DE2531588A1 - NON-ANTIGENT, NON-THROMBIC, INFECTION-RESISTANT GAPS FROM UMBRELLA CORD AND METHOD OF MANUFACTURING AND USING THE SAME - Google Patents

NON-ANTIGENT, NON-THROMBIC, INFECTION-RESISTANT GAPS FROM UMBRELLA CORD AND METHOD OF MANUFACTURING AND USING THE SAME

Info

Publication number
DE2531588A1
DE2531588A1 DE19752531588 DE2531588A DE2531588A1 DE 2531588 A1 DE2531588 A1 DE 2531588A1 DE 19752531588 DE19752531588 DE 19752531588 DE 2531588 A DE2531588 A DE 2531588A DE 2531588 A1 DE2531588 A1 DE 2531588A1
Authority
DE
Germany
Prior art keywords
blood vessel
aldehyde
infection
reagent
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19752531588
Other languages
German (de)
Other versions
DE2531588C2 (en
Inventor
Irving I Dr Dardik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/543,462 external-priority patent/US3974526A/en
Priority claimed from US05/563,998 external-priority patent/US3988782A/en
Application filed by Individual filed Critical Individual
Publication of DE2531588A1 publication Critical patent/DE2531588A1/en
Application granted granted Critical
Publication of DE2531588C2 publication Critical patent/DE2531588C2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin

Claims (9)

ITur Ansprüche, da die Unterlagen zur fotomechanischen Vervielfäl- 15.07.197t tigung nicht geeignet sind (v£l. Mitteilung des Präsidenten d*s ο r ο -ι QQQ Deutschen Patentamts fTr. 6/7·Λ vom 28. Apiil / ''^ ' )no 1970, Bl.f.PMZ 1970, 141) ^·. Irving I. DardiK i.·: -· -■ ■ ..-.....-. TenafLy, New Yersey um Dr. Herbert Dardik in Teaneck, New Yersey (U.S.A.) Patentansprüche :IT Only claims, since the documents are not suitable for photomechanical reproduction (July 15, 1997) ^ ') no 1970, Bl.f.PMZ 1970, 141) ^ ·. Irving I. DardiK i. ·: - · - ■ ■ ..-.....-. TenafLy, New Yersey to Dr. Herbert Dardik in Teaneck, New Yersey (U.S.A.) Claims: 1. Michtantiger.e, nichtth^ombogene, infektiorsbeständige Transplantate, dadurch gekennzeichnet, daß sie aus den üafcelschnurgefäiien eines Säugetieres bestehen.1. Michtantiger.e, non-thombogenic, infection-resistant Transplants, characterized in that they are made from the cord vessels of a mammal. 2. Transplantat nach Anspruch 1, dadurch gekennzeichnet, daß es in Form eines flexiblen Segmentes vorliegt.2. Transplant according to claim 1, characterized in that that it is in the form of a flexible segment. 3. Transplantat nach den Ansprüchen 1 und 2, dadurch rekenn?eichnet, daß es in geformtem und gehärtetem Zustand vorliegt .3. Transplant according to claims 1 and 2, characterized It is recognized that it is in a molded and hardened state . 4. Transplantat nach den Ansprüchen 1 und 3, dadurch genennzeichnet, daß es röhrenförmig ist und durch ein biegsanes Kunststoffnetz außen verstärkt ist.4. Transplant according to claims 1 and 3, characterized characterized in that it is tubular and bendable by a Plastic mesh is reinforced on the outside. 5. Verfahren zur Herstellung von nichtantigenen, nichtthrombogenen, infektionsbeständigen Transplantaten nach Anspruch 1 dadurch gekennzeichnet, daß5. Process for the production of non-antigenic, non-thrombogenic, Infection-resistant transplants according to claim 1, characterized in that a) wenigstens eines der Hauptblutgefäße einer Nabelschnur abgetrennt wird,a) at least one of the main blood vessels of an umbilical cord is severed, b) das Blutgefäß mit Hilfe eines Reagenz gehärtet wird undb) the blood vessel is hardened with the aid of a reagent and c) das blutgefäß geformt wird.c) the blood vessel is formed. 15.07.197507/15/1975 9 ? s :m h ρ R9? s: m h ρ R 6. Verfahren nach Anspruch 5, dadurch gekennzeichnet, Ίπ,Ι als Härtungsmittel ein Aldehyd, wie insbesondere Glutaralciehy:, Formaldehyd, Dialdehydstarke und Glyoxal, verwendet wird.6. The method according to claim 5, characterized in that Ίπ, Ι an aldehyde, such as in particular Glutaralciehy :, formaldehyde, dialdehyde starch and glyoxal, is used as the hardening agent. 7. Verfahren nach Anspruch 6, dadurch gekennzeichnet:, ria:J. die Härtung durchgeführt wird, inden; das Blutgefäß in Kontakt ni.it einer Lösung von GlutaraJdenyd in einer Konzentration von o,15-c,6 Gew.-% für einen Zeitraum von 15-^5 min gebracht wird.7. The method according to claim 6, characterized in :, ria: J. the hardening is carried out inden; the blood vessel is not in contact a solution of GlutaraJdenyd in a concentration of o, 15-c, 6 wt .-% is brought for a period of 15- ^ 5 min. 8. Verfahren nach Anspruch 5, dadurch gekennzeichnet, und. außerdem das mit Aldehyd behandelte Blutgefäß mit Wasser, Kochsalzlösung oder verdünntem Natriumbicarbonat zur Entfernung von Aldehyd gewaschen und dann mit einem Reagenz zur Entfernung von restlichem Aldehyd behandelt wird, wobei dieses Reagenz eine Aminosäure, ein Alkalisalz einer Aminosäure, ein Hydroxylamin, eine Persäure, ein Peroxyd oder ein Hypochlorid ist.8. The method according to claim 5, characterized in, and. In addition, the aldehyde-treated blood vessel is washed with water, saline or dilute sodium bicarbonate to remove aldehyde and then treated with a reagent to remove residual aldehyde, this reagent being an amino acid, an alkali salt of an amino acid, a hydroxylamine, a peracid, a peroxide or is a hypochlorite. 9. Verfahren nach Anspruch 5, dadurch gekennzeichnet, daß das Transplantat in einem sterilen, versiegelten Behälter gelagert wird .9. The method according to claim 5, characterized in that the graft is stored in a sterile, sealed container. 609032/Ub^5
BAD ORIGINAL 609032 / Ub ^ 5
BATH ORIGINAL LeerseiteBlank page
DE2531588A 1975-01-23 1975-07-15 Umbilical cord vessel transplants and their manufacture Expired DE2531588C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/543,462 US3974526A (en) 1973-07-06 1975-01-23 Vascular prostheses and process for producing the same
US05/563,998 US3988782A (en) 1973-07-06 1975-04-01 Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same

Publications (2)

Publication Number Publication Date
DE2531588A1 true DE2531588A1 (en) 1976-08-05
DE2531588C2 DE2531588C2 (en) 1983-11-03

Family

ID=27067341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2531588A Expired DE2531588C2 (en) 1975-01-23 1975-07-15 Umbilical cord vessel transplants and their manufacture

Country Status (14)

Country Link
JP (1) JPS521011A (en)
AT (1) ATA541675A (en)
AU (1) AU497462B2 (en)
BR (1) BR7504424A (en)
CA (1) CA1055843A (en)
DE (1) DE2531588C2 (en)
DK (1) DK140086B (en)
ES (1) ES441295A1 (en)
FR (1) FR2298312A1 (en)
GB (1) GB1493459A (en)
IL (1) IL47667A (en)
NL (1) NL7508306A (en)
NO (1) NO752465L (en)
SE (1) SE7508047L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902434A1 (en) * 1978-01-26 1979-08-02 Daniel George Holman Umbilical cord pre-shaping for use as blood-vessel implants - takes place by placing on mandrel, extracting water, fixing with aldehyde soln. and pref. roughening

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2502489A1 (en) * 1981-03-30 1982-10-01 Ufim I Glaznykh Bolezn Homo:transplant material, esp. for conjunctiva - comprising retro:peritoneal fascia tissue
FR2523810B1 (en) * 1982-03-23 1988-11-25 Carpentier Alain ORGANIC GRAFT FABRIC AND PROCESS FOR ITS PREPARATION
ZA843751B (en) * 1983-06-10 1984-12-24 University Patents Inc Body implants of extracellular matrix and means and methods of making and using such implants
WO1985001651A1 (en) * 1983-10-20 1985-04-25 Vettivetpillai Ketharanathan Biomaterial
US4674488A (en) * 1985-03-04 1987-06-23 American Hospital Supply Corporation Method of treating bone fractures to reduce formation of fibrous adhesions
US4786287A (en) * 1986-10-10 1988-11-22 Baxter Travenol Laboratories Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue
CN113733532B (en) * 2021-08-25 2022-10-11 中山大学 Flexible polyester patch and preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Wörterbuch der Medizin, Berlin 1968, 922 u. 923 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902434A1 (en) * 1978-01-26 1979-08-02 Daniel George Holman Umbilical cord pre-shaping for use as blood-vessel implants - takes place by placing on mandrel, extracting water, fixing with aldehyde soln. and pref. roughening

Also Published As

Publication number Publication date
IL47667A0 (en) 1975-10-15
ATA541675A (en) 1979-02-15
AU8296975A (en) 1977-01-13
DK140086B (en) 1979-06-18
DK318975A (en) 1976-07-24
IL47667A (en) 1978-04-30
CA1055843A (en) 1979-06-05
NL7508306A (en) 1976-07-27
DE2531588C2 (en) 1983-11-03
GB1493459A (en) 1977-11-30
DK140086C (en) 1979-11-12
FR2298312B1 (en) 1978-07-28
JPS6122981B2 (en) 1986-06-03
NO752465L (en) 1976-07-26
ES441295A1 (en) 1977-03-16
FR2298312A1 (en) 1976-08-20
AU497462B2 (en) 1978-12-14
JPS521011A (en) 1977-01-06
BR7504424A (en) 1976-08-17
SE7508047L (en) 1976-07-26

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Legal Events

Date Code Title Description
8125 Change of the main classification

Ipc: A61K 35/44

8126 Change of the secondary classification

Ipc: A61L 15/00

8181 Inventor (new situation)

Free format text: ERFINDER IST ANMELDER

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee