ATE424826T1 - 4-(2-fluorophenyl)-6-methyl-2(1- piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungen - Google Patents
4-(2-fluorophenyl)-6-methyl-2(1- piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungenInfo
- Publication number
- ATE424826T1 ATE424826T1 AT03762820T AT03762820T ATE424826T1 AT E424826 T1 ATE424826 T1 AT E424826T1 AT 03762820 T AT03762820 T AT 03762820T AT 03762820 T AT03762820 T AT 03762820T AT E424826 T1 ATE424826 T1 AT E424826T1
- Authority
- AT
- Austria
- Prior art keywords
- thieno
- piperazinyl
- fluorophenyl
- pyrimidine
- methyl
- Prior art date
Links
- FVIVKIGLBDRWNR-UHFFFAOYSA-N 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine Chemical compound N1=C2SC(C)=CC2=C(C=2C(=CC=CC=2)F)N=C1N1CCNCC1 FVIVKIGLBDRWNR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000968 intestinal effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0216027.3A GB0216027D0 (en) | 2002-07-10 | 2002-07-10 | New therapeutic use |
| GB0304648A GB0304648D0 (en) | 2003-02-28 | 2003-02-28 | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperzinyl)thieno(2,3-D)pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE424826T1 true ATE424826T1 (de) | 2009-03-15 |
Family
ID=30117107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03762820T ATE424826T1 (de) | 2002-07-10 | 2003-07-09 | 4-(2-fluorophenyl)-6-methyl-2(1- piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1519728B1 (de) |
| JP (1) | JP2005533829A (de) |
| CN (1) | CN1668307A (de) |
| AT (1) | ATE424826T1 (de) |
| AU (1) | AU2003255712B2 (de) |
| BR (1) | BR0312511A (de) |
| CA (1) | CA2491836C (de) |
| DE (1) | DE60326585D1 (de) |
| WO (1) | WO2004004734A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0216027D0 (en) | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| JP2006516977A (ja) | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ，インコーポレイテッド | 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法 |
| JP2006516976A (ja) * | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ，インコーポレイテッド | 機能性腸障害を処置する方法 |
| EP1539181B1 (de) | 2003-04-04 | 2007-06-27 | Dynogen Pharmaceuticals Inc. | Methode zur behandlung von erkrankungen der unteren harnwege |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60146891A (ja) * | 1984-01-05 | 1985-08-02 | Mitsubishi Chem Ind Ltd | 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩 |
| GB9721139D0 (en) * | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| DE10063223A1 (de) * | 2000-12-19 | 2002-06-20 | Merck Patent Gmbh | Pharmazeutische Formulierung enthaltend Thienopyrimidine und Antithrombotica (1) |
-
2003
- 2003-07-09 AT AT03762820T patent/ATE424826T1/de not_active IP Right Cessation
- 2003-07-09 BR BR0312511-4A patent/BR0312511A/pt not_active IP Right Cessation
- 2003-07-09 AU AU2003255712A patent/AU2003255712B2/en not_active Expired - Fee Related
- 2003-07-09 WO PCT/GB2003/002974 patent/WO2004004734A1/en not_active Ceased
- 2003-07-09 CA CA2491836A patent/CA2491836C/en not_active Expired - Fee Related
- 2003-07-09 JP JP2004519012A patent/JP2005533829A/ja active Pending
- 2003-07-09 DE DE60326585T patent/DE60326585D1/de not_active Expired - Lifetime
- 2003-07-09 EP EP03762820A patent/EP1519728B1/de not_active Expired - Lifetime
- 2003-07-09 CN CNA038162903A patent/CN1668307A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1519728B1 (de) | 2009-03-11 |
| CN1668307A (zh) | 2005-09-14 |
| CA2491836C (en) | 2011-01-25 |
| DE60326585D1 (de) | 2009-04-23 |
| BR0312511A (pt) | 2005-04-12 |
| AU2003255712B2 (en) | 2007-03-15 |
| EP1519728A1 (de) | 2005-04-06 |
| WO2004004734A1 (en) | 2004-01-15 |
| JP2005533829A (ja) | 2005-11-10 |
| CA2491836A1 (en) | 2004-01-15 |
| AU2003255712A1 (en) | 2004-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA03010810A (es) | Pirimidinas inhibidoras de cdk, su obtencion y su uso como medicamentos. | |
| JO2534B1 (en) | Pyrimidines carrying alternatives of sulfoximine as CDK and / or VEGF inhibitors and their production and use as pharmaceutical agents | |
| ATE377592T1 (de) | Neurotropische substituierte pyrimidine | |
| ATE433978T1 (de) | 5,7-diaminopyrazolo 4,3-d pyrimidine zur verwendung in der behandlung von bluthochdruck | |
| DE60316013D1 (de) | Heteroaryl-pyrimidinderivate als jak-inhibitoren | |
| EA200500721A1 (ru) | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств | |
| PL377239A1 (pl) | Nowe amino-podstawione pochodne dihydropirymido [4,5-d]-pirymidynonu, ich wytwarzanie i zastosowanie jako środków framaceutycznych | |
| PT1235830E (pt) | Compostos de pirrolo¬2,3-d|pirimidina como inibidores das proteina cinases | |
| DE602004005814D1 (de) | Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus | |
| TW200628452A (en) | Substituted 2-anilinopyrimidines as cell-cycle-kinase or receptor-tyrosine-kinase inhibitors, their production and use as pharmaceutical agents | |
| ES2195785A1 (es) | Nuevos derivados de piridazin-3(2h)-ona. | |
| WO2001066534A3 (en) | Cyclic and bicyclic diamino histamine-3 receptor antagonists | |
| GB0209891D0 (en) | Novel compounds | |
| ATE506353T1 (de) | Die hiv-replikation inhibierende indan- substituierte pyrimidine | |
| ATE316785T1 (de) | Jak-3 hemmer zur behandlung von allergischen störungen | |
| NO20023527D0 (no) | Pyrido(2,3-d)pyrimidin-2,7-diamin kinaseinhibitorer | |
| DK1339406T3 (da) | Piperazinderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf til behandling af lidelser i centralnervesystemet | |
| ATE389655T1 (de) | Pyrimidinderivate | |
| DE60108626D1 (de) | Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer | |
| ATE424826T1 (de) | 4-(2-fluorophenyl)-6-methyl-2(1- piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungen | |
| GB0202265D0 (en) | New therapeutic use | |
| NO20052628L (no) | Nye pyrimidin-4,6-dikarboksamider for selektiv inhibering av kollagenaser | |
| EA200601592A1 (ru) | Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора | |
| ATE414081T1 (de) | Bizyklische heteroaromatische verbindungen als kinase hemmstoffe | |
| GB0216027D0 (en) | New therapeutic use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |