DE2929101A1 - SUN PROTECTION PREPARATIONS AND THEIR USE - Google Patents

Description

The invention relates to that characterized in the claims Object.

UV energy absorbed by human skin can be a Cause erythema (reddening of the skin). The intensity of this process depends on the amount of energy absorbed. The UV radiation from both sunlight and artificial UV sources is divided into three bands (UV-A, UV-B and UV-C), each emitting different amounts of energy, causing the occurrence of a Erythema occurs at different times after the irradiation. The amount of energy each UV source at which a barely recognizable reddening of the skin can be determined is called the "minimum erythema dose" or MED.

The UV-A radiation is contained in the sunlight that reaches the earth's surface and has a wavelength of 320 to 400 nanometers (nm). This radiation is suitable for tanning the skin and causes only a slight reddening of the skin. About 20 to 50 joules (J) / cm ² of UV-A energy are necessary to generate a MED. The erythema reaction has its maximum intensity 72 hours after the irradiation.

30 UV-B radiation is also in the sunlight spectrum, the

reached the surface of the earth. It has a wavelength of 290 to 320 nm. The radiation causes sunburn, which also causes the pigmentation (tanning) of the skin. About 20 to 50 mJ / cm ² of UV-B energy are necessary to achieve a MED (that is, about 1000 times lower doses than with UV-A radiation). About 6 to 20 hours

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After irradiation, the erythema reaction reaches its maximum Intensity.

UV-C radiation has a wavelength of 200 to 290 nm
on. The radiation is not contained in the sunlight spectrum that reaches the earth's surface. However, she will go through
emits artificial UV sources. The radiation is not effective in stimulating pigmentation, but it is caused
she an erythema. About 5 to 20 mJ / cm ² are required to achieve a MED.

An individual's ability to burn is genetically predetermined and depends on the individual's ability to
after stimulation by UV-B and UV-A rays melamine pigments

to form within the pigment cells. The extent of any erythema reaction depends on the color of the skin, so
less time is required for people with fair skin,
to achieve a MED, while this time is longer in people with darker skin.

The fastest way to achieve a tan is to create a skin erythema through exposure to the sun. To achieve erythema that is sufficient to induce a tan but not severe enough to cause pain only takes half the time it takes to cause painful sunburn.

Sun tanning can be achieved with UV-A wavelengths, but tanning takes place under natural conditions only slowly. The tanning is mostly achieved by exposure to the "sunburn" (UV-B) rays.

Sunscreen formulations are commercially available that increase the amount of time it takes to achieve sunburn is required. These preparations contain chemical substances that are capable of various UV rays Absorb wavelengths. Examples of this sub-

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punches are 2-hydroxy-4-methoxybenzophenone _/ which absorbs UV-A radiation or opaque substances that reflect or scatter UV rays in a physical way, e.g. talc.

For example, UV-absorbing compounds and compounds containing them are described in the following patents Sunscreen preparations described: US Patents 3,004,896; 3,189,615; 3,403,207; 3,479,428; 3,644,614; 3,670,074; 3,751,563; 3,821,363; 3,892,844; GB-PS 1,291,917.

Since sunscreen preparations are often used by people who have to perform a physical exertion

J ₅ , especially in warm climates, or by people who come into frequent contact with water, there is a need for moisture-proof sun protection preparations. Attempts to manufacture such products have led to the development of polymeric substances which absorb UV rays and compositions containing these compounds (see, for example, US Patents 3,666,732; 3,795,733; 3,864,473; 3,895,104; 3,980,617; 4 004 047; etc.).

The invention is based on the object of providing moisture-resistant sun blockers or sun protection preparations increased UV absorption effect for both the "sunburn" (UV-B) radiation and the tanning (UV-A) radiation areas to accomplish.

This object is achieved by the invention.

The sun protection preparations according to the invention contain at least one known UV absorber and 2 to 15 percent by weight Polyethylene. The sun protection preparations according to the invention can also contain various other ingredients, for example plasticizers, emulsifiers, preservatives

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* agents, antioxidants, odorants, dyes or humectants.

The sun protection preparations according to the invention are preferably located as water-in-oil emulsions (W / O emulsions), as this results in them an additional moisture resistance is achieved. The sun protection preparations according to the invention can however, they are also available as oil-in-water emulsions (O / W emulsions), or in the form of cranes or oils. Depending on the choice of ingredients The preparations according to the invention can be in semi-solid, cream-like form and thus in plastic squeeze tubes be bottled. However, the sun protection preparations according to the invention can also be in the form of a lotion are present and filled into a squeeze container made of plastic. The container can have a closure with a flow opening or have a dispenser with a pump device.

The sun protection preparations according to the invention contain at least one known UV absorber, preferably at least one compound that absorbs in the UV-B range and at least one compound that absorbs in the UV-A range. The total amount of the sunscreen preparations contained UV absorber is 3 to 15 percent by weight. 25th

Examples of UV-A absorbers that can preferably be used are: 2- (2 -hydroxy-5'-methylphenyl) -benzotriazole (trademark Tinuvin P) j 2- (2'-hydroxy-5'-tert.-octylphenyl) -benzotriazole ( WM: Spectra-Sorb UV 5411); 2,4-dihydroxybenzophenone (TM: Uvinul 400); 2-hydroxy-4-methoxybenzophenone (Oxybenzone, TM: Spectra-Sorb UV9, Uvinul M-40); 2,2 ', 4,4'-tetrahydroxybenzophenone (TM: Uvinul D50); 2,2'-dihydroxy-4,4'-dimethoxybenzophenone (TM: Uvinul D49); 2,2'-dihydroxy-4-methoxybenzophenone (dioxybenzone, TM: Spectra-Sorb UV24); 2-ethylhexyl-4-phenyl-benzophenone carbonate (trademark: Eusolex 3573); 2-Hydroxy-4-methoxy-4'-methylbenzophenone (Mexenone,

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WZ: üvistat 2211); 2-hydroxy-4- (n-octyloxy) benzophenone (Octabenzon, TM: Spectra-Sorb UV531); 4-phenylbenzophenone (WZ Eusolex 3490) and 2-ethylhexyl-2-cyano-3,3'-diphenyl acrylate (WM: Uvinul N539). The UV absorber (s) are present in the sun protection preparations according to the invention in quantities from 0.5 to 10 percent by weight, based on the preparations. The amount added depends on the type of used UV absorber and whether the sun protection preparations according to the invention are used to prevent or to achieve of tanning should be used. The compound 2-hydroxy-4-methoxybenzophenone is alone or in Combination with 2,2'-dihydroxy-4-methoxybenzophenone one particularly preferred UV absorbers.

Specific examples of preferred UV-B absorbers are:

Ethyl 4- (dimethylamine) benzoate; 2- (Dimethylamino) -benzoic acid-2-ethylhexyl ester (trade mark: Escalol 507); 4- (dimethylamino) benzoic acid pentyl ester (trademark: Escalol 506); Glyceryl p-aminobenzoate (TM: Escalol 106) _; isobutyl p-aminobenzoate (cycloform) and isopropyl p-aminobenzoate. The UV-B absorber (s) are contained in the sun protection preparations according to the invention in amounts of 3 to 10 percent by weight, based on the end product. The amount added depends on the type of UV absorber used and on the desired level of protection in the end product. A particularly preferred UV-B absorber is 4- (dimethylamino) benzoic acid 2-ethylhexyl ester.

As an essential component of the invention Polyethylene is sun blocker or sun protection preparations in an addition amount of 2 to 15 percent by weight, preferably 2.5 to 6 percent by weight. It was determined, that the addition of at least 2.0 percent by weight of polyethylene in sun protection preparations results in an increased UV absorption effect can be achieved, both in terms of the UV-A and the UV-B range. By adding

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• j more polyethylene one achieves a correspondingly increased one UV absorption up to a value of about 5.5 percent by weight polyethylene content. An increase in the polyethylene content more than 5.5 percent by weight does not lead to a substantial increase in the UV absorption compared to the values can be achieved with 5.5 percent by weight. The upper limit of 15 weight percent polyethylene is based on the fact that a higher Polyethylene content leads to products of undesirable consistency and viscosity.

Suitable forms of the polyethylene used in the invention are low molecular weight homopolymers of low density with a molecular weight of 1,100 to 2,000 and a density of 0.88 to 0.92 g / ml. Copolymers of polyethylene and vinyl acetate with a molecular weight can also be used from 2000 to 3500 and a density of 0.91 to 0.93 g / ml can be used. Preferably a low molecular weight Polyethylene homopolymer used with a low density.

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That used in the sun protection preparations according to the invention Polyethylene also has the effect of increasing the moisture resistance and washability of the invention Sunscreen preparations. Furthermore, the polyethylene serves to stabilize the W / 0 emulsion and improves it the consistency and spreadability of the preparations according to the invention.

The sun protection preparations according to the invention contain also 40 to 65 percent by weight of water, 15 to 30 percent by weight of plasticizers, at most 1 percent by weight of preservatives and antioxidants and at most 1 percent by weight Odor and colorants.

Specific examples of suitable plasticizers are mineral oil, squalane, octyl palmitate, cocoa butter, sesame oil and Pristan. The preparations according to the invention contain pre-

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preferably a mixture of the abovementioned plasticizers or other plasticizers suitable for cosmetic use.

Specific examples of emulsifiers that can preferably be used are polyoxyethylene (3) oleyl ether (Oleth 3), polyglyceryl 4-oleate, Polyoxyethylene (2O) sorbitan monooleate (a mixture of oleate esters of sorbitol and sorbitol anhydride, consisting of mainly from the monoester condensed with about 20 moles of ethylene oxide; other name: Polysorbate 80 or Tween 80, trademark of ICI, USA.

The preparations according to the invention preferably contain a Mixture of at least two of the aforementioned emulsifiers or other emulsifiers suitable for cosmetic use.

Specific examples of suitable preservatives are Methylparaben (WS: Tegosept M), Quaternium-15 (N- (3-Chlorallyl) -hexaminiumchlorid) or chlorallyl methine amine chloride or propyl paraben (TM: Tegosept P). Preferred antioxidants are mixtures of butylated hydroxyanisole, propylene glycol, Propyl gallate and citric acid (trademark Tenox 2 from Eastman Chemical Products Inc., USA).

The preparations according to the invention preferably contain a mixture of antioxidants and at least one of the preservatives mentioned or others for the cosmetic Use suitable preservatives and anti-

30 oxidizing agents.

As mentioned above, the preparations according to the invention can by varying the percentage of the ingredients either in the form of a lotion or in a semi-solid form are present. For example, the preparations according to the invention contain about 60 in the case of a lotion

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up to 65 percent by weight, based on the end product, of water and at least one humectant such as propylene glycol, glycerine, 1,3-butylene glycol, sorbitol or sodium pyroglutamate (Sodium PCA) in an added amount of no more than about 7.5

5 percent by weight, based on the end product.

The production of the sun protection preparations according to the invention depends in part on the type of ingredients used. In general, most of them are used Plasticizers, emulsifiers, UV absorbers, preservatives and antioxidants by carefully mixing with one another mixed and then heated to temperatures above 90.degree. C., preferably to about 92 to 95.degree. Afterward the mixture is slowly mixed with the polyethylene and stirred, heated to temperatures of at least 90 ° C will. Preferably, the polyethylene to be added can initially slowly become one of those not yet contained in the main mixture Plasticizers can be added while stirring at high speed to completely remove the polyethylene disperse. The resulting second mixture can then be slowly added to the main mixture, with is stirred and heated. Mixing is continued until no undissolved polyethylene particles are visible and the oil phase is kept above 90 ° C.

At the same time, water, preferably deionized water, is heated to at least 90 ° C., again preferably to about 92 to 95 ° C. Any water-soluble constituents can be added to the water can be added.

The resulting aqueous phase is then stirred at a moderate speed slowly introduced into the oily phase. After the addition has ended, the stirring speed is increased and that Mixture is maintained at temperatures of at least 90 ° C until the mixture is uniform. The resulting mixture will gradually cooled to room temperature, with constant stirring. The mixture is then homogenized and

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1 either stored or supplied to the packaging.

A preferred sun protection preparation according to the invention is for example a sun block with maximum protective effect, which has the following composition:

50 to 60 percent by weight of water, 4.5 to 6 percent by weight of a low molecular weight polyethylene homopolymer lower Density, 2.5 to 3.5 percent by weight of a UV-A absorber from the group 2-hydroxy-4-methoxybenzophenone (oxybenzone) and 2,2'-dihydroxy-4-ynethoxybenzophenone (dioxybenzone), 5 to 10 percent by weight 4- (dimethylamine) -benzoic acid-2-ethylhexyl ester (TM: Escalol 507) as UV-B absorber, 20 to 27 percent by weight plasticizer, 4 to 7 percent by weight Emulsifiers and a maximum of 1 percent by weight of a combination of preservatives, antioxidants and Odorous substances.

A particularly preferred sun block with maximum sun protection has the following composition:

55 percent by weight of deionized water, 5.5 percent by weight of a polyethylene homopolymer with an average Molecular weight of about 2000 and a density of about 0.92 g / ml, 2.0 to 2.5 percent by weight of 2-hydroxy-4-methoxybenzophenone, a maximum of 1 percent by weight of 2,2-dihydroxy-4-methoxybenzophenone, 7 percent by weight 4- (dimethylamine) -benzoic acid-2-ethylhexyl ester, 23 to 25 percent by weight plasticizers, 5 percent by weight emulsifiers and at most 1 percent by weight a combination of preservatives, antioxidants and odorous substances.

Preferred sun protection preparations according to the invention, which on the one hand provide protection, but on the other hand a gradual one Allow browning, for example, have the following composition: 55 to 65 percent by weight water, 2.5 to 4.5 percent by weight of a low molecular weight polyethylene homopolymer of low density, at most 1 percent by weight

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cent 2-hydroxy-4-methoxybenzophenone (oxybenzone) 3 to 5 percent by weight 4- (Dimethylamine) -benzoic acid-2-ethylhexyl ester (TM: Escalol 507), a maximum of 7.5 percent by weight humectant, 20 to 25 percent by weight plasticizer, 4 to 7 percent by weight of emulsifiers and a maximum of 1 percent by weight of a combination of preservatives and antioxidants and odorous substances.

A particularly preferred sun protection preparation that allows tanning is a lotion with the following composition: 60 to 61 percent by weight of deionized water, about 3.5 percent by weight of a polyethylene homopolymer having an average molecular weight of about 1500 and a density of about 0.91 g / ml, about 0.6 weight percent • J5 2-hydroxy-4-methoxybenzophenone, about 3.5 weight percent 4- (Dimethylamino) -benzoic acid-2-ethylhexyl ester, about 5 percent by weight Glycerine or propylene glycol, 20 to 22 percent by weight plasticizers, 5 to 6 percent by weight emulsifiers and at most 1 percent by weight of a combination of preservatives, antioxidants and fragrances.

The examples illustrate the invention.

25 Examples 1 to 4

Sun blockers with a sun protection factor (SSF) higher than 15 are made. The SSF factor is determined as follows: The minimum erythema dose (MED dose) for ^{skin protected by applying 2 mg / cm 2 of} the sun protection preparation is divided by the value of the MED dose for unprotected skin.

In the examples below, the specifications are for the components on a weight percent basis. In the examples are chemical names, CTFA (Cosmetic, Toiletry and Fragrance Association, Inc.) - names and / or trademarks contain-

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ten. With all four sun protection preparations according to the examples it is W / 0 emulsions in a thickened lotion form.

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ω cn

ω ο

ins οι

cn

cn

ο oo cn

Deionized water Polyethylene (homopolymer)

(Allied Chemical A-C 6A, average molecular weight 2000, Density 0.92 g / ml)

LTV-A absorber

2-Hydroxy-4-methoxybenzophenone (Oxybenzone, Uvinul * ^

2,2'-dihydroxy-4-methoxybenzophenone (dioxybenzone, Spectra-Sorb UV 24)

UV-B absorber

4- (Dimethylamino) -benzoic acid 2-ethylhexyl ester (Escalol © 507)

Plasticizers

Mineral oil (Blandol ^) Squalane (Robane ®) Octyl palmitate (Ceraphyl sesame oil cocoa butter

368)

Examples:

J. ²

55.00 55.00

5.5

2.5

7.0

55.00

5.5

2.5

0.5

7.0

55.00

13.48 13.98 13.48 13.48 8.00 8.00 - 8.00 - - 8.00 - 2.00 2.00 2.00 2.00 0.50 0.50 0.50 0.50

Γ ω co ro to - »-» * ~ ι

cn ο cn ο cn o cn- * '

Emulsifiers

Polyoxyethylene- (1) -ο leylather (Oleth-3, Volpo © 3) Polyglyceryl-4-oleate (Witconol © 14)

Conservatives Methylparaben (Tegosept ^ M) ο Propylparaben (Tegosept ^ P) ro Quaternium-15 (N- (3-chloroallyl) -oo hexaminium chloride, .Dowicil © 200) cn

"* - Antioxidants

σ

co propylene glycol and butylated 0.02 0.02 0.02 0.02

οι hydroxyanisole and ^.

*** Propyl gallate and citric acid (Tenox ^ 2)

Examples: 3 4th 1 2 3.50 3.50 3.50 3.50 1.50 1, 50 1, 50 1.50 0.20 0.20 0.20 o,:> o 0.10 0.10 0.10 0.10 0.20 0.20 0.20 0.20

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j The production of the preparations according to Examples 1 to 4 is done in practically the same way. Below are the exact instructions for making the preparation according to Example 3 given:

3.5 kg polyoxyethylene (3) oleyl ether, 1.5 kg polyglyceryl 4-oleate, 7 kg 4- (dimethylamine) benzoic acid 2-ethylhexyl ester, 2.5 g 2-hydroxy-4-methoxybenzophenone, 0 , 5 kg of 2,2'-dihydroxy-4-methoxybenzophenone, 2 kg of sesame oil, 13.48 kg of mineral oil, 0.5 kg of cocoa butter, 0.02 kg of the above-mentioned antioxidant mixture (Tenox ^ 2) and 0.1 kg of propyl paraben mixed with one another with slow mixing and heating to 92 to 95 ^{° C.} Mixing is continued until the mixture is uniform and clear ^{at 92 to 95 ° C.}

At the same time, 8 kg of octyl palmitate are added for about 15 minutes slowly mixed with 5.5 kg of polyethylene while stirring at high speed until the polyethylene is completely is dispersed.

Subsequently, the Polyäthylengemenge is added to the main batch previously prepared slowly, while stirring at a temperature of 92-95 ⁰ C. Mixing is continued until the oily mixture is completely liquid and clear and no undissolved polyethylene particles are visible.

Subsequently, 54.5 kg of deionized water at 92-95 ⁰ C are heated and mixed at the same temperature with 0.2 kg methyl paraben and slowly stirred. Stirring (mixing) is continued until the methyl paraben is completely dissolved.

The resulting aqueous solution is then slowly introduced into the previously prepared oil-like mixture , with slow mixing. When the addition is complete, the mixing speed is increased until the resulting mixture is uniform.

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The mixture is kept at 90 to 95 ⁰ C. The batch is then rapidly cooled to 60 ° C. and mixed at this temperature for about 30 minutes. The mixture is then cooled to 50 ° C. with continuous mixing. At the same time, 0.2 kg of chlorallyl methenamine chloride are added

(Quaternium-15) dissolved in 0.5 kg of deionized water. The resulting aqueous solution is then slowly introduced into the oily mixture, stirring until the seat is uniform, which takes about 15 minutes. The IQ resulting mixture is then cooled to room temperature, being continuously stirred, and then homogenized. 100 kg of end product are obtained.

Examples 5 and 6

In this example, sunscreen preparations are made with a Sun protection factor of 7 or 8 produced- The specified components relate to weight, and there are both the CTFA names as well as trademarks are given. The preparations made in the examples are W / O emulsions in lotion form.

Examples:

Deionized water 60.05 60.55

Polyethylene (homopolymer) 3.50 3.50

²⁵ (Allied Chemical AC 617A, average molecular weight: 1500, density 0.91 g / ml)

UV-A absorber 0.50 0.60

2-hydroxy-4-methoxybenzophenone (Oxybenzone, Uvinul ^ M-40)

UV-B absorber 3.0 3.50

4- (dimethylamino) -benzoic acid-2-ethylhexyl (Escalol 507 *) 35 humectants

Propylene glycol 5, OO -

Glycerin - 5.00

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1 examples

5 6

Plasticizers

Mineral oil (Blandol ^) 11.48

Mineral oil (Klearol®) - 20.88

Pristan 10.00 -

Emulsifiers

Polyoxyethylene (3) -oley lather 3.50 3.50

(Oleth-3, Volpo® 3)

Polyglyceryl-4-oleate (Witconol ^ 14) 1.50 1.50 Poly sorbate 80 (Tween®80, 0.50 0.50

see claim 16)

Preservatives

Methyl paraben (Tegosept ^ * M) 0.2 0.2

Propyl paraben (Tegosept ^ P) 0.1 0.1

Quaternium-15 (N- (3-chloroallyl) -

hexaminium chloride; Dowicil ^ 200) 0.15 0.15

Antioxidants
Propylene glycol, butylated 0.02 0.02

Hydroxyanisole, propyl gallate

(S) and citric acid (Tenox ^w 2)

Odor substances 0.50

The production of the sun protection preparations according to the examples 5 and 6 is carried out according to the procedure given in the preceding examples. Make the final products Lotions that are more liquid compared to the preparations from Examples 1 to 4.

Examples 7 and 8

The following sun blockers or sun protection preparations can also be produced according to Example 3. The details of the constituent parts are based on weight percent and both the CTFA designations and trademarks are indicated. In the case of Examples 7 and

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8 sun protection preparations produced are W / O emulsions. The preparation according to Example 7 represents a thickened lotion or cream, whereas the preparation from Example 8 is more liquid.

Examples

7 8

Deionized water 55.00 60.55

Polyethylene (vinyl acetate - 5.5 3.5

Copolymer i sat)
10

(Allied Chemical A-C 400,

average molecular weight 3500,
Density 0.92 g / ml)

UV-A absorber

2-hydroxy-4-methoxybenzophenone 2.5 0.6

(Oxybenzone, Uvinul ^ M-40)

2,2'-dihydroxy-4-methoxybenzo-0.5 -

phenone (dioxybenzone, Spectra-Sorb® UV24)

UV-B absorber

4- (dimethylamine) benzoic acid 7.0 3.5

2-ethylhexyl ester (Escalol ® 507)

Plasticizers

Mineral oil (Blandol®) 13.48

Mineral oil (Klearol ^) - 20.88

Octyl palmitate (Ceraphyl ^{{& /} 368) 8.00

Sesame oil 2, OO

Cocoa butter 0.50 humectant

Glycerin - 5.0

Emulsifiers

Polyoxyethylene (3) oleyl ether 3.50 3.50 (Oleth-3, Volpo ® 3)

Polyglyceryl 4-oleate 1.50 1.50

(Witconol ® 14)

Polysorbate 80 (Tween® 80) - 0.50

(see claim 16)

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Preservatives Methylparaben (Tegosept ^ M) Propylparaben (Tegosept ^ P) Quaternium-15 (N- (3-Chlorallyl) -hexaminiuinchlorid; Dowicil ® 200) Antioxidant Propylene Glycol, Butylated Hydroxyanisole, Propyl Gallate and Citric Acid (Tenox 2) 2S2S101

Examples 8th , 20 7th 0 , 1O 0 , 20 0 , 15 0 , 10 0 0 , 20

0.02

O 02

example

The UV absorption of two similar preparations, one containing polyethylene (P) and the other polyethylene does not contain (NP) are compared. The components are based on weight.

Components in% by weight

Deionized water

Polyethylene (Allied Chemical AC 6A)

UV-A absorber 2-Hydroxy-4-methoxybenzophenone (Oxybenzone, Uvinul ^ M-40) 2,2'-Dihydroxy-4-methoxybenzophenone (Dioxybenzone, Spectra-Sorb ® UV24)

UV-B absorber 4- (Dimethylamine) -benzoic acid-

2-ethylhexyl ester (Escalol® 507) P
55.00

5.50

2.50 0.5

7.00

NP 55.00

2.5O

0.5

7.00

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Components
in% by weight NP 98 P. 18 00 13.48 8th, 00 8, OO 2, 50 2.00 0, 50 O, 5O 3, 50 3.5O 1/ 20th 1.5O 0, 10 O, 2O O, 20th O, 1O ö, 0.20

Plasticizer mineral oil (Blandol ^) squalane (Robane ^)

Softener (continued) sesame oil

Cocoa butter

Emulsifiers

Polyoxyethylene (3) oleyl ether
(Oleth-3, Volpo ® 3)
Polyglyceryl-4-oleate (Witconol ^ 14)

Preservatives Methylparaben (Tegosept ^ M) Propylparaben (Tegosept P) Quaternium-15 (N- (3-Chlorallyl) -hexaminiumchlorid; Dowicil ^{V £ y} 200)

Antioxidants

Propylene glycol and butyl value 0.02 0.02

Hydroxyanisole, propyl gallate and citric acid

(Tenox® 2)

The two comparative preparations are produced as described above. The evaluation takes place in vitro according to the information in Cumpelik, "Analytical Procedures and Evaluation of Sunscreens", J. Soc. Cosmet. Chem., 23, pp. 333-345 (1972).

Thin films of each of the above preparations are dried with hot air. The UV absorption is at Measured wavelengths from 240-400 nm. This area becomes the percentage of UV rays that are in the erythema area (Area of sunburn) from 292.5 to 342.5 nm

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j, as well as the proportion of rays that pass in the sun-tanning range from 322.5 to 372.5 nm are determined. The greater the percentage of UV radiation transmitted through the comparative preparation— The lower the protective effect that is provided by the respective preparation.

Each of the preparations examined is tested three times.

IQ For the polyethylene-containing preparation according to the invention (P) the relative average percentage of transmitted erytham radiation is 5.105 and the relative percentage average percentage of transmitted tanning radiation 19,569. For the other preparation that does not have Contains polyethylene (NP), is the relative average percentage of transmitted erythema radiation 6.58 and the relative average percentage of transmitted tanning radiation 55.23. From this it follows found that the preparation without polyethylene (NP) 1.28 times as much UV radiation in the erythema area and 2.82 times as much Radiation in the tanning area lets through than the preparation with polyethylene (P).

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Claims (18)

Claims 1. Sun protection preparation containing 3 to 15% by weight of an ultraviolet absorber (UV absorber), 2 to 15% by weight of polyethylene, 40 to 65% by weight of water, 15 to 30% by weight of plasticizer, 3 to 10 wt .- ^ emulsifiers, at most 1 wt -.% of combined preservatives, antioxidants and at most 1 wt -.% combined odor and dyes. 2. Sun protection preparation according to claim 1, characterized in that that at least one UV-A absorber and at least one UV-B absorber are contained as the UV absorber. 3. Sun protection preparation according to claim 2, characterized in that the UV-A absorber or the UV-A absorber in an addition amount of 0.5 to 10 wt .-% and the UV-B absorber or the addition amount of 3 to 10 wt .- # are included. 909885/0857 4. Sun protection preparation according to claim 3, characterized in that the UV-A absorber contains at least one compound from the following group: 2- (2'-hydroxy-5'-methylphenyl) benzotriazole; 2- (2'-hydroxy-5'-tert-octylphenyl) benzotriazole; 2,4-dihydroxybenzophenone; 2-hydroxy-4-methoxybenzophenone; 2,2 ', 4,4'-tetrahydroxybenzophenone;2,2'-dihydroxy-4,4'-dimethoxybenzophenone; 2.2 ^! -Dihydroxy-4-methoxybenzophenone; 2-ethylhexyl-4-phenylbenzophenone carbonate j 2-hyaroxy-4-methoxy-4'-methylbenzophenone; 2-hydroxy-4- (n-octyloxy) benzophenone; 4-phenylbenzophenone; 2-A "ethylhexyl-2-cyano-3,3'-diphenyl acrylate, and that the UV-B absorber contains at least one compound from the following group: ethyl 4- (dimethylamino) benzoate, 4- (dimethylamino) 2-ethylhexyl benzoate; pentyl 4- (dimethylamino) benzoate; glyceryl paminobenzoate; isobutyl p-aminobenzoate; isopropyl p-aminobenzoate. 5- Sun protection preparation according to claim 4, characterized in that that a low molecular weight homopolymer of low density is contained as polyethylene, which has a molecular weight from 1100 to 2000 and has a density of 0.88 to 0.92 g / ml, or that a copolymer of polyethylene and vinyl acetate is included, which has a molecular weight of 2000 to 3500 and a density of 0.91 to 0.93 g / ml. 25th 6. Sun protection preparation according to claim 5 »characterized in that that as UV-A absorber 2-hyaroxy-4-methoxybenzophenone alone or in combination with 2,2'-dihydroxy-4-methoxybenzophenone , and as UV-B absorber '4- (dimethylamino) -benzoic acid-2- ³⁰ ethylhexyl ester is used. 7. Sun protection preparation according to claim 6, characterized in that that it is in the form of a water-in-oil emulsion (W / O emulsion), and that the polyethylene contained is a low molecular weight homopolymer of low density with a molecular weight of 909885/0857 1100 to 2000 and a density of 0.88 to 0.92 g / ml and in an amount of 2.5 to 6 wt - is included.%. 8. Sun protection preparation according to claim 7, containing 5-50 to 6o % by weight of water, 4.5 to 6% by weight of a polyethylene homopolymer, 2.5 to 3.5 wt .- ^ 2-hydroxy-4-methoxybenzophenone alone or in combination with 2,2'-dihydroxy-4-methoxybenzophenone, - 5 to 10 % by weight of 4- (dimethylamine) -benzoic acid-2-ethylhexyl ester, 20 to 27 wt -.% Plasticizer, 4 to 7 wt -.% Emulsifiers, and - a maximum of 1% by weight of a combination of preservatives, antioxidants and odorous substances. 9. Sun protection preparation according to claim 8, containing 55 wt .- ^ deionized water, 5 * 5 wt -.% Of a polyethylene homopolymer having an average molecular weight of about 2000 and a density of about 0.92 g / ml, 2.0 to 2.5 wt .- # 2-hydroxy-4-methoxybenzophenone, at most 1 wt -.% Of 2,2 'dihydroxy-4-methoxybenzophenone *, ~ 7 wt% of 4- (Dimethylamine). - 2-ethylhexyl benzoate, - 23 to 25 wt .- ^ plasticizers, 25 - about 5 wt .- # emulsifiers as well - a maximum of 1% by weight of a combination of preservatives, antioxidants and odorous substances. 10. Sun protection preparation according to claim 9, characterized by the following composition on a weight basis: Deionized water 55jO % Polyethylene 5.5 % 2-hydroxy-4-methoxybenzophenone 2.5 % 2,2'-dihydroxy-4-methoxybenzophenone o _; 5 % 4- (dimethylamino) -benzoic acid-2-ethyl- hexyl ester 7 / ° % 909885/0857 mineral oil 2929101 - 4 - Squalane 13.48 % sesame oil 8.0 % Cocoa butter 2.0 % Polyoxyethylene (3) oleyl ether 0.5 % Polyglyceryl-4-oleate 3.5 pounds Methyl paraben 1.5 % Propyl paraben 0.2 % Chlorail'yl methenamine chloride 0.1 % Propylene glycol, butylated hydroxyanisole, 0.2 % Propyl gallate and citric acid 0.02 % 11. Sun protection preparation according to claim 9, characterized by the following composition on a weight basis: 15th Deionized water 55.0 % Polyethylene 5.5 % 2-hydroxy-4-methoxybenzophenone 2.5 % 4- (dimethylamino) -benzoic acid-2-ethyl- hexyl ester 7.0 % Mineral oil £ 13.98 Squalane 8.0 # Sesame oil 2.0 % Cocoa butter 0.5 % Polyoxyethylene (3) oleyl ether 3.5 % Polyglyceryl-4-oleate 1.5 % Methyl paraben 0.2 % Propyl paraben 0.1 % Chlorallyl methenamine chloride - 0.2 % Propylene glycol, butylated hydroxyanisole, Propyl gallate and citric acid 0.02 <£ 12. Sun protection preparation according to claim 9, characterized by the following composition in wt -% - based. 35 909885/0857 Deionized water 55.0 % polyethylene 5.5 % 2-hydroxy-4-methoxybenzophenone 2.5 % 2,2'-dihydroxy-4-methoxybenzophenone 0.5 % 5 4- (Dimethylamine) -benzoic acid-2-ethyl- hexyl ester 7.0 % Mineral oil 13.48 fo octyl palmitate 8.0 % Sesame oil 2.0 % Cocoa butter 0.5 % Polyoxyethylene (3) oleyl ether 3.5 % Polyclyceryl 4 oleate 1.5 % Methyl paraben 0.2 % Propyl paraben 0.1 % Chloral IyI-Methenaminchlorid 0,2 # Propylene glycol, butylated hydroxyanisole, Propyl gallate and citric acid 0.02 % 13 · Sun protection preparation according to claim 9, characterized by the following composition on a % by weight basis: Deionized water 55.0 % polyethylene 5.5 % 2 ~ hydroxy-4-methoxybenzophenone 2.0 % 2,2'-dihydroxy-4-methoxybenzophenone 1.0 % 4- (Dimethylamino) -benzoic acid-2-ethylhexyl ester 1.0% Mineral oil 13.48 % squalane. . 8.0 % Sesame oil 2.0 % Cocoa butter 0.5 ¹ ^ Polyoxyethylene (3) oleyl ether 3.5 % Polyglyceryl-4-oleate 1.5 % Methyl paraben Q, 2% Propyl Paraben $ 0.1 Chlorallyl methenamine chloride 0.2 ^ Propylene glycol, butylated hydroxyanisole, Propyl gallate and citric acid 0.02 % 909885/0857 14. Sun protection preparation according to claim 7, containing 55 to 65 wt .- ^ water, 2.5 to 4.5 wt .- ^ of a polyethylene homopolymer, at most 1 wt -.% 2-hydroxy-4-methoxybenzophenone, 5 - 3 to 5 wt -.% of 4- (Dimethylamine) -benzoic acid 2-ethyl hexyl ester, a maximum of 7 »5 wt .- $ humectant, 20 to 25 wt .- ^ plasticizer, 4 to 7 wt .- # emulsifiers as well ¹⁰ - at most 1 wt .- ^ a combination of preservatives, antioxidants and odorous substances. 15. Sun protection preparation according to claim 14, containing 60 to 6l wt .- ^ deionized water, 15 _ about 3 * 5 wt .- ^ of a polyethylene homopolymer with an average molecular weight of about 1500 and a density of about 0.91 g / ml, about 0.6 % by weight of 2-hydroxy-4-methoxybenzophenone, about 3 * 5 wt .- # 4- (Dimethylamine) -benzoic acid-2-ethyl- hexyl ester, about 5 wt .- # glycerine or propylene glycol, 20 to 22 wt .- % plasticizer, 5 to 6 % by weight of emulsifiers and a maximum of 1 % by weight of a combination of preservatives, antioxidants and odorous substances. 16. Sun protection preparation according to claim I5, characterized by the following composition on a weight basis: Deionized water 60.55 % Polyethylene 3.5 % 2-Hydroxy-4-methoxybenzophenone $ 0.6 4- (Dimethylamine) benzoic acid 3 * 5 / ^ 2 ~ ethylhexyl ester 3.5 ^ Glycerine 5.0 % Mineral oil 20.88 % 909885/0857 - ⁷ - 2329101 Polyoxyethylene (3) oleyl ether 3.5% Polyglycerol-4-oleate 1.5% Polyoxyethylene (20) sorbitan monooleate (a mixture from oleate esters of sorbitol and sorbitol anhydride, consisting mainly of the monoester, which is condensed with about 20 moles of ethylene oxide. Other name: Polysorbate 80) 0.5% Methyl paraben 0.2% Propyl paraben 0.1% Chlorallyl methenamine chloride 0.15% Propylene glycol, butylated hydroxyanisole,
Propyl gallate and citric acid 0.02% 17. Use of sunscreen preparations that contain at least contain a UV absorber to achieve a increased ÜV supervisory effect and to achieve a Gradual tan, characterized in that the sunscreen preparations contain at least 2% by weight of polyethylene. 18. Use of the sun protection preparations according to claim 1 to 16 to achieve an increased UV absorption effect and achieve a gradual tan. 909885/0857