DE2126261A1 - Verfahren zur Herstellung von neuen, virustatisch wirksamen 1,3 4 Thiadiazo len - Google Patents
Verfahren zur Herstellung von neuen, virustatisch wirksamen 1,3 4 Thiadiazo lenInfo
- Publication number
- DE2126261A1 DE2126261A1 DE19712126261 DE2126261A DE2126261A1 DE 2126261 A1 DE2126261 A1 DE 2126261A1 DE 19712126261 DE19712126261 DE 19712126261 DE 2126261 A DE2126261 A DE 2126261A DE 2126261 A1 DE2126261 A1 DE 2126261A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- virustatically
- thiadiazo
- len
- effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
Vtrfahrta stur Htrattllaag ro· atata, Tiraatatiaok
wirkaaata 1,3,4-Tkiadiasol«n
Di· irfiaiaag »«trifft tit Ytrfahrta «ar Htrtttllaag tob
» riraatatiaoh. wlrkaajrai 1,3,4-Tkiadlastlta
BtkaiBt ist tilt Rtikt ro· 5-aubttItalert·· 2-lllylaeiio-1,3,4-thiadiaxolta,
dtnto ti·· oytoatatiaoh.· Wlrkaag »ag·—
sohrl·»·· wiT*. Si· war«·· tyotftttiaitit darok Gyοlieitrang
tob 1~loyl-4~allyltaioa«Bioaroacii·· «it koas» 3tkwtftlilan
JF.aagia tt al, J.pr.Ck. 3», S. 108 (1W)] ·
Ftretr aiBd 1· dtr DlS 1 642 991 «la« Aasahl tod i« 5-Sttilling
aatatltalart·· 2-JLeiBo-i,3,4-ikiadiaeoltB al« Atarattita
btaahrittte·. Si· word·· htrgtattllt dartk Cyoliaitraeg to·
1-AoylthioateioajfkaaidtB ait Ιε··>· 3ekw«ftlaäart.
SeklitAliok alad Ib US Pat· Ir· 3 4·3 204 »ahlrtioht 5-JLlkylaaiao-2-ataaaBtyl-1,3t4-tkia4ia»olt
alt faagiaiA·· Blg··-
aohafttn tteohritbti. Ihr· Dartttllaag trfelgt taroh. CyοIi-•!•raag
too aakatitaiertta ir-Adamaataaoarealdtkyd-tkieatmioarbaaoaaa
ait t tit lit t ar-II I-o kl or id.
Dl· BrfiaduDg »txwtolrt di· Auawaitaag dtr 1,3,4-Thiadiaaol·
aaf tin nttitt AawtndtDgagtfeitt dtr Pharaasl··
AKfgab· lat aa aoeit, ηtut Ttrtindaagta au fladtη, dl«
Tiraetatitoht Wirkung kaa···
- 2 109884/1872
2Ί2626Ί
Is ward· bub gafaadaa, d«A aioh. is 4-Stellung aubatitalart·
1-Aoyltbitataioarbaeiit Bit waaaerabapaltendta Mitt ti·, iaabaaendara
Pheapb.oroxyohl«rid oder lconz. Sohwafalattare, io an
«lob. bakaaatar Weis· χα naaaa, rirustatiaoh. wirke ame!
2i>-diiabatitaie>tti 2-laino-1,3,4-tbJ.adiaBoltB oyoliaierti
laaatB.
Baiapiel 1t
5 g 1-»i.da«antoyl.-4-jph.tayltbJ.oainiioarbazid wirdea la 20 ml
innoDiak aeatraliaiirt. Ea wird abgtaaugt und mit Waastr
luabetttt al 2-Aniliao-5-adauaBtjl-1,3,4-thladiaEol 4,3 g,
T. 253-2550C.
laalag wurdta atbta aaAarao folgtttde 1,3»4-Thiadiasole aua
dan aataprtokftadaa 4-aubatitalertaa I-Aoylthlosamioarbazidaa.
dargtattllt·
2-All7lABiiBe-9-a«laaaBt7l-(i)-1>3,4-tBlftdiaJB0l, Fd4-7°, 62 %
2-ABiliBe-5-»yri4yl-(4)-1,3,4-taladlaeel, ?.216-17°, ti *
2-B-B»tylMiBO-5-iätayl-1,3,4-tbiadia«ol, F.111°, 79 %
2-(4-Chla*aBiliae)-5-iyri4yl-.(*)-1)3,4-tbla4ia*ol, F.2620, 9i
2-B-BtttylaJiia*-5-Krrityl-(4)-1,3,4-tkiadia»ol, F.1530, 85 %
2-Cyol#kexyla«ine-5-phtayl-1,3,4-tbla*ia*ol, F.133°, 80 %
P,21t°, 94
109884/1872
2-CyolohexylaaiBo-5-(2-hydroxjphtnyl)-1,3f4-ttiiadiaEol, F
Bi«-[2-all7laHino-1,3,4-thladiazolyl-(5)]~Biethai3, F»207°y A3 %
Bis- [2-oyolohtxylaaino-i ,3,4-thiadia*elyl-(5)] -nethas, F.2980,
>2-Bie-[2-(4-ohloraiilii*)-1,3,4-t
F.3420, 95
- 4 1 0988 A/1872
Claims (1)
- ffPattataiipracaAb «jr tiefe 1sYorfakroB «er HorstollaBg too bouoBj riruetatisoh. wlrksaaoB Ib 5-SttllttBg BaeatitalortOB 2-Alkyl- bzw· 2-thladl«sei«B der allgtoiBlBBB Faraelbei dBBBB H^ - AdejMtatyl-, Ph·ajl-, 2-Hjdr«xj^htayl-,(4·)·*, BtB«yl- KBd I2 « PkeBjl-, Cjelohexyl-, B-B»tyl-|4-ChIOrPbBDjI- odtr Alljl- soiB leanB, d*duroh.dais aaB i-Aoyl^-allQritaiosoaloarbasMo ait waaeeraiepalteBdeaMitttli, rorsKgewoiB· Pfaioepaeroxjohlorld odor koBS· Soawofol-aftar·, oyolielozt·▲BBprnoh. 2:TerfahrtB mwt Hoaretolleiai tob rirmetatieob. wlrlcea««», bokob AlkyliB bii-i,3,4--tliladia«ol*n dor allgoaolBOB Feraol/ B ■■ '" B B """β"· HI I I109884/1872Ί»·1 dtata B1 - Methyl« «dar itkylea and B2 4it la f«Baaat«a Btdtataagaa ¥*aitm*B, daimrek fektaBstiofeatti d»B awa la 4-Sttllmtf antat It «ltvt· Alkyl*B-oL,»»-dltArl»eiyl atailoariiasid· «Btayvaahtad Aaepraea. 1 eyollalazt·10988A/1872
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DD14880270 | 1970-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2126261A1 true DE2126261A1 (de) | 1972-01-20 |
Family
ID=5482716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19712126261 Withdrawn DE2126261A1 (de) | 1970-07-14 | 1971-05-27 | Verfahren zur Herstellung von neuen, virustatisch wirksamen 1,3 4 Thiadiazo len |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH546254A (de) |
DE (1) | DE2126261A1 (de) |
FR (1) | FR2104783A1 (de) |
SU (1) | SU455108A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT8148047A0 (it) * | 1981-03-18 | 1981-03-18 | Manetti & Roberts Italo Brit | Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione |
JP6666263B2 (ja) * | 2014-01-06 | 2020-03-13 | ライゼン・ファーマシューティカルズ・エスアー | グルタミナーゼの新規阻害剤 |
-
1971
- 1971-03-31 FR FR7111316A patent/FR2104783A1/fr active Granted
- 1971-05-18 SU SU1658172A patent/SU455108A1/ru active
- 1971-05-27 DE DE19712126261 patent/DE2126261A1/de not_active Withdrawn
- 1971-06-24 CH CH546254D patent/CH546254A/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SU455108A1 (ru) | 1974-12-30 |
CH546254A (de) | 1974-02-28 |
FR2104783A1 (en) | 1972-04-21 |
FR2104783B1 (de) | 1975-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8139 | Disposal/non-payment of the annual fee |