DE2444524A1 - Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen - Google Patents
Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilenInfo
- Publication number
- DE2444524A1 DE2444524A1 DE19742444524 DE2444524A DE2444524A1 DE 2444524 A1 DE2444524 A1 DE 2444524A1 DE 19742444524 DE19742444524 DE 19742444524 DE 2444524 A DE2444524 A DE 2444524A DE 2444524 A1 DE2444524 A1 DE 2444524A1
- Authority
- DE
- Germany
- Prior art keywords
- precipitation
- blood plasma
- drain line
- container
- precipitation tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 18
- 210000002381 plasma Anatomy 0.000 title claims description 18
- 238000001556 precipitation Methods 0.000 claims description 48
- 238000003860 storage Methods 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 230000029219 regulation of pH Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742444524 DE2444524A1 (de) | 1974-09-18 | 1974-09-18 | Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen |
| AT693575A AT339484B (de) | 1974-09-18 | 1975-09-09 | Verfahren und vorrichtung zur ausfallung von human-blutplasma-bestandteilen |
| CH1188175A CH617439A5 (US06373033-20020416-M00002.png) | 1974-09-18 | 1975-09-12 | |
| SE7510292A SE7510292L (sv) | 1974-09-18 | 1975-09-16 | Forfarande och anordning for utfellning av bestandsdelar i mensklig blodplasma |
| FR7529454A FR2285398A1 (fr) | 1974-09-18 | 1975-09-17 | Procede et dispositif pour la separation par precipitation des constituants du plasma du sang humain |
| ES441037A ES441037A1 (es) | 1974-09-18 | 1975-09-17 | Procedimiento y dispositivo para precipitar componentes del plasma sanguineo humano. |
| JP50112174A JPS5199369A (US06373033-20020416-M00002.png) | 1974-09-18 | 1975-09-18 | |
| US05/614,419 US4066549A (en) | 1974-09-18 | 1975-09-18 | Apparatus for the precipitation of human blood plasma components |
| BE833542A BE833542A (fr) | 1974-09-18 | 1975-09-18 | Procédé et dispositif pour la séparation par précipitation des contituants du plasma du sang humain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742444524 DE2444524A1 (de) | 1974-09-18 | 1974-09-18 | Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2444524A1 true DE2444524A1 (de) | 1976-04-08 |
Family
ID=5926048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742444524 Withdrawn DE2444524A1 (de) | 1974-09-18 | 1974-09-18 | Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen |
Country Status (9)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040397A1 (de) * | 1980-05-16 | 1981-11-25 | BEHRINGWERKE Aktiengesellschaft | Verfahren zur Herstellung von Blutplasma-Fraktionen |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5598196A (en) * | 1979-01-16 | 1980-07-25 | Meito Sangyo Kk | Fractionation of fibrinogen or its constituents and their use |
| GR68187B (US06373033-20020416-M00002.png) * | 1979-05-04 | 1981-11-09 | Univ Minnesota | |
| DE3210444A1 (de) * | 1981-04-02 | 1982-11-11 | National Research Development Corp., London | Verfahren und vorrichtung zur behandlung von blutplasma |
| US4624780A (en) * | 1982-06-28 | 1986-11-25 | Alpha Therapeutic Corporation | Fractionation of blood plasma |
| US4486341A (en) * | 1982-06-28 | 1984-12-04 | Alpha Therapeutic Corporation | Fractionation of blood plasma |
| US6083383A (en) * | 1998-06-25 | 2000-07-04 | Huang; Xun Yang | Apparatus for production of fibrin ogen or fibrin glue |
| CN1326463A (zh) * | 1998-11-20 | 2001-12-12 | 雀巢制品公司 | 连续分离活性蛋白的方法 |
| US7832566B2 (en) * | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| EP1622691B1 (en) | 2003-03-14 | 2011-05-25 | The Trustees of Columbia University in the City of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| CN101534917A (zh) * | 2006-05-22 | 2009-09-16 | 纽约市哥伦比亚大学理事会 | 采用萃取流体排出流过滤的微流无膜交换系统和方法 |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| EP2125867A4 (en) * | 2006-12-22 | 2011-05-11 | Bayer Technology Services Gmbh | DEVICE AND METHOD FOR PRECIPITATING PEPTIDES |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| CN102065926A (zh) * | 2008-02-04 | 2011-05-18 | 纽约市哥伦比亚大学理事会 | 流体分离装置、系统和方法 |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) * | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2470332A (en) * | 1945-09-29 | 1949-05-17 | Great Lakes Carbon Corp | Decolorization and clarification of sugar liquors |
| US2632733A (en) * | 1949-07-06 | 1953-03-24 | Carroll P Sherwood | Water purification process and apparatus |
| GB1323681A (en) * | 1969-03-28 | 1973-07-18 | Nat Res Dev | Apparatus for use in the fractionation of solutions of protein aceous materials |
| US3536450A (en) * | 1969-06-11 | 1970-10-27 | Univ California | System for analyzing compounds |
| US3698870A (en) * | 1971-03-02 | 1972-10-17 | Technicon Instr | Apparatus for pumping with viscosity control |
-
1974
- 1974-09-18 DE DE19742444524 patent/DE2444524A1/de not_active Withdrawn
-
1975
- 1975-09-09 AT AT693575A patent/AT339484B/de not_active IP Right Cessation
- 1975-09-12 CH CH1188175A patent/CH617439A5/de not_active IP Right Cessation
- 1975-09-16 SE SE7510292A patent/SE7510292L/xx not_active Application Discontinuation
- 1975-09-17 FR FR7529454A patent/FR2285398A1/fr active Granted
- 1975-09-17 ES ES441037A patent/ES441037A1/es not_active Expired
- 1975-09-18 JP JP50112174A patent/JPS5199369A/ja active Pending
- 1975-09-18 US US05/614,419 patent/US4066549A/en not_active Expired - Lifetime
- 1975-09-18 BE BE833542A patent/BE833542A/fr unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040397A1 (de) * | 1980-05-16 | 1981-11-25 | BEHRINGWERKE Aktiengesellschaft | Verfahren zur Herstellung von Blutplasma-Fraktionen |
| DK155499B (da) * | 1980-05-16 | 1989-04-17 | Behringwerke Ag | Fremgangsmaade til fremstilling af blodplasma-fraktioner |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2285398B1 (US06373033-20020416-M00002.png) | 1979-10-05 |
| AT339484B (de) | 1977-10-25 |
| BE833542A (fr) | 1976-01-16 |
| ATA693575A (de) | 1977-02-15 |
| JPS5199369A (US06373033-20020416-M00002.png) | 1976-09-01 |
| ES441037A1 (es) | 1977-06-01 |
| CH617439A5 (US06373033-20020416-M00002.png) | 1980-05-30 |
| US4066549A (en) | 1978-01-03 |
| SE7510292L (sv) | 1976-03-19 |
| FR2285398A1 (fr) | 1976-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| 8139 | Disposal/non-payment of the annual fee |