DE3478605D1 - 21-hydroxycorticosteroid esters, and compositions containing them - Google Patents

21-hydroxycorticosteroid esters, and compositions containing them

Info

Publication number
DE3478605D1
DE3478605D1 DE8484300332T DE3478605T DE3478605D1 DE 3478605 D1 DE3478605 D1 DE 3478605D1 DE 8484300332 T DE8484300332 T DE 8484300332T DE 3478605 T DE3478605 T DE 3478605T DE 3478605 D1 DE3478605 D1 DE 3478605D1
Authority
DE
Germany
Prior art keywords
hydroxycorticosteroid
esters
compositions containing
compositions
hydroxycorticosteroid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484300332T
Other languages
German (de)
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE3478605D1 publication Critical patent/DE3478605D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484300332T 1983-01-21 1984-01-19 21-hydroxycorticosteroid esters, and compositions containing them Expired DE3478605D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/459,742 US4472392A (en) 1983-01-21 1983-01-21 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
DE3478605D1 true DE3478605D1 (en) 1989-07-13

Family

ID=23825979

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484300332T Expired DE3478605D1 (en) 1983-01-21 1984-01-19 21-hydroxycorticosteroid esters, and compositions containing them

Country Status (8)

Country Link
US (1) US4472392A (enExample)
EP (1) EP0120557B1 (enExample)
JP (1) JPS59137500A (enExample)
CA (1) CA1199908A (enExample)
DE (1) DE3478605D1 (enExample)
HK (1) HK43993A (enExample)
MX (1) MX9203197A (enExample)
ZA (1) ZA838826B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US5446177A (en) * 1984-12-28 1995-08-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
AU2138988A (en) * 1987-07-16 1989-02-13 Upjohn Company, The Amine salts of alkane-1,n-dicarboxylic acid mono- (2-sulfato-ethyl)amides
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
EP1562627A4 (en) * 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
EP1663999A2 (en) * 2003-08-29 2006-06-07 Ranbaxy Laboratories, Ltd. Inhibitors of phosphodiesterase type-iv
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
EP1948167A1 (en) * 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Compositions of phosphodiesterase type iv inhibitors
MX2009003100A (es) * 2006-09-22 2009-05-11 Ranbaxy Lab Ltd Inhibidores de fosfodiesterasa tipo iv.
WO2008035316A2 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
JP5607930B2 (ja) 2006-10-12 2014-10-15 ビーエイチアイ リミテッド パートナーシップ ３−アミノ−１−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
AU2008224541B2 (en) 2007-03-14 2013-08-22 Sun Pharmaceutical Industries Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
US20090306579A1 (en) 2008-02-25 2009-12-10 Eyegate Pharmaceuticals, Inc. Delivery of corticosteroids through iontophoresis
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
WO2022037704A1 (zh) * 2020-08-21 2022-02-24 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3171846A (en) * 1962-07-10 1965-03-02 Erba Carlo Spa Prednisolone-21-double esters
NL124139C (enExample) * 1964-11-04
FR6590M (enExample) * 1967-10-31 1968-12-30
US3609712A (en) * 1969-01-15 1971-09-28 Ibm Insulated gate field effect transistor memory array
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SU818489A3 (ru) * 1978-10-04 1981-03-30 Шеринг Аг (Фирма) Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй
DE2848423A1 (de) * 1978-11-08 1980-05-29 Merck Patent Gmbh Hydrocortisonester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
US4472392A (en) 1984-09-18
JPH0226639B2 (enExample) 1990-06-12
EP0120557A3 (en) 1985-02-06
HK43993A (en) 1993-05-14
MX9203197A (es) 1992-09-01
ZA838826B (en) 1984-07-25
EP0120557A2 (en) 1984-10-03
JPS59137500A (ja) 1984-08-07
EP0120557B1 (en) 1989-06-07
CA1199908A (en) 1986-01-28

Similar Documents

Publication Publication Date Title
AR244895A1 (es) Una composicion sensible a la radiacion, un elemento sensible a la radiacion que la comprende y procedimiento para producir una imagen litografica en dicho elemento.
GB8406898D0 (en) Bis-maleimide-epoxy compositions
GB8417625D0 (en) Compounds and compositions
DE3478605D1 (en) 21-hydroxycorticosteroid esters, and compositions containing them
GB8417624D0 (en) Compounds and compositions
GB8417626D0 (en) Compounds and compositions
DE3479891D1 (en) 21-hydroxycorticosteroid esters, and compositions containing them
ZA84734B (en) Compositions
DE3460573D1 (en) Aluminium-filled compositions
GB8334423D0 (en) Composition
DE3374569D1 (en) Siloxane-polyester compositions and use thereof
GB8502534D0 (en) Compositions
DE3367105D1 (en) 21-hydroxycorticosteroid esters, and compositions containing them
NZ209095A (en) Piperidinoquinazolines and pharmaceutical compositions
KR920009397B1 (en) Bitumenous compositions
IL73471A (en) N,n-di-n-propyl-4-hydroxy-3-methanesulfonamido-phenethylamine and pharmaceutical compositions containing them
NZ208244A (en) Phenyl-pyrazol-3-ones and pharmaceutical compositions
ZA849896B (en) Fumigating composition
GB8321178D0 (en) Compositions
GB8334422D0 (en) Composition
PH19896A (en) 4-phenyl-tetrahydro-furano-pyridine and pharmaceutical compositions containing them
GB8420001D0 (en) Compositions
GB8412144D0 (en) Compounds and compositions
GB8412145D0 (en) Compounds and compositions
DE3463383D1 (en) 4-alkylindolonaphthyridines and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee