DE3068549D1 - Plasminogen activators useful as therapeutic and diagnostic agents and their isolation - Google Patents

Plasminogen activators useful as therapeutic and diagnostic agents and their isolation

Info

Publication number
DE3068549D1
DE3068549D1 DE8080902378T DE3068549T DE3068549D1 DE 3068549 D1 DE3068549 D1 DE 3068549D1 DE 8080902378 T DE8080902378 T DE 8080902378T DE 3068549 T DE3068549 T DE 3068549T DE 3068549 D1 DE3068549 D1 DE 3068549D1
Authority
DE
Germany
Prior art keywords
therapeutic
isolation
diagnostic agents
plasminogen activators
activators useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080902378T
Other languages
English (en)
Inventor
Syed Shaukat Husain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VASCULAR LABORATORY, INC., BOSTON, MASS., US
Original Assignee
Syed Shaukat Husain
Lipinski Boguslaw
Gurewich Victor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22237919&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3068549(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syed Shaukat Husain, Lipinski Boguslaw, Gurewich Victor filed Critical Syed Shaukat Husain
Application granted granted Critical
Publication of DE3068549D1 publication Critical patent/DE3068549D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8080902378T 1979-11-13 1980-10-29 Plasminogen activators useful as therapeutic and diagnostic agents and their isolation Expired DE3068549D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9324679A 1979-11-13 1979-11-13
PCT/US1980/001450 WO1981001417A1 (en) 1979-11-13 1980-10-29 Isolation of plasminogen activators useful as therapeutic and diagnostic agents

Publications (1)

Publication Number Publication Date
DE3068549D1 true DE3068549D1 (en) 1984-08-16

Family

ID=22237919

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080902378T Expired DE3068549D1 (en) 1979-11-13 1980-10-29 Plasminogen activators useful as therapeutic and diagnostic agents and their isolation

Country Status (11)

Country Link
EP (1) EP0040238B1 (de)
JP (2) JPH0734743B2 (de)
AU (1) AU6642281A (de)
CA (1) CA1164341A (de)
CY (1) CY1382A (de)
DE (1) DE3068549D1 (de)
HK (1) HK85987A (de)
IT (1) IT1147788B (de)
MY (1) MY8700685A (de)
SG (1) SG40587G (de)
WO (1) WO1981001417A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040238B1 (de) * 1979-11-13 1984-07-11 HUSAIN, Syed Shaukat Plasminogen-aktivatoren verwendbar als heil- und diagnosemittel und deren isolierung
GR78180B (de) * 1982-04-15 1984-09-26 Genentech Inc
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
DE3486023T2 (de) * 1983-09-13 1993-06-24 Green Cross Corp Verfahren zur herstellung von urokinase zymogen.
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
EP0156169B1 (de) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha Wässrige Lösung eines darin in erhöhter Konzentration aufgelösten Gewebe-Plasminogen-Aktivators und Herstellungsverfahren
GB8613221D0 (en) * 1986-05-30 1986-07-02 Bp Chem Int Ltd Recovery process
EP0323983A1 (de) * 1987-05-15 1989-07-19 Genzyme Corporation Substanzen zur auffindung von blutgerinnseln
EP0307774A3 (de) * 1987-09-16 1990-02-28 W.R. Grace & Co.-Conn. Verfahren zur Reinigung von Plasminogenaktivator

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE549167A (de) * 1955-07-01
US2961382A (en) * 1957-07-25 1960-11-22 Ortho Pharma Corp Urokinase-a plasmiogen activator and methods of obtaining the same
US2989440A (en) * 1959-01-23 1961-06-20 Ortho Pharmacentical Corp Urokinase-alpha plasminogen activator and methods of obtaining the same
US3042667A (en) * 1959-03-10 1962-07-03 Pharmacia Ab Process for producing dextran derivatives and products resulting therefrom
US3140984A (en) * 1961-11-30 1964-07-14 Univ Alberta Production of high activity fibrinolytic agents
US3256158A (en) * 1963-03-22 1966-06-14 Abbott Lab Purification of urokinase
US3355361A (en) * 1964-10-15 1967-11-28 Sterling Drug Inc Recovery and purification of urokinase
JPS4810232B1 (de) * 1970-09-04 1973-04-02
US3755083A (en) * 1971-08-30 1973-08-28 Rand Labor Inc Method for recovering urokinase from urine containing the same
GB1417003A (en) * 1972-06-22 1975-12-10 Radiochemical Centre Ltd Stabilisation of fibrinogen
DE2239791A1 (de) * 1972-08-12 1974-02-21 Hoechst Ag Verfahren zur herstellung von mit indium-113m markiertem humantransferrin
US3812245A (en) * 1972-08-21 1974-05-21 Research Corp Novel compositions for radiotracer localization of deep vein thrombi
US3957582A (en) * 1974-11-20 1976-05-18 Abbott Laboratories Purification of urokinase
FR2347048A2 (fr) * 1976-04-07 1977-11-04 Choay Sa Compositions constituees par des composes du type plasminogene, notamment d'origine placentaire, procede d'obtention des ces compositions, et medicaments contenant ces compositions
JPS51123885A (en) * 1975-04-18 1976-10-28 Hitachi Chem Co Ltd Process for purifying urokinase
US4036945A (en) * 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same
DE2812609A1 (de) * 1977-04-09 1978-10-19 Tanabe Seiyaku Co Verfahren zur reinigung roher urokinase
FR2387242A1 (fr) * 1977-04-12 1978-11-10 Choay Sa Compositions purifiees d'urokinase et procede pour leur obtention
LU80716A1 (fr) * 1978-12-22 1979-05-16 Green Cross Corp Procede pour la production d'une preparation thrombolytique
EP0040238B1 (de) * 1979-11-13 1984-07-11 HUSAIN, Syed Shaukat Plasminogen-aktivatoren verwendbar als heil- und diagnosemittel und deren isolierung
JPH0736755B2 (ja) * 1983-09-13 1995-04-26 株式会社ミドリ十字 プラスミノーゲン・アクチベーター前駆体含有組成物

Also Published As

Publication number Publication date
CY1382A (en) 1987-12-18
EP0040238A4 (de) 1982-07-13
EP0040238A1 (de) 1981-11-25
WO1981001417A1 (en) 1981-05-28
JPS6296085A (ja) 1987-05-02
EP0040238B1 (de) 1984-07-11
AU6642281A (en) 1981-06-03
SG40587G (en) 1987-07-24
JPS56501474A (de) 1981-10-15
IT1147788B (it) 1986-11-26
HK85987A (en) 1987-11-27
CA1164341A (en) 1984-03-27
IT8068733A0 (it) 1980-11-12
JPH0734743B2 (ja) 1995-04-19
MY8700685A (en) 1987-12-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: VASCULAR LABORATORY, INC., BOSTON, MASS., US

8381 Inventor (new situation)

Free format text: HUSAIN, SYED SHAUKAT, NEWTON HIGHLAND, MASS., US LIPINSKI, BOGUSLAW, NEWTONVILLE, MASS., US GUREWICH, VICTOR, CAMBRIDGE, MASS., US

8328 Change in the person/name/address of the agent

Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8310 Action for declaration of annulment
8312 Partial invalidation
8328 Change in the person/name/address of the agent

Free format text: EITLE, W., DIPL.-ING. HOFFMANN, K., DIPL.-ING. DR.RER.NAT. LEHN, W., DIPL.-ING. FUECHSLE, K., DIPL.-ING. HANSEN, B., DIPL.-CHEM. DR.RER.NAT. BRAUNS, H., DIPL.-CHEM. DR.RER.NAT. GOERG, K., DIPL.-ING. KOHLMANN, K., DIPL.-ING. RITTER UND EDLER VON FISCHERN, B., DIPL.-ING. KOLB, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE NETTE, A., RECHTSANW., 8000 MUENCHEN

8310 Action for declaration of annulment
8339 Ceased/non-payment of the annual fee