DE3279029D1 - Luminescent labelling materials and procedures - Google Patents

Luminescent labelling materials and procedures

Info

Publication number
DE3279029D1
DE3279029D1 DE8282306557T DE3279029T DE3279029D1 DE 3279029 D1 DE3279029 D1 DE 3279029D1 DE 8282306557 T DE8282306557 T DE 8282306557T DE 3279029 T DE3279029 T DE 3279029T DE 3279029 D1 DE3279029 D1 DE 3279029D1
Authority
DE
Germany
Prior art keywords
procedures
labelling materials
luminescent labelling
luminescent
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282306557T
Other languages
English (en)
Inventor
Anthony Keith Campbell
James Stuart Woodhead
Ian Weeks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welsh National School of Medicine
Original Assignee
Welsh National School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10526563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3279029(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Welsh National School of Medicine filed Critical Welsh National School of Medicine
Application granted granted Critical
Publication of DE3279029D1 publication Critical patent/DE3279029D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE8282306557T 1981-12-11 1982-12-08 Luminescent labelling materials and procedures Expired DE3279029D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8137522 1981-12-11

Publications (1)

Publication Number Publication Date
DE3279029D1 true DE3279029D1 (en) 1988-10-20

Family

ID=10526563

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282306557T Expired DE3279029D1 (en) 1981-12-11 1982-12-08 Luminescent labelling materials and procedures

Country Status (4)

Country Link
US (1) US4946958A (de)
EP (1) EP0082636B2 (de)
DE (1) DE3279029D1 (de)
GB (1) GB2112779B (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122671B1 (en) * 1979-07-19 2006-10-17 University College Cardiff Consultants Limited Luminescent labelling materials and procedures
US6414152B1 (en) * 1981-12-11 2002-07-02 University Of Wales College Of Medicine Of Heath Park Luminescent labelling material and procedures
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
GB8401368D0 (en) * 1984-01-19 1984-02-22 Amersham Int Plc Assay method
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
US5155216A (en) * 1985-08-15 1992-10-13 Amoco Corporation Nucleic acids labeled with a chemiluminescent acridine ester
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ATE111083T1 (de) * 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US6004745A (en) * 1987-09-21 1999-12-21 Gen-Probe Incorporated Hybridization protection assay
PT88550A (pt) * 1987-09-21 1989-07-31 Ml Tecnology Ventures Lp Processo para a preparacao de reagentes de ligacao nao nucleotidicos para sondas nucleotidicas
US5639604A (en) * 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
WO1989002476A1 (en) * 1987-09-21 1989-03-23 Ml Technology Ventures, L.P. Homogeneous protection assay
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5284952A (en) * 1987-12-31 1994-02-08 London Diagnostics, Inc. Sulfonyl substituted chemiluminescent labels and their conjugates, and assays therefrom
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
DE3805318C2 (de) * 1988-02-20 1998-07-23 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US6002007A (en) * 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
AU630122B2 (en) * 1988-11-15 1992-10-22 Abbott Laboratories N-arylation of isatins
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents
EP0511366A1 (de) * 1990-11-21 1992-11-04 Beckman Instruments, Inc. Chemilumineszierende derivate
US6436349B1 (en) 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
US6498037B1 (en) 1991-03-04 2002-12-24 Bayer Corporation Method of handling reagents in a random access protocol
CA2384535C (en) * 1991-03-04 2006-08-15 Bayer Corporation Automated analyzer
DE69215983T2 (de) * 1991-07-10 1997-05-22 Tdk Corp Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz
US5395938A (en) * 1992-08-21 1995-03-07 Nichols Institute Diagnostics Biotinylated chemiluminescent labels and their conjugates, assays and assay kits
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
US6087188A (en) * 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5523212A (en) * 1993-05-17 1996-06-04 Lumigen, Inc. Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection
GB9310612D0 (en) * 1993-05-22 1993-07-07 Rhone Poulenc Diagnostics Limi New method of detection of bacteria
GB2280265B (en) * 1993-07-21 1997-06-04 Molecular Light Technology Lim Monitoring of chemical additives
GB2289334B (en) * 1994-05-10 1998-08-26 Molecular Light Technology Lim Enzyme linked chemiluminescent assay
EP0709466B1 (de) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
EP0761652A1 (de) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridiniumverbindung mit mehreren lumineszierenden Gruppen und Bindungsgruppen und Konjugate derselben
WO1997033884A1 (fr) 1996-03-15 1997-09-18 Ss Pharmaceutical Co., Ltd. Reactifs pour marquer les groupes sh, procede pour les preparer et procede pour les marquer
WO1999009012A1 (en) * 1997-08-21 1999-02-25 Maine Medical Center Peroxide-based chemiluminescent assays and chemiluminescent compounds used therein
US6126870A (en) * 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
DE10012007T1 (de) 1998-05-01 2012-01-26 Gen-Probe Inc. Automatisches Diagnoseanalysegerät und Verfahren
WO2003012445A1 (en) 2001-07-30 2003-02-13 Quest Diagnostics Investments Incorporated Methods and kits for detecting ita in a biological sample
US6627457B2 (en) 2001-07-30 2003-09-30 Quest Diagnostics Investments Incorporated Methods for detecting pregnancy
US20030027234A1 (en) * 2001-07-30 2003-02-06 Pandian Murugan R. Methods for detecting Down's syndrome
US6867005B2 (en) * 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US6723851B2 (en) 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
WO2003097808A2 (en) * 2002-05-17 2003-11-27 Becton, Dickinson And Company Automated system for isolating, amplyifying and detecting a target nucleic acid sequence
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US20050148096A1 (en) * 2004-01-07 2005-07-07 Cole Laurence A. Methods for detecting pregnancy
EP1735621A4 (de) * 2004-04-14 2012-12-12 Brij P Giri Neue ultraempfindliche chemielumineszenzsubstrate für enzyme und deren konjugate
EP1921454B1 (de) 2005-03-10 2015-08-12 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
WO2019116234A1 (en) 2017-12-12 2019-06-20 Nestec S.A. Methods for determining microbiome ribosomal rna composition changes
US11237170B2 (en) 2018-12-04 2022-02-01 Aat Bioquest, Inc. Styryl phenols, derivatives and their use in methods of analyte detection
CN109852669A (zh) * 2019-01-04 2019-06-07 南京航思生物科技有限公司 一种吖啶酯标记核酸的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352791A (en) * 1965-01-22 1967-11-14 American Cyanamid Co Generation of light by the reaction of peroxide with heterocyclic derivatives
US3431264A (en) * 1965-11-05 1969-03-04 American Cyanamid Co 9-cyanoacridans and process for their production
FR2043486B1 (de) * 1969-05-28 1973-07-13 Roussel Uclaf
US3689391A (en) * 1970-05-13 1972-09-05 Synvar Ass Method for chemically initiating photochemical reactions
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
IN142734B (de) * 1975-04-28 1977-08-20 Miles Lab
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
SE7811630L (sv) * 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
GB2025609B (en) * 1978-06-14 1983-01-26 Univ Birmingham Determination of concentration of an analyte in a sample
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4767718A (en) * 1984-06-18 1988-08-30 Southern Illinois University Foundation Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters

Also Published As

Publication number Publication date
US4946958A (en) 1990-08-07
GB2112779A (en) 1983-07-27
EP0082636B1 (de) 1988-09-14
GB2112779B (en) 1986-10-15
EP0082636A1 (de) 1983-06-29
EP0082636B2 (de) 2006-10-18

Similar Documents

Publication Publication Date Title
DE3279029D1 (en) Luminescent labelling materials and procedures
HK138295A (en) Labels and manufacture thereof
DE3278284D1 (en) Polyimide-esters and filaments
EP0200557A3 (en) Sealing material
JPS57153065A (en) Adhesive and use
GB8420521D0 (en) Fluorescent label
EP0184708A3 (en) Friction material
GB2154506B (en) Labels and manufacture thereof
DE3374472D1 (en) Composite label and its manufacture
CS684085A1 (en) Hemostaticky material
GB8504944D0 (en) Label
ZA857124B (en) 13-halomilbemycins and 13-hydroxymilbemycins
GB2166109B (en) Labels and manufacture thereof
GB8518250D0 (en) Lining material
GB2125765B (en) Label and holder assembly
GB8613991D0 (en) Phosphorescent material
EP0220604A3 (en) Electrophotographic-recording material
GB2160884B (en) Luminescent material
JPS57165474A (en) Adhesive and sealing composition
EP0218981A3 (en) Electrophotographic-recording material
GB8610844D0 (en) Material
JPS57135973A (en) Indication of sign, illumination and the like
GB8511430D0 (en) Passageway lining material
CA48026S (en) Combined step-stool and work-unit
IE852410L (en) Metallic material

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings