DE29723120U1 - Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams - Google Patents

Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams

Info

Publication number
DE29723120U1
DE29723120U1 DE29723120U DE29723120U DE29723120U1 DE 29723120 U1 DE29723120 U1 DE 29723120U1 DE 29723120 U DE29723120 U DE 29723120U DE 29723120 U DE29723120 U DE 29723120U DE 29723120 U1 DE29723120 U1 DE 29723120U1
Authority
DE
Germany
Prior art keywords
carrier
pct
sorting
objects
microinjection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE29723120U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
P.A.L.M. MICROLASER TECHNOLOGIES AG, DE
Original Assignee
PALM GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26022617&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE29723120(U1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19603996A external-priority patent/DE19603996C2/en
Priority claimed from DE1996116216 external-priority patent/DE19616216A1/en
Application filed by PALM GmbH filed Critical PALM GmbH
Priority to DE29723120U priority Critical patent/DE29723120U1/en
Publication of DE29723120U1 publication Critical patent/DE29723120U1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N2001/045—Laser ablation; Microwave vaporisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G01N2001/284—Collecting samples on a sticky, tacky, adhesive surface using local activation of adhesive, i.e. Laser Capture Microdissection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/2886—Laser cutting, e.g. tissue catapult
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte

Abstract

PCT No. PCT/EP97/00429 Sec. 371 Date Aug. 5, 1998 Sec. 102(e) Date Aug. 5, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/29355 PCT Pub. Date Aug. 14, 1997The invention discloses a process for sorting and harvesting biological objects on a planar carrier (2). On a planar carrier (2) an object field or the object itself, located on the carrier (2), is cut out with a laser beam (6) and transferred by means of a laser-induced transport process to a collector substrate (5) which is disposed directly above or below the carrier. During the cutting-out process, either the laser beam (6) moves in a closed curve about the object or the object itself is cut directly out of the carrier (2) in a computerized manner. This method enables individually selected objects to be spatially separated and sorted from a very large number of objects. The method can also be used to separate specific cells from tissue sections.
DE29723120U 1996-02-05 1997-01-31 Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams Expired - Lifetime DE29723120U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE29723120U DE29723120U1 (en) 1996-02-05 1997-01-31 Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19603996A DE19603996C2 (en) 1996-02-05 1996-02-05 Sorting process for planar biological objects with laser beams
DE1996116216 DE19616216A1 (en) 1996-04-23 1996-04-23 Laser beam process and assembly separates individual cells from tissue mass
PCT/EP1997/000429 WO1997029355A1 (en) 1996-02-05 1997-01-31 Method and device for the contactless laser-assisted microinjection, sorting and production of biological objects generated in a planar manner
DE29723120U DE29723120U1 (en) 1996-02-05 1997-01-31 Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams

Publications (1)

Publication Number Publication Date
DE29723120U1 true DE29723120U1 (en) 1998-05-14

Family

ID=26022617

Family Applications (2)

Application Number Title Priority Date Filing Date
DE59702347T Expired - Lifetime DE59702347D1 (en) 1996-02-05 1997-01-31 METHOD FOR SORTING AND OBTAINING BIOLOGICAL OBJECTS ON A PLANAR CARRIER BY FREE-PREPARATION BY MEANS OF A LASER BEAM AND SUBJECT CATEGULATING THROUGH A LASER SHOT
DE29723120U Expired - Lifetime DE29723120U1 (en) 1996-02-05 1997-01-31 Device for non-contact microinjection as well as for sorting and for obtaining planar biological objects with laser beams

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE59702347T Expired - Lifetime DE59702347D1 (en) 1996-02-05 1997-01-31 METHOD FOR SORTING AND OBTAINING BIOLOGICAL OBJECTS ON A PLANAR CARRIER BY FREE-PREPARATION BY MEANS OF A LASER BEAM AND SUBJECT CATEGULATING THROUGH A LASER SHOT

Country Status (8)

Country Link
US (1) US5998129A (en)
EP (1) EP0879408B1 (en)
JP (1) JP3311757B2 (en)
AT (1) ATE196360T1 (en)
CA (1) CA2245553C (en)
DE (2) DE59702347D1 (en)
ES (1) ES2150754T3 (en)
WO (2) WO1997029354A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004022483A1 (en) * 2004-05-07 2006-01-19 P.A.L.M. Microlaser Technologies Ag Holder for a recording device for recording biological objects
WO2018001679A1 (en) * 2016-06-28 2018-01-04 Leica Microsystems Cms Gmbh Contamination prevention device for a laser microdissection system, and laser microdissection system

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10136481A1 (en) * 2001-07-27 2003-02-20 Leica Microsystems Arrangement for micromanipulating biological objects
US6819411B1 (en) 1997-01-31 2004-11-16 Xy, Inc. Optical apparatus
US5859699A (en) * 1997-02-07 1999-01-12 Arcturus Engineering, Inc. Laser capture microdissection analysis vessel
US6495195B2 (en) 1997-02-14 2002-12-17 Arcturus Engineering, Inc. Broadband absorbing film for laser capture microdissection
WO1999015875A1 (en) * 1997-09-25 1999-04-01 Macquarie Research Ltd. Apparatus for removing a sample from an array of samples and a cutting tool for use with that apparatus
DE19818425A1 (en) * 1997-10-18 1999-07-15 Malte Dr Med Boehm Microdissection sample handling device for histology or cytology
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
JP3465613B2 (en) * 1999-01-13 2003-11-10 松下電器産業株式会社 Operating device for fine objects
JP3582390B2 (en) * 1999-01-13 2004-10-27 松下電器産業株式会社 Automatic search device for fine objects
AU762242B2 (en) * 1999-03-16 2003-06-19 Proteome Systems Ltd Method and apparatus for manipulating arrays
AUPP924099A0 (en) * 1999-03-16 1999-04-15 Proteome Systems Ltd Method and apparatus for manipulating arrays
DE19921236C2 (en) * 1999-05-07 2003-10-30 Evotec Ag Method and device for taking samples on cryosubstrates
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
DE10003588C2 (en) * 2000-01-25 2002-10-02 Sl Microtest Wissenschaftliche Method of isolating part of a layer of biological material
AU2001238462A1 (en) * 2000-02-16 2001-08-27 Arcturus Engineering, Inc. Transfer film for laser microcapture
DE10015157A1 (en) * 2000-03-27 2001-10-18 P A L M Gmbh Collecting device for objects dissolved out of mass, especially by laser radiation, has control system automatically generating accommodation unit displacement signals
DE10015156A1 (en) * 2000-03-27 2001-10-18 P A L M Gmbh Recovering biological object from biological material located on support, comprises dissolving away object from material by irradiating it using laser beam, and catapulting from support to collecting device
DE10018255C2 (en) * 2000-04-13 2003-08-28 Leica Microsystems Laser cutting process and laser cutting device for laser cutting with microscopic samples
DE10018251C2 (en) 2000-04-13 2003-08-14 Leica Microsystems Laser cutting device with microscope
DE10018253C2 (en) * 2000-04-13 2003-08-21 Leica Microsystems Laser microdissection
DE10037203C1 (en) * 2000-07-31 2002-04-04 P A L M Gmbh microscope stage
DE10039979A1 (en) * 2000-08-16 2002-03-07 P A L M Gmbh Carrier device for a preparation for separating individual objects from the preparation by means of laser radiation
DE10043504C2 (en) 2000-09-01 2002-07-04 Leica Microsystems Method for laser microdissection and use of a device for laser microdissection
DE10043506C1 (en) * 2000-09-01 2001-12-06 Leica Microsystems Laser micro dissection of tissue samples for culture uses a laser beam to cut border around section, leaving connecting strip which is cut using single, focused laser impulse which is wider than previous cut, so that section falls out
JP3773831B2 (en) * 2000-10-31 2006-05-10 富士写真フイルム株式会社 Biological sample cutting method and apparatus used therefor
DE10057292C2 (en) * 2000-11-17 2003-02-13 Leica Microsystems Device for receiving mirodissectates
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002043574A2 (en) 2000-11-29 2002-06-06 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
DE10102134A1 (en) * 2001-01-18 2002-08-01 Christoph Viebahn Glass cutter for slides
DE10102034A1 (en) * 2001-01-18 2002-08-08 Leica Microsystems Slide, microdissection device with slide and method for microdissection
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
EP1372828A4 (en) * 2001-03-24 2008-10-29 Aviva Biosciences Corp Biochips including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
DE10135091A1 (en) * 2001-07-15 2003-01-30 Universitaetsklinikum Charite Method, device and slide for microdissection
DE10147950C2 (en) * 2001-09-28 2003-12-04 Olympus Biosystems Gmbh Method and device for extracting cell material from a tissue sample
DE10152404C5 (en) * 2001-10-24 2017-06-08 Carl Zeiss Microscopy Gmbh Laser microdissection
US8722357B2 (en) * 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
US10156501B2 (en) 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
US8715955B2 (en) * 2004-09-09 2014-05-06 Life Technologies Corporation Laser microdissection apparatus and method
US7264966B2 (en) * 2002-01-23 2007-09-04 Olympus Optical Co., Ltd. Method of isolating cell or sample to be analyzed in cell
JP3820227B2 (en) * 2002-01-23 2006-09-13 オリンパス株式会社 Cell isolation method
WO2003093494A2 (en) * 2002-05-04 2003-11-13 Aviva Biosciences Corporation Apparatus including ion transport detecting structures and methods of use
WO2003101171A1 (en) * 2002-05-24 2003-12-04 Koninklijke Philips Electronics N.V. Method suitable for transferring a component supported by a carrier to a desired position on a substrate, and a device designed for this
DE10234755A1 (en) * 2002-07-30 2004-02-26 Leica Microsystems Wetzlar Gmbh New carrier for a biological sample, to be cut by laser micro-dissection, comprises film which is absorbent to laser light forming the base of a Petri dish
JP4595067B2 (en) 2002-08-01 2010-12-08 エックスワイ，エルエルシー Low-pressure sperm cell separation system
JP2005535346A (en) 2002-08-15 2005-11-24 エックスワイ，インコーポレイテッド High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
TWI226280B (en) * 2002-09-25 2005-01-11 Au Optronics Corp Precision notching device and method for cutting test piece
TWI236500B (en) * 2002-10-18 2005-07-21 Ind Tech Res Inst Device and method for capturing biological tissues
JP2004170930A (en) * 2002-10-31 2004-06-17 Olympus Corp Microdissection apparatus and method
DE10254229B4 (en) * 2002-11-20 2004-10-28 P.A.L.M. Microlaser Technologies Ag Positioning device for positioning a collecting device of a laser microdissection system
DE10300091A1 (en) * 2003-01-04 2004-07-29 Lubatschowski, Holger, Dr. microtome
BRPI0408857B1 (en) 2003-03-28 2018-09-11 Inguran Llc apparatus, methods and processes for separating particles and for providing sex-separated animal sperm
DE10320871B3 (en) * 2003-05-09 2004-09-16 Evotec Technologies Gmbh Sample distribution, for a cell sorter, comprises a fixed feed tube in a guide to deposit separate PCR samples at a moving micro-titration plate or sample strip without interfering with cell sorting
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
DE60334252D1 (en) * 2003-08-22 2010-10-28 Secretary APPARATUS AND METHOD FOR TRANSPORTING MICROSCOPIC OBJECT (S)
DE10346458A1 (en) * 2003-10-02 2005-05-12 Leica Microsystems Method for laser microdissection
JP2007509334A (en) * 2003-10-21 2007-04-12 ライカ マイクロシステムス ツェーエムエス ゲーエムベーハー Automatic generation method of laser cutting line in laser micro incision
DE10358565B4 (en) * 2003-12-15 2007-06-28 P.A.L.M. Microlaser Technologies Ag A receiving element for receiving an object released from a biological mass by means of laser radiation and method for obtaining and processing a biological object
DE10358566B4 (en) 2003-12-15 2012-03-01 P.A.L.M. Microlaser Technologies Ag A holding device for holding a biological object receiving means and a corresponding laser microdissection method
US7438859B2 (en) * 2003-12-31 2008-10-21 Protedyne Corporation Method and apparatus for laser impulse sample deposition
BRPI0509485A (en) 2004-03-29 2007-09-11 Monsanto Technology Llc sperm suspensions for use in insemination
US7951580B2 (en) * 2004-04-21 2011-05-31 The Regents Of The University Of California Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays
DE102004021904B4 (en) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Method and device for generating an analysis arrangement with discrete, separate measurement ranges for biological, biochemical or chemical analysis
DE102004022484B4 (en) 2004-05-07 2007-12-20 P.A.L.M. Microlaser Technologies Ag microscope stage
DE102004023262B8 (en) 2004-05-11 2013-01-17 Carl Zeiss Microimaging Gmbh Method for processing a mass by means of laser irradiation and control system
DE102004026744A1 (en) * 2004-05-28 2005-12-29 Philipps-Universität Marburg Invention relating to cDNA production from cells after laser microdissection
JP5334006B2 (en) * 2004-07-05 2013-11-06 株式会社発明屋 Protein chip
EP2269617B1 (en) 2004-07-22 2016-04-27 Inguran, LLC Process for enriching a population of sperm cells
DE102004041941B4 (en) * 2004-08-30 2007-01-11 P.A.L.M. Microlaser Technologies Ag Method for obtaining biological objects with a recording unit
CA2580853C (en) * 2004-10-04 2014-04-29 The Regents Of The University Of California Micropatterned plate with micro-pallets for addressable biochemical analysis
US7695954B2 (en) * 2004-10-04 2010-04-13 The Regents Of The University Of California Micropatterned plate with micro-pallets for addressable biochemical analysis
DE202005000844U1 (en) * 2005-01-18 2005-04-14 Passow, Harald Assembly to test the effect of a dental laser on a preparation on a platform with a moving preparation bench
WO2006091868A2 (en) * 2005-02-24 2006-08-31 The Regents Of The University Of California High throughput screening of molecular libraries using laser induced sorting
CA2604237A1 (en) * 2005-04-18 2006-10-26 Veriloc, Llc Ultraviolet activating system for preventing digital piracy from recording media
CN100526453C (en) 2005-05-20 2009-08-12 麦克奥迪实业集团有限公司 Cell collection method after laser microdissection
DE102005026540A1 (en) * 2005-06-08 2006-12-14 P.A.L.M. Microlaser Technologies Ag Method and device for handling objects
DE102005036326A1 (en) * 2005-07-29 2007-02-01 P.A.L.M. Microlaser Technologies Ag Method for analyzing a biological object, e.g. single cell, comprises recording a digital holographic micro-interferometric image of the object and analyzing the object by evaluating the image
US8383378B2 (en) * 2005-10-10 2013-02-26 The Regents Of The University Of California Micro-bubble plate for patterning biological and non-biological materials
GB0525847D0 (en) * 2005-12-20 2006-02-01 Univ Bristol Parallel Laser Direct Write
DE102005061561A1 (en) 2005-12-22 2007-06-28 P.A.L.M. Microlaser Technologies Ag Microdessection method for separation of e.g. individual cells, of e.g. biological preparation, involves cutting preparation through laser irradiation to divide cut layer into low cut and non cut sections, where non cut section is removed
DE102006000934A1 (en) * 2006-01-05 2007-07-12 P.A.L.M. Microlaser Technologies Ag Microdissection and microdissection system
DE102006009564B4 (en) * 2006-02-28 2014-05-15 Carl Zeiss Microscopy Gmbh Method for processing a mass by means of a laser beam and corresponding device
GB0603923D0 (en) * 2006-02-28 2006-04-05 Perkinelmer Ltd Apparatus and methods for imaging and modification of biological samples
KR101087809B1 (en) * 2006-04-10 2011-11-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Systems for collection of single cells and colonies
EP1887340A1 (en) * 2006-08-11 2008-02-13 Molecular Machines & Industries AG Method and device for cutting and collecting dissected specimens
US8785193B2 (en) 2006-09-14 2014-07-22 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Dissection tool and methods of use
DE102006045620B4 (en) * 2006-09-25 2009-10-29 Roland Dr. Kilper Device and method for receiving, transporting and storing microscopic samples
DE102006051460A1 (en) * 2006-10-31 2008-05-08 P.A.L.M. Microlaser Technologies Gmbh Apparatus, methods and tape material for collecting and transporting sample material
DE102007016301A1 (en) 2007-04-04 2008-10-09 P.A.L.M. Microlaser Technologies Gmbh Laser microdissection method and laser microdissection device
DE102007030320B4 (en) 2007-06-29 2015-04-02 Carl Zeiss Microscopy Gmbh Laser microdissection method and laser microdissection system
WO2009015361A1 (en) * 2007-07-25 2009-01-29 The Regents Of The University Of California Use of photosensitized epon epoxy resin 1002f for mems and biomems applications
US9487745B2 (en) 2007-07-27 2016-11-08 The Regents Of The University Of California Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls
EP2053377A1 (en) 2007-10-22 2009-04-29 MMI GmbH Method and device for 3D micro dissection
US8464619B2 (en) * 2008-07-14 2013-06-18 John Welsh Device for dissecting thin samples and methods thereof
JP5530081B2 (en) * 2008-07-16 2014-06-25 オリンパス株式会社 Ultrasonic dissection apparatus and ultrasonic dissection method
DE102008048618B3 (en) * 2008-09-23 2009-12-10 Universität Zu Lübeck Method for the laser-induced transport of materials from a transparent carrier substrate
DE202010017281U1 (en) 2010-04-15 2011-06-22 Mmi Ag Sample container carrier for the storage of single cells under a microscope
WO2011149009A1 (en) 2010-05-28 2011-12-01 オリンパス株式会社 Cell sorter, cell sorting system, and cell sorting method
WO2012066827A1 (en) 2010-11-19 2012-05-24 オリンパス株式会社 Method for preparing biological sample
KR101144594B1 (en) * 2010-12-28 2012-05-11 주식회사 세니젠 Method for collecting microorganism sample from solid surface using non-contact segmenting method and segmenting apparatus for the same
EP2711683B1 (en) 2011-05-20 2016-08-03 Olympus Corporation Method of manufacturing base sheet
JP5996550B2 (en) 2011-11-24 2016-09-21 オリンパス株式会社 Cell sorting device and cell sorting method
JP6210882B2 (en) * 2011-11-25 2017-10-11 オリンパス株式会社 Tissue division device, cell sorting device, cell sorting system, tissue display system, tissue dividing method and cell sorting method
CN102628758B (en) * 2012-03-01 2014-04-16 麦克奥迪实业集团有限公司 Collection device for collecting cells after laser microdissection, method and system thereof
US9719894B2 (en) 2012-05-24 2017-08-01 Leica Microsystems Cms Gmbh Specimen collector for collecting a laser micro-dissectate
WO2014065101A1 (en) * 2012-10-24 2014-05-01 オリンパス株式会社 Substrate recovery device
EP2799872B1 (en) 2013-05-01 2017-10-18 F. Hoffmann-La Roche AG Selective release of sub-group of biological units
DE102013212811A1 (en) * 2013-07-01 2015-01-08 Leica Microsystems Cms Gmbh Laser microdissection system and assay procedure for nucleic acid containing samples
EP3282241B1 (en) * 2015-04-06 2019-12-11 National University Corporation Nagoya University Laser microdissection apparatus, analyzing apparatus including laser microdissection apparatus, sample collecting method, and device employed in laser microdissection apparatus
JP6765192B2 (en) * 2016-01-20 2020-10-07 地方独立行政法人東京都立産業技術研究センター Laser microdissection and laser microdissection method
GB201603088D0 (en) * 2016-02-23 2016-04-06 Isis Innovation Cell sorting
DE102016111938B4 (en) * 2016-06-29 2023-06-29 Leica Microsystems Cms Gmbh Laser microdissection methods and laser microdissection systems
JP6799248B2 (en) * 2016-09-28 2020-12-16 澁谷工業株式会社 How to cut the cell sheet
CA3045227A1 (en) 2016-12-30 2018-07-05 Stefan Seeger Method and apparatus for the isolation and treatment of particulate targets
CN107490545A (en) * 2017-07-21 2017-12-19 中国科学院青岛生物能源与过程研究所 A kind of unicellular automation of high-flux microorganism sorts and reception system
CN110042053B (en) * 2018-01-16 2022-07-01 中国科学院青岛生物能源与过程研究所 Single-cell laser ejection substrate, method and application
SG11202011133VA (en) 2018-06-21 2020-12-30 Genomic Health Inc Systems and methods for pre-analytical substrate processing
KR20210003287A (en) * 2018-06-21 2021-01-11 게노믹 헬쓰, 인코포레이티드 Automated sample preparation system and its applications
CN108872238A (en) * 2018-07-08 2018-11-23 苏州美丽澄电子技术有限公司 A kind of optical tweezer gecko regenerative cell is to the method and device under microscope
WO2020146037A1 (en) 2019-01-09 2020-07-16 Google Llc Augmented reality laser capture microdissection machine
WO2020213674A1 (en) 2019-04-19 2020-10-22 Sony Corporation Microfluidic system, microfluidic chip, and operating method
CN110421258A (en) * 2019-08-15 2019-11-08 珠海冠宇电源有限公司 Laser welding and solder joint detect all-in-one machine
EP4053533A1 (en) * 2021-03-01 2022-09-07 Leica Microsystems CMS GmbH Method for obtaining dissectates from a microscopic sample, laser microdissection system and computer program
CN113176263A (en) * 2021-05-06 2021-07-27 云南省农业科学院粮食作物研究所 Method for auxiliary identification of corn haploid seedling plant by high power microscope

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2505774C3 (en) * 1975-02-12 1979-04-19 Remy, Ernst, Dipl.-Phys. Dr., 8000 Muenchen Alignment device for a laser arrangement consisting of a power laser and an alignment laser
FR2328960A1 (en) * 1975-10-08 1977-05-20 Coulter Electronics DEVICE FOR PRESERVATION AND IDENTIFICATION OF PARTICLES ANALYZED BY A THROUGH-FLOW DEVICE
DE2649912A1 (en) * 1975-11-28 1977-06-08 Macourt SEPARATION AND ANALYSIS OF COATING OF PARTICLES
CA1057592A (en) * 1975-12-19 1979-07-03 Technicon Instruments Corporation Transfer process and apparatus therefor
DE2819711C2 (en) * 1978-05-05 1984-02-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Method and device for analyzing a sample with the aid of pulsed laser radiation
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
DE3426473C1 (en) * 1984-07-18 1986-02-20 Hermann Dipl.-Geol. 3400 Göttingen Mader Reading device for microscopic objects, in particular microfossils
DE3509273A1 (en) * 1985-03-15 1986-09-18 Basf Ag, 6700 Ludwigshafen Method for producing incisions in biological material
JP2779414B2 (en) * 1988-12-01 1998-07-23 セイコーインスツルメンツ株式会社 Processing and observation method of micro section
DE4017804C2 (en) * 1989-08-22 1994-11-24 Finnigan Mat Gmbh Method and use of a device for matrix-assisted laser desorption of analyte molecules, in particular biomolecules
JP2774884B2 (en) * 1991-08-22 1998-07-09 株式会社日立製作所 Method for separating sample and method for analyzing separated sample obtained by this separation method
JPH0728714B2 (en) * 1991-09-17 1995-04-05 工業技術院長 Multi-beam type small object processing device
DE4138468A1 (en) * 1991-11-22 1993-06-03 Stiftung Fuer Lasertechnologie Laser device for removing material from biological surfaces - has liq.-gas spray units which intersect laser sepn. ensuring that surrounding areas are not dehydrated
DE4300698A1 (en) * 1993-01-13 1994-07-14 Raimund Schuetze Device and method for handling, processing and observing small particles, in particular biological particles
FR2714464B1 (en) * 1993-12-23 1996-02-09 Cogema Method for controlling the surface contamination of a solid and device for implementing it.
US5843644A (en) * 1994-03-01 1998-12-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation of cellular material under microscopic visualization using an adhesive/extraction reagent tipped probe
WO1997000430A1 (en) * 1995-06-19 1997-01-03 Optikzentrum Nrw Gmbh (Oz) Measuring device for short and ultrashort light pulses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004022483A1 (en) * 2004-05-07 2006-01-19 P.A.L.M. Microlaser Technologies Ag Holder for a recording device for recording biological objects
DE102004022483B4 (en) * 2004-05-07 2006-05-04 P.A.L.M. Microlaser Technologies Ag Holder for a recording device for recording biological objects
WO2018001679A1 (en) * 2016-06-28 2018-01-04 Leica Microsystems Cms Gmbh Contamination prevention device for a laser microdissection system, and laser microdissection system

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