DE3481419D1 - Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. - Google Patents

Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Info

Publication number
DE3481419D1
DE3481419D1 DE8484109811T DE3481419T DE3481419D1 DE 3481419 D1 DE3481419 D1 DE 3481419D1 DE 8484109811 T DE8484109811 T DE 8484109811T DE 3481419 T DE3481419 T DE 3481419T DE 3481419 D1 DE3481419 D1 DE 3481419D1
Authority
DE
Germany
Prior art keywords
gallen
contain
production
acid derivatives
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484109811T
Other languages
English (en)
Inventor
Virginio Castagnola
E Giuliano Frigerio
Roberto Pellicciari
Aldo Roda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gipharmex SpA
Original Assignee
Gipharmex SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gipharmex SpA filed Critical Gipharmex SpA
Application granted granted Critical
Publication of DE3481419D1 publication Critical patent/DE3481419D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8484109811T 1983-08-18 1984-08-17 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. Expired - Fee Related DE3481419D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8322572A IT1212835B (it) 1983-08-18 1983-08-18 Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Publications (1)

Publication Number Publication Date
DE3481419D1 true DE3481419D1 (de) 1990-04-05

Family

ID=11197972

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484109811T Expired - Fee Related DE3481419D1 (de) 1983-08-18 1984-08-17 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Country Status (7)

Country Link
US (1) US4981983A (de)
EP (1) EP0135782B1 (de)
JP (1) JPH0144197B2 (de)
AT (1) ATE50583T1 (de)
DE (1) DE3481419D1 (de)
ES (1) ES535267A0 (de)
IT (1) IT1212835B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196377B (it) * 1984-12-21 1988-11-16 Lehner Ag Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
HU206367B (en) * 1988-04-30 1992-10-28 Sandoz Ag Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
IT1255449B (it) * 1992-06-30 1995-10-31 Fabio Berlati Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
IT1270853B (it) * 1993-05-20 1997-05-13 Sanofi Elf Procedimento per la preparazione di derivati taurocolanici
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
US6350738B1 (en) 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
DK1392714T3 (da) 2001-03-12 2006-01-09 Intercept Pharmaceuticals Inc Steroider som agonister for FXR
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
ES2609395T5 (es) 2004-03-12 2021-08-06 Intercept Pharmaceuticals Inc Tratamiento de la fibrosis usando ligandos de Fxr
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
AU2008209566C1 (en) * 2007-01-19 2013-02-14 Intercept Pharmaceuticals, Inc. 23-substituted bile acids as TGR5 modulators and methods of use thereof
EP1947108A1 (de) * 2007-01-19 2008-07-23 Intercept Pharmaceuticals, Inc. TGR5-Modulatoren und Anwendungsverfahren dafür
EP2324046B1 (de) 2008-07-30 2014-09-03 Intercept Pharmaceuticals, Inc. Tgr5-modulatoren und anwendungsverfahren dafür
SI2698375T1 (sl) 2008-11-19 2018-10-30 Intercept Pharmaceuticals, Inc. Modulatorji TGR5 in njihova uporaba
JP2015521621A (ja) 2012-06-19 2015-07-30 インターセプト ファーマシューティカルズ， インコーポレイテッド オベチコール酸の調製、使用および固体形態
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997664A (en) * 1971-02-09 1976-12-14 Sandoz, Inc. Substituted carbinol derivatives
US4104285A (en) * 1977-04-22 1978-08-01 Hoffmann-La Roche Inc. Taurine and glycine derivatives
US4117121A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. Method of increasing bile flow and decreasing lipid levels
NL8003999A (nl) * 1980-07-11 1982-02-01 Akzo Nv Nieuwe 8 alfa-oestra-1,3,5(10)-trieen-derivaten en de bereiding daarvan.
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3260539D1 (en) * 1981-05-29 1984-09-13 Glaxo Group Ltd 11-alpha-amino-androstanes
EP0066468B1 (de) * 1981-05-29 1984-07-25 Glaxo Group Limited 11-Alpha-Amino-androstane
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3366932D1 (en) * 1982-07-29 1986-11-20 Lehner Ag New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
FR2610933B1 (fr) * 1987-02-18 1989-06-09 Roussel Uclaf Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
IT1212835B (it) 1989-11-30
ATE50583T1 (de) 1990-03-15
JPH0144197B2 (en) 1989-09-26
US4981983A (en) 1991-01-01
ES8506047A1 (es) 1985-06-16
ES535267A0 (es) 1985-06-16
IT8322572A0 (it) 1983-08-18
JPS6075495A (ja) 1985-04-27
EP0135782B1 (de) 1990-02-28
EP0135782A3 (en) 1985-12-11
EP0135782A2 (de) 1985-04-03

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Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER PATENTINHABER LAUTET RICHTIG: GIULIANI S.P.A., MAILAND/MILANO, IT

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee