DE3375300D1 - 9-oxalysergic-acid derivatives, their salts, process and intermediates for their preparation, their use as pharmaceutical preparations and compositions containing them - Google Patents
9-oxalysergic-acid derivatives, their salts, process and intermediates for their preparation, their use as pharmaceutical preparations and compositions containing themInfo
- Publication number
- DE3375300D1 DE3375300D1 DE8383400908T DE3375300T DE3375300D1 DE 3375300 D1 DE3375300 D1 DE 3375300D1 DE 8383400908 T DE8383400908 T DE 8383400908T DE 3375300 T DE3375300 T DE 3375300T DE 3375300 D1 DE3375300 D1 DE 3375300D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- alkyl
- group
- hydrogen
- oxalysergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000003946 Prolactin Human genes 0.000 abstract 1
- 108010057464 Prolactin Proteins 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229940052760 dopamine agonists Drugs 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229940097325 prolactin Drugs 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000002295 serotoninergic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8208249A FR2526797A1 (fr) | 1982-05-12 | 1982-05-12 | Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3375300D1 true DE3375300D1 (en) | 1988-02-18 |
Family
ID=9273954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383400908T Expired DE3375300D1 (en) | 1982-05-12 | 1983-05-05 | 9-oxalysergic-acid derivatives, their salts, process and intermediates for their preparation, their use as pharmaceutical preparations and compositions containing them |
Country Status (7)
Country | Link |
---|---|
US (1) | US4493836A (en, 2012) |
EP (1) | EP0094305B1 (en, 2012) |
JP (1) | JPS5925395A (en, 2012) |
AT (1) | ATE31929T1 (en, 2012) |
CA (1) | CA1209573A (en, 2012) |
DE (1) | DE3375300D1 (en, 2012) |
FR (1) | FR2526797A1 (en, 2012) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4774243A (en) * | 1985-12-24 | 1988-09-27 | Merck & Co., Inc. | Dopamine agonists for treating elevated intraocular pressure |
FR2594828B1 (fr) * | 1986-02-24 | 1988-07-01 | Roussel Uclaf | Derives du tetrahydrobenz (c,d) indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires |
FR2626279B1 (fr) * | 1988-01-26 | 1990-07-13 | Roussel Uclaf | Nouveaux derives de l'indolo(3,2,1-de)(1,4)-oxazino(2,3,4-ij)(1,5) naphthyridine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
US5466689A (en) * | 1993-02-08 | 1995-11-14 | Takeda Chemical Industries, Ltd. | Morpholine derivatives and their use |
AU3649599A (en) * | 1998-04-16 | 1999-11-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Salivary prolactin test for serotonergic activity |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
US4238486A (en) * | 1979-11-23 | 1980-12-09 | Merck & Co., Inc. | Indolobenzoxazines |
FR2479830A1 (fr) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | Nouveaux derives de l'indolobenzoxazine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
-
1982
- 1982-05-12 FR FR8208249A patent/FR2526797A1/fr active Granted
-
1983
- 1983-05-05 EP EP83400908A patent/EP0094305B1/fr not_active Expired
- 1983-05-05 AT AT83400908T patent/ATE31929T1/de not_active IP Right Cessation
- 1983-05-05 DE DE8383400908T patent/DE3375300D1/de not_active Expired
- 1983-05-10 US US06/493,355 patent/US4493836A/en not_active Expired - Lifetime
- 1983-05-11 CA CA000427905A patent/CA1209573A/fr not_active Expired
- 1983-05-12 JP JP58081858A patent/JPS5925395A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
CA1209573A (fr) | 1986-08-12 |
EP0094305B1 (fr) | 1988-01-13 |
ATE31929T1 (de) | 1988-01-15 |
EP0094305A1 (fr) | 1983-11-16 |
FR2526797A1 (fr) | 1983-11-18 |
US4493836A (en) | 1985-01-15 |
FR2526797B1 (en, 2012) | 1984-12-28 |
JPH0513955B2 (en, 2012) | 1993-02-23 |
JPS5925395A (ja) | 1984-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL103944A0 (en) | Piperazine derivatives,their preparation and pharmaceutical compositions containing them | |
ES476786A1 (es) | Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol. | |
ES8304567A1 (es) | "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". | |
AU601687B2 (en) | New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them | |
IE43847L (en) | N-substituted phenylpiperidine derivatives. | |
DE3375300D1 (en) | 9-oxalysergic-acid derivatives, their salts, process and intermediates for their preparation, their use as pharmaceutical preparations and compositions containing them | |
DK84380A (da) | Phenylpiperazinderivater fremgangsmaade til deres fremstilling og deres anvendelse | |
DE3165179D1 (en) | Indolobenzoxazine derivatives, their salts, process for their preparation, their use as medicaments and compositions containing them | |
PH24762A (en) | 1,6-naphthyridine derivatives, pharmaceutical compositions and method of use | |
ES8403129A1 (es) | Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas. | |
DE3362323D1 (en) | C-homo-9-oxaergoline derivatives, their salts, process and intermediates for their preparation, use as medicaments and compositions containing them | |
DE3569376D1 (en) | 1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | |
DE3163567D1 (en) | Cycloheptindole derivatives and their acid-addition salts, their preparation, their use as medicaments and compositions containing them | |
ZA83771B (en) | Substituted thienobenzodiazepinones and acid addition salts thereof,processes for the preparation thereof and pharmaceutical compositions containing these compounds | |
DE3874920D1 (de) | Benzimidazol-2-one-derivate, deren salze, verfahren und zwischenprodukte zu deren herstellung, deren anwendung als arzneimittel und sie enthaltende zusammensetzungen. | |
IL61695A (en) | 2-(2,6-dihalophenyl-amino)-and 2-(2-fluoro-6-trifluoromethyl-phenyl-amino)-2-imidazoline derivatives,their preparation and pharmaceutical compositions containing them | |
ES8201135A1 (es) | Un procedimiento para preparar derivados de cicloheptilindo-lol | |
ZA838139B (en) | Semicarbazides,process for preparing these,and pharmaceutical compositions thereof | |
HU894471D0 (en) | Process for the preparation of 15-amino-20,21-dinor-eburnamenine derivatives and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |