DE3580227D1 - Leukotrien-antagonisten, ihre herstellung und verwendung und pharmazeutische zusammensetzungen, die sie enthalten, und deren herstellung. - Google Patents

Leukotrien-antagonisten, ihre herstellung und verwendung und pharmazeutische zusammensetzungen, die sie enthalten, und deren herstellung.

Info

Publication number
DE3580227D1
DE3580227D1 DE8585306077T DE3580227T DE3580227D1 DE 3580227 D1 DE3580227 D1 DE 3580227D1 DE 8585306077 T DE8585306077 T DE 8585306077T DE 3580227 T DE3580227 T DE 3580227T DE 3580227 D1 DE3580227 D1 DE 3580227D1
Authority
DE
Germany
Prior art keywords
production
contain
pharmaceutical compositions
leukotria
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585306077T
Other languages
English (en)
Inventor
Robert N Young
Joshua Rokach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of DE3580227D1 publication Critical patent/DE3580227D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
DE8585306077T 1984-08-30 1985-08-27 Leukotrien-antagonisten, ihre herstellung und verwendung und pharmazeutische zusammensetzungen, die sie enthalten, und deren herstellung. Expired - Lifetime DE3580227D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/645,596 US4666928A (en) 1984-08-30 1984-08-30 Propylphenoxy pyridine carboxylates as leukotriene antagonists

Publications (1)

Publication Number Publication Date
DE3580227D1 true DE3580227D1 (de) 1990-11-29

Family

ID=24589660

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585306077T Expired - Lifetime DE3580227D1 (de) 1984-08-30 1985-08-27 Leukotrien-antagonisten, ihre herstellung und verwendung und pharmazeutische zusammensetzungen, die sie enthalten, und deren herstellung.

Country Status (5)

Country Link
US (1) US4666928A (de)
EP (1) EP0174770B1 (de)
JP (1) JPS6160656A (de)
CA (1) CA1245655A (de)
DE (1) DE3580227D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
US4845108A (en) * 1984-08-30 1989-07-04 Merck Frosst Canada, Inc. Certain pyridyl derivatives useful as leukotriene antagonists
EP0270690B1 (de) * 1986-06-21 1991-05-15 Dainippon Ink And Chemicals, Inc. Arzneimittel zur behandlung und prophylaxe von leber- und nierenkrankheiten
EP0516069B1 (de) * 1991-05-31 1996-04-24 Sumitomo Pharmaceuticals Company, Limited Leukotrien-B4-Antagonisten
WO2001022791A2 (en) * 1999-09-28 2001-04-05 Panacea Biotec Limited Controlled release compositions comprising nimesulide
CA2574956A1 (en) * 2004-07-30 2006-02-09 Merck & Co., Inc. Heterocyclic acetophenone potentiators of metabotropic glutamate receptors
PL1817301T3 (pl) 2004-11-22 2012-08-31 Lilly Co Eli Związki wzmacniające receptory glutaminianu
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193995A (en) * 1972-05-05 1980-03-18 Merck Sharp & Dohme (I.A.) Corp. 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
US4219477A (en) * 1977-12-06 1980-08-26 Nippon Chemiphar Company Limited Penicillin derivatives
GB2058785B (en) * 1979-09-05 1983-05-25 Glaxo Group Ltd Phenol derivatives
PT73640B (en) * 1980-09-17 1983-10-19 Merck & Co Inc Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase

Also Published As

Publication number Publication date
EP0174770B1 (de) 1990-10-24
JPS6160656A (ja) 1986-03-28
US4666928A (en) 1987-05-19
EP0174770A1 (de) 1986-03-19
CA1245655A (en) 1988-11-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee