DE3271269D1 - Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same - Google Patents
Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the sameInfo
- Publication number
- DE3271269D1 DE3271269D1 DE8282110215T DE3271269T DE3271269D1 DE 3271269 D1 DE3271269 D1 DE 3271269D1 DE 8282110215 T DE8282110215 T DE 8282110215T DE 3271269 T DE3271269 T DE 3271269T DE 3271269 D1 DE3271269 D1 DE 3271269D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- composition containing
- benzimidazole derivatives
- group
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56178804A JPS5879983A (ja) | 1981-11-06 | 1981-11-06 | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3271269D1 true DE3271269D1 (en) | 1986-06-26 |
Family
ID=16054937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282110215T Expired DE3271269D1 (en) | 1981-11-06 | 1982-11-05 | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same |
Country Status (5)
Country | Link |
---|---|
US (1) | US4430343A (de) |
EP (1) | EP0079545B1 (de) |
JP (1) | JPS5879983A (de) |
AT (1) | ATE19878T1 (de) |
DE (1) | DE3271269D1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59199679A (ja) * | 1983-04-27 | 1984-11-12 | Kanebo Ltd | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
JPS608274A (ja) * | 1983-06-27 | 1985-01-17 | Fujisawa Pharmaceut Co Ltd | 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤 |
JPH0383924A (ja) * | 1989-08-28 | 1991-04-09 | Kanebo Ltd | 経皮投与用組成物 |
FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
FR2668150B1 (fr) * | 1990-10-17 | 1994-11-18 | Theramex | Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
ES2038532B1 (es) * | 1991-05-10 | 1994-02-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
ES2048109B1 (es) * | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
JP3527256B2 (ja) * | 1992-12-09 | 2004-05-17 | ロート製薬株式会社 | 抗アレルギー点眼剤 |
US5668133A (en) * | 1992-12-09 | 1997-09-16 | Alcon Laboratories, Inc. | Ophthalmic compositions comprising emedastine and methods for their use |
EP0699668A4 (de) * | 1993-05-20 | 1996-09-18 | Kissei Pharmaceutical | 1-(2-benzimidazolyl)-1,5-diazacyclooctan-derivate |
ES2072193B1 (es) * | 1993-05-21 | 1996-02-16 | Espanola Prod Quimicos | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
WO1996033722A1 (fr) * | 1995-04-27 | 1996-10-31 | Kanebo, Ltd. | Preparation externe contenant de l'emedastine |
US5676992A (en) | 1995-12-13 | 1997-10-14 | Recot, Inc. | Process for preventing accumulation of material on a cutting mechanism |
EP0888338B1 (de) * | 1996-02-21 | 2004-11-17 | Aventis Pharmaceuticals Inc. | Neue substituierte n-methyl-n-(4-(4-(1h-benzimidazol-2-yl) (1,4)diazepan-1-yl)-2-(aryl)butyl)benzamide zur behandlung von allergischen krankheiten |
US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
US20040097486A1 (en) * | 1999-11-18 | 2004-05-20 | Yanni John M. | Use of an H1 antagonist and a safe steroid to treat eye conditions |
TWI225488B (en) * | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
EP1250133B1 (de) | 2000-01-25 | 2005-03-30 | Alcon Inc. | Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen |
EP1467762B1 (de) * | 2001-12-05 | 2006-02-08 | Alcon, Inc. | Verwendung eines h1-antagonisten und von rimexolon als sicheres steroid zur behandlung von rhinitis |
US20040224916A1 (en) | 2003-01-14 | 2004-11-11 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
MX2007006233A (es) | 2004-11-24 | 2007-11-23 | Medpointe Healthcare Inc | Composiciones que comprenden azelastina y metodos de uso de la misma. |
US20070020330A1 (en) * | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
TWI375560B (en) * | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
US8367704B2 (en) | 2008-02-12 | 2013-02-05 | Yuhan Corporation | Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds |
CN105939718B (zh) | 2014-01-31 | 2020-07-17 | 久光制药株式会社 | 含依美斯汀的贴剂 |
WO2017061393A1 (ja) * | 2015-10-06 | 2017-04-13 | 久光製薬株式会社 | 貼付剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2689853A (en) | 1954-09-21 | Certain i | ||
DE1620449C3 (de) | 1964-07-23 | 1974-02-21 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Substituierte Benzimidazole und Verfahren zu ihrer Herstellung |
JPS50126682A (de) * | 1974-03-25 | 1975-10-04 | ||
US4093726A (en) | 1976-12-02 | 1978-06-06 | Abbott Laboratories | N-(2-benzimidazolyl)-piperazines |
-
1981
- 1981-11-06 JP JP56178804A patent/JPS5879983A/ja active Granted
-
1982
- 1982-10-22 US US06/436,032 patent/US4430343A/en not_active Expired - Lifetime
- 1982-11-05 EP EP82110215A patent/EP0079545B1/de not_active Expired
- 1982-11-05 DE DE8282110215T patent/DE3271269D1/de not_active Expired
- 1982-11-05 AT AT82110215T patent/ATE19878T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS5879983A (ja) | 1983-05-13 |
JPH0224821B2 (de) | 1990-05-30 |
EP0079545A1 (de) | 1983-05-25 |
ATE19878T1 (de) | 1986-06-15 |
EP0079545B1 (de) | 1986-05-21 |
US4430343A (en) | 1984-02-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL |