DE3583287D1 - Substituierte isochinolinsulfonyl-verbindungen. - Google Patents

Substituierte isochinolinsulfonyl-verbindungen.

Info

Publication number
DE3583287D1
DE3583287D1 DE8585116520T DE3583287T DE3583287D1 DE 3583287 D1 DE3583287 D1 DE 3583287D1 DE 8585116520 T DE8585116520 T DE 8585116520T DE 3583287 T DE3583287 T DE 3583287T DE 3583287 D1 DE3583287 D1 DE 3583287D1
Authority
DE
Germany
Prior art keywords
isochinolinsulfonyl
substituted
compounds
substituted isochinolinsulfonyl
isochinolinsulfonyl compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585116520T
Other languages
English (en)
Inventor
Hiroyoshi Hidaka
Takanori Sone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP27390884A external-priority patent/JPS61152658A/ja
Priority claimed from JP6851285A external-priority patent/JPS61227581A/ja
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE3583287D1 publication Critical patent/DE3583287D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8585116520T 1984-12-27 1985-12-23 Substituierte isochinolinsulfonyl-verbindungen. Expired - Lifetime DE3583287D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27390884A JPS61152658A (ja) 1984-12-27 1984-12-27 置換されたイソキノリンスルホンアミド誘導体
JP6851285A JPS61227581A (ja) 1985-04-02 1985-04-02 血管拡張剤

Publications (1)

Publication Number Publication Date
DE3583287D1 true DE3583287D1 (de) 1991-07-25

Family

ID=26409724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585116520T Expired - Lifetime DE3583287D1 (de) 1984-12-27 1985-12-23 Substituierte isochinolinsulfonyl-verbindungen.

Country Status (2)

Country Link
EP (1) EP0187371B1 (de)
DE (1) DE3583287D1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0667926B2 (ja) * 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
US4857301A (en) * 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
US5245034A (en) * 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
GB2248235B (en) * 1988-12-26 1993-03-31 Hiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
CA2005741C (en) * 1988-12-26 1998-06-02 Hiroyoshi Hidaka Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity
FR2679907B1 (fr) * 1991-07-31 1995-01-20 Adir Nouveaux n-[(isoquinolein-5 yl)sulfonyl] azacycloalcanes, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JP3176619B2 (ja) * 1991-09-05 2001-06-18 ファルノ−ヴェトロファルム ゲゼルシャフト ミット ベシュレンクテル ハフツング 芳香族スルホンアミド化合物、阻害剤及びそれを含有する医薬組成物
JP2893029B2 (ja) * 1992-08-10 1999-05-17 旭化成工業株式会社 心臓保護剤
CA2263425C (en) 1996-08-12 2008-09-30 Yoshitomi Pharmaceutical Industries Ltd. Pharmaceutical agent containing rho kinase inhibitor
WO1999000117A2 (en) * 1997-06-27 1999-01-07 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
AU4990599A (en) * 1998-07-14 2000-02-07 Brigham And Women's Hospital Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
JP4260370B2 (ja) * 1998-08-10 2009-04-30 旭化成ファーマ株式会社 塩酸ファスジルの経口徐放性製剤
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
EP1064944A1 (de) * 1999-06-25 2001-01-03 Schering Aktiengesellschaft Protein-Kinase N Hemmer enthaltend Fasudil
DE19934272A1 (de) * 1999-07-21 2001-01-25 Bayer Ag Neue antivirale Mittel
EP1426051B1 (de) * 2001-09-11 2008-07-16 Asahi Kasei Pharma Corporation Medizinische zusammensetzung zur prävention oder behandlung von zerebrovaskulären störungen
US7645878B2 (en) 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
WO2004096222A1 (en) * 2003-04-30 2004-11-11 Switch Biotech Ag Use of 1-(5-isoquinolinesulfonyl)homopiperazine, its active metabolites, isomers and salts for treating and preventing hypopigmentary disorders
EP1479386A1 (de) * 2003-04-30 2004-11-24 Switch Biotech Aktiengesellschaft Verwendung von Isochinolin-Derivaten zur Behandlung und Prophylaxe von Pigmentierungsstörungen
WO2007120955A2 (en) 2006-01-27 2007-10-25 Translational Genomics Research Institute Genes affecting human memory performance
CA2753679C (en) 2009-02-27 2021-03-02 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
EP2332917B1 (de) 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Verbindungen zur PIM-Kinasehemmung und zur Behandlung von Malignitäten
CN101962379B (zh) * 2010-09-28 2013-02-27 山西普德药业股份有限公司 一种磺酰基异喹啉衍生物的精制方法
CN101973982A (zh) * 2010-10-09 2011-02-16 河南省健康伟业医药科技有限公司 一种盐酸法舒地尔的生产方法
CN102060844B (zh) * 2010-12-28 2014-05-28 天津红日药业股份有限公司 一种法舒地尔的晶型ⅳ及其制备方法和用途
CN102060845B (zh) * 2010-12-28 2013-07-03 天津红日药业股份有限公司 一种法舒地尔的晶型ⅲ及其制备方法和用途
JP6339998B2 (ja) 2012-04-24 2018-06-06 ダン エス． カウフマン， 幹細胞よりナチュラルキラー細胞を発生させる方法
CN102633779B (zh) * 2012-04-26 2014-01-22 齐鲁制药有限公司 法舒地尔乙酸盐及其制备方法和应用
JP2016520291A (ja) 2013-03-14 2016-07-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ｉｎｖｉｔｒｏでの内側神経節隆起前駆細胞の作製
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
CN104327052A (zh) * 2014-10-20 2015-02-04 郑州四环医药用品有限公司 一种高纯度盐酸法舒地尔的制备方法
GB2548740A (en) 2014-11-25 2017-09-27 Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
WO2019015608A1 (zh) * 2017-07-19 2019-01-24 南京明德新药研发股份有限公司 异喹啉磺酰衍生物及其应用
CN111116555B (zh) * 2018-10-30 2023-06-02 北京盈科瑞创新药物研究有限公司 一种Rho激酶抑制剂及其制备方法和应用
CA3236332A1 (en) 2021-10-30 2023-05-04 Ziev B. Moses Treatments for disturbed cerebral homeostasis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPS5993054A (ja) * 1982-11-18 1984-05-29 Asahi Chem Ind Co Ltd イソキノリンスルホン酸アミド誘導体

Also Published As

Publication number Publication date
EP0187371A2 (de) 1986-07-16
EP0187371B1 (de) 1991-06-19
EP0187371A3 (en) 1986-12-17

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Legal Events

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