DE2251250C3 - Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten - Google Patents
Verfahren zur Herstellung hochdosierter Antibiotica-TablettenInfo
- Publication number
- DE2251250C3 DE2251250C3 DE2251250A DE2251250A DE2251250C3 DE 2251250 C3 DE2251250 C3 DE 2251250C3 DE 2251250 A DE2251250 A DE 2251250A DE 2251250 A DE2251250 A DE 2251250A DE 2251250 C3 DE2251250 C3 DE 2251250C3
- Authority
- DE
- Germany
- Prior art keywords
- tablets
- magnesium stearate
- production
- ultraamylopectin
- starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 4
- 230000003115 biocidal effect Effects 0.000 title description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 18
- 235000019359 magnesium stearate Nutrition 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 229920000881 Modified starch Polymers 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 6
- 229940088710 antibiotic agent Drugs 0.000 claims description 6
- 235000019426 modified starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 239000000454 talc Substances 0.000 claims description 6
- 229910052623 talc Inorganic materials 0.000 claims description 6
- 229930182555 Penicillin Natural products 0.000 claims description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 claims 1
- 229960000603 cefalotin Drugs 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical class C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 229960000723 ampicillin Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 229940090663 penicillin v potassium Drugs 0.000 description 3
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical class N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 229930186147 Cephalosporin Natural products 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001780 cephalosporins Chemical class 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 150000002960 penicillins Chemical class 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000009492 tablet coating Methods 0.000 description 2
- 239000002700 tablet coating Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229960003311 ampicillin trihydrate Drugs 0.000 description 1
- 239000006067 antibiotic powder Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229960001019 oxacillin Drugs 0.000 description 1
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical class N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- -1 ultraamylopectin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2251250A DE2251250C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten |
| NL7314085A NL7314085A (enExample) | 1972-10-19 | 1973-10-12 | |
| CH1464573A CH608964A5 (en) | 1972-10-19 | 1973-10-16 | Auxiliary mixture for the production of tablets |
| SE7314143A SE416176B (sv) | 1972-10-19 | 1973-10-17 | Forfarande for framstellning av hogdoserade autibiotikatabletter |
| AU61513/73A AU486083B2 (en) | 1972-10-19 | 1973-10-17 | Process forthe manufacture of tablets containing high doses of antibiotics |
| DK565773AA DK143436B (da) | 1972-10-19 | 1973-10-18 | Fremgangsmaade til fremstilling af tabletter med et hoejt indhold af antiob ld af antibiotika |
| AT884973A AT338430B (de) | 1972-10-19 | 1973-10-18 | Verfahren zur herstellung von hochdosierten formlingen mit antibiotika vom penicillin- bzw. cephalotin-typ |
| FR7337173A FR2247208B1 (enExample) | 1972-10-19 | 1973-10-18 | |
| ZA00738100A ZA738100B (en) | 1972-10-19 | 1973-10-18 | Process for the manufacture of tablets containing high doses of antibiotics |
| GB4883473A GB1451804A (en) | 1972-10-19 | 1973-10-19 | Pharmaceutical preparations comprising antibiotics |
| BE136881A BE806294A (fr) | 1972-10-19 | 1973-10-19 | Procede de preparation de comprimes a forte teneur en antibiotique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2251250A DE2251250C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2251250A1 DE2251250A1 (de) | 1974-05-02 |
| DE2251250B2 DE2251250B2 (de) | 1979-10-04 |
| DE2251250C3 true DE2251250C3 (de) | 1981-06-25 |
Family
ID=5859487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2251250A Expired DE2251250C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT338430B (enExample) |
| BE (1) | BE806294A (enExample) |
| CH (1) | CH608964A5 (enExample) |
| DE (1) | DE2251250C3 (enExample) |
| DK (1) | DK143436B (enExample) |
| FR (1) | FR2247208B1 (enExample) |
| GB (1) | GB1451804A (enExample) |
| NL (1) | NL7314085A (enExample) |
| SE (1) | SE416176B (enExample) |
| ZA (1) | ZA738100B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4034035A (en) * | 1975-07-14 | 1977-07-05 | Merck & Co., Inc. | Method of preparing multi-toned tablets |
| US4115563A (en) * | 1977-03-14 | 1978-09-19 | Sterling Drug Inc. | Pharmaceutical steroid formulation |
| EP0281200B1 (en) * | 1987-03-02 | 1994-01-19 | Yamanouchi Europe B.V. | Pharmaceutical composition, pharmaceutical granulate and process for their preparation |
| DK0801559T3 (da) * | 1995-02-08 | 2002-06-17 | Yamanouchi Europ Bv | Fremgangsmåde til fremstilling af orale doseringsformer indeholdende et beta-lactam antibiotikum |
| KR20040058360A (ko) * | 1996-02-29 | 2004-07-03 | 후지사와 야꾸힝 고교 가부시키가이샤 | 합성 감미료 |
| TWI225402B (en) * | 1996-03-13 | 2004-12-21 | Biochemie Gmbh | Auxiliary-free agglomerates |
| AU6496498A (en) * | 1997-02-07 | 1998-08-26 | Gist-Brocades B.V. | Homogeneous granulated formulations for dose sipping technology |
| WO1999011261A1 (en) * | 1997-08-29 | 1999-03-11 | Dsm N.V. | Granules free of excipients |
| JP2001516365A (ja) * | 1997-11-17 | 2001-09-25 | ギスト ブロカデス ベスローテン フェンノートシャップ | クラブラネート及び１種以上の賦形剤を含む顆粒 |
| CN114939113A (zh) * | 2022-06-01 | 2022-08-26 | 澳美制药(苏州)有限公司 | 青霉素v钾片及其制备方法 |
-
1972
- 1972-10-19 DE DE2251250A patent/DE2251250C3/de not_active Expired
-
1973
- 1973-10-12 NL NL7314085A patent/NL7314085A/xx not_active Application Discontinuation
- 1973-10-16 CH CH1464573A patent/CH608964A5/xx not_active IP Right Cessation
- 1973-10-17 SE SE7314143A patent/SE416176B/xx unknown
- 1973-10-18 AT AT884973A patent/AT338430B/de not_active IP Right Cessation
- 1973-10-18 ZA ZA00738100A patent/ZA738100B/xx unknown
- 1973-10-18 FR FR7337173A patent/FR2247208B1/fr not_active Expired
- 1973-10-18 DK DK565773AA patent/DK143436B/da not_active Application Discontinuation
- 1973-10-19 BE BE136881A patent/BE806294A/xx not_active IP Right Cessation
- 1973-10-19 GB GB4883473A patent/GB1451804A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE806294A (fr) | 1974-04-19 |
| ZA738100B (en) | 1975-05-28 |
| DK143436B (da) | 1981-08-24 |
| CH608964A5 (en) | 1979-02-15 |
| FR2247208B1 (enExample) | 1978-11-03 |
| AU6151373A (en) | 1975-04-17 |
| GB1451804A (en) | 1976-10-06 |
| ATA884973A (de) | 1976-12-15 |
| NL7314085A (enExample) | 1974-04-23 |
| DE2251250B2 (de) | 1979-10-04 |
| FR2247208A1 (enExample) | 1975-05-09 |
| SE416176B (sv) | 1980-12-08 |
| AT338430B (de) | 1977-08-25 |
| DE2251250A1 (de) | 1974-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |