DE2606533A1 - Therapeutisches mittel - Google Patents
Therapeutisches mittelInfo
- Publication number
- DE2606533A1 DE2606533A1 DE19762606533 DE2606533A DE2606533A1 DE 2606533 A1 DE2606533 A1 DE 2606533A1 DE 19762606533 DE19762606533 DE 19762606533 DE 2606533 A DE2606533 A DE 2606533A DE 2606533 A1 DE2606533 A1 DE 2606533A1
- Authority
- DE
- Germany
- Prior art keywords
- xylitol
- weight
- therapeutic agent
- caries
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 title claims abstract description 49
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 235000010447 xylitol Nutrition 0.000 title claims abstract description 45
- 208000002925 dental caries Diseases 0.000 title claims abstract description 22
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 title claims description 42
- 239000000811 xylitol Substances 0.000 title claims description 42
- 229960002675 xylitol Drugs 0.000 title claims description 42
- 239000000126 substance Substances 0.000 title abstract description 14
- 229940112822 chewing gum Drugs 0.000 claims abstract description 19
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 14
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 14
- 239000002324 mouth wash Substances 0.000 claims abstract description 8
- 239000000606 toothpaste Substances 0.000 claims abstract description 8
- 229940034610 toothpaste Drugs 0.000 claims abstract description 7
- 239000007921 spray Substances 0.000 claims abstract description 6
- 235000009508 confectionery Nutrition 0.000 claims abstract description 5
- 229940051866 mouthwash Drugs 0.000 claims description 6
- 239000007937 lozenge Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 4
- 239000012876 carrier material Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 235000010603 pastilles Nutrition 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003902 lesion Effects 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000001013 cariogenic effect Effects 0.000 description 4
- 230000001055 chewing effect Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000000185 sucrose group Chemical group 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 235000006694 eating habits Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000021092 sugar substitutes Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Confectionery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH215875 | 1975-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2606533A1 true DE2606533A1 (de) | 1976-08-26 |
Family
ID=4227233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762606533 Ceased DE2606533A1 (de) | 1975-02-20 | 1976-02-18 | Therapeutisches mittel |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS51106741A (enrdf_load_stackoverflow) |
| AU (1) | AU1098076A (enrdf_load_stackoverflow) |
| BE (1) | BE838702A (enrdf_load_stackoverflow) |
| DE (1) | DE2606533A1 (enrdf_load_stackoverflow) |
| DK (1) | DK69776A (enrdf_load_stackoverflow) |
| IL (1) | IL48997A (enrdf_load_stackoverflow) |
| LU (1) | LU74377A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7601550A (enrdf_load_stackoverflow) |
| PH (1) | PH13252A (enrdf_load_stackoverflow) |
| SE (1) | SE7601894L (enrdf_load_stackoverflow) |
| ZA (1) | ZA76735B (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2420970A2 (fr) * | 1978-03-28 | 1979-10-26 | Goupil Jean Jacques | Procede de preparation d'une gomme a macher, non cariogene et contenant du fluor et produits en resultant |
| US5226435A (en) * | 1991-08-01 | 1993-07-13 | Gillette Canada Inc. | Flavored dental floss and method |
| EP0696449A3 (en) * | 1994-07-14 | 1996-11-06 | Colgate Palmolive Co | Antimicrobial oral composition |
| WO1998003165A1 (en) * | 1996-07-24 | 1998-01-29 | Leiras Oy | New use of xylitol and pharmaceutical compositions therefor |
| US5900230A (en) * | 1997-08-18 | 1999-05-04 | Squigle, Inc. | Dental products to treat and prevent periodontal disease |
| WO2002080946A1 (en) * | 2001-04-02 | 2002-10-17 | Wakamoto Pharmaceutical Co.,Ltd. | Compositions for preventing and/or treating oral diseases |
| EP1745823A1 (de) * | 2005-07-12 | 2007-01-24 | Henkel Kommanditgesellschaft auf Aktien | Gebrauchsfertige Mundwasserzusammensetzung und Verwendung derselben |
| US20120213715A1 (en) * | 2011-02-23 | 2012-08-23 | Chifu Huang | Method and composition for the prevention and treatment of early childhood dental caries |
| US20120213714A1 (en) * | 2011-02-23 | 2012-08-23 | Chifu Huang | Method and compositions as an adjunct for the prevention and treatment of periodontal disease |
| WO2018194948A1 (en) * | 2017-04-19 | 2018-10-25 | Wm. Wrigley Jr. Company | Licorice extract synergy with menthol for breath freshening in a confectionary product |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2556967B1 (fr) * | 1983-10-13 | 1987-05-29 | Goupil Jean Jacques | Composition destinee a l'hygiene et a la sante du parodonte, des gencives et des dents |
-
1976
- 1976-02-09 IL IL48997A patent/IL48997A/xx unknown
- 1976-02-09 ZA ZA735A patent/ZA76735B/xx unknown
- 1976-02-10 AU AU10980/76A patent/AU1098076A/en not_active Expired
- 1976-02-16 NL NL7601550A patent/NL7601550A/xx not_active Application Discontinuation
- 1976-02-18 LU LU74377A patent/LU74377A1/xx unknown
- 1976-02-18 SE SE7601894A patent/SE7601894L/ not_active Application Discontinuation
- 1976-02-18 DE DE19762606533 patent/DE2606533A1/de not_active Ceased
- 1976-02-18 PH PH18115A patent/PH13252A/en unknown
- 1976-02-19 DK DK69776*#A patent/DK69776A/da unknown
- 1976-02-19 BE BE164427A patent/BE838702A/xx not_active IP Right Cessation
- 1976-02-20 JP JP51017159A patent/JPS51106741A/ja active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2420970A2 (fr) * | 1978-03-28 | 1979-10-26 | Goupil Jean Jacques | Procede de preparation d'une gomme a macher, non cariogene et contenant du fluor et produits en resultant |
| US5226435A (en) * | 1991-08-01 | 1993-07-13 | Gillette Canada Inc. | Flavored dental floss and method |
| US5357990A (en) * | 1991-08-01 | 1994-10-25 | Gillette Canada Inc. | Flavored dental floss and process |
| EP0696449A3 (en) * | 1994-07-14 | 1996-11-06 | Colgate Palmolive Co | Antimicrobial oral composition |
| US6066677A (en) * | 1996-07-24 | 2000-05-23 | Leiras Oy | Use of xylitol and pharmaceutical compositions therefor |
| WO1998003165A1 (en) * | 1996-07-24 | 1998-01-29 | Leiras Oy | New use of xylitol and pharmaceutical compositions therefor |
| US5900230A (en) * | 1997-08-18 | 1999-05-04 | Squigle, Inc. | Dental products to treat and prevent periodontal disease |
| WO2002080946A1 (en) * | 2001-04-02 | 2002-10-17 | Wakamoto Pharmaceutical Co.,Ltd. | Compositions for preventing and/or treating oral diseases |
| EP1745823A1 (de) * | 2005-07-12 | 2007-01-24 | Henkel Kommanditgesellschaft auf Aktien | Gebrauchsfertige Mundwasserzusammensetzung und Verwendung derselben |
| US20120213715A1 (en) * | 2011-02-23 | 2012-08-23 | Chifu Huang | Method and composition for the prevention and treatment of early childhood dental caries |
| US20120213714A1 (en) * | 2011-02-23 | 2012-08-23 | Chifu Huang | Method and compositions as an adjunct for the prevention and treatment of periodontal disease |
| WO2018194948A1 (en) * | 2017-04-19 | 2018-10-25 | Wm. Wrigley Jr. Company | Licorice extract synergy with menthol for breath freshening in a confectionary product |
| US11071710B2 (en) | 2017-04-19 | 2021-07-27 | Wm. Wrigley Jr. Company | Licorice extract synergy with menthol for breath freshening in a confectionary product |
Also Published As
| Publication number | Publication date |
|---|---|
| LU74377A1 (enrdf_load_stackoverflow) | 1977-09-12 |
| JPS51106741A (enrdf_load_stackoverflow) | 1976-09-21 |
| IL48997A (en) | 1978-10-31 |
| IL48997A0 (en) | 1976-04-30 |
| BE838702A (fr) | 1976-08-19 |
| DK69776A (da) | 1976-08-21 |
| SE7601894L (sv) | 1976-08-21 |
| AU1098076A (en) | 1977-08-18 |
| NL7601550A (nl) | 1976-08-24 |
| PH13252A (en) | 1980-02-20 |
| ZA76735B (en) | 1977-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69011783T2 (de) | Verfahren zur Erhöhung der Speichelerzeugung für Xerostomie-Patienten. | |
| DE60035344T2 (de) | Anti-sensibilitätsdentalmasse | |
| US6169118B1 (en) | Flavor blend for masking unpleasant taste of zinc compounds | |
| DE69920766T2 (de) | Zahnpasta enthaltend rosensamenöl | |
| DE68916004T2 (de) | Kaugummi mit glycerolmonolaurat. | |
| DD202245A5 (de) | Verfahren zur herstellung oraler kompositionen | |
| AT390371B (de) | Festes mundpflegemittel gegen zahnstein und mundgeruch | |
| US6746697B2 (en) | Composition containing Heliopsis longipes root extract and oral carrier | |
| DE3011182A1 (de) | Zur oralen verabreichung geeignete zusammensetzung | |
| DE2510412A1 (de) | Arzneimittel gegen gingivitis | |
| DE69006069T2 (de) | Mittel für die orale Hygiene. | |
| DE60037410T2 (de) | Kaugummi und konfekt zur mundpflege | |
| DE2606533A1 (de) | Therapeutisches mittel | |
| DE2629884A1 (de) | Mund- und zahnpflegemittel | |
| DE69008555T3 (de) | Dentalzusammensetzung für überempfindliche Zähne. | |
| DE69008153T2 (de) | Mundwasser und verfahren zur beseitigung des zahnsteins. | |
| DE69016665T3 (de) | Orales s(+)-flurbiprofen- oder ketoprofenhaltiges mittel. | |
| DE2317539C2 (de) | Cyclohexancarbonsäureamide und ihre Verwendung als Mittel zur Stimulierung der Kaltrezeptoren des menschlichen Nervensystems | |
| DE3437679C1 (de) | Präparat gegen schlechten Mundgeruch | |
| EP0912162B1 (de) | Feste orale, antikariogene zusammensetzung zum reinigen der mundhöhle und zähne sowie verfahren zur herstellung derselben | |
| EP2192891B1 (de) | Stoffzusammensetzung für mundhygieneprodukt | |
| EP0757554B1 (de) | Lutschbonbon mit zahnbelags-neutralisierender wirkung | |
| CH506292A (de) | Mundpflegemittel | |
| DE2000851C3 (de) | Kaugummi | |
| DE3620469A1 (de) | Mund-mittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8126 | Change of the secondary classification |
Ipc: A61K 31/045 |
|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |