DE3382721D1 - Halopyridone. - Google Patents
Halopyridone.Info
- Publication number
- DE3382721D1 DE3382721D1 DE87108073T DE3382721T DE3382721D1 DE 3382721 D1 DE3382721 D1 DE 3382721D1 DE 87108073 T DE87108073 T DE 87108073T DE 3382721 T DE3382721 T DE 3382721T DE 3382721 D1 DE3382721 D1 DE 3382721D1
- Authority
- DE
- Germany
- Prior art keywords
- halo
- halopyridones
- useful
- methylpyridines
- pyridyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/433,273 US4473696A (en) | 1982-10-07 | 1982-10-07 | Synthesis of 2-substituted-5-methyl-pyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3382721D1 true DE3382721D1 (de) | 1993-12-23 |
DE3382721T2 DE3382721T2 (de) | 1994-04-21 |
Family
ID=23719529
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87108073T Expired - Lifetime DE3382721T2 (de) | 1982-10-07 | 1983-09-23 | Halopyridone. |
DE8383305662T Expired DE3379167D1 (en) | 1982-10-07 | 1983-09-23 | Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383305662T Expired DE3379167D1 (en) | 1982-10-07 | 1983-09-23 | Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor |
Country Status (10)
Country | Link |
---|---|
US (1) | US4473696A (de) |
EP (2) | EP0108483B1 (de) |
JP (1) | JPS5988466A (de) |
AT (2) | ATE40686T1 (de) |
AU (3) | AU561029B2 (de) |
CA (2) | CA1242729A (de) |
DE (2) | DE3382721T2 (de) |
IN (1) | IN160698B (de) |
MX (1) | MX157902A (de) |
ZA (1) | ZA837359B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308822D0 (en) * | 1983-03-30 | 1983-05-11 | Ici Plc | Chemical process |
AU571683B2 (en) * | 1984-05-23 | 1988-04-21 | Zeneca Ag Products Inc. | 2-substituted-5-methylpyridines from methylcyclobutane- carbonitrile, valeronitrile and pentenonitrile intermediates |
US5053516A (en) * | 1984-05-23 | 1991-10-01 | Ici Americas Inc. | Synthesis of 2-substituted-5-methylpyridines from methylcyclobutanecarbonitrile, valeronitrile and pentenonitrile intermediates |
DE4217021A1 (de) * | 1991-12-13 | 1993-06-17 | Bayer Ag | Verfahren zur herstellung von 5-substituierten 2-chlor-pyridinen |
DE4223013A1 (de) * | 1992-07-13 | 1994-01-20 | Bayer Ag | Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen |
DE4234637A1 (de) * | 1992-10-14 | 1994-04-21 | Bayer Ag | Verfahren zur Herstellung von 2-substituierten 5-Alkyl-pyridinen |
US5508410A (en) * | 1993-11-30 | 1996-04-16 | Reilly Industries, Inc. | Process for preparing 2-halo-5-substituted pyridines |
WO2003026727A1 (en) * | 2001-09-28 | 2003-04-03 | Lifevent Limited | sETHOD AND APPARATUS FOR DELIVERY OF MEDICATION |
ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
WO2012107831A1 (en) | 2011-02-11 | 2012-08-16 | Signa S.A. De C.V. | Method of making a pyridone compound, 5-ethyl-1-phenyl-2-(1h)-pyridone, and intermediates thereof |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
CA2943363A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
CN107325042B (zh) * | 2017-08-08 | 2019-09-27 | 江苏扬农化工集团有限公司 | 一种催化合成5-甲基-3,4二氢吡啶-2(1h)-酮化工中间体的方法 |
CN108129321B (zh) * | 2018-01-24 | 2021-06-25 | 江苏扬农化工集团有限公司 | 一种农药中间体4-甲酰基戊酸甲酯的合成方法 |
CN109824580A (zh) * | 2019-04-10 | 2019-05-31 | 江苏扬农化工集团有限公司 | 一种制备2-氯-5-甲基吡啶的方法 |
CN110078660B (zh) * | 2019-05-16 | 2021-01-01 | 江苏扬农化工集团有限公司 | 2-氯-5-甲基吡啶的制备方法 |
CN111333568B (zh) * | 2020-04-16 | 2021-10-26 | 江苏扬农化工集团有限公司 | 一种2-氯-5-甲基吡啶和2,3-二氯-5-甲基吡啶的选择性合成方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB726378A (en) * | 1952-07-03 | 1955-03-16 | Basf Ag | Improvements in the production of compounds of the pyridine series |
US3074940A (en) | 1958-09-10 | 1963-01-22 | Monsanto Chemicals | Process for the manufacture of enamines |
GB967177A (en) * | 1959-10-13 | 1964-08-19 | Rohm & Haas | A method for preparing pyrrolidinones and piperidinones |
US3051622A (en) | 1959-11-25 | 1962-08-28 | Bristol Myers Co | Analgesic cyclobutanes |
US3133924A (en) | 1960-05-31 | 1964-05-19 | Bristol Myers Co | Amino-substituted cyclobutane carboxamides |
GB955945A (en) * | 1961-01-11 | 1964-04-22 | Farmaceutici Italia | Saturated n-hydroxylactams |
US3369024A (en) | 1961-06-07 | 1968-02-13 | Eastman Kodak Co | Tertiaryaminocyclobutanes with electronegative substituents |
DE1187618B (de) * | 1962-07-31 | 1965-02-25 | Dynamit Nobel Ag | Verfahren zur Herstellung von ungesaettigten 6gliedrigen Lactamen bzw. isomeren Verbindungen |
NL130531C (de) * | 1964-09-10 | |||
US3481936A (en) | 1965-03-15 | 1969-12-02 | Eastman Kodak Co | Tertiaryaminocyclobutanes with electronegative substituents |
US3481939A (en) | 1965-03-15 | 1969-12-02 | Eastman Kodak Co | Tertiaryaminocyclobutanes with electronegative substituents |
GB1141671A (en) * | 1966-01-27 | 1969-01-29 | Ici Ltd | Preparation of -Ï-cyanoalkanoic acids |
DE2245097A1 (de) * | 1972-09-14 | 1974-03-21 | Texaco Ag | Verfahren zur herstellung von alkylsubstituierten ungesaettigten deltalactamen |
DE2718666B2 (de) * | 1977-04-27 | 1981-05-21 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von cyclischen Enamiden |
TR19824A (tr) | 1977-07-21 | 1980-01-24 | Ishihara Sangyo Kaisha | Trilorometilpiridoksifenoksipropionik as tuerevleri ve bunlari ihtiva eden herbisidler |
EP0001473B1 (de) | 1977-08-12 | 1988-07-27 | Imperial Chemical Industries Plc | Herbizide Halogenomethyl-pyridyloxy-phenoxy-alkancarbonsäuren und Derivate; Verfahren zur Regulierung unerwünschten Pflanzenwachstums |
JPS5461182A (en) | 1977-10-20 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-phenoxy-5-trifluoromethylpyridine compounds |
JPS5461183A (en) * | 1977-10-21 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-substituted-5-trifluoromethyl pyridine compounds |
US4245098A (en) * | 1978-12-05 | 1981-01-13 | Ciba-Geigy Corporation | Process for producing 2,3,5-trichloropyridine, 2,4,4-trichloro-4-formyl-butyronitrile as a novel compound and a process for producing it |
AU571683B2 (en) * | 1984-05-23 | 1988-04-21 | Zeneca Ag Products Inc. | 2-substituted-5-methylpyridines from methylcyclobutane- carbonitrile, valeronitrile and pentenonitrile intermediates |
US6300282B1 (en) | 1999-07-30 | 2001-10-09 | Platte Chemical Company, A Nebraska Corporation | Technique for reducing nitrogen leaching in soils and improving potato crop yield by application of surfactants to crop root zone |
-
1982
- 1982-10-07 US US06/433,273 patent/US4473696A/en not_active Expired - Lifetime
-
1983
- 1983-09-23 EP EP83305662A patent/EP0108483B1/de not_active Expired
- 1983-09-23 DE DE87108073T patent/DE3382721T2/de not_active Expired - Lifetime
- 1983-09-23 EP EP87108073A patent/EP0246669B1/de not_active Expired - Lifetime
- 1983-09-23 AT AT83305662T patent/ATE40686T1/de not_active IP Right Cessation
- 1983-09-23 AT AT87108073T patent/ATE97406T1/de not_active IP Right Cessation
- 1983-09-23 DE DE8383305662T patent/DE3379167D1/de not_active Expired
- 1983-09-27 CA CA000437645A patent/CA1242729A/en not_active Expired
- 1983-09-29 IN IN1200/CAL/83A patent/IN160698B/en unknown
- 1983-09-30 ZA ZA837359A patent/ZA837359B/xx unknown
- 1983-09-30 AU AU19802/83A patent/AU561029B2/en not_active Expired
- 1983-10-06 MX MX199028A patent/MX157902A/es unknown
- 1983-10-07 JP JP58187196A patent/JPS5988466A/ja active Granted
-
1987
- 1987-05-29 AU AU73672/87A patent/AU595036B2/en not_active Expired
- 1987-07-30 AU AU76322/87A patent/AU595053B2/en not_active Expired
-
1988
- 1988-09-22 CA CA000578201A patent/CA1300160C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1980283A (en) | 1984-04-12 |
AU7632287A (en) | 1987-10-29 |
DE3379167D1 (en) | 1989-03-16 |
AU561029B2 (en) | 1987-04-30 |
EP0246669B1 (de) | 1993-11-18 |
EP0246669A2 (de) | 1987-11-25 |
AU7367287A (en) | 1987-09-24 |
EP0108483B1 (de) | 1989-02-08 |
EP0108483A2 (de) | 1984-05-16 |
AU595036B2 (en) | 1990-03-22 |
ZA837359B (en) | 1984-05-30 |
EP0246669A3 (en) | 1988-07-06 |
CA1242729A (en) | 1988-10-04 |
MX157902A (es) | 1988-12-20 |
JPS5988466A (ja) | 1984-05-22 |
CA1300160C (en) | 1992-05-05 |
EP0108483A3 (en) | 1984-09-26 |
ATE40686T1 (de) | 1989-02-15 |
AU595053B2 (en) | 1990-03-22 |
US4473696A (en) | 1984-09-25 |
JPH0450303B2 (de) | 1992-08-13 |
ATE97406T1 (de) | 1993-12-15 |
DE3382721T2 (de) | 1994-04-21 |
IN160698B (de) | 1987-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ZENECA AG PRODUCTS INC., WILMINGTON, DEL., US |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: SYNGENTA CROP PROTECTION, INC., GREENSBORO, N.C., |