DE2960583D1 - Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing them - Google Patents
Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- DE2960583D1 DE2960583D1 DE7979103669T DE2960583T DE2960583D1 DE 2960583 D1 DE2960583 D1 DE 2960583D1 DE 7979103669 T DE7979103669 T DE 7979103669T DE 2960583 T DE2960583 T DE 2960583T DE 2960583 D1 DE2960583 D1 DE 2960583D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- heterocyclylindoles
- novel
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/947,979 US4225711A (en) | 1978-10-02 | 1978-10-02 | Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2960583D1 true DE2960583D1 (en) | 1981-11-05 |
Family
ID=25487067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE7979103669T Expired DE2960583D1 (en) | 1978-10-02 | 1979-09-27 | Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing them |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4225711A (en:Method) |
| EP (1) | EP0010617B1 (en:Method) |
| JP (1) | JPS5566578A (en:Method) |
| AT (1) | ATE135T1 (en:Method) |
| AU (1) | AU526088B2 (en:Method) |
| CA (1) | CA1128944A (en:Method) |
| DE (1) | DE2960583D1 (en:Method) |
| DK (1) | DK411279A (en:Method) |
| FI (1) | FI793035A7 (en:Method) |
| GR (1) | GR73698B (en:Method) |
| IL (1) | IL58367A (en:Method) |
| NZ (1) | NZ191710A (en:Method) |
| ZA (1) | ZA795070B (en:Method) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3706427A1 (de) * | 1987-02-27 | 1988-09-08 | Boehringer Mannheim Gmbh | Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel |
| ES2080064T3 (es) * | 1988-07-11 | 1996-02-01 | Akzo Nobel Nv | Derivados de piridazinona. |
| KR100720220B1 (ko) * | 2000-10-17 | 2007-05-21 | 이하라케미칼 고교가부시키가이샤 | 치환 아닐린 화합물의 제조방법 |
| ITMI20040874A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL23847A (en) * | 1964-08-07 | 1969-02-27 | Merck & Co Inc | Benzimidazoles useful as antifungals |
| US3370063A (en) * | 1964-10-05 | 1968-02-20 | Mcneilab Inc | Substituted dimethoxy indoles and method of making the same |
| DE1695647A1 (de) * | 1967-09-01 | 1971-05-13 | Rhein Pharma Arzneimittel Gmbh | 3-Pyridyl(4)-indole und Verfahren zu ihrer Herstellung |
| US3927023A (en) * | 1974-05-24 | 1975-12-16 | Warner Lambert Co | Imidazolyl benzofurans |
| GB1523276A (en) * | 1974-09-20 | 1978-08-31 | Lafon Labor | Sulphur-containing amino compounds |
| US4059583A (en) * | 1975-11-13 | 1977-11-22 | Mcneil Laboratories, Incorporated | Substituted indoles |
-
1978
- 1978-10-02 US US05/947,979 patent/US4225711A/en not_active Expired - Lifetime
-
1979
- 1979-09-25 ZA ZA00795070A patent/ZA795070B/xx unknown
- 1979-09-27 DE DE7979103669T patent/DE2960583D1/de not_active Expired
- 1979-09-27 AT AT79103669T patent/ATE135T1/de not_active IP Right Cessation
- 1979-09-27 EP EP79103669A patent/EP0010617B1/en not_active Expired
- 1979-10-01 FI FI793035A patent/FI793035A7/fi not_active Application Discontinuation
- 1979-10-01 DK DK411279A patent/DK411279A/da not_active Application Discontinuation
- 1979-10-01 NZ NZ191710A patent/NZ191710A/en unknown
- 1979-10-02 AU AU51345/79A patent/AU526088B2/en not_active Ceased
- 1979-10-02 IL IL58367A patent/IL58367A/xx unknown
- 1979-10-02 JP JP12725179A patent/JPS5566578A/ja active Granted
- 1979-10-02 CA CA336,840A patent/CA1128944A/en not_active Expired
-
1980
- 1980-02-12 GR GR60160A patent/GR73698B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4225711A (en) | 1980-09-30 |
| JPS5566578A (en) | 1980-05-20 |
| IL58367A0 (en) | 1980-01-31 |
| GR73698B (en:Method) | 1984-04-03 |
| CA1128944A (en) | 1982-08-03 |
| DK411279A (da) | 1980-04-03 |
| EP0010617A1 (en) | 1980-05-14 |
| ZA795070B (en) | 1981-05-27 |
| JPS6345386B2 (en:Method) | 1988-09-09 |
| AU526088B2 (en) | 1982-12-16 |
| EP0010617B1 (en) | 1981-08-05 |
| NZ191710A (en) | 1984-04-27 |
| FI793035A7 (fi) | 1981-01-01 |
| IL58367A (en) | 1984-05-31 |
| ATE135T1 (de) | 1981-08-15 |
| AU5134579A (en) | 1980-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |