DE2608667A1 - Diagnostisches feststoffreagens und verfahren zu dessen herstellung - Google Patents
Diagnostisches feststoffreagens und verfahren zu dessen herstellungInfo
- Publication number
- DE2608667A1 DE2608667A1 DE19762608667 DE2608667A DE2608667A1 DE 2608667 A1 DE2608667 A1 DE 2608667A1 DE 19762608667 DE19762608667 DE 19762608667 DE 2608667 A DE2608667 A DE 2608667A DE 2608667 A1 DE2608667 A1 DE 2608667A1
- Authority
- DE
- Germany
- Prior art keywords
- antigen
- reagent
- specific
- buffer
- radioactively labeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 45
- 238000000034 method Methods 0.000 title claims description 32
- 239000007787 solid Substances 0.000 title claims description 12
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 claims description 52
- 102000036639 antigens Human genes 0.000 claims description 52
- 108091007433 antigens Proteins 0.000 claims description 52
- 229940034208 thyroxine Drugs 0.000 claims description 23
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 23
- 238000012360 testing method Methods 0.000 claims description 22
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 19
- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- 108010074605 gamma-Globulins Proteins 0.000 claims description 18
- 229920001223 polyethylene glycol Polymers 0.000 claims description 18
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 11
- 229940098773 bovine serum albumin Drugs 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 229960000648 digitoxin Drugs 0.000 claims description 6
- 229940035722 triiodothyronine Drugs 0.000 claims description 6
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 5
- 229960005156 digoxin Drugs 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 claims description 5
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 claims description 4
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims description 4
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 claims description 4
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims description 4
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims description 4
- 239000007982 barbital buffer Substances 0.000 claims description 3
- 230000036039 immunity Effects 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 description 20
- 210000002966 serum Anatomy 0.000 description 16
- 239000007790 solid phase Substances 0.000 description 16
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 14
- 241000473945 Theria <moth genus> Species 0.000 description 13
- 238000003127 radioimmunoassay Methods 0.000 description 12
- 229960002319 barbital Drugs 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 102000002248 Thyroxine-Binding Globulin Human genes 0.000 description 4
- 108010000259 Thyroxine-Binding Globulin Proteins 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 230000027455 binding Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 101710145634 Antigen 1 Proteins 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- RNAMYOYQYRYFQY-UHFFFAOYSA-N 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine Chemical compound N1=C(N2CCC(F)(F)CC2)N=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C1NC1CCN(C(C)C)CC1 RNAMYOYQYRYFQY-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 241000353097 Molva molva Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960002478 aldosterone Drugs 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Chemical class [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- HYOVDYVSLXAFAL-UHFFFAOYSA-M sodium;8-aminonaphthalene-1-sulfonate Chemical compound [Na+].C1=CC(S([O-])(=O)=O)=C2C(N)=CC=CC2=C1 HYOVDYVSLXAFAL-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/555,215 US3995019A (en) | 1975-03-04 | 1975-03-04 | Diagnostic reagent system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2608667A1 true DE2608667A1 (de) | 1976-09-09 |
Family
ID=24216433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762608667 Withdrawn DE2608667A1 (de) | 1975-03-04 | 1976-03-03 | Diagnostisches feststoffreagens und verfahren zu dessen herstellung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3995019A (enExample) |
| JP (1) | JPS51112516A (enExample) |
| AU (1) | AU499184B2 (enExample) |
| BE (1) | BE839142A (enExample) |
| DE (1) | DE2608667A1 (enExample) |
| DK (1) | DK92076A (enExample) |
| ES (1) | ES445768A1 (enExample) |
| FR (1) | FR2303292A1 (enExample) |
| GB (1) | GB1528071A (enExample) |
| IT (1) | IT1056844B (enExample) |
| NL (1) | NL7602152A (enExample) |
| SE (1) | SE7602834L (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044041A1 (de) * | 1980-07-14 | 1982-01-20 | Hoechst Aktiengesellschaft | Verfahren zum Binden und Trennen für den kompetitiven Radioimmunoassay und Reagenz hierzu |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069352A (en) * | 1976-07-02 | 1978-01-17 | Baxter Travenol Laboratories, Inc. | Immunoadsorbent polymeric material and method of making same |
| US4098876A (en) * | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4182750A (en) * | 1977-04-21 | 1980-01-08 | Sullivan Thomas E | Bloodcompatible functional polymers |
| US4307071A (en) * | 1977-08-02 | 1981-12-22 | Kallestad Laboratories, Inc. | Analytical reagent and method |
| NL7713952A (nl) * | 1977-12-16 | 1979-06-19 | Philips Nv | Radio-immunologische methode voor het bepalen van de schildklierfunktie door een in vitro onderzoek in bloedserum. |
| US4244940A (en) * | 1978-09-05 | 1981-01-13 | Bio-Rad Laboratories, Inc. | Single-incubation two-site immunoassay |
| US4241175A (en) * | 1978-12-18 | 1980-12-23 | Merck & Co., Inc. | Assay for hepatitis B core antibody |
| US4273867A (en) * | 1979-04-05 | 1981-06-16 | Mallinckrodt, Inc. | Method and reagent for counteracting lipemic interference |
| US4298592A (en) * | 1979-04-05 | 1981-11-03 | Mallinckrodt, Inc. | Double antibody separation method |
| GB8307156D0 (en) * | 1983-03-15 | 1983-04-20 | Celltech Ltd | Heterogeneous binding assays |
| US4935339A (en) * | 1985-05-07 | 1990-06-19 | Nichols Institute Diagnostics | Delayed solid phase immunologic assay |
| US4855242A (en) * | 1986-04-14 | 1989-08-08 | Joslin Diabetes Center, Inc. | Method of detecting antibodies |
| US4764475A (en) * | 1986-12-01 | 1988-08-16 | The University Of British Columbia | Pancreas dependant immunoassay for determining subpopulations of monoclonal antibodies to somatostatin. |
| US5306623A (en) * | 1989-08-28 | 1994-04-26 | Lifescan, Inc. | Visual blood glucose concentration test strip |
| US6395227B1 (en) * | 1989-08-28 | 2002-05-28 | Lifescan, Inc. | Test strip for measuring analyte concentration over a broad range of sample volume |
| AU640162B2 (en) * | 1989-08-28 | 1993-08-19 | Lifescan, Inc. | Blood separation and analyte detection techniques |
| US6730023B1 (en) * | 1999-10-15 | 2004-05-04 | Hemopet | Animal genetic and health profile database management |
| US7548839B2 (en) * | 1999-10-15 | 2009-06-16 | Hemopet | System for animal health diagnosis |
| US8234099B2 (en) * | 1999-10-15 | 2012-07-31 | Hemopet | Computer program for determining a nutritional diet product for a canine or feline animal |
| WO2006138451A2 (en) * | 2005-06-15 | 2006-12-28 | Panterra Engineered Plastics, Inc. | Method of creating high strength expanded thermoformable honeycomb structures with cementitious reinforcement |
| US8012769B2 (en) * | 2008-11-12 | 2011-09-06 | Hemopet | Thyroid analyte detection and measurement |
| US7799532B2 (en) * | 2008-11-12 | 2010-09-21 | Hemopet | Detection and measurement of thyroid hormone autoantibodies |
| US7794954B2 (en) * | 2008-11-12 | 2010-09-14 | Hemopet | Detection and measurement of thyroid analyte profile |
| US7873482B2 (en) * | 2008-12-16 | 2011-01-18 | Bruno Stefanon | Diagnostic system for selecting nutrition and pharmacological products for animals |
| US20100151062A1 (en) * | 2008-12-16 | 2010-06-17 | Bruno Stefanon | Determining nutrients for animals through gene expression |
| CN108982836A (zh) * | 2018-05-31 | 2018-12-11 | 湖南远璟生物技术有限公司 | 一种总甲状腺素磁微粒化学发光免疫定量检测试剂盒及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL286954A (enExample) * | 1962-01-03 | |||
| US3655838A (en) * | 1969-03-20 | 1972-04-11 | Organon | Method of pelletizing analytical or immunological reagents |
-
1975
- 1975-03-04 US US05/555,215 patent/US3995019A/en not_active Expired - Lifetime
-
1976
- 1976-02-26 GB GB7548/76A patent/GB1528071A/en not_active Expired
- 1976-02-27 SE SE7602834A patent/SE7602834L/xx not_active Application Discontinuation
- 1976-03-02 JP JP51023020A patent/JPS51112516A/ja active Pending
- 1976-03-02 NL NL7602152A patent/NL7602152A/xx not_active Application Discontinuation
- 1976-03-03 FR FR7605978A patent/FR2303292A1/fr active Granted
- 1976-03-03 IT IT20817/76A patent/IT1056844B/it active
- 1976-03-03 AU AU11614/76A patent/AU499184B2/en not_active Expired
- 1976-03-03 DK DK92076*#A patent/DK92076A/da unknown
- 1976-03-03 DE DE19762608667 patent/DE2608667A1/de not_active Withdrawn
- 1976-03-03 BE BE164815A patent/BE839142A/xx unknown
- 1976-03-04 ES ES445768A patent/ES445768A1/es not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044041A1 (de) * | 1980-07-14 | 1982-01-20 | Hoechst Aktiengesellschaft | Verfahren zum Binden und Trennen für den kompetitiven Radioimmunoassay und Reagenz hierzu |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1161476A (en) | 1977-09-08 |
| BE839142A (fr) | 1976-07-01 |
| ES445768A1 (es) | 1977-10-16 |
| SE7602834L (sv) | 1976-09-05 |
| GB1528071A (en) | 1978-10-11 |
| NL7602152A (nl) | 1976-09-07 |
| FR2303292A1 (fr) | 1976-10-01 |
| FR2303292B3 (enExample) | 1978-12-01 |
| JPS51112516A (en) | 1976-10-05 |
| DK92076A (da) | 1976-09-05 |
| IT1056844B (it) | 1982-02-20 |
| US3995019A (en) | 1976-11-30 |
| AU499184B2 (en) | 1979-04-05 |
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