DE3569244D1 - Process for n-demethylating morphinane alkaloids - Google Patents

Process for n-demethylating morphinane alkaloids

Info

Publication number
DE3569244D1
DE3569244D1 DE8585107895T DE3569244T DE3569244D1 DE 3569244 D1 DE3569244 D1 DE 3569244D1 DE 8585107895 T DE8585107895 T DE 8585107895T DE 3569244 T DE3569244 T DE 3569244T DE 3569244 D1 DE3569244 D1 DE 3569244D1
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
carbon atoms
benzoyloxy
acyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585107895T
Other languages
German (de)
English (en)
Inventor
Sandor Dr Hosztafi
Tibor Dr Timar
Geb Vajda Julianna Nagy
Geb Orban Ilona Fabian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkaloida Chemical Co Zrt
Original Assignee
Alkaloida Chemical Co Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Chemical Co Zrt filed Critical Alkaloida Chemical Co Zrt
Application granted granted Critical
Publication of DE3569244D1 publication Critical patent/DE3569244D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Finger-Pressure Massage (AREA)
  • Stringed Musical Instruments (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Photolithography (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Cephalosporin Compounds (AREA)
DE8585107895T 1984-07-17 1985-06-26 Process for n-demethylating morphinane alkaloids Expired DE3569244D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842774A HU197750B (en) 1984-07-17 1984-07-17 Process for n-demethylation of morphine alkaloids

Publications (1)

Publication Number Publication Date
DE3569244D1 true DE3569244D1 (en) 1989-05-11

Family

ID=10961043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585107895T Expired DE3569244D1 (en) 1984-07-17 1985-06-26 Process for n-demethylating morphinane alkaloids

Country Status (18)

Country Link
EP (1) EP0168686B1 (OSRAM)
JP (1) JPS6193184A (OSRAM)
AT (1) ATE41933T1 (OSRAM)
BG (1) BG44029A3 (OSRAM)
CS (1) CS251792B2 (OSRAM)
DD (1) DD235639A5 (OSRAM)
DE (1) DE3569244D1 (OSRAM)
DK (1) DK322385A (OSRAM)
ES (1) ES8603716A1 (OSRAM)
FI (1) FI81583C (OSRAM)
HU (1) HU197750B (OSRAM)
IL (2) IL75509A0 (OSRAM)
IN (1) IN166255B (OSRAM)
NO (1) NO161915C (OSRAM)
PL (1) PL254552A1 (OSRAM)
RO (1) RO91516B (OSRAM)
SU (1) SU1398776A3 (OSRAM)
YU (1) YU45264B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101896463B (zh) * 2007-12-17 2016-08-24 马林克罗特有限公司 制备(+)阿片类的方法和化合物
EP2222643B1 (en) * 2007-12-17 2019-03-20 SpecGx LLC Sinomenine derivatives and processes for their synthesis
DE112010001980T8 (de) * 2009-05-12 2012-11-08 Board Of Regents, The University Of Texas System Synthese von Morphin und verwandten Derivaten
PL2593095T3 (pl) * 2010-07-16 2019-12-31 Mallinckrodt Llc (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania
PL2753622T3 (pl) 2011-09-08 2016-07-29 SpecGx LLC Wytwarzanie alkaloidów bez oddzielania związków pośrednich

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA948198A (en) * 1967-08-04 1974-05-28 Gerhard Walther Production of cyclic amino compounds
DE2254298A1 (de) * 1972-11-06 1974-05-16 Boehringer Sohn Ingelheim Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon

Also Published As

Publication number Publication date
FI81583C (fi) 1990-11-12
CS251792B2 (en) 1987-08-13
HUT38645A (en) 1986-06-30
DD235639A5 (de) 1986-05-14
YU117485A (en) 1988-04-30
RO91516A (ro) 1987-06-30
EP0168686B1 (de) 1989-04-05
IL78503A (en) 1990-01-18
SU1398776A3 (ru) 1988-06-15
HU197750B (en) 1989-05-29
DK322385D0 (da) 1985-07-15
FI852779L (fi) 1986-01-18
ES8603716A1 (es) 1986-01-16
YU45264B (en) 1992-05-28
IN166255B (OSRAM) 1990-03-31
IL75509A0 (en) 1985-10-31
FI81583B (fi) 1990-07-31
FI852779A0 (fi) 1985-07-15
EP0168686A1 (de) 1986-01-22
PL254552A1 (en) 1986-07-15
NO161915B (no) 1989-07-03
JPS6193184A (ja) 1986-05-12
DK322385A (da) 1986-01-18
ES544385A0 (es) 1986-01-16
NO852838L (no) 1986-01-20
BG44029A3 (en) 1988-09-15
CS528085A2 (en) 1986-12-18
NO161915C (no) 1989-10-11
RO91516B (ro) 1987-07-01
ATE41933T1 (de) 1989-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee