DE3401178A1 - Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegel - Google Patents
Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegelInfo
- Publication number
- DE3401178A1 DE3401178A1 DE19843401178 DE3401178A DE3401178A1 DE 3401178 A1 DE3401178 A1 DE 3401178A1 DE 19843401178 DE19843401178 DE 19843401178 DE 3401178 A DE3401178 A DE 3401178A DE 3401178 A1 DE3401178 A1 DE 3401178A1
- Authority
- DE
- Germany
- Prior art keywords
- cholesterol
- epoxicholesterol
- levels
- glycosides
- phytosterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000010235 enterohepatic circulation Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 210000001819 pancreatic juice Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 229940083492 sitosterols Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- GHIZCSMTYWOBQA-BZSCQJQFSA-N spinasterol Natural products CC[C@H](C=C[C@@H](C)[C@@H]1CC[C@@]2(C)C3=CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C)C(C)C GHIZCSMTYWOBQA-BZSCQJQFSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843401178 DE3401178A1 (de) | 1984-01-14 | 1984-01-14 | Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegel |
| EP85100085A EP0151385B1 (en) | 1984-01-14 | 1985-01-04 | Use of phytosterolglycosides for the preparation of medicaments for treatment of elevated 5(6)alpha-epoxycholesterol levels |
| AT85100085T ATE42201T1 (de) | 1984-01-14 | 1985-01-04 | Verwendung von phytosterolglycosiden zur herstellung von arzneimitteln zur behandlung von erhoehtem 5(6)alpha-epoxycholesterolgehalt. |
| DE8585100085T DE3569469D1 (en) | 1984-01-14 | 1985-01-04 | Use of phytosterolglycosides for the preparation of medicaments for treatment of elevated 5(6)alpha-epoxycholesterol levels |
| JP60004801A JPS61112094A (ja) | 1984-01-14 | 1985-01-14 | 予防用又は治療用のフイトステリルグリコシド類又はそのエステル |
| US07/262,130 US4929603A (en) | 1984-01-14 | 1988-10-25 | Use of phytosteryl glycosides for the treatment of epoxycholesterol levels |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843401178 DE3401178A1 (de) | 1984-01-14 | 1984-01-14 | Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3401178A1 true DE3401178A1 (de) | 1985-07-18 |
| DE3401178C2 DE3401178C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-10-10 |
Family
ID=6224995
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843401178 Granted DE3401178A1 (de) | 1984-01-14 | 1984-01-14 | Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegel |
| DE8585100085T Expired DE3569469D1 (en) | 1984-01-14 | 1985-01-04 | Use of phytosterolglycosides for the preparation of medicaments for treatment of elevated 5(6)alpha-epoxycholesterol levels |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585100085T Expired DE3569469D1 (en) | 1984-01-14 | 1985-01-04 | Use of phytosterolglycosides for the preparation of medicaments for treatment of elevated 5(6)alpha-epoxycholesterol levels |
Country Status (5)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4004920C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1990-02-16 | 1991-09-19 | Kanoldt Arzneimittel Gmbh, 8884 Hoechstaedt, De | |
| US5128324A (en) * | 1988-09-01 | 1992-07-07 | Roecar Holdings | Transdermally applicable pharmaceutical preparations with sterolines and/or spiroketalines |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| AU1122301A (en) * | 1999-11-01 | 2001-05-14 | Forbes Medi-Tech Inc. | Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2113215A1 (de) * | 1970-03-18 | 1971-10-07 | Liebenberg Roclof Wilke | Therapeutisches Kompositum |
| DE2659466A1 (de) * | 1976-12-30 | 1979-02-15 | Roecar Holdings Nv | Steroline und deren verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS518259A (en) * | 1974-07-13 | 1976-01-23 | Nippon Shinyaku Co Ltd | Suteriru 6600 ashiru beetaaadd gurukoshidooyobisuteriru 2*3*4*6600 tetoraashiru beetaaadd gurukoshidono seizohoho |
| FR2312257A1 (fr) * | 1975-05-28 | 1976-12-24 | Nippon Shinyaku Co Ltd | Produits pharmaceutiques a action hemostatique comprenant des steryl-b-d-glucosides et leurs monopalmitates |
| DE2759171A1 (de) * | 1977-12-31 | 1979-07-12 | Roecar Holdings Nv | Arzneimittel mit wirkung als prostaglandinsynthetaseninhibitor |
| US4254111A (en) * | 1978-07-05 | 1981-03-03 | Roecar Holdings (Netherlands Antilles) Nv | Sterolin products |
-
1984
- 1984-01-14 DE DE19843401178 patent/DE3401178A1/de active Granted
-
1985
- 1985-01-04 EP EP85100085A patent/EP0151385B1/en not_active Expired
- 1985-01-04 DE DE8585100085T patent/DE3569469D1/de not_active Expired
- 1985-01-04 AT AT85100085T patent/ATE42201T1/de not_active IP Right Cessation
- 1985-01-14 JP JP60004801A patent/JPS61112094A/ja active Granted
-
1988
- 1988-10-25 US US07/262,130 patent/US4929603A/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2113215A1 (de) * | 1970-03-18 | 1971-10-07 | Liebenberg Roclof Wilke | Therapeutisches Kompositum |
| DE2659466A1 (de) * | 1976-12-30 | 1979-02-15 | Roecar Holdings Nv | Steroline und deren verwendung |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128324A (en) * | 1988-09-01 | 1992-07-07 | Roecar Holdings | Transdermally applicable pharmaceutical preparations with sterolines and/or spiroketalines |
| DE4004920C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1990-02-16 | 1991-09-19 | Kanoldt Arzneimittel Gmbh, 8884 Hoechstaedt, De |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3401178C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-10-10 |
| JPS61112094A (ja) | 1986-05-30 |
| EP0151385A3 (en) | 1985-12-27 |
| EP0151385A2 (en) | 1985-08-14 |
| EP0151385B1 (en) | 1989-04-19 |
| US4929603A (en) | 1990-05-29 |
| ATE42201T1 (de) | 1989-05-15 |
| JPH0564614B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-09-16 |
| DE3569469D1 (en) | 1989-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: HOYER GMBH & CO KG, 41469 NEUSS, DE |
|
| 8339 | Ceased/non-payment of the annual fee |