DE239558C - - Google Patents
Info
- Publication number
- DE239558C DE239558C DENDAT239558D DE239558DA DE239558C DE 239558 C DE239558 C DE 239558C DE NDAT239558 D DENDAT239558 D DE NDAT239558D DE 239558D A DE239558D A DE 239558DA DE 239558 C DE239558 C DE 239558C
- Authority
- DE
- Germany
- Prior art keywords
- copper
- citric acid
- sodium
- water
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JQKUCPUQTWLCNU-UHFFFAOYSA-N copper;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Cu].OC(=O)CC(O)(C(O)=O)CC(O)=O JQKUCPUQTWLCNU-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- -1 boron citric acid sodium Chemical compound 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- OQUFOZNPBIIJTN-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;sodium Chemical compound [Na].OC(=O)CC(O)(C(O)=O)CC(O)=O OQUFOZNPBIIJTN-UHFFFAOYSA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 6
- 229910052802 copper Inorganic materials 0.000 description 6
- 239000010949 copper Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N Citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
- 239000002674 ointment Substances 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 206010044325 Trachoma Diseases 0.000 description 3
- 241000390203 Trachoma Species 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- STDMRMREKPZQFJ-UHFFFAOYSA-H tricopper;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Cu+2].[Cu+2].[Cu+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O STDMRMREKPZQFJ-UHFFFAOYSA-H 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 240000002268 Citrus limon Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 239000011778 trisodium citrate Substances 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 206010061446 Conjunctival disease Diseases 0.000 description 1
- 241000031711 Cytophagaceae Species 0.000 description 1
- 208000006641 Skin Disease Diseases 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- IRJNTBRBTUYLDI-UHFFFAOYSA-K copper;sodium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Cu+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O IRJNTBRBTUYLDI-UHFFFAOYSA-K 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000002458 infectious Effects 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
;-M 239558 KLASSE 30 h. GRUPPE ; -M 239558 CLASS 30 h. GROUP
Dr. FERDINAND Ritter von ARLT in WIEN.Dr. FERDINAND Ritter von ARLT in VIENNA.
enthaltenden Arzneimittels.containing drug.
Den Gegenstand der Erfindung bildet dieThe subject of the invention forms the
Herstellung eines Präparats für Kupfertherapie, dessen Anwendung trotz seiner erheblichen Löslichkeit in Wasser keine Schmerzen verursacht. Manufacture of a preparation for copper therapy, its application despite its considerable Solubility in water does not cause pain.
Bisher wurden vorwiegend Kupferalaun, schwefelsaures, essigsaures und zitronensaures Kupfer verwendet. Die Anwendung der drei erstgenannten Salze beruht vorwiegend auf ίο ihrer ätzenden Wirkung und ist daher, von anderen Ubelständen abgesehen, ungemein schmerzhaft.So far, copper alum, sulfuric acid, acetic acid and lemon acid have been predominantly used Copper used. The use of the first three salts is based mainly on ίο its caustic effect and is therefore, of apart from other afflictions, extremely painful.
Das zitronensaure Kupfer jedoch äußert kräftige bakterizide Wirkung; seine Anwendung verursacht keinerlei Beschwerden; die Heilung beispielsweise von Trachom erfolgt in etwa 85 Prozent der Fälle glatt und ohne Beschwerden für den Patienten.The citric acid copper, however, expresses itself powerful bactericidal effect; its use does not cause any discomfort; the Trachoma, for example, heals smoothly and without discomfort in about 85 percent of cases for the patient.
Einen Übelstand bildet jedoch die geringe Löslichkeit des Präparats in Wasser (1 : 9143) oder in ι prozentiger Kochsalzlösung (ι :770ο). Hierdurch erscheint seine Anwendung als Augenwasser, die vielfach wünschenswert wäre, als ausgeschlossen, und auch die Wirkung einer durch Verreiben des Präparats mit Unguentum glycerini (5 bis 10 : 100) hergestellten Salbe besitzt noch nicht die häufig wünschenswerte , Stärke.One drawback, however, is the low solubility of the preparation in water (1: 9143) or in ι percent saline solution (ι: 770ο). As a result, it appears to be used as an eye wash, which would be desirable in many cases, as excluded, and also the effect of rubbing the preparation with Unguentum glycerini (5 to 10: 100) made ointment not yet the often desirable strength.
Die allgemeine Vermutung ging dahin, daß die schmerzlos erfolgende Wirkung des Präparats bei seiner Anwendung in Salbenform auf seiner Schwerlöslichkeit beruhte. Tatsächlich läßt sich die Löslichkeit des zitronensauren Kupfers in Wasser durch Zusatz anderer Salze ! wesentlich erhöhen, jedoch nicht ohne daß das j Einträufeln dieser stärkeren Lösung ins Auge lange andauernde Schmerzen hervorriefe.The general assumption was that the painless effect of the preparation when used in ointment form was based on its poor solubility. Indeed The solubility of the citric acid copper in water can be increased by adding other salts ! increase substantially, but not without instilling this stronger solution into the eye caused long-lasting pain.
Erfinder hat nun gefunden, daß es gelingt, die Löslichkeit des Zitronensäuren Kupfers in , Wasser sehr erheblich zu steigern, ohne Schmerzempfindung bei der Anwendung des Präparats hervorzurufen. Zu diesem Zweck wird dem Zitronensäuren Kupfer die erforderliche Menge borzitronensaures. Natrium hinzugefügt.The inventor has now found that the solubility of citric acids copper in, To increase the water considerably, without any pain sensation when using the preparation to evoke. For this purpose, the citric copper is given the required amount boric acid. Sodium added.
Unter borzitronensaurem Natrium werden sowohl das Natriumsalz der als einheitliche Verbindung geltenden BorzitronensäureUnder boron-citric acid sodium both the sodium salt of the as uniform Compound applicable boricitric acid
CTT JD /1 //^ Λ /1 IT I ι /^ TT f~\ TT //~* /~i S) TT 1
3 .O4 ti U (C U U rlJ3 + G3 JtI4U rl (C U U rlJ3 CTT JD / 1 // ^ Λ / 1 IT I ι / ^ TT f ~ \ TT // ~ * / ~ i S) TT 1
3 .O 4 ti U (CUU rlJ 3 + G 3 JtI 4 U rl (C UU rlJ 3
j verstanden, als auch die im Handel üblichen Borocitrate, die bekanntlich Mischungen von Natriumborat in Natriumeitrat darstellen. Die beste Löslichkeit des Kupfercitrats erhält man durch Anwendung von so viel neutralem Borocitrat, daß auf 1 Mol. unlösliches Kupfercitrat 2 Mol. Zitronensäure in Anwendung kommen. Den Präparaten wird vorteilhaft für manche Zwecke ein Zusatz von Kochsalz beigegeben.j understood, as well as the commercially available borocitrates, which are known to be mixtures of Represent sodium borate in sodium citrate. The best solubility of the copper citrate is obtained by using so much neutral borocitrate that 1 mol of insoluble copper citrate 2 moles of citric acid are used. The supplements will be beneficial to some Purposes an addition of table salt added.
Eine zur Trachombehandlung sehr geeignete Lösung wird z. B. so hergestellt, daß in 100 Teilen Wasser 0,28 Teile zitronensaures Kupfer, 0,4 Teile Natrium borocitricum des Handels (Gemisch von Natriumborat und Natriumcitrat) gelöst werden. Diese Lösung hat sich zur Verwendung als Collyrium bei einer Reihe von infektiösen Bindehauterkrankungen und Hauterkrankungen geeignet erwiesen.A very suitable one for trachoma treatment Solution is z. B. made so that in 100 parts of water 0.28 part of citric acid copper, 0.4 parts of commercial sodium borocitricum (mixture of sodium borate and sodium citrate) be solved. This solution has been found to be used as a collyrium in a number of cases Proven suitable for infectious conjunctival diseases and skin diseases.
In fester Form erhält man ein sehr leichtIn solid form you can get a very easily
lösliches, reizloses Präparat z. B. dadurch, daß man 6,1 kg kristallisiertes Kupfercitrat mit 5,3 kg Natriumborocitratsoluble, non-irritating preparation z. B. by having 6.1 kg of crystallized copper citrate 5.3 kg of sodium borocitrate
CzHiB0 (C00Na)s + C3 H4OH(C00Na)3 C z H i B0 (C00Na) s + C 3 H 4 OH (C00Na) 3
zusammenreibt oder besser die Salze im genannten Verhältnis zusammen in Wasser, löst und die erhaltene Lösung zur Trockne bringt. Das so erhaltene Kupfercitrat-Natriumborocitrat ist ein blaues Pulver das bereits in der gleichen Gewichtsmenge Wasser gelöst werden kann. . ..rubs together or, better, the salts in the stated ratio together in water, dissolves and bring the resulting solution to dryness. The copper citrate-sodium borocitrate thus obtained is a blue powder that is already in the equal weight of water can be dissolved. . ..
Zur Herstellung einer bei Trachom vorteilhaft verwendbaren.Salbe werden z. B. 5 bis 10 Prozent zitronensaures Kupfer, 0,5 Prozent Natrium borocitricum sowie 1 Prozent Kochsalz einer geeigneten Salbengrundmasse, z. B. Unguentum glycerini, einverleibt.For the production of an advantageously usable in trachoma, z. B. 5 to 10 percent Lemon acid copper, 0.5 percent sodium borocitricum and 1 percent table salt suitable ointment base, e.g. B. Unguentum glycerini incorporated.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE239558C true DE239558C (en) |
Family
ID=498989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT239558D Active DE239558C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE239558C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5253912A (en) * | 1991-04-10 | 1993-10-19 | Axis Usa, Inc. | Gripper apparatus for electric motor components |
| US5257689A (en) * | 1991-04-10 | 1993-11-02 | Axis Usa, Inc. | Apparatus for substantially simultaneously processing multiple electric motor parts |
-
0
- DE DENDAT239558D patent/DE239558C/de active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5253912A (en) * | 1991-04-10 | 1993-10-19 | Axis Usa, Inc. | Gripper apparatus for electric motor components |
| US5257689A (en) * | 1991-04-10 | 1993-11-02 | Axis Usa, Inc. | Apparatus for substantially simultaneously processing multiple electric motor parts |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2659152A1 (en) | NEW ANTIBIOTIC PREPARATIONS FOR PHARMACEUTICAL USE | |
| DE3414629A1 (en) | Composition with pharmaceutical action, therapeutic use of the composition and process for its preparation | |
| DE1804801C3 (en) | Acne treatment agents | |
| DE239558C (en) | ||
| EP0037009B1 (en) | Composition for cleaning the hair and body | |
| WO1989005627A1 (en) | Preparation and process for permanently waving the hair | |
| DE3316597C1 (en) | Gelatinous preparation, and the use thereof as a medicament | |
| EP0625041B1 (en) | Aqueous cleaning products | |
| DE2659462C3 (en) | Process for the preparation of a pharmaceutically acceptable moist silica hydrogel | |
| DE1492071A1 (en) | Antiseborrhoeic agents | |
| DE2426393C3 (en) | Ready-to-use liquid gargle with antimicrobial effectiveness | |
| DE2729888A1 (en) | Make-up removal lotion for the eyes | |
| DE2725525A1 (en) | COSMETIC PREPARATION | |
| DE2226927A1 (en) | COMPOSITION AND ADMINISTRATION FORM EFFECTIVE AGAINST ADDICTION AND CELLULITIS | |
| DE2121766A1 (en) | Preparations for preventing discoloration of teeth and for combating tartar. Änm: Beecham Inc., Clifton, N.J. (V.StA.) | |
| DE244827C (en) | ||
| DE2445400C3 (en) | Injectable single-phase preparation and process for its manufacture | |
| DE702769C (en) | Process for the preparation of phosphoric acid esters of dithymol and dihalodithymol | |
| DE961657C (en) | Process for the stabilization of chlorine dioxide-containing, antiseptic, aqueous solutions | |
| DE2526986A1 (en) | Aqueous RAFOXANIDE PREPARATIONS | |
| DE3129685C2 (en) | Antiseptic solution | |
| AT164264B (en) | Process for the manufacture of a liquid medicinal product for dermatological purposes | |
| DE862341C (en) | Process for the preparation of aqueous solutions of derivatives of p-aminobenzene sulfonamide | |
| DE638839C (en) | Process for the production of aqueous-alcoholic cholesterol solutions | |
| DE69100027T2 (en) | CARRIER FOR THERAPEUTIC, EXTERNALLY APPLICABLE ACTIVE SUBSTANCES AND ANTISEPTIC CONTAINING THIS CARRIER. |