DE2718880A1 - Verfahren zur untersuchung biologischer proben - Google Patents
Verfahren zur untersuchung biologischer probenInfo
- Publication number
- DE2718880A1 DE2718880A1 DE19772718880 DE2718880A DE2718880A1 DE 2718880 A1 DE2718880 A1 DE 2718880A1 DE 19772718880 DE19772718880 DE 19772718880 DE 2718880 A DE2718880 A DE 2718880A DE 2718880 A1 DE2718880 A1 DE 2718880A1
- Authority
- DE
- Germany
- Prior art keywords
- mass
- sample
- samples
- values
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000354 decomposition reaction Methods 0.000 title abstract description 4
- 238000004458 analytical method Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 51
- 241000894006 Bacteria Species 0.000 claims abstract description 18
- 238000003491 array Methods 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 230000002596 correlated effect Effects 0.000 claims abstract description 8
- 210000004698 lymphocyte Anatomy 0.000 claims abstract description 8
- 238000005979 thermal decomposition reaction Methods 0.000 claims abstract description 6
- 241000233866 Fungi Species 0.000 claims abstract description 4
- 241000700605 Viruses Species 0.000 claims abstract description 4
- 230000006378 damage Effects 0.000 claims abstract description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 3
- 210000001772 blood platelet Anatomy 0.000 claims abstract description 3
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 3
- 239000000523 sample Substances 0.000 claims description 40
- 230000036962 time dependent Effects 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 9
- 239000007857 degradation product Substances 0.000 claims description 6
- 230000000875 corresponding effect Effects 0.000 claims description 5
- 210000000265 leukocyte Anatomy 0.000 claims description 3
- 210000001539 phagocyte Anatomy 0.000 claims description 2
- 230000000763 evoking effect Effects 0.000 claims 1
- 150000002500 ions Chemical class 0.000 abstract description 50
- 238000001228 spectrum Methods 0.000 description 27
- 238000001819 mass spectrum Methods 0.000 description 9
- 241000894007 species Species 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 238000000451 chemical ionisation Methods 0.000 description 5
- 241000186074 Arthrobacter globiformis Species 0.000 description 4
- 241000185994 Pseudarthrobacter oxydans Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000588698 Erwinia Species 0.000 description 3
- 241000588722 Escherichia Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 241000186063 Arthrobacter Species 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- 241000589776 Pseudomonas putida Species 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000002076 thermal analysis method Methods 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000588694 Erwinia amylovora Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 229910000833 kovar Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000009 pyrolysis mass spectrometry Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 241001624918 unidentified bacterium Species 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/12—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using combustion
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
- H01J49/0472—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for pyrolysis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Combustion & Propulsion (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/682,781 US4075475A (en) | 1976-05-03 | 1976-05-03 | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| US05/777,366 US4122343A (en) | 1976-05-03 | 1977-03-14 | Method to generate correlative data from various products of thermal degradation of biological specimens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2718880A1 true DE2718880A1 (de) | 1977-11-24 |
Family
ID=27102962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772718880 Ceased DE2718880A1 (de) | 1976-05-03 | 1977-04-28 | Verfahren zur untersuchung biologischer proben |
Country Status (3)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3907120B2 (ja) * | 2004-02-05 | 2007-04-18 | 株式会社リガク | Ｘ線分析用試料支持装置及びｘ線分析装置 |
| JP5170650B2 (ja) * | 2008-02-29 | 2013-03-27 | 株式会社リガク | ガス定量分析方法及びガス定量分析装置 |
-
1977
- 1977-04-28 DE DE19772718880 patent/DE2718880A1/de not_active Ceased
- 1977-05-02 CA CA277,624A patent/CA1082311A/en not_active Expired
- 1977-05-04 JP JP5172577A patent/JPS52138992A/ja active Granted
- 1977-05-04 JP JP5172477A patent/JPS531081A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS611708B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-01-20 |
| CA1082311A (en) | 1980-07-22 |
| JPS531081A (en) | 1978-01-07 |
| JPS52138992A (en) | 1977-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |