DE3120312C2 - Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung - Google Patents

Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung

Info

Publication number
DE3120312C2
DE3120312C2 DE3120312A DE3120312A DE3120312C2 DE 3120312 C2 DE3120312 C2 DE 3120312C2 DE 3120312 A DE3120312 A DE 3120312A DE 3120312 A DE3120312 A DE 3120312A DE 3120312 C2 DE3120312 C2 DE 3120312C2
Authority
DE
Germany
Prior art keywords
asn
peptide
lys
arg
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3120312A
Other languages
German (de)
English (en)
Other versions
DE3120312A1 (de
Inventor
Noboru Shizuoka Yanaihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE3120312A1 publication Critical patent/DE3120312A1/de
Application granted granted Critical
Publication of DE3120312C2 publication Critical patent/DE3120312C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE3120312A 1980-05-21 1981-05-21 Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung Expired DE3120312C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6804080A JPS56163456A (en) 1980-05-21 1980-05-21 Preparation of antigen

Publications (2)

Publication Number Publication Date
DE3120312A1 DE3120312A1 (de) 1982-03-04
DE3120312C2 true DE3120312C2 (de) 1985-08-29

Family

ID=13362282

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3120312A Expired DE3120312C2 (de) 1980-05-21 1981-05-21 Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung

Country Status (8)

Country Link
US (1) US4407965A (US20030199744A1-20031023-C00003.png)
JP (1) JPS56163456A (US20030199744A1-20031023-C00003.png)
BE (1) BE888906A (US20030199744A1-20031023-C00003.png)
DE (1) DE3120312C2 (US20030199744A1-20031023-C00003.png)
DK (1) DK159163C (US20030199744A1-20031023-C00003.png)
FR (1) FR2482861A1 (US20030199744A1-20031023-C00003.png)
GB (1) GB2079289B (US20030199744A1-20031023-C00003.png)
SE (1) SE454301B (US20030199744A1-20031023-C00003.png)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572800A (en) * 1982-09-30 1986-02-25 Otsuka Pharmaceutical Co., Ltd. Human leukemia virus-related peptides, a process for production thereof, antibodies of the peptides and a process for production of the antibodies
CA1256795A (en) * 1983-12-28 1989-07-04 Dennis A. Carson Anti-idiotype antibodies induced by synthetic polypeptides
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB2160312B (en) * 1984-04-13 1987-09-16 South African Inventions Adjuvant for immunisation
US4654419A (en) * 1984-08-08 1987-03-31 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen
US5116725A (en) * 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
JPS62500452A (ja) * 1984-09-19 1987-02-26 ザ　リ−ジエンツ　オブ　ザ　ユニバ−シテイ　オブ　カリフオルニア ヒト細胞形質転換に関連するレトロウイルスポリペプチド
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
JPH0792458B2 (ja) * 1986-03-14 1995-10-09 郁男 山科 糖鎖特異抗体アツセイプレ−ト及びその製造方法
US5202270A (en) * 1986-05-15 1993-04-13 Abbott Laboratories Cocaine and cocaine metabolites assay tracers, immunogens and antibodies
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
EA201790377A1 (ru) 2014-09-16 2017-08-31 Регенерон Фармасьютикалз, Инк. Антитела к глюкагону и их применения
SG11201901355SA (en) 2016-08-30 2019-03-28 Regeneron Pharma Methods of treating severe insulin resistance by interfering with glucagon receptor signaling
EP3529278A1 (en) 2016-10-20 2019-08-28 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
EP3672620A1 (en) 2017-08-22 2020-07-01 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (ja) * 1977-02-10 1983-08-08 大塚製薬株式会社 抗体の製造方法
US4206199A (en) * 1977-07-22 1980-06-03 Takeda Chemical Industries, Ltd. Novel glucagon fragment and its derivatives

Also Published As

Publication number Publication date
US4407965A (en) 1983-10-04
JPS56163456A (en) 1981-12-16
GB2079289A (en) 1982-01-20
FR2482861A1 (fr) 1981-11-27
JPS6223822B2 (US20030199744A1-20031023-C00003.png) 1987-05-25
DK159163C (da) 1991-02-11
DE3120312A1 (de) 1982-03-04
GB2079289B (en) 1983-10-26
SE454301B (sv) 1988-04-18
SE8103198L (sv) 1981-11-22
DK159163B (da) 1990-09-10
FR2482861B1 (US20030199744A1-20031023-C00003.png) 1983-09-09
BE888906A (fr) 1981-11-23
DK222081A (da) 1981-11-22

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8125 Change of the main classification

Ipc: C07C103/52

8126 Change of the secondary classification

Free format text: A61K 37/02 G01N 33/54

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee