DE3168509D1 - 4-0-substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them - Google Patents

4-0-substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them

Info

Publication number
DE3168509D1
DE3168509D1 DE8181304323T DE3168509T DE3168509D1 DE 3168509 D1 DE3168509 D1 DE 3168509D1 DE 8181304323 T DE8181304323 T DE 8181304323T DE 3168509 T DE3168509 T DE 3168509T DE 3168509 D1 DE3168509 D1 DE 3168509D1
Authority
DE
Germany
Prior art keywords
alpha
protected
beta
amino
aprosaminide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181304323T
Other languages
English (en)
Inventor
Herbert Andrew Kirst
Brenda Alethia Truedell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3168509D1 publication Critical patent/DE3168509D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE8181304323T 1980-09-22 1981-09-21 4-0-substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them Expired DE3168509D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18944080A 1980-09-22 1980-09-22

Publications (1)

Publication Number Publication Date
DE3168509D1 true DE3168509D1 (en) 1985-03-07

Family

ID=22697337

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181304323T Expired DE3168509D1 (en) 1980-09-22 1981-09-21 4-0-substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them

Country Status (5)

Country Link
EP (1) EP0048613B1 (de)
JP (1) JPS5782399A (de)
AT (1) ATE11416T1 (de)
DE (1) DE3168509D1 (de)
GB (1) GB2084149B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4482707A (en) * 1981-12-08 1984-11-13 Toyo Jozo Kabushiki Kaisha Aminoglycoside antibiotic saccharocins
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
EP3498723A1 (de) * 2015-07-30 2019-06-19 Microbial Chemistry Research Foundation Neues wirksames aminoglykosid-antibiotikum für bakterien mit mehrfacher wirkstoffresistenz

Also Published As

Publication number Publication date
JPS5782399A (en) 1982-05-22
EP0048613A1 (de) 1982-03-31
GB2084149B (en) 1984-08-15
ATE11416T1 (de) 1985-02-15
GB2084149A (en) 1982-04-07
EP0048613B1 (de) 1985-01-23

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee