FR2387242A1 - Compositions purifiees d'urokinase et procede pour leur obtention - Google Patents

Compositions purifiees d'urokinase et procede pour leur obtention

Info

Publication number
FR2387242A1
FR2387242A1 FR7711004A FR7711004A FR2387242A1 FR 2387242 A1 FR2387242 A1 FR 2387242A1 FR 7711004 A FR7711004 A FR 7711004A FR 7711004 A FR7711004 A FR 7711004A FR 2387242 A1 FR2387242 A1 FR 2387242A1
Authority
FR
France
Prior art keywords
urokinase
ion
isolated
exchange chromatography
contg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7711004A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7711004A priority Critical patent/FR2387242A1/fr
Priority to JP4258078A priority patent/JPS53130485A/ja
Priority to DK159878A priority patent/DK159878A/da
Priority to ES468720A priority patent/ES468720A1/es
Priority to LU79426A priority patent/LU79426A1/fr
Priority to IT48859/78A priority patent/IT1156188B/it
Priority to BE186750A priority patent/BE865926A/fr
Priority to SE7804141A priority patent/SE7804141L/xx
Priority to NL7803888A priority patent/NL7803888A/xx
Priority to DE19782815853 priority patent/DE2815853A1/de
Publication of FR2387242A1 publication Critical patent/FR2387242A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Urokinase de poids moléculaire de l'ordre de 54 000, sensiblement exempte d'une urokinase ayant un poids moléculaire de l'ordre de 33 000. L'urokinase de poids moléculaire de l'ordre de 54 000 est obtenue à partir d'une solution contenant cette urokinase de poids moléculaire de l'ordre de 54 000, une urokinase de poids moléculaire de l'ordre de 33 000 et un sel minéral, par un procédé comprenant la mise en contact de cette solution avec un gel ayant, du point de vue ionique, les caractéristiques d'une résine échangeuse d'ions, et permettant la fixation des deux types d'urokinase et les élutions des deux urokinases dans des conditions de développement permettant la séparation complète de l'urokinase de poids moléculaire 33 000. Application à la constitution de médicaments.
FR7711004A 1977-04-12 1977-04-12 Compositions purifiees d'urokinase et procede pour leur obtention Withdrawn FR2387242A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7711004A FR2387242A1 (fr) 1977-04-12 1977-04-12 Compositions purifiees d'urokinase et procede pour leur obtention
JP4258078A JPS53130485A (en) 1977-04-12 1978-04-11 Separating method of urokinase and medicin containg urokinase as useful component
DK159878A DK159878A (da) 1977-04-12 1978-04-12 Fremgangsmaade til fremstilling af urokinase
ES468720A ES468720A1 (es) 1977-04-12 1978-04-12 Un procedimiento de separacion de dos tipos de uroquinasa.
LU79426A LU79426A1 (fr) 1977-04-12 1978-04-12 Compositions purifiees d'urokinase et procede pour leur obtention
IT48859/78A IT1156188B (it) 1977-04-12 1978-04-12 Composizioni furificate di urochinasi e procedimento per ottenerle
BE186750A BE865926A (fr) 1977-04-12 1978-04-12 Compositions purifiees d'urokinase et procede pour leur obtention
SE7804141A SE7804141L (sv) 1977-04-12 1978-04-12 Renade kompositioner av urokinas och forfarande for framstellning derav
NL7803888A NL7803888A (nl) 1977-04-12 1978-04-12 Werkwijze voor het scheiden van een urokinase en een fractie, die een ander urokinase bevat, alsmede farma- ceutisch preparaat en werkwijze voor het bereiden daar- van.
DE19782815853 DE2815853A1 (de) 1977-04-12 1978-04-12 Gereinigte urokinasepraeparate und verfahren zu ihrer herstellung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7711004A FR2387242A1 (fr) 1977-04-12 1977-04-12 Compositions purifiees d'urokinase et procede pour leur obtention

Publications (1)

Publication Number Publication Date
FR2387242A1 true FR2387242A1 (fr) 1978-11-10

Family

ID=9189313

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7711004A Withdrawn FR2387242A1 (fr) 1977-04-12 1977-04-12 Compositions purifiees d'urokinase et procede pour leur obtention

Country Status (10)

Country Link
JP (1) JPS53130485A (fr)
BE (1) BE865926A (fr)
DE (1) DE2815853A1 (fr)
DK (1) DK159878A (fr)
ES (1) ES468720A1 (fr)
FR (1) FR2387242A1 (fr)
IT (1) IT1156188B (fr)
LU (1) LU79426A1 (fr)
NL (1) NL7803888A (fr)
SE (1) SE7804141L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040238A1 (fr) * 1979-11-13 1981-11-25 Syed Shaukat Husain Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation.

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5411219A (en) * 1977-06-25 1979-01-27 Green Cross Corp:The Thrombolytic agent and its preparation
JPS606191A (ja) * 1983-06-02 1985-01-12 Wakamoto Pharmaceut Co Ltd 低分子ウロキナ−ゼと高分子ウロキナ−ゼの分離方法
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US20030040095A1 (en) * 2001-03-16 2003-02-27 Achille Arini Method for the production of pharmaceutically active recombinant proteins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040238A1 (fr) * 1979-11-13 1981-11-25 Syed Shaukat Husain Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation.
EP0040238A4 (fr) * 1979-11-13 1982-07-13 Syed Shaukat Husain Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation.

Also Published As

Publication number Publication date
IT7848859A0 (it) 1978-04-12
IT1156188B (it) 1987-01-28
JPS53130485A (en) 1978-11-14
SE7804141L (sv) 1978-10-13
BE865926A (fr) 1978-10-12
DE2815853A1 (de) 1978-10-19
ES468720A1 (es) 1978-12-16
DK159878A (da) 1978-10-13
NL7803888A (nl) 1978-10-16
LU79426A1 (fr) 1978-11-28

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Legal Events

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