DE3225155A1 - Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3225155A1
DE3225155A1 DE19823225155 DE3225155A DE3225155A1 DE 3225155 A1 DE3225155 A1 DE 3225155A1 DE 19823225155 DE19823225155 DE 19823225155 DE 3225155 A DE3225155 A DE 3225155A DE 3225155 A1 DE3225155 A1 DE 3225155A1
Authority
DE
Germany
Prior art keywords
group
general formula
compound
carbon atoms
piperidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823225155
Other languages
German (de)
English (en)
Inventor
Bernhard Dipl.-Chem. Dr. 7950 Biberach Eisele
Wolfgang Dipl.-Chem. Dr. Grell
Gerhart Dipl.-Chem. Dr. 7950 Biberach Griss
Rudolf Dipl.-Chem. Dr. Hurnaus
Joachim Dr. Kähling
Eckhard Dipl.-Biol. Dr. 7960 Aulendorf-Tannhausen Rupprecht
Robert Dipl.-Chem. Dr. 7958 Laupheim Sauter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19823225155 priority Critical patent/DE3225155A1/de
Priority to EP83106233A priority patent/EP0099017B1/de
Priority to DE8383106233T priority patent/DE3375783D1/de
Priority to AT83106233T priority patent/ATE32717T1/de
Priority to SU833608901A priority patent/SU1170969A3/ru
Priority to FI832374A priority patent/FI78477C/fi
Priority to KR1019830003043A priority patent/KR900004925B1/ko
Priority to DD83252755A priority patent/DD210907A5/de
Priority to GR71859A priority patent/GR78661B/el
Priority to NO832430A priority patent/NO159590C/no
Priority to YU01468/83A priority patent/YU146883A/xx
Priority to NZ204814A priority patent/NZ204814A/en
Priority to CA000431796A priority patent/CA1214773A/en
Priority to PL1983242873A priority patent/PL143992B1/pl
Priority to IE1573/83A priority patent/IE56171B1/en
Priority to PT76986A priority patent/PT76986B/pt
Priority to AU16576/83A priority patent/AU561274B2/en
Priority to CS835089A priority patent/CS240970B2/cs
Priority to HU832420A priority patent/HU195651B/hu
Priority to ES523869A priority patent/ES8501382A1/es
Priority to DK310883A priority patent/DK159850C/da
Priority to JP58123101A priority patent/JPS5921657A/ja
Priority to GB08318250A priority patent/GB2124220B/en
Priority to IL69172A priority patent/IL69172A/xx
Publication of DE3225155A1 publication Critical patent/DE3225155A1/de
Priority to ES529806A priority patent/ES8500923A1/es
Priority to ES529808A priority patent/ES529808A0/es
Priority to ES529807A priority patent/ES8500924A1/es
Priority to US06/734,252 priority patent/US4735959A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE19823225155 1981-01-10 1982-07-06 Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE3225155A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE19823225155 DE3225155A1 (de) 1982-07-06 1982-07-06 Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP83106233A EP0099017B1 (de) 1982-07-06 1983-06-27 Neue Phenylessigsäure-Derivate, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
DE8383106233T DE3375783D1 (en) 1982-07-06 1983-06-27 Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them
AT83106233T ATE32717T1 (de) 1982-07-06 1983-06-27 Neue phenylessigsaeure-derivate, ihre herstellung und diese verbindungen enthaltende arzneimittel.
SU833608901A SU1170969A3 (ru) 1982-07-06 1983-06-27 Способ получени производных фенилуксусной кислоты или их солей
FI832374A FI78477C (fi) 1982-07-06 1983-06-29 Foerfarande foer framstaellning av farmakologiskt anvaendbara fenylaettiksyra-derivat.
KR1019830003043A KR900004925B1 (ko) 1982-07-06 1983-07-04 페닐 아세트산 유도체의 제조방법
DD83252755A DD210907A5 (de) 1982-07-06 1983-07-04 Verfahren zur herstellung von phenylessigsaeure-derivaten
GR71859A GR78661B (cs) 1982-07-06 1983-07-04
NO832430A NO159590C (no) 1982-07-06 1983-07-04 Analogifremgangsm te for fremstilling av terapeutisk aktive fenyleddiksyre-derivater.
PL1983242873A PL143992B1 (en) 1982-07-06 1983-07-05 Process for preparing novel derivatives of phenylacetic acid
ES523869A ES8501382A1 (es) 1982-07-06 1983-07-05 Procedimiento para la preparacion de derivados de acido fenilacetico.
CA000431796A CA1214773A (en) 1982-07-06 1983-07-05 Phenylacetic acid derivatives, the preparation thereof and pharmaceutical compositions containing these compounds
YU01468/83A YU146883A (en) 1982-07-06 1983-07-05 Process for preparing new phenylacetic acid deivatives
IE1573/83A IE56171B1 (en) 1982-07-06 1983-07-05 N-substituted phenylacetamides
PT76986A PT76986B (de) 1982-07-06 1983-07-05 Neue phenylessigsaeure-derivate ihre herstellung und diese verbindungen enthaltende arzneimittel
AU16576/83A AU561274B2 (en) 1982-07-06 1983-07-05 Phenyl acetic acid amides
CS835089A CS240970B2 (en) 1982-07-06 1983-07-05 Process for preparating substituted phenylalkylamides ofphenylacetic acid
HU832420A HU195651B (en) 1982-07-06 1983-07-05 Process for production of new derivatives of phenil acetic acid and medical compounds containing them
NZ204814A NZ204814A (en) 1982-07-06 1983-07-05 Phenylacetic acid derivatives and pharmaceutical compositions
DK310883A DK159850C (da) 1982-07-06 1983-07-05 Analogifremgangsmaade til fremstilling af phenyledddikesyrederivater
JP58123101A JPS5921657A (ja) 1982-07-06 1983-07-06 新規なフエニル酢酸誘導体
GB08318250A GB2124220B (en) 1982-07-06 1983-07-06 Substituted phenylacetamides
IL69172A IL69172A (en) 1982-07-06 1983-07-06 Phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
ES529806A ES8500923A1 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico
ES529808A ES529808A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico
ES529807A ES8500924A1 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico
US06/734,252 US4735959A (en) 1981-01-10 1985-05-14 Carboxylic acid amides and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823225155 DE3225155A1 (de) 1982-07-06 1982-07-06 Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE3225155A1 true DE3225155A1 (de) 1984-01-12

Family

ID=6167698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823225155 Withdrawn DE3225155A1 (de) 1981-01-10 1982-07-06 Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel

Country Status (2)

Country Link
JP (1) JPS5921657A (cs)
DE (1) DE3225155A1 (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208200A1 (de) * 1985-07-01 1987-01-14 Dr. Karl Thomae GmbH Phenylessigsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahen zu ihrer Herstellung
US7582766B2 (en) * 2003-06-09 2009-09-01 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2010493B1 (en) * 2006-04-12 2016-01-27 Merck Sharp & Dohme Corp. Pyridyl amide t-type calcium channel antagonists

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208200A1 (de) * 1985-07-01 1987-01-14 Dr. Karl Thomae GmbH Phenylessigsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahen zu ihrer Herstellung
US7582766B2 (en) * 2003-06-09 2009-09-01 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus

Also Published As

Publication number Publication date
JPS5921657A (ja) 1984-02-03
JPH0379335B2 (cs) 1991-12-18

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Legal Events

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8139 Disposal/non-payment of the annual fee