DE3472106D1 - Thieno(2,3-d)pyrimidine derivatives and salts thereof - Google Patents
Thieno(2,3-d)pyrimidine derivatives and salts thereofInfo
- Publication number
- DE3472106D1 DE3472106D1 DE8484116052T DE3472106T DE3472106D1 DE 3472106 D1 DE3472106 D1 DE 3472106D1 DE 8484116052 T DE8484116052 T DE 8484116052T DE 3472106 T DE3472106 T DE 3472106T DE 3472106 D1 DE3472106 D1 DE 3472106D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- carbon atoms
- salts
- alkyl group
- pyrimidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- DDWBRNXDKNIQDY-UHFFFAOYSA-N thieno[2,3-d]pyrimidine Chemical class N1=CN=C2SC=CC2=C1 DDWBRNXDKNIQDY-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59000479A JPS60146891A (ja) | 1984-01-05 | 1984-01-05 | 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3472106D1 true DE3472106D1 (en) | 1988-07-21 |
Family
ID=11474905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484116052T Expired DE3472106D1 (en) | 1984-01-05 | 1984-12-21 | Thieno(2,3-d)pyrimidine derivatives and salts thereof |
Country Status (8)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1307786C (en) * | 1984-12-14 | 1992-09-22 | Keiichi Yokoyama | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
| US4703120A (en) * | 1986-04-28 | 1987-10-27 | Ortho Pharmaceutical Corporation | Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof |
| GB8912335D0 (en) * | 1989-05-30 | 1989-07-12 | Smithkline Beckman Intercredit | Compounds |
| DE19636769A1 (de) * | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| JPH10298078A (ja) * | 1997-05-06 | 1998-11-10 | Mitsubishi Chem Corp | 抗不安薬 |
| GB0112494D0 (en) * | 2001-05-22 | 2001-07-11 | Arachnova Therapeutics Ltd | New therapeutic use |
| GB0216027D0 (en) | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| WO2004004734A1 (en) * | 2002-07-10 | 2004-01-15 | Arachnova Therapeutics Ltd. | 4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-d) pyrimidine in the treatment of functional bowel disorder |
| DE10232750A1 (de) * | 2002-07-18 | 2004-02-05 | Basf Ag | Verfahren zur Herstellung von macrocyclischen Ketonen durch Dieckmann-Kondensation in der Gasphase |
| EP1539172A1 (en) * | 2002-08-29 | 2005-06-15 | Arachnova Therapeutics Ltd. | New therapeutic uses of (4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl) thieno[2,3-d]pyrimidine |
| MXPA05007381A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para el tratamiento de transtornos funcionales del intestino. |
| ES2285407T3 (es) * | 2003-01-13 | 2007-11-16 | Dynogen Pharmaceuticals Inc. | Metodo para el tratamiento de nauseas, vomitos, arcadas o cualquiera de sus combinaciones. |
| DE602004007225T2 (de) * | 2003-04-04 | 2008-03-06 | Dynogen Pharmaceuticals Inc., Waltham | Methode zur behandlung von erkrankungen der unteren harnwege |
| WO2005002583A1 (en) * | 2003-07-07 | 2005-01-13 | Mitsubishi Pharma Corporation | Use of thieno`2,3-d ! pyrimidines for the prophylaxis or treatment of hyperactivity disorder |
| WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| CA2647329A1 (en) * | 2006-03-31 | 2008-05-02 | Dynogen Pharmaceuticals, Inc. | Crystalline forms of 4-(2-fluorophenyl)-6-methyl-2-(piperazin-1-yl)thieno(2,3-d)pyrimidine |
| WO2007120445A1 (en) * | 2006-03-31 | 2007-10-25 | Dynogen Pharmaceuticals, Inc. | SOLUBLE SALTS OF THIENO [2,3-d] PYRIMIDINE DERIVATIVES |
| ES2827233T3 (es) * | 2013-01-18 | 2021-05-20 | Guangzhou Maxinovel Pharmaceuticals Co Ltd | Compuesto heterocíclico de cinco y seis miembros, y método de preparación, composición farmacéutica y uso del mismo |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3883651A (en) * | 1969-08-08 | 1975-05-13 | Boehringer Sohn Ingelheim | Pharmaceutical compositions containing a 2-(aminoalkylamino)-4-amino-thieno{8 3,2-d{9 pyrimidine and method of use |
| US4054656A (en) * | 1975-09-10 | 1977-10-18 | Mead Johnson & Company | Thieno[2,3-d]pyrimidine antiallergic agents |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| US4196207A (en) * | 1977-05-23 | 1980-04-01 | Ici Australia Limited | Process for controlling eradicating or preventing infestations of animals by Ixodid ticks |
| US4471117A (en) * | 1979-06-21 | 1984-09-11 | Janssen Pharmaceutica N.V. | 3,4-Dihydro-2H-pyrimido(2,1-b)benzothiazoles |
| JPS5692875A (en) * | 1979-12-27 | 1981-07-27 | Dainippon Pharmaceut Co Ltd | 2-aminoquinazoline derivative |
| FI824314A7 (fi) * | 1981-12-16 | 1983-06-17 | Sankyo Co | Thienopyrimidiinijohdannaiset, niiden valmistus ja niiden lääketieteellinen käyttö. |
| FR2521144A1 (fr) * | 1982-02-08 | 1983-08-12 | Sanofi Sa | Nouveaux derives de la piperazinyl-2 phenyl-4 quinazoline possedant des proprietes antidepressives, methode de preparation desdits composes et medicaments en contenant |
-
1984
- 1984-01-05 JP JP59000479A patent/JPS60146891A/ja active Granted
- 1984-12-20 DK DK617184A patent/DK165744C/da not_active IP Right Cessation
- 1984-12-21 EP EP84116052A patent/EP0150469B1/en not_active Expired
- 1984-12-21 AT AT84116052T patent/ATE35137T1/de not_active IP Right Cessation
- 1984-12-21 DE DE8484116052T patent/DE3472106D1/de not_active Expired
- 1984-12-24 US US06/685,768 patent/US4695568A/en not_active Expired - Lifetime
- 1984-12-28 CA CA000471183A patent/CA1224782A/en not_active Expired
-
1985
- 1985-01-03 HU HU8513A patent/HU191161B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0367071B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-10-21 |
| EP0150469A1 (en) | 1985-08-07 |
| DK165744B (da) | 1993-01-11 |
| DK617184A (da) | 1985-07-06 |
| HUT37435A (en) | 1985-12-28 |
| US4695568A (en) | 1987-09-22 |
| EP0150469B1 (en) | 1988-06-15 |
| JPS60146891A (ja) | 1985-08-02 |
| ATE35137T1 (de) | 1988-07-15 |
| CA1224782A (en) | 1987-07-28 |
| DK165744C (da) | 1993-06-07 |
| DK617184D0 (da) | 1984-12-20 |
| HU191161B (en) | 1987-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3472106D1 (en) | Thieno(2,3-d)pyrimidine derivatives and salts thereof | |
| EP0163599A3 (en) | Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents | |
| EP0401958A3 (en) | Photochromic compound, composition and use thereof | |
| EP0219876A3 (en) | Antihypertensive agents comprising 2-alkynyladenosines as active ingredients | |
| EP0150937A3 (en) | Dihydropyridazinones | |
| HUT52059A (en) | Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components | |
| IL62110A (en) | Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation | |
| GR3004250T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| AU1739092A (en) | 1-methylcarbapenem derivatives, their preparation and their use as antibiotics | |
| ES8704492A1 (es) | Metodo de preparar derivados de b-carbolin-3-oxadiazolilo | |
| TW429255B (en) | Pyrazine compounds having treatment of central nervous system diseases and disorders | |
| ES2046641T3 (es) | Composicion antitumoral. | |
| MY102310A (en) | New 5-oxy deravatives of tetrahydrofuran | |
| ES8604960A1 (es) | Procedimiento para preparar derivados de 1,6-naftiridina | |
| ES2003086A6 (es) | Procedimiento de obtencion de tienoquinolicinsulfonamidas | |
| EP0347880A3 (en) | Imidazo[2,1-b]benzothiazole compounds and antiulcer compositions containing the same | |
| DE3268541D1 (en) | Benzodioxane-imidazoline compounds, their preparation and use | |
| EP0202086A3 (en) | Hexenoic acids | |
| ES8802425A1 (es) | Procedimiento para preparar derivados de esparteina. | |
| ES8600637A1 (es) | Procedimiento de preparacion de derivados de piperacina | |
| HUT41029A (en) | Process for preparing dioxolo-benzisoxazole derivatives | |
| MY104048A (en) | New allylaminoethylazoles. | |
| PH23966A (en) | Imidazoquinozoline compounds as agent for treatment of nephritis | |
| IL108225A (en) | 2-THIENYLIMIDAZO £2, 1-b| BENZOTHIAZOLE-3-ACETIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| ES2009283A6 (es) | Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MITSUBISHI KASEI CORP., TOKIO/TOKYO, JP |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |