibitoren
SE8702556D0 (sv) * 1987-06-18 1987-06-18 Kabivitrum Ab Bestemning av vid proteolys aktiva komponenter
US5312745A (en) * 1987-06-18 1994-05-17 Chromogenix Ab Determination of components active in proteolysis
EP0421109A3 (en) * 1989-09-11 1992-01-08 American Cyanamid Company Screening methods for protease inhibitors
ATE200107T1 (de) * 1990-10-15 2001-04-15 Tecnogen Scpa Verfahren zur feststellung von proteolitischen wirkungen und/oder deren inhibitoren
GB9100833D0 (en) * 1991-01-15 1991-02-27 Univ Alberta Methods for assaying proteinases and proteinase inhibitors
JPH078298A (ja) * 1993-06-28 1995-01-13 Nippon Shoji Kk アンチトロンビンｉｉｉ活性の測定方法および該測定用試薬キット
EP0814167A1 (de) * 1996-06-21 1997-12-29 Kabushiki Kaisha Kyoto Daiichi Kagaku Eine Methode zur Messung der Konzentration von Proteaseinhibitoren, Testsatz zur Verwendung bei einer solchen Methode und Methode zum Auflösen eines Substrats
JP3626982B2 (ja) * 1997-08-29 2005-03-09 アークレイ株式会社 タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
IL140994A (en) * 2000-05-15 2005-12-18 Bayer Ag Urinary trypsin inhibitor assay containing a chelating agent
EP2484775A1 (de) * 2011-02-07 2012-08-08 Siemens Healthcare Diagnostics Products GmbH Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2446317A1 (fr) * 1979-01-12 1980-08-08 Solvay Granules complexes contenant des substances proteiniques actives et procedes pour leur fabrication, leur utilisation, et leur regeneration
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
US4473639A (en) * 1982-09-15 1984-09-25 Miles Laboratories, Inc. Reagent strip test for antithrombin-III
FI68262C (fi) * 1982-12-17 1985-08-12 Labsystems Oy Foerfarande foer konstatering av juverinflammation
US4543335A (en) * 1982-12-20 1985-09-24 Miles Laboratories, Inc. Device and method for the quantitative determination of heparin in mammalian blood plasma

Also Published As

Publication number Publication date
CA1254119A (en) 1989-05-16
EP0168738A2 (de) 1986-01-22
JPS6137100A (ja) 1986-02-21
EP0168738A3 (en) 1988-08-03
EP0168738B1 (de) 1992-09-16
DE3586640T2 (de) 1993-01-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee