DE2645527A1 - Neue cholesterinderivate - Google Patents

Neue cholesterinderivate

Info

Publication number
DE2645527A1
DE2645527A1 DE19762645527 DE2645527A DE2645527A1 DE 2645527 A1 DE2645527 A1 DE 2645527A1 DE 19762645527 DE19762645527 DE 19762645527 DE 2645527 A DE2645527 A DE 2645527A DE 2645527 A1 DE2645527 A1 DE 2645527A1
Authority
DE
Germany
Prior art keywords
compound
formula
solvent
alkoxy
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19762645527
Other languages
German (de)
English (en)
Inventor
John Joseph Partridge
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/621,319 external-priority patent/US3994878A/en
Priority claimed from US05/623,859 external-priority patent/US4038272A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2645527A1 publication Critical patent/DE2645527A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19762645527 1975-10-10 1976-10-08 Neue cholesterinderivate Ceased DE2645527A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/621,319 US3994878A (en) 1975-10-10 1975-10-10 Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof
US05/623,859 US4038272A (en) 1975-10-20 1975-10-20 Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof

Publications (1)

Publication Number Publication Date
DE2645527A1 true DE2645527A1 (de) 1977-04-21

Family

ID=27088923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762645527 Ceased DE2645527A1 (de) 1975-10-10 1976-10-08 Neue cholesterinderivate

Country Status (8)

Country Link
JP (1) JPS5246061A (fr)
AT (1) AT355236B (fr)
CH (1) CH628907A5 (fr)
DE (1) DE2645527A1 (fr)
FR (2) FR2407941A1 (fr)
GB (5) GB1564810A (fr)
IT (1) IT1068692B (fr)
NL (1) NL7611155A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3104948A1 (de) * 1980-02-12 1981-12-10 F. Hoffmann-La Roche & Co. AG, 4002 Basel Verfahren zur herstellung von cholesterinderivaten

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160480A1 (fr) 2013-03-13 2014-10-02 Sage Therapeutics, Inc. Stéroïdes neuroactifs et leurs procédés d'utilisation
US11117924B2 (en) 2015-07-06 2021-09-14 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP4316591A3 (fr) * 2015-07-06 2024-04-24 Sage Therapeutics, Inc. Oxystérols et leurs procédés d'utilisation
BR112018070123A2 (pt) 2016-04-01 2019-02-05 Sage Therapeutics Inc oxiesterós e métodos de uso dos mesmos
WO2017193046A1 (fr) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxystérols et méthodes d'utilisation associées
CA3029900A1 (fr) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols et leurs methodes d'utilisation
EP3519422B1 (fr) 2016-09-30 2022-08-31 Sage Therapeutics, Inc. Oxystérols substitués en c7 et ces composés pour l'utilisation en tant que modulateurs nmda
CN115181153A (zh) 2016-10-18 2022-10-14 萨奇治疗股份有限公司 氧甾醇及其使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822254A (en) * 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol
DE2409971A1 (de) * 1973-03-02 1974-09-05 Eisai Co Ltd 5-cholestenderivate und verfahren zu ihrer herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2409971A1 (de) * 1973-03-02 1974-09-05 Eisai Co Ltd 5-cholestenderivate und verfahren zu ihrer herstellung
US3822254A (en) * 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Fried, J.: Organic Reactions in Steroid Chemistry, Vol. 1, S. 132 u. Vol. II, S. 14, 1972 *
Tetrahedron Letters, Nr. 1, 1975, S. 15-18 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3104948A1 (de) * 1980-02-12 1981-12-10 F. Hoffmann-La Roche & Co. AG, 4002 Basel Verfahren zur herstellung von cholesterinderivaten

Also Published As

Publication number Publication date
GB1564807A (en) 1980-04-16
GB1564810A (en) 1980-04-16
FR2407941A1 (fr) 1979-06-01
ATA751376A (de) 1979-07-15
FR2351998B1 (fr) 1980-04-25
IT1068692B (it) 1985-03-21
NL7611155A (nl) 1977-04-13
JPS5246061A (en) 1977-04-12
GB1564808A (en) 1980-04-16
FR2351998A1 (fr) 1977-12-16
GB1564809A (en) 1980-04-16
GB1564806A (en) 1980-04-16
FR2407941B1 (fr) 1980-05-16
AT355236B (de) 1980-02-25
CH628907A5 (en) 1982-03-31

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection