DE2349271A1 - Vorrichtung zum ermitteln von parametern von blutzellen - Google Patents
Vorrichtung zum ermitteln von parametern von blutzellenInfo
- Publication number
- DE2349271A1 DE2349271A1 DE19732349271 DE2349271A DE2349271A1 DE 2349271 A1 DE2349271 A1 DE 2349271A1 DE 19732349271 DE19732349271 DE 19732349271 DE 2349271 A DE2349271 A DE 2349271A DE 2349271 A1 DE2349271 A1 DE 2349271A1
- Authority
- DE
- Germany
- Prior art keywords
- radiation
- optical system
- cell
- detector
- essentially
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000601 blood cell Anatomy 0.000 title claims description 35
- 210000004027 cell Anatomy 0.000 claims description 56
- 230000005855 radiation Effects 0.000 claims description 56
- 230000003287 optical effect Effects 0.000 claims description 29
- 230000001419 dependent effect Effects 0.000 claims description 17
- 239000007788 liquid Substances 0.000 description 25
- 238000005259 measurement Methods 0.000 description 22
- 239000002245 particle Substances 0.000 description 21
- 239000000975 dye Substances 0.000 description 19
- 239000000523 sample Substances 0.000 description 14
- 238000010521 absorption reaction Methods 0.000 description 12
- 210000003855 cell nucleus Anatomy 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 210000004940 nucleus Anatomy 0.000 description 9
- 239000003085 diluting agent Substances 0.000 description 8
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
- 230000003204 osmotic effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000000805 cytoplasm Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 241000702021 Aridarum minimum Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010023321 Factor VII Proteins 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1497—Particle shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4711—Multiangle measurement
- G01N2021/4716—Using a ring of sensors, or a combination of diaphragm and sensors; Annular sensor
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00294245A US3819270A (en) | 1972-10-02 | 1972-10-02 | Blood cell analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2349271A1 true DE2349271A1 (de) | 1974-04-18 |
Family
ID=23132527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732349271 Pending DE2349271A1 (de) | 1972-10-02 | 1973-10-01 | Vorrichtung zum ermitteln von parametern von blutzellen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3819270A (enrdf_load_stackoverflow) |
| JP (1) | JPS505098A (enrdf_load_stackoverflow) |
| CA (1) | CA984175A (enrdf_load_stackoverflow) |
| CH (1) | CH573600A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2349271A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2201064B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1424388A (enrdf_load_stackoverflow) |
| NL (1) | NL7313531A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008061695A1 (de) | 2008-12-10 | 2010-06-17 | Laser- und Medizin-Technologie, Berlin GmbH | Anordnung zur Bestimmung optischer Eigenschaften bei mehreren Wellenlängen |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3941479A (en) * | 1974-09-26 | 1976-03-02 | G. D. Searle & Co. | Use of modulated stimulus to improve detection sensitivity for signals from particles in a flow chamber |
| US3992096A (en) * | 1975-08-04 | 1976-11-16 | Minnesota Mining And Manufacturing Company | Detecting system |
| US4577964A (en) * | 1978-09-06 | 1986-03-25 | Ortho Diagnostics, Inc. | Apparatus and method for detecting platelets in whole blood |
| US4286876A (en) * | 1979-01-02 | 1981-09-01 | Coulter Electronics, Inc. | Apparatus and method for measuring scattering of light in particle detection systems |
| GB2041516B (en) * | 1979-01-02 | 1983-04-13 | Coulter Electronics | Methods and apparatus for measurement of reradiation in particle flow cell systems |
| US4338024A (en) * | 1980-05-02 | 1982-07-06 | International Remote Imaging Systems, Inc. | Flow analyzer and system for analysis of fluids with particles |
| CA1292628C (en) * | 1986-02-12 | 1991-12-03 | James Phinazee Sutton Iii | In situ particle size measuring device |
| US4999513A (en) * | 1988-09-09 | 1991-03-12 | Canon Kabushiki Kaisha | Particle measuring apparatus |
| US5116125A (en) * | 1990-10-31 | 1992-05-26 | Biophos Medical Ab | Fertility analyzer |
| GB9202887D0 (en) * | 1992-02-12 | 1992-03-25 | Cambridge Consultants | A particle sizing system based on incoherent structured illumination |
| US5999256A (en) * | 1992-02-12 | 1999-12-07 | Cambridge Consultants Limited | Particle measurement system |
| US5691132A (en) | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
| US6177441B1 (en) | 1995-06-05 | 2001-01-23 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
| US5872627A (en) * | 1996-07-30 | 1999-02-16 | Bayer Corporation | Method and apparatus for detecting scattered light in an analytical instrument |
| US5844685A (en) * | 1996-07-30 | 1998-12-01 | Bayer Corporation | Reference laser beam sampling apparatus |
| JP2000304689A (ja) * | 1999-04-21 | 2000-11-02 | Hiroyuki Ogawa | 投影観察方法、微生物検査方法および投影検出装置 |
| US6359683B1 (en) * | 2000-04-27 | 2002-03-19 | Becton, Dickinson And Company | Method for determining the volume of particles suspended in liquids |
| US6473172B1 (en) | 2000-09-20 | 2002-10-29 | International Remote Imaging Systems, Inc. | Flow cell and method of operating therefor |
| US7029631B2 (en) * | 2002-04-19 | 2006-04-18 | Agilent Technologies, Inc. | Apparatus for improved light collection |
| US7867778B2 (en) * | 2007-02-23 | 2011-01-11 | Visiongate, Inc. | Fluid focusing for positional control of a specimen for 3-D imaging |
| CA2784073A1 (en) * | 2010-05-18 | 2011-05-24 | Partec Gmbh | Arrangement for measuring the optical properties of particles of a dispersion |
| US20210121884A1 (en) * | 2012-12-21 | 2021-04-29 | Leica Biosystems Melbourne Pty Ltd | Method of producing a reagent on-board an instrument |
| EP3842785B1 (en) | 2013-03-15 | 2024-01-17 | Iris International, Inc. | Sheath fluid systems and methods for particle analysis in blood samples |
| KR101855490B1 (ko) * | 2016-01-22 | 2018-05-08 | 한국과학기술원 | 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법 |
| GB2593194B (en) * | 2020-03-18 | 2022-09-07 | Refeyn Ltd | Methods and apparatus for optimised interferometric scattering microscopy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB785356A (en) * | 1953-01-30 | 1957-10-30 | Mullard Radio Valve Co Ltd | Improvements in or relating to flying spot scanning systems |
| US3315229A (en) * | 1963-12-31 | 1967-04-18 | Ibm | Blood cell recognizer |
| DE1673023A1 (de) * | 1967-10-13 | 1971-04-29 | Rwk Rhein Westfael Kalkwerke | Verfahren und Vorrichtung zur Ermittlung des Kornaufbaus von Schuettgut |
| US3675768A (en) * | 1969-03-17 | 1972-07-11 | Gildardo Legorreta Sanchez | Method and apparatus for classifying and segregating particles with electrical and optical means |
| US3528742A (en) * | 1969-07-23 | 1970-09-15 | Herbert H Dobbs | Optical anemometer |
| US3669542A (en) * | 1969-10-09 | 1972-06-13 | Coulter Electronics | Liquid borne particle sensor |
| US3662176A (en) * | 1970-04-06 | 1972-05-09 | Bio Physics Systems Inc | Photo-optical particle analysis method and apparatus |
| BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
-
1972
- 1972-10-02 US US00294245A patent/US3819270A/en not_active Expired - Lifetime
-
1973
- 1973-09-17 GB GB4343073A patent/GB1424388A/en not_active Expired
- 1973-09-28 FR FR7334853A patent/FR2201064B1/fr not_active Expired
- 1973-10-01 DE DE19732349271 patent/DE2349271A1/de active Pending
- 1973-10-01 CA CA182,299A patent/CA984175A/en not_active Expired
- 1973-10-01 CH CH1401273A patent/CH573600A5/xx not_active IP Right Cessation
- 1973-10-02 NL NL7313531A patent/NL7313531A/xx unknown
- 1973-10-02 JP JP48110908A patent/JPS505098A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008061695A1 (de) | 2008-12-10 | 2010-06-17 | Laser- und Medizin-Technologie, Berlin GmbH | Anordnung zur Bestimmung optischer Eigenschaften bei mehreren Wellenlängen |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS505098A (enrdf_load_stackoverflow) | 1975-01-20 |
| US3819270A (en) | 1974-06-25 |
| AU6072373A (en) | 1975-03-27 |
| FR2201064B1 (enrdf_load_stackoverflow) | 1977-05-27 |
| CA984175A (en) | 1976-02-24 |
| GB1424388A (en) | 1976-02-11 |
| CH573600A5 (enrdf_load_stackoverflow) | 1976-03-15 |
| NL7313531A (enrdf_load_stackoverflow) | 1974-04-04 |
| FR2201064A1 (enrdf_load_stackoverflow) | 1974-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |