DE3271236D1 - Dipeptides containing thialysine and homologs as antihypertensives - Google Patents

Dipeptides containing thialysine and homologs as antihypertensives

Info

Publication number
DE3271236D1
DE3271236D1 DE8282102329T DE3271236T DE3271236D1 DE 3271236 D1 DE3271236 D1 DE 3271236D1 DE 8282102329 T DE8282102329 T DE 8282102329T DE 3271236 T DE3271236 T DE 3271236T DE 3271236 D1 DE3271236 D1 DE 3271236D1
Authority
DE
Germany
Prior art keywords
thialysine
antihypertensives
homologs
dipeptides containing
dipeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282102329T
Other languages
German (de)
English (en)
Inventor
Arthur A Patchett
Mu Tsu Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3271236D1 publication Critical patent/DE3271236D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE8282102329T 1981-03-23 1982-03-22 Dipeptides containing thialysine and homologs as antihypertensives Expired DE3271236D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24653281A 1981-03-23 1981-03-23
US06/341,741 US4512979A (en) 1981-03-23 1982-01-26 Dipeptides containing thialysine and related amino acids as antihypertensives

Publications (1)

Publication Number Publication Date
DE3271236D1 true DE3271236D1 (en) 1986-06-26

Family

ID=26938058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282102329T Expired DE3271236D1 (en) 1981-03-23 1982-03-22 Dipeptides containing thialysine and homologs as antihypertensives

Country Status (8)

Country Link
US (1) US4512979A (enExample)
EP (1) EP0061186B1 (enExample)
DE (1) DE3271236D1 (enExample)
DK (1) DK127482A (enExample)
ES (1) ES510663A0 (enExample)
GR (1) GR76467B (enExample)
IE (1) IE52294B1 (enExample)
PT (1) PT74618B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
DE3378266D1 (en) * 1982-01-11 1988-11-24 Merck & Co Inc Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4584299A (en) * 1984-05-21 1986-04-22 Warner-Lambert Company Method of treating heart failure and medicaments therefor
JPH0662671B2 (ja) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 プロリン誘導体
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
DE69009476T2 (de) * 1989-06-30 1994-12-22 Massachusetts Inst Technology Hemmung des reaktionswegs für die n-ende-regel in lebenden zellen.
MY117948A (en) * 1997-01-13 2004-08-30 Glaxo Group Ltd Nitride oxide synthase inhibitors.
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US6620848B2 (en) * 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
JP6321658B2 (ja) 2012-09-24 2018-05-09 メディミューン リミテッド アミノ酸誘導体
CN110724707A (zh) 2013-03-15 2020-01-24 米迪缪尼有限公司 新型核酸分子
CA2918064C (en) * 2013-08-05 2022-04-26 Medimmune Limited Amino acid derivatives
CN114920676B (zh) * 2022-06-07 2024-04-05 四川国康药业有限公司 一种治疗呼吸系统疾病的化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
GR73585B (enExample) * 1978-09-11 1984-03-26 Univ Miami
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides

Also Published As

Publication number Publication date
GR76467B (enExample) 1984-08-10
PT74618B (en) 1984-11-26
PT74618A (en) 1982-04-01
EP0061186A1 (en) 1982-09-29
ES8305700A1 (es) 1983-04-16
IE52294B1 (en) 1987-09-02
EP0061186B1 (en) 1986-05-21
DK127482A (da) 1982-09-24
US4512979A (en) 1985-04-23
IE820637L (en) 1982-09-23
ES510663A0 (es) 1983-04-16

Similar Documents

Publication Publication Date Title
DE3172089D1 (en) Antihypertensives
DE3261688D1 (en) Screen-printable composition
DE3261538D1 (en) Sun tracking apparatus
DE3161062D1 (en) Nutrient composition
DE3271236D1 (en) Dipeptides containing thialysine and homologs as antihypertensives
AU8448182A (en) Radiation sensitive composition
AU8507382A (en) Pvc composition
JPS57157136A (en) Detector
AU7347681A (en) Acylmuramyl and acyldesmethylmuramyl dipeptides
GB2159160B (en) Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
GB2096321B (en) Combustible-gas detectors
JPS57163844A (en) Detector
DE3269354D1 (en) Allele specific immunotherapeutic method and dosage form
JPS57125250A (en) Stabilized polyarylate composition
JPS57194683A (en) Detector
GB2112144B (en) Detector
GB8507385D0 (en) Films
GB2125046B (en) Human leucocyte pepsin like enzyme
GB2104120B (en) Sealing arrangements in gutters
GB2108151B (en) Fermenter
IE812981L (en) Substituted dipeptides
JPS57124660A (en) Frost detector
DE3378266D1 (en) Aminoacyl-containing dipeptide derivatives useful as antihypertensives
AU553426B2 (en) Am detection
GB2093671B (en) Fitt-on bite detector

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee