DE20309757U1 - Chemical product for cleaning and disinfecting toothbrushes and tooth beakers, contains e.g. cetylpyridinium chloride or chlorhexidine - Google Patents

Abstract

Chemical cleaning product (A) for toothbrushes and tooth beakers. Chemical cleaning product (A) for toothbrushes and tooth beakers is prepared from: (1) cetylpyridinium chloride and/or chlorhexidine, including its derivatives; (2) cleaning salts (sodium hydrogencarbonate and sodium gluconate); (3) surfactants, or their derivatives, particularly Igepon, Mersolat, Gardinal or Tergitol; (4) plant extracts or ethereal oils; (5) hydrogen peroxide/catalase compositions; (6) alcohol, preferably ethanol, or derivatives; (7) acids, preferably citric or salicylic, or their derivatives; or (8) tanning agents. Compositions (1)-(3) may also contain a dye; various flavors (e.g. E124) and/or plant extracts (sage, peppermint, witch hazel, menthol or tea tree).

Description

I agree a toothbrush is taken - namely not just the electric toothbrush, which with stronger Pressure on the gums acts as the manual toothbrush, and where one more often is more careful than with the manual toothbrush - but also the manual one Toothbrush - more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms.

Now is the toothbrush not a medical device but a commodity for which the Cosmetics regulation and parent the Food and Consumer Goods Act are responsible. In this respect, there are certainly no medical principles here. Yet It can be helpful when dealing with the toothbrush dental expertise is accompanied.

It is problematic to note

Self a fork or a spoon, which are also in the oral cavity have a better hygiene status than one toothbrush (so.).

solutions

cetylpyridinium and chlorhexidine are considered the most effective and sustainable Antiseptics.

Self at only 0.11 ppm chlorhexidine there is still a bacteriostatic So the bacteria in their movement and multiplication on "paralyzing" effect.

On added surfactant could e.g. in the sense of comprehensive toothbrush hygiene for cleaning the bristles, the dye serves e.g. as an indicator solution for visual demarcation or similar and the flavorings can can be added in different flavors.

(For example, Peppermint, chamomile, lemon, strawberry, orange, etc.). Also the Manufacturing in gel form, foam form, powder form etc. is conceivable.

On specially made cleaning vessel (e.g. narrower than a normal one Toothed cup with a marking strip for exact dosing would also be conceivable, similar applies to a cleaning brush or a cleaning sponge).

application

In this cetylpyridinium chloride or chlorhexidine surfactant solution / (- Gel) the toothbrush should at least 20 minutes - or also about Night - for disinfection remain.

Afterwards should the brush under flowing Rinsed off water be and the solution discarded become. Also rinse and dry the disinfection container. This process should be done at least once or twice a week. With viral Diseases daily. The dosage should be as low as possible respectively.

Further Variants (e.g. based on cleaning salts, tannins, acids, alcohols, Hydrogen superoxide catalase, plant extracts etc.) are in the attached protection claims contain.

background

I agree a toothbrush is taken - namely not just the electric toothbrush, which with stronger Pressure on the gums acts as the manual toothbrush, and where one more often is more careful than with the manual toothbrush - but also the manual one Toothbrush - more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms. Even cutlery, which is also in the oral cavity is introduced; has a better hygiene status than a toothbrush, which occasion should give you food for thought.

The regular use chemical disinfectant substances in the general area of toothbrush care is, in contrast to denture cleaners or oral rinsing solutions, not yet given what m. E. is a necessity!

As a reason: dental care and toothbrush care

The most people hold the disease that the teeth first wiggle, then drop out as before for age-related wear on the gums. However, periodontitis is the most common infectious disease after caries of the world.

bacteria in the oral cavity are not just for that known holes etching in the tooth but also to eat deeper into the gums.

A The direct result is tooth loss, but heart attacks and diabetes also go and premature babies to the account of periodontitis germs.

always Scientists recognize more clearly the influence of microbes have in the mouth on the whole human organism.

Bacteria in the oral cavity are also present very sociable. Apparently there are far more microorganisms here than previously thought.

Approximately 500 species are currently identified. But with the most modern gene probes researchers are tracking down more and more germs. Some of these are Germs harmless, but sometimes they also provide one for the teeth not to be underestimated Danger.

In Not only the tooth is in the line of fire of the bacteria the holes dig and thus cause tooth decay, also gets the gums to feel the attacks. Initially unnoticed, the bacteria target the vulnerability of the gums. They colonize the hem cells, which Adhere directly to the tooth and anchor the tooth in the bony tooth compartment. The bacteria release toxins, which in turn penetrate the cuticle and loosen it up. The organism then replies with defense cells. These stream into the tissue and increase its permeability. Subsequently is it possible for the toxins push into the connective tissue of the gums. Inflammation of the Gums (gingivitis) are the result.

If not at the latest now with the right dental care and a visit to the dentist is offered, redden see the gums and swell (periodontitis).

At the Eating begins even with light touch the tissue to bleed. There are so-called "pockets" between the tooth and the flesh, which can be easily removed can dig in between six to 30 millimeters deep. leftovers give the bacteria more food so that it almost can multiply explosively.

the At this stage, gums only have to withdraw. The Bacteria in the gum pocket activate tissue-degrading collagenases. The tooth loosens and the likelihood of tooth loss increases considerably.

So far it has not been possible to pinpoint the loss of mouth in individual species assigned. Clinical symptoms such as bleeding or deep pockets correlate well with the presence of certain types of bacteria in the plaque, on the other hand, they have also been found in healthy gum areas. So microbiologists now suspect that the tissue damage by the combination of bacteria is caused in a plaque living together.

Indeed the scientists were able to identify certain key germs. one Porphyromonas gingivalis is one of them. Porphyromonas gingivalis is with Evidence of 63 percent of all patients. Porphyromonas ginqivalis possesses of all possible periodontal Pathogens the broadest spectrum of tissue-degrading enzymes. The proteases build quickly Collagen, immunoglobulins or complement, taking off the connective tissue of the gums is gradually dismembered. Porphyromonas forms gingivalis membrane vesicles. These are released into the surrounding tissue in large numbers distributed, with the result that the secreted proteases receive become.

On another problem is Actinobacillus actinomycetemcomitans, that affects around 30 percent of patients and that, for example associated with urinary tract infections, meningitis or osteomyelitis becomes.

P. actinomycetemcomitans enveloped himself with a capsule and is therefore largely complementary and phagocytosis immune. Otherwise, collagenases and fimbriae also belong to his equipment. This consists of a lipopolysaccharide with extremely strong bones absorbing activity and the ability not negligibly affect the function of neutrophils.

there A. actinomycetemcomitans also forms membrane vesicles, some of these substances spread in the environment.

bacteria love the community. The oral bacteria do not form either Exception. They create collaborative out of polymer carbohydrates and protein molecules Living room. Every bacterium that adheres becomes a docking point for others Germs. If the bacteria are not removed daily, they form a tough one Rubber that drives a wedge between the tooth and the flesh. Various Microbe species live together in this biofilm, their different ones eating habits make such communities profitable for everyone involved. The slimy accommodation also offers a certain amount to its residents Protection against adverse environmental influences, about attacks from the immune system or the brush. Even with antibiotics is much more difficult to manage these biotopes than free-living Bacteria.

People with profound periodontitis have an approximately eight by nine centimeter wound area in the mouth, informs the Center for Tooth, Oral and Maxillofacial Surgery of the University of Cologne. This wound area is populated with about 10 ¹¹ microorganisms. Whenever the inflamed periodontal is stressed, for example when eating or brushing teeth, bacteremia occurs. The microbes get into the bloodstream through the small wounds and thus into every corner of the body. That is why periodontitis does not only damage the mouth directed. It is suspected of being able to trigger or fuel systemic diseases. The spectrum ranges from atherosclerosis to premature birth and diabetes.

Apparently, the settlers in the plaque are able to release various inflammation mediators, which means that more cholesterol adheres to the walls of the vessels and stimulates platelet aggregation. Studies by another working group suggest that they mislead blood clotting. For example, Streptococcus sanguis causes blood to clot. The researchers found that streptococcal protein is similar to human collagen, which plays a role in wound healing. The bacteria appear to be faking a wound on the immune system. The coagulation cascade is started and the blood vessel constricted. The bacteria prefer to settle on prostheses such as artificial heart valves or hip joints because they find conditions as good as those on teeth.

A quarter of premature babies in the United States cannot be explained by known triggers such as smoking, alcohol, or multiple pregnancies. It is known from animal experiments that bacterial toxins can cause premature birth. Therefore, it is reasonable to assume that pregnant women with periodontitis are more likely to give birth to "early marriage". Endotoxins are able to stimulate the production of labor-promoting prostaglandins via cytokines. In fact, women have been found to have had a premature birth, higher blood levels of prostaglandin E2.Taking all studies together increases the risk of premature birth in pregnant women with periodontitis by a factor of seven.

There are still uncertainties regarding the relationship between periodontitis and diabetes. What is certain is that both type 1 and type 2 diabetes roughly double the risk of developing periodontitis. Conversely, periodontitis as an infectious disease seems to have an unfavorable effect on the diabetic's blood sugar control. How the two diseases actually influence has not yet been clarified. Lipopolysaccharides, which are produced by the periodontitis germs, probably cause the metabolic setting to falter.

To There are many smaller sporadic issues in this complex Investigations, from which, however, no general rules of conduct can be derived. At least they suggest one thing:

diabetic should pay special attention to their dental care and one Gingivitis get treated immediately.

Yourself Catching the bacteria doesn't need to be neglected. The caries trigger number one, Streptococcus mutans, is transmitted from mouth to mouth via saliva.

And so the germ between siblings and partners is easily passed on. Studies from Finland and the USA showed that there were up to sixty Percent of children A. actinomycetemcomitans get from their parents.

in principle applies to all people provision. It is periodontitis after caries probably the most common chronic infectious disease in the world (see above). Already a quarter the kindergarten children have caries that needs treatment.

Loud the society for Periodontology is around 80 to 90 percent of the gums Ignited Germans and around a third of them have the bacteria already dug deep enough in the gums that periodontitis has manifested itself.

Mouth and Dental hygiene Hygiene

dental disease but are not fate. You literally have it with a brush and mouthwash The meaning of the word itself in hand, whether caries, gingivitis and periodontitis have a chance.

With correct oral hygiene, supplemented by biannual dental Care, can dental disease 90 percent can be avoided.

How but apart from dental care, does it take care of the toothbrush?

Now is the toothbrush not a medical device but a commodity for which the Cosmetics regulation and parent the Food and Consumer Goods Act are responsible. In this respect, there are certainly no medical principles here. Yet It can be helpful when dealing with the toothbrush dental expertise is accompanied.

I agree the toothbrush is taken namely but more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms. Even a fork or spoon that also introduced into the oral cavity have a better hygiene status than a toothbrush (see above).

of course is a clean toothbrush not a "panacea" alone. But a contaminated one Toothbrush is certainly not beneficial to health. Poor hygiene accelerates the onset of periodontitis.

"The A and o dental health is the number of germs in the mouth to be kept low from the start, " says e.g. Jörn Muehlenbeck, resident dentist in Hamburg.

GLASS and LARE (1986) instructed toothbrushes except the usual Oral cavity germs pathogenic and opportunistic microorganisms that not only can cause oral diseases but also in connection with special organ infections become. (However, it must be emphasized that the proof a potentially pathogenic type of germ does not come into being a specific disease). On experimental contaminated toothbrushes were survival rates oral bacteria species studied. BUNETEL et al. (2000) demonstrated that cultures of Porphyromonas gingivalis, Streptococcus mutans and Candida albicans to 0.2 to two percent after 24 hours their initial number of germs were reduced, the toothbrush type some impact on survival possessed. Herpes simplex viruses were still from GLASS and JENSEN (1988) seven days in active form. Starting from your own Experience in the chemistry laboratory, where word has long since got around that used toothbrushes for breeding of bacterial cultures, (Petri dishes with agar agar and nutrient solution e.g. with prints "inoculated" with used toothbrushes) my husband advised me Mr. Dipl.-Chem. Patrick Schmidt, currently a PhD student in the field of biological Chemistry / biochemistry at the University of Konstanz, but my toothbrush just go through regularly Boil out, clean with denture tablets or with ethanol. I have been doing this since then but have been asking why the m. E. obvious Need for proper oral hygiene, toothbrush hygiene so neglected. These solutions also appeared to me only as the second best choice, since it seemed more sensible to me, a concrete one To develop toothbrush cleaning product instead of resorting to emergency remedies. The bit cleaners are e.g. overdosed and it's difficult to break through in the middle. That too Boiling has disadvantages. This is how it deforms on some models Toothbrushes so that they are no longer usable.

General objections to separate toothbrush hygiene

Now may be object that some ingredients in toothpastes are an antimicrobial Possess effectiveness. So everyone could do usual in toothpaste An inhibition of the growth of oral germs is assigned to surfactants, (GERCKENS et al. 1992), as well as the combination sodium laurysulfate with sodium monofluorophosphate or with sodium fluoride, the best Inhibitory effects developed amine fluorides (BENTHIN et al. 1994). all Superior active ingredients seems to be the combination of amine and tin fluoride. (SAXER, 1991).

Nevertheless, it was still possible, even with the use of these products, to grow whole colonies of bacteria from the domestic toothbrush, so that it seems obvious to me here - not only in a private setting - to remedy the situation. All of the above options did not seem optimal to me. Which means could be more suitable than the above-mentioned remedies? What about other markets?

Which approaches exist it in the innovative markets? (U.S.A. and Japan)

In There are various toothbrush disinfectors on the U.S.A. market

The "self-sanitizing toothbrush", a self cleaning elaborate System, has not been very successful so far. Is on the market, however also a device in the toothbrush to be disinfected with ultraviolet light. Both the "self-sanitizing toothbrush" and the devices for disinfection are Products that have to be purchased and operated. In Japan are similar Products in the development phase. However, they do one costly and cumbersome Impression, so these options too appeared to me as not optimal. So I continued to search for suitable ones Alternatives.

suitable alternatives

cetylpyridinium and chlorhexidine are considered the most effective and sustainable antiseptics for use in the mouth and throat for oral inflammation.

chlorhexidine counts to chemical group of bis-biguandine. It turns out to be effective against a broad spectrum of pathogenic germs.

In high concentrations, 100 ppm, chlorhexidine destroys the cell membrane of the bacteria and is therefore bactericidal. A bacteriostatic, So the bacteria in their movement and multiplication "paralyzing" effect still occurs at only 0.11 ppm chlorhexidine. (Experiments are still running).

It is also of high substantivity and favors the length its effect through electrostatic bonds and interactions with the proteins and glycoproteins of those stored in the toothbrush Saliva and the plaque or the enamel hydroxyapatite.

Self at only 0.11 ppm chlorhexidine there is still a bacteriostatic So the bacteria in their movement and multiplication on "paralyzing" effect.

An admixed surfactant could now be used in the sense of comprehensive toothbrush hygiene for cleaning the bristles. B. as an indicator solution, for visual differentiation or the like and the flavors can be added in different flavors.
(Eg peppermint, chamomile, lemon, strawberry, orange, etc.). Manufacturing in gel form is also conceivable.

On specially made cleaning vessel (e.g. narrower than a normal one Toothed cup with a marking strip for precise dosing would be conceivable).

application

In this cetylpyridinium chloride or chlorihexidine surfactant solution / (- Gel) the toothbrush should at least 20 minutes - or also about Night - for disinfection remain.

Afterwards should the brush under flowing Rinsed off water be and the solution discarded become.

Also rinse and dry the disinfection container.

This The process should take place at least once or twice a week. at viral diseases daily.

As Variant could I started developing toothbrush cleaner tablets the basis of denture cleaner tablets, which contain cleaning salts work, introduce.

This could doing it especially for Chlorhexidine allergy sufferers will be useful.

Here must be the exact dosage and size of the tablets still to be explored.

Why is there such a thing? Toothbrush cleaner Product not yet?

I can also give me economic reasons imagine. possibly it's the fear of economic Losses. (Decline buying new toothbrushes). But this argument can be countered that disinfection a toothbrush does not help against bristle material wear.

economic Conclusion

This is a sensible way to counteract the development of a much more expensive and cumbersome "toothbrush cleaner station" (see above). Such a device as I have outlined will be much easier to sell to a wide audience. Toothbrush cleaner drops / gel (or chlorhexidine Allergy sufferers: Toothbrush cleaner tabs based on denture cleaner fabs but in a different dosage size and in a different, "more youthful" design, see above) are essentially more practical, more precise to dose and cheaper to buy.

medical Conclusion

"The A and o dental health is the number of germs in the mouth to be kept low from the outset ". (so.)

I agree the toothbrush is taken more than a commodity, as for example with inflamed tissue can come into contact and, above all, bearers of countless different ones Is microorganisms.

cetylpyridinium and chlorhexidine are considered the most effective and sustainable Antiseptics.

from that surrendered for me the idea for and the development of the toothbrush cleaning product outlined above.

Bibliography

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Claims (32)

Chemical toothbrush / toothbrush cleaning product, characterized in that it is produced on the basis of a cetylpyridinium chloride and / or chlorhexidine mixture (derivatives included) optionally with dye and variable flavoring agents (eg E 124) and / or plant extracts. Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on cleaning salts, (e.g. based on sodium bicarbonate, sodium gluconate) optional with color and variable flavors and / or plant extracts (e.g. sage, peppermint, mutton, menthol, tea tree) is. Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on surfactants (derivatives, included), (e.g. based on Igeponen, Mersolat, Gardinal, Tergitol) optionally with color and variable flavors and / or plant extracts is made. Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on plant extracts / essential oils is. Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on a hydrogen peroxide-catalase combination is made. Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on alcohols (e.g. based on ethyl alcohol) (derivatives included). Chemical toothbrush / tooth cup cleaning product, characterized in that it is based on acids (e.g. based on citric acid, salicylic acid) (derivatives included). Chemical toothbrush / tooth cup cleaning product, characterized in that it is made on the basis of tannins is. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in the form of a cleaning gel. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in the form of a soluble cleaning tablet. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a cleaning drop. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a cleaning solution. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a cleaning foam. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a soluble cleaning powder. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is used as cleaning granules is present. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a cleaning spray. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is present as a cleaning paste. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a tooth cup with a radius of approx. 2 cm. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a cleaning sponge. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is a combined cleaning set along with a groomed cleaning surface (e.g. soaked sponge or similar) is present. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is a combined cleaning set together with a cleaning brush about the size of one Toothbrush is present. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a package, on which by writing or symbols expressly on the area of application (toothbrush cleaning / Tooth cup cleaning). Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a dosage / concentration is available, which can be individually metered to the area of application (Toothbrush cleaning) is coordinated. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is used both for cleaning Toothbrushes as well as for the simultaneous cleaning of toothbrush cups. Chemical toothbrush / tooth cup cleaning product according to at least one of claims 1 to 8, characterized in that it is also used for cleaning dentures that can. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a dosage / concentration is available, which can be individually metered to the area of application (Dentures) is coordinated. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is also for cleaning of braces can be used. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a dosage / concentration is available, which can be individually metered to the area of application (Braces) is matched. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is also for cleaning can be used by mouthguards. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a dosage / concentration is available, which can be individually metered to the area of application (Mouthguard) is coordinated. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is also for cleaning of tooth cleaning sponges can be used. Chemical toothbrush / tooth cup cleaning product, according to at least one of the claims 1 to 8, characterized in that it is in a dosage / concentration is available, which can be individually metered to the area of application (Zahnreinigungsschwämmchen) is coordinated.