DE2427659C3 - Verfahren zur Herstellung von radioaktiv markierten Erythrozyten - Google Patents
Verfahren zur Herstellung von radioaktiv markierten ErythrozytenInfo
- Publication number
- DE2427659C3 DE2427659C3 DE2427659A DE2427659A DE2427659C3 DE 2427659 C3 DE2427659 C3 DE 2427659C3 DE 2427659 A DE2427659 A DE 2427659A DE 2427659 A DE2427659 A DE 2427659A DE 2427659 C3 DE2427659 C3 DE 2427659C3
- Authority
- DE
- Germany
- Prior art keywords
- erythrocytes
- solution
- erythrocyte
- marked
- isotonic saline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000003743 erythrocyte Anatomy 0.000 title claims description 59
- 238000000034 method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000013049 sediment Substances 0.000 claims description 12
- 230000002285 radioactive effect Effects 0.000 claims description 10
- 239000008139 complexing agent Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003058 plasma substitute Substances 0.000 claims description 6
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims description 5
- 229910052733 gallium Inorganic materials 0.000 claims description 5
- 229910052738 indium Inorganic materials 0.000 claims description 5
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000011534 incubation Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 229910052716 thallium Inorganic materials 0.000 claims description 3
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims description 3
- 125000005594 diketone group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 30
- 238000002372 labelling Methods 0.000 description 10
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000009206 nuclear medicine Methods 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- -1 B. 67Ga Chemical compound 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000003505 heat denaturation Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2427659A DE2427659C3 (de) | 1974-06-07 | 1974-06-07 | Verfahren zur Herstellung von radioaktiv markierten Erythrozyten |
| NL7415094A NL7415094A (nl) | 1974-06-07 | 1974-11-20 | Radio-actief gemarkeerde erythrocieten, werk- wijze voor het vervaardigen van zulke erythro- cieten, middel voor scintigrafische weergave en werkwijze voor het bereiden van zo'n middel. |
| GB5178774A GB1476656A (en) | 1974-06-07 | 1974-11-29 | Process for the preparation of radioactively tagged erythro cytes and agents containing them |
| FR7441208A FR2273871A1 (fr) | 1974-06-07 | 1974-12-13 | Erythrocytes marques radioactivement et produits qui en renferment |
| BE156679A BE829451A (fr) | 1974-06-07 | 1975-05-23 | Erythrocytes marques radioactivement et produits qui en renferment |
| US05/582,028 US3991173A (en) | 1974-06-07 | 1975-05-29 | Radioactively tagged erythrocytes and agents containing them |
| AT424475A AT341114B (de) | 1974-06-07 | 1975-06-04 | Verfahren zur herstellung einer suspension von radioaktiv markierten roten blutkorperchen fur szintigraphische zwecke |
| JP50067732A JPS517114A (enExample) | 1974-06-07 | 1975-06-06 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2427659A DE2427659C3 (de) | 1974-06-07 | 1974-06-07 | Verfahren zur Herstellung von radioaktiv markierten Erythrozyten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2427659A1 DE2427659A1 (de) | 1975-12-11 |
| DE2427659B2 DE2427659B2 (de) | 1978-07-13 |
| DE2427659C3 true DE2427659C3 (de) | 1979-08-16 |
Family
ID=5917605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2427659A Expired DE2427659C3 (de) | 1974-06-07 | 1974-06-07 | Verfahren zur Herstellung von radioaktiv markierten Erythrozyten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3991173A (enExample) |
| JP (1) | JPS517114A (enExample) |
| AT (1) | AT341114B (enExample) |
| BE (1) | BE829451A (enExample) |
| DE (1) | DE2427659C3 (enExample) |
| FR (1) | FR2273871A1 (enExample) |
| GB (1) | GB1476656A (enExample) |
| NL (1) | NL7415094A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU580958B2 (en) * | 1983-07-07 | 1989-02-09 | Mallinckrodt, Inc. | Sterile radioactive indium-containing aqueous solution |
| JPS6058927A (ja) * | 1983-09-09 | 1985-04-05 | Nippon Mejifuijitsukusu Kk | 放射能標識血小板製剤 |
| US4755375A (en) * | 1984-01-27 | 1988-07-05 | Associated Universities, Inc. | Method and kit for the selective labeling of red blood cells in whole blood with TC-99M |
| US4935223A (en) * | 1988-08-04 | 1990-06-19 | Board Of Regents, The University Of Texas System | Labeled cells for use in imaging |
| US7985210B2 (en) | 2004-02-09 | 2011-07-26 | The Procter & Gamble Company | Absorbent article comprising a flap handle that aids in the application of said absorbent article |
-
1974
- 1974-06-07 DE DE2427659A patent/DE2427659C3/de not_active Expired
- 1974-11-20 NL NL7415094A patent/NL7415094A/xx unknown
- 1974-11-29 GB GB5178774A patent/GB1476656A/en not_active Expired
- 1974-12-13 FR FR7441208A patent/FR2273871A1/fr active Granted
-
1975
- 1975-05-23 BE BE156679A patent/BE829451A/xx unknown
- 1975-05-29 US US05/582,028 patent/US3991173A/en not_active Expired - Lifetime
- 1975-06-04 AT AT424475A patent/AT341114B/de not_active IP Right Cessation
- 1975-06-06 JP JP50067732A patent/JPS517114A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2427659B2 (de) | 1978-07-13 |
| ATA424475A (de) | 1977-05-15 |
| BE829451A (fr) | 1975-09-15 |
| JPS517114A (enExample) | 1976-01-21 |
| NL7415094A (nl) | 1975-12-09 |
| FR2273871A1 (fr) | 1976-01-02 |
| FR2273871B3 (enExample) | 1977-09-16 |
| GB1476656A (en) | 1977-06-16 |
| US3991173A (en) | 1976-11-09 |
| DE2427659A1 (de) | 1975-12-11 |
| AT341114B (de) | 1978-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |