DE3569115D1 - Cephalosporin derivatives, process for their preparation and their antibiotic application - Google Patents
Cephalosporin derivatives, process for their preparation and their antibiotic applicationInfo
- Publication number
- DE3569115D1 DE3569115D1 DE8585401837T DE3569115T DE3569115D1 DE 3569115 D1 DE3569115 D1 DE 3569115D1 DE 8585401837 T DE8585401837 T DE 8585401837T DE 3569115 T DE3569115 T DE 3569115T DE 3569115 D1 DE3569115 D1 DE 3569115D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- defined above
- cyclohexylene
- phenylene
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- 230000003115 biocidal effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000002947 alkylene group Chemical group 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 7
- -1 2-piperidyl Chemical group 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 229910052717 sulfur Chemical group 0.000 abstract 6
- 125000004434 sulfur atom Chemical group 0.000 abstract 6
- 125000003277 amino group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 abstract 4
- 125000004955 1,4-cyclohexylene group Chemical group [H]C1([H])C([H])([H])C([H])([*:1])C([H])([H])C([H])([H])C1([H])[*:2] 0.000 abstract 4
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical group OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 abstract 1
- IPNPIHIZVLFAFP-UHFFFAOYSA-N phosphorus tribromide Chemical compound BrP(Br)Br IPNPIHIZVLFAFP-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8414878A FR2570702B1 (fr) | 1984-09-27 | 1984-09-27 | Derives des cephalosporines, procedes d'obtention et leur application a titre d'antibiotiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3569115D1 true DE3569115D1 (en) | 1989-05-03 |
Family
ID=9308149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585401837T Expired DE3569115D1 (en) | 1984-09-27 | 1985-09-23 | Cephalosporin derivatives, process for their preparation and their antibiotic application |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4950661A (de) |
| EP (1) | EP0178980B1 (de) |
| JP (1) | JPS6185393A (de) |
| KR (1) | KR860002513A (de) |
| AT (1) | ATE41777T1 (de) |
| AU (1) | AU573034B2 (de) |
| CA (1) | CA1281317C (de) |
| DE (1) | DE3569115D1 (de) |
| DK (1) | DK436285A (de) |
| ES (2) | ES8609342A1 (de) |
| FR (1) | FR2570702B1 (de) |
| GR (1) | GR852358B (de) |
| IL (1) | IL76418A (de) |
| NZ (1) | NZ213618A (de) |
| PT (1) | PT81191B (de) |
| ZA (1) | ZA857342B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
| ZA874696B (en) * | 1986-07-03 | 1988-01-04 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Acyl derivatives |
| ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
| FR2621589B1 (fr) * | 1987-10-08 | 1990-03-02 | Sanofi Sa | Derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5250725A (en) * | 1986-11-20 | 1993-10-05 | Elf Sanofi | Aromatic acid intermediates |
| FR2607135B1 (fr) * | 1986-11-20 | 1989-04-28 | Sanofi Sa | Nouveaux derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5189157A (en) * | 1987-06-16 | 1993-02-23 | Hoffmann La Roche Inc. | Antibacterial cephalosporin compounds |
| JP2703964B2 (ja) * | 1987-11-10 | 1998-01-26 | ジ・アップジョン・カンパニー | セファロスポリン抗生物質類 |
| US5223496A (en) * | 1987-11-10 | 1993-06-29 | The Upjohn Company | Cephalosporin antibiotics |
| NZ227470A (en) * | 1987-12-28 | 1991-06-25 | Hoffmann La Roche | Acyl derivatives of substituted cephem compounds; pharmaceutical compositions and methods for preparation and treatment |
| CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
| US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
| US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1279402A (en) * | 1968-06-14 | 1972-06-28 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
| US3769277A (en) * | 1970-01-23 | 1973-10-30 | Glaxo Lab Ltd | Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group |
| BE789817A (fr) * | 1971-10-07 | 1973-04-06 | Glaxo Lab Ltd | Perfectionnements aux composes de cephalosporine |
| US4304770A (en) * | 1976-04-12 | 1981-12-08 | Fujisawa Pharmaceutical Co., Ltd. | Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof |
| US4223133A (en) * | 1979-02-01 | 1980-09-16 | Eli Lilly And Company | Cephalosporin reduction process |
| FR2479229B1 (fr) * | 1980-03-26 | 1986-01-17 | Clin Midy | Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives |
| GR75711B (de) * | 1980-06-30 | 1984-08-02 | Sanofi Sa | |
| FR2501209B1 (fr) * | 1981-03-03 | 1986-07-04 | Sanofi Sa | Nouveaux derives des cephalosporines et medicaments antibiotiques contenant lesdits derives |
| FR2546520B1 (fr) * | 1983-05-27 | 1985-08-30 | Sanofi Sa | Nouveaux composes antibiotiques derives des cephalosporines |
-
1984
- 1984-09-27 FR FR8414878A patent/FR2570702B1/fr not_active Expired
-
1985
- 1985-09-17 CA CA000490887A patent/CA1281317C/en not_active Expired - Fee Related
- 1985-09-19 AU AU47601/85A patent/AU573034B2/en not_active Ceased
- 1985-09-19 IL IL76418A patent/IL76418A/xx not_active IP Right Cessation
- 1985-09-23 DE DE8585401837T patent/DE3569115D1/de not_active Expired
- 1985-09-23 AT AT85401837T patent/ATE41777T1/de active
- 1985-09-23 EP EP85401837A patent/EP0178980B1/de not_active Expired
- 1985-09-24 ZA ZA857342A patent/ZA857342B/xx unknown
- 1985-09-25 PT PT81191A patent/PT81191B/pt not_active IP Right Cessation
- 1985-09-26 NZ NZ213618A patent/NZ213618A/en unknown
- 1985-09-26 ES ES547955A patent/ES8609342A1/es not_active Expired
- 1985-09-26 GR GR852358A patent/GR852358B/el unknown
- 1985-09-26 KR KR1019850007110A patent/KR860002513A/ko not_active Withdrawn
- 1985-09-26 DK DK436285A patent/DK436285A/da not_active Application Discontinuation
- 1985-09-27 JP JP60214382A patent/JPS6185393A/ja active Pending
-
1986
- 1986-04-30 ES ES554534A patent/ES8704500A1/es not_active Expired
-
1988
- 1988-04-28 US US07/188,073 patent/US4950661A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL76418A0 (en) | 1986-01-31 |
| ES8609342A1 (es) | 1986-09-01 |
| DK436285D0 (da) | 1985-09-26 |
| AU573034B2 (en) | 1988-05-26 |
| ES8704500A1 (es) | 1987-04-01 |
| ZA857342B (en) | 1986-05-28 |
| ES547955A0 (es) | 1986-09-01 |
| AU4760185A (en) | 1986-04-24 |
| GR852358B (de) | 1986-01-28 |
| EP0178980A1 (de) | 1986-04-23 |
| CA1281317C (en) | 1991-03-12 |
| EP0178980B1 (de) | 1989-03-29 |
| NZ213618A (en) | 1988-03-30 |
| FR2570702A1 (fr) | 1986-03-28 |
| ATE41777T1 (de) | 1989-04-15 |
| DK436285A (da) | 1986-03-28 |
| US4950661A (en) | 1990-08-21 |
| FR2570702B1 (fr) | 1987-01-09 |
| IL76418A (en) | 1989-06-30 |
| JPS6185393A (ja) | 1986-04-30 |
| PT81191A (fr) | 1985-10-01 |
| PT81191B (pt) | 1987-10-20 |
| KR860002513A (ko) | 1986-04-26 |
| ES554534A0 (es) | 1987-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |