JPS5566578A - Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them - Google Patents

Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them

Info

Publication number
JPS5566578A
JPS5566578A JP12725179A JP12725179A JPS5566578A JP S5566578 A JPS5566578 A JP S5566578A JP 12725179 A JP12725179 A JP 12725179A JP 12725179 A JP12725179 A JP 12725179A JP S5566578 A JPS5566578 A JP S5566578A
Authority
JP
Japan
Prior art keywords
indoles
novel
manufacture
composition containing
medical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12725179A
Other languages
English (en)
Other versions
JPS6345386B2 (ja
Inventor
Suteinman Maachin
Taabazu Pirouzu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JPS5566578A publication Critical patent/JPS5566578A/ja
Publication of JPS6345386B2 publication Critical patent/JPS6345386B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP12725179A 1978-10-02 1979-10-02 Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them Granted JPS5566578A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/947,979 US4225711A (en) 1978-10-02 1978-10-02 Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants

Publications (2)

Publication Number Publication Date
JPS5566578A true JPS5566578A (en) 1980-05-20
JPS6345386B2 JPS6345386B2 (ja) 1988-09-09

Family

ID=25487067

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12725179A Granted JPS5566578A (en) 1978-10-02 1979-10-02 Novel 22substitutedd33heterocyclic indoles* their manufacture and medical composition containing them

Country Status (13)

Country Link
US (1) US4225711A (ja)
EP (1) EP0010617B1 (ja)
JP (1) JPS5566578A (ja)
AT (1) ATE135T1 (ja)
AU (1) AU526088B2 (ja)
CA (1) CA1128944A (ja)
DE (1) DE2960583D1 (ja)
DK (1) DK411279A (ja)
FI (1) FI793035A (ja)
GR (1) GR73698B (ja)
IL (1) IL58367A (ja)
NZ (1) NZ191710A (ja)
ZA (1) ZA795070B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535520A (ja) * 2004-04-30 2007-12-06 ニケム・リサーチ・ソシエタ・ア・レスポンサビリタ・リミタータ 抗腫瘍作用を有するインドール及びアザインドール誘導体

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
DE68924308T2 (de) * 1988-07-11 1996-04-04 Akzo Nobel Nv Pyridazinon-Derivate.
JP4189217B2 (ja) * 2000-10-17 2008-12-03 イハラケミカル工業株式会社 置換アニリン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
DE1695647A1 (de) * 1967-09-01 1971-05-13 Rhein Pharma Arzneimittel Gmbh 3-Pyridyl(4)-indole und Verfahren zu ihrer Herstellung
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
GB1523276A (en) * 1974-09-20 1978-08-31 Lafon Labor Sulphur-containing amino compounds
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535520A (ja) * 2004-04-30 2007-12-06 ニケム・リサーチ・ソシエタ・ア・レスポンサビリタ・リミタータ 抗腫瘍作用を有するインドール及びアザインドール誘導体

Also Published As

Publication number Publication date
IL58367A (en) 1984-05-31
AU526088B2 (en) 1982-12-16
NZ191710A (en) 1984-04-27
FI793035A (fi) 1980-04-03
EP0010617A1 (en) 1980-05-14
GR73698B (ja) 1984-04-03
DK411279A (da) 1980-04-03
EP0010617B1 (en) 1981-08-05
ATE135T1 (de) 1981-08-15
IL58367A0 (en) 1980-01-31
ZA795070B (en) 1981-05-27
DE2960583D1 (en) 1981-11-05
JPS6345386B2 (ja) 1988-09-09
US4225711A (en) 1980-09-30
AU5134579A (en) 1980-04-17
CA1128944A (en) 1982-08-03

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