DE3472106D1 - Thieno(2,3-d)pyrimidine derivatives and salts thereof - Google Patents

Thieno(2,3-d)pyrimidine derivatives and salts thereof

Info

Publication number
DE3472106D1
DE3472106D1 DE8484116052T DE3472106T DE3472106D1 DE 3472106 D1 DE3472106 D1 DE 3472106D1 DE 8484116052 T DE8484116052 T DE 8484116052T DE 3472106 T DE3472106 T DE 3472106T DE 3472106 D1 DE3472106 D1 DE 3472106D1
Authority
DE
Germany
Prior art keywords
sup
carbon atoms
salts
alkyl group
pyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484116052T
Other languages
German (de)
English (en)
Inventor
Kunihiro Ninomiya
Issei Nitta
Akihiro Tobe
Mitsuo Egawa
Ryoji Kikumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Chemical Industries Ltd
Application granted granted Critical
Publication of DE3472106D1 publication Critical patent/DE3472106D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484116052T 1984-01-05 1984-12-21 Thieno(2,3-d)pyrimidine derivatives and salts thereof Expired DE3472106D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59000479A JPS60146891A (ja) 1984-01-05 1984-01-05 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩

Publications (1)

Publication Number Publication Date
DE3472106D1 true DE3472106D1 (en) 1988-07-21

Family

ID=11474905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484116052T Expired DE3472106D1 (en) 1984-01-05 1984-12-21 Thieno(2,3-d)pyrimidine derivatives and salts thereof

Country Status (8)

Country Link
US (1) US4695568A (enEXAMPLES)
EP (1) EP0150469B1 (enEXAMPLES)
JP (1) JPS60146891A (enEXAMPLES)
AT (1) ATE35137T1 (enEXAMPLES)
CA (1) CA1224782A (enEXAMPLES)
DE (1) DE3472106D1 (enEXAMPLES)
DK (1) DK165744C (enEXAMPLES)
HU (1) HU191161B (enEXAMPLES)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
US4703120A (en) * 1986-04-28 1987-10-27 Ortho Pharmaceutical Corporation Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
GB8912335D0 (en) * 1989-05-30 1989-07-12 Smithkline Beckman Intercredit Compounds
DE19636769A1 (de) * 1996-09-10 1998-03-12 Basf Ag 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
JPH10298078A (ja) * 1997-05-06 1998-11-10 Mitsubishi Chem Corp 抗不安薬
GB0216027D0 (en) 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
GB0112494D0 (en) * 2001-05-22 2001-07-11 Arachnova Therapeutics Ltd New therapeutic use
ATE424826T1 (de) * 2002-07-10 2009-03-15 Dynogen Pharmaceuticals Inc 4-(2-fluorophenyl)-6-methyl-2(1- piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungen
DE10232750A1 (de) * 2002-07-18 2004-02-05 Basf Ag Verfahren zur Herstellung von macrocyclischen Ketonen durch Dieckmann-Kondensation in der Gasphase
CN1678322A (zh) * 2002-08-29 2005-10-05 阿瑞科诺沃治疗有限公司 (4－(2－氟苯基)－6－甲基－2－(1－哌嗪基)噻吩并[2,3－d]嘧啶的新治疗用途
NZ541008A (en) * 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating functional bowel disorders
DE602004005814T2 (de) * 2003-01-13 2008-01-10 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus
CA2519379A1 (en) * 2003-04-04 2004-10-21 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
WO2005002583A1 (en) * 2003-07-07 2005-01-13 Mitsubishi Pharma Corporation Use of thieno`2,3-d ! pyrimidines for the prophylaxis or treatment of hyperactivity disorder
US20060293309A1 (en) * 2005-03-28 2006-12-28 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
WO2007120445A1 (en) * 2006-03-31 2007-10-25 Dynogen Pharmaceuticals, Inc. SOLUBLE SALTS OF THIENO [2,3-d] PYRIMIDINE DERIVATIVES
WO2008051282A2 (en) * 2006-03-31 2008-05-02 Dynogen Pharmaceuticals, Inc. Crystalline forms of 4-(2-fluorophenyl)-6-methyl-2-(piperazin-1-yl)thieno(2,3-d)pyrimidine
EP2947084B8 (en) * 2013-01-18 2021-03-10 Guangzhou Maxinovel Pharmaceuticals Co. Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883651A (en) * 1969-08-08 1975-05-13 Boehringer Sohn Ingelheim Pharmaceutical compositions containing a 2-(aminoalkylamino)-4-amino-thieno{8 3,2-d{9 pyrimidine and method of use
US4054656A (en) * 1975-09-10 1977-10-18 Mead Johnson & Company Thieno[2,3-d]pyrimidine antiallergic agents
GB1570494A (en) * 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
ZA782648B (en) * 1977-05-23 1979-06-27 Ici Australia Ltd The prevention,control or eradication of infestations of ixodid ticks
US4471117A (en) * 1979-06-21 1984-09-11 Janssen Pharmaceutica N.V. 3,4-Dihydro-2H-pyrimido(2,1-b)benzothiazoles
JPS5692875A (en) * 1979-12-27 1981-07-27 Dainippon Pharmaceut Co Ltd 2-aminoquinazoline derivative
EP0082023A3 (en) * 1981-12-16 1983-07-20 Sankyo Company Limited Thienopyrimidine derivatives, their preparation and their medical use
FR2521144A1 (fr) * 1982-02-08 1983-08-12 Sanofi Sa Nouveaux derives de la piperazinyl-2 phenyl-4 quinazoline possedant des proprietes antidepressives, methode de preparation desdits composes et medicaments en contenant

Also Published As

Publication number Publication date
EP0150469B1 (en) 1988-06-15
EP0150469A1 (en) 1985-08-07
HU191161B (en) 1987-01-28
CA1224782A (en) 1987-07-28
ATE35137T1 (de) 1988-07-15
DK165744B (da) 1993-01-11
JPS60146891A (ja) 1985-08-02
DK617184A (da) 1985-07-06
US4695568A (en) 1987-09-22
DK617184D0 (da) 1984-12-20
JPH0367071B2 (enEXAMPLES) 1991-10-21
HUT37435A (en) 1985-12-28
DK165744C (da) 1993-06-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI KASEI CORP., TOKIO/TOKYO, JP

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee