DE2828369C3 - Gefäßprothese zusammengesetzten Aufbaues sowie Verfahren zu deren Herstellung - Google Patents
Gefäßprothese zusammengesetzten Aufbaues sowie Verfahren zu deren HerstellungInfo
- Publication number
- DE2828369C3 DE2828369C3 DE2828369A DE2828369A DE2828369C3 DE 2828369 C3 DE2828369 C3 DE 2828369C3 DE 2828369 A DE2828369 A DE 2828369A DE 2828369 A DE2828369 A DE 2828369A DE 2828369 C3 DE2828369 C3 DE 2828369C3
- Authority
- DE
- Germany
- Prior art keywords
- tube material
- polyethyleneimine
- porous
- polytetrafluoroethylene
- prosthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002792 vascular Effects 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000002131 composite material Substances 0.000 title description 5
- 239000000463 material Substances 0.000 claims description 104
- 229920002873 Polyethylenimine Polymers 0.000 claims description 73
- -1 polytetrafluoroethylene Polymers 0.000 claims description 43
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 41
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 41
- 239000011148 porous material Substances 0.000 claims description 35
- 229920000669 heparin Polymers 0.000 claims description 34
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 32
- 229960002897 heparin Drugs 0.000 claims description 32
- 239000000835 fiber Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000005956 quaternization reaction Methods 0.000 claims description 6
- 150000001350 alkyl halides Chemical class 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
- 238000009877 rendering Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 28
- 102000009123 Fibrin Human genes 0.000 description 17
- 108010073385 Fibrin Proteins 0.000 description 17
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 17
- 229950003499 fibrin Drugs 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 208000034827 Neointima Diseases 0.000 description 13
- 230000001407 anti-thrombic effect Effects 0.000 description 11
- 210000002950 fibroblast Anatomy 0.000 description 11
- 210000001367 artery Anatomy 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000002513 implantation Methods 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 7
- 235000016709 nutrition Nutrition 0.000 description 7
- 230000035764 nutrition Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 6
- 210000002808 connective tissue Anatomy 0.000 description 6
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 6
- 210000003462 vein Anatomy 0.000 description 6
- 102000004506 Blood Proteins Human genes 0.000 description 5
- 108010017384 Blood Proteins Proteins 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 230000002308 calcification Effects 0.000 description 4
- 239000002826 coolant Substances 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005470 impregnation Methods 0.000 description 4
- 238000005245 sintering Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000005786 degenerative changes Effects 0.000 description 3
- 229940015043 glyoxal Drugs 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920004934 Dacron® Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 230000002429 anti-coagulating effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- SBHRWOBHKASWGU-UHFFFAOYSA-M tridodecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(CCCCCCCCCCCC)CCCCCCCCCCCC SBHRWOBHKASWGU-UHFFFAOYSA-M 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- MPPPKRYCTPRNTB-UHFFFAOYSA-N 1-bromobutane Chemical compound CCCCBr MPPPKRYCTPRNTB-UHFFFAOYSA-N 0.000 description 1
- CYNYIHKIEHGYOZ-UHFFFAOYSA-N 1-bromopropane Chemical compound CCCBr CYNYIHKIEHGYOZ-UHFFFAOYSA-N 0.000 description 1
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 1
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 1
- OSDWBNJEKMUWAV-UHFFFAOYSA-N Allyl chloride Chemical compound ClCC=C OSDWBNJEKMUWAV-UHFFFAOYSA-N 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical class N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 229960003750 ethyl chloride Drugs 0.000 description 1
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- GRHBQAYDJPGGLF-UHFFFAOYSA-N isothiocyanic acid Chemical class N=C=S GRHBQAYDJPGGLF-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000010687 lubricating oil Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 150000003512 tertiary amines Chemical group 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7938577A JPS5413694A (en) | 1977-07-01 | 1977-07-01 | Composite blood vessel prosthesis and method of producing same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2828369A1 DE2828369A1 (de) | 1979-01-11 |
| DE2828369B2 DE2828369B2 (de) | 1980-09-04 |
| DE2828369C3 true DE2828369C3 (de) | 1988-07-28 |
Family
ID=13688390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2828369A Expired DE2828369C3 (de) | 1977-07-01 | 1978-06-28 | Gefäßprothese zusammengesetzten Aufbaues sowie Verfahren zu deren Herstellung |
Country Status (12)
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6037734B2 (ja) * | 1978-10-12 | 1985-08-28 | 住友電気工業株式会社 | 管状臓器補綴材及びその製造方法 |
| US4713070A (en) * | 1978-11-30 | 1987-12-15 | Sumitom Electric Industries, Ltd. | Porous structure of polytetrafluoroethylene and process for production thereof |
| US4604762A (en) * | 1981-02-13 | 1986-08-12 | Thoratec Laboratories Corporation | Arterial graft prosthesis |
| SE456347B (sv) * | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| JPS5934359A (ja) * | 1982-08-18 | 1984-02-24 | 加賀防水工業株式会社 | 建造物の防水施工法 |
| US5034265A (en) * | 1983-08-01 | 1991-07-23 | Washington Research Foundation | Plasma gas discharge treatment for improving the compatibility of biomaterials |
| US4562596A (en) * | 1984-04-25 | 1986-01-07 | Elliot Kornberg | Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair |
| FR2566667B1 (fr) * | 1984-06-27 | 1986-11-21 | Delcroix Jean Pierre | Procede de traitement antithrombogene de catheters et catheters ainsi obtenus |
| JPS61282194A (ja) * | 1985-06-06 | 1986-12-12 | Yukio Nakamura | ジエツト推進式舟艇の推進軸とその製造法 |
| US4632842A (en) * | 1985-06-20 | 1986-12-30 | Atrium Medical Corporation | Glow discharge process for producing implantable devices |
| US4718907A (en) * | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
| US5061276A (en) * | 1987-04-28 | 1991-10-29 | Baxter International Inc. | Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation |
| US4816339A (en) * | 1987-04-28 | 1989-03-28 | Baxter International Inc. | Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation |
| US4892539A (en) * | 1988-02-08 | 1990-01-09 | D-R Medical Systems, Inc. | Vascular graft |
| US5207706A (en) * | 1988-10-05 | 1993-05-04 | Menaker M D Gerald | Method and means for gold-coating implantable intravascular devices |
| US5376118A (en) * | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
| US5217495A (en) * | 1989-05-10 | 1993-06-08 | United States Surgical Corporation | Synthetic semiabsorbable composite yarn |
| US4990158A (en) * | 1989-05-10 | 1991-02-05 | United States Surgical Corporation | Synthetic semiabsorbable tubular prosthesis |
| US5147400A (en) * | 1989-05-10 | 1992-09-15 | United States Surgical Corporation | Connective tissue prosthesis |
| US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| ATE138256T1 (de) * | 1990-10-31 | 1996-06-15 | Baxter Int | Vaskularisation erlaubendes implantatmaterial |
| US5632776A (en) * | 1990-11-22 | 1997-05-27 | Toray Industries, Inc. | Implantation materials |
| FR2675038B3 (fr) * | 1991-04-10 | 1993-07-16 | France Chirurgie Instrumentation | Support de mesoprothese. |
| US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
| EP0630432B1 (en) * | 1992-03-13 | 1999-07-14 | Atrium Medical Corporation | Controlled porosity expanded fluoropolymer (e.g. polytetrafluoroethylene) products and fabrication |
| DE69326631T2 (de) * | 1992-03-19 | 2000-06-08 | Medtronic, Inc. | Intraluminales Erweiterungsgerät |
| US20020055710A1 (en) | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
| ATE260757T1 (de) | 1994-05-06 | 2004-03-15 | Impra Inc A Subsidiary Of C R | Vorrichtung zur behandlung eines körpergefässes |
| EP0767684B1 (en) * | 1994-06-27 | 2005-05-25 | Bard Peripheral Vascular, Inc. | Radially expandable polytetrafluoroethylene and expandable endovascular stents formed therewith |
| US6156305A (en) * | 1994-07-08 | 2000-12-05 | Baxter International Inc. | Implanted tumor cells for the prevention and treatment of cancer |
| EP0698396B1 (en) * | 1994-08-12 | 2001-12-12 | Meadox Medicals, Inc. | Vascular graft impregnated with a heparin-containing collagen sealant |
| US5665114A (en) * | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
| EP0782497B1 (en) * | 1994-09-23 | 2001-07-11 | Impra, Inc. | Vascular graft containing carbon and method for making same |
| US5532311A (en) * | 1995-02-01 | 1996-07-02 | Minnesota Mining And Manufacturing Company | Process for modifying surfaces |
| JP3799626B2 (ja) * | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
| US5628786A (en) * | 1995-05-12 | 1997-05-13 | Impra, Inc. | Radially expandable vascular graft with resistance to longitudinal compression and method of making same |
| US5583213A (en) * | 1995-05-12 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Process to activate sulfated polysaccharides |
| US5916585A (en) * | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
| US5855618A (en) | 1996-09-13 | 1999-01-05 | Meadox Medicals, Inc. | Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin |
| US6306165B1 (en) | 1996-09-13 | 2001-10-23 | Meadox Medicals | ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin |
| US5741881A (en) * | 1996-11-25 | 1998-04-21 | Meadox Medicals, Inc. | Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions |
| US5877263A (en) | 1996-11-25 | 1999-03-02 | Meadox Medicals, Inc. | Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents |
| US5728751A (en) * | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
| US6203536B1 (en) * | 1997-06-17 | 2001-03-20 | Medtronic, Inc. | Medical device for delivering a therapeutic substance and method therefor |
| US6106454A (en) * | 1997-06-17 | 2000-08-22 | Medtronic, Inc. | Medical device for delivering localized radiation |
| US6146771A (en) * | 1997-07-01 | 2000-11-14 | Terumo Cardiovascular Systems Corporation | Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine |
| US6197289B1 (en) | 1997-07-01 | 2001-03-06 | Terumo Cardiovascular Systems Corporation | Removal of biologically active agents |
| IL122153A (en) * | 1997-11-10 | 2005-03-20 | Alomone Labs Ltd | Biocompatible polymeric coating material |
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-
1977
- 1977-07-01 JP JP7938577A patent/JPS5413694A/ja active Granted
-
1978
- 1978-06-28 DE DE2828369A patent/DE2828369C3/de not_active Expired
- 1978-06-29 BR BR7804126A patent/BR7804126A/pt unknown
- 1978-06-29 NL NLAANVRAGE7807024,A patent/NL177656C/xx not_active IP Right Cessation
- 1978-06-29 CA CA306,564A patent/CA1110402A/en not_active Expired
- 1978-06-30 FR FR7819631A patent/FR2395740A1/fr active Granted
- 1978-06-30 AU AU37661/78A patent/AU519350B2/en not_active Expired
- 1978-06-30 SE SE7807436A patent/SE423863B/sv not_active IP Right Cessation
- 1978-06-30 BE BE188974A patent/BE868624A/xx not_active IP Right Cessation
- 1978-06-30 IT IT50119/78A patent/IT1105224B/it active
- 1978-07-03 GB GB7828665A patent/GB2000978B/en not_active Expired
- 1978-07-03 US US05/921,680 patent/US4229838A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT1105224B (it) | 1985-10-28 |
| DE2828369A1 (de) | 1979-01-11 |
| IT7850119A0 (it) | 1978-06-30 |
| SE7807436L (sv) | 1979-03-01 |
| CA1110402A (en) | 1981-10-13 |
| BE868624A (fr) | 1978-10-16 |
| JPS5650581B2 (US20100268047A1-20101021-C00004.png) | 1981-11-30 |
| DE2828369B2 (de) | 1980-09-04 |
| JPS5413694A (en) | 1979-02-01 |
| NL7807024A (nl) | 1979-01-03 |
| GB2000978A (en) | 1979-01-24 |
| FR2395740A1 (fr) | 1979-01-26 |
| NL177656C (nl) | 1985-11-01 |
| SE423863B (sv) | 1982-06-14 |
| GB2000978B (en) | 1982-01-13 |
| FR2395740B1 (US20100268047A1-20101021-C00004.png) | 1982-03-05 |
| AU3766178A (en) | 1980-01-03 |
| US4229838A (en) | 1980-10-28 |
| AU519350B2 (en) | 1981-11-26 |
| BR7804126A (pt) | 1979-04-10 |
| NL177656B (nl) | 1985-06-03 |
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