DE19933719A1 - Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung - Google Patents
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und VerwendungInfo
- Publication number
- DE19933719A1 DE19933719A1 DE19933719A DE19933719A DE19933719A1 DE 19933719 A1 DE19933719 A1 DE 19933719A1 DE 19933719 A DE19933719 A DE 19933719A DE 19933719 A DE19933719 A DE 19933719A DE 19933719 A1 DE19933719 A1 DE 19933719A1
- Authority
- DE
- Germany
- Prior art keywords
- structural protein
- protein according
- mutation
- aav
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933719A DE19933719A1 (de) | 1999-07-19 | 1999-07-19 | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
| US10/031,187 US7285381B1 (en) | 1999-07-19 | 2000-07-18 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
| EP00951400A EP1198580B1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| DE50012863T DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| ES00951400T ES2263481T3 (es) | 1999-07-19 | 2000-07-18 | Proteina estructural de virus adenoasociados con propiedades cromatograficas modificadas. |
| AT00951400T ATE328101T1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| JP2001511201A JP4938189B2 (ja) | 1999-07-19 | 2000-07-18 | 修飾されたクロマトグラフィー特性を有するアデノ随伴ウイルスの構造タンパク質と、その製造及び使用 |
| CA2379564A CA2379564C (en) | 1999-07-19 | 2000-07-18 | Structural protein of adeno-associated virus with modified chromatographic properties, its production and use |
| PCT/EP2000/006861 WO2001005991A1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften, seine herstellung und verwendung |
| AU64354/00A AU777885B2 (en) | 1999-07-19 | 2000-07-18 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
| US11/903,662 US20100105123A2 (en) | 1999-07-19 | 2007-09-24 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933719A DE19933719A1 (de) | 1999-07-19 | 1999-07-19 | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19933719A1 true DE19933719A1 (de) | 2001-01-25 |
Family
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| DE50012863T Expired - Lifetime DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
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| DE50012863T Expired - Lifetime DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
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| US (2) | US7285381B1 (https=) |
| EP (1) | EP1198580B1 (https=) |
| JP (1) | JP4938189B2 (https=) |
| AT (1) | ATE328101T1 (https=) |
| AU (1) | AU777885B2 (https=) |
| CA (1) | CA2379564C (https=) |
| DE (2) | DE19933719A1 (https=) |
| ES (1) | ES2263481T3 (https=) |
| WO (1) | WO2001005991A1 (https=) |
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| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| US7465566B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
| US7429471B2 (en) | 2000-02-23 | 2008-09-30 | The Trustees Of The University Of Pennsylvania | Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals |
| US8313908B2 (en) | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
| US7981611B2 (en) | 2000-02-23 | 2011-07-19 | The Trustees Of The University Of Pennsylvania | Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields |
| US7465546B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
| US7374916B2 (en) | 2000-02-23 | 2008-05-20 | The Trustees Of The University Of Pennsylvania | Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals |
| US7022506B2 (en) | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| JP4801802B2 (ja) | 2004-01-12 | 2011-10-26 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 特定の選択的な電気信号および電磁信号によって生成される電場の印加を介して骨細胞における骨形成タンパク質（ｂｍｐ）遺伝子発現を上方制御するシステムおよび方法 |
| US7893985B1 (en) | 2004-03-15 | 2011-02-22 | Grandeye Ltd. | Wide angle electronic camera with improved peripheral vision |
| JP5136766B2 (ja) | 2004-12-15 | 2013-02-06 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | キメラベクター |
| ES2602610T3 (es) | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
| EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| ES2742180T3 (es) | 2009-03-04 | 2020-02-13 | Deutsches Krebsforsch | Proteína activadora del ensamblaje (AAP) y su uso para la fabricación de partículas de parvovirus que consisten esencialmente en VP3 |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CN105755044A (zh) | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| WO2013037961A1 (en) | 2011-09-15 | 2013-03-21 | Medigene Ag | Anti-her2 vaccine based upon aav derived multimeric structures |
| EP3003391B1 (en) | 2013-05-31 | 2021-09-22 | The Regents of The University of California | Adeno-associated virus variants and methods of use thereof |
| ES2739288T3 (es) | 2013-09-13 | 2020-01-30 | California Inst Of Techn | Recuperación selectiva |
| EP3800191B1 (en) | 2014-03-17 | 2025-08-20 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
| US11021519B2 (en) | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| AU2017302013B2 (en) | 2016-07-29 | 2022-05-26 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| PE20200488A1 (es) * | 2017-06-27 | 2020-03-03 | Regeneron Pharma | Vectores virales recombinantes con tropismo modificado y usos de estos para la introduccion dirigida de material genetico a celulas humanas |
| CA3053154A1 (en) | 2017-06-30 | 2019-01-03 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsids and methods of use thereof |
| JP2020534788A (ja) | 2017-08-28 | 2020-12-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アデノ随伴ウイルスカプシド変異体及びその使用方法 |
| CN113966399A (zh) | 2018-09-26 | 2022-01-21 | 加州理工学院 | 用于靶向基因疗法的腺相关病毒组合物 |
| AU2020368539A1 (en) | 2019-10-16 | 2022-04-28 | Massachusetts Institute Of Technology | Engineered muscle targeting compositions |
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| EP0567578A1 (en) * | 1991-01-25 | 1993-11-03 | The Regents Of The University Of Minnesota | Laminin a chain domain vi polypeptides |
| FR2716893B1 (fr) | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US5837520A (en) * | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
| EP0927044A4 (en) * | 1996-04-16 | 1999-09-08 | Immusol Inc | DEFINED TARGET VIRAL VECTORS |
| US20010031463A1 (en) | 1997-09-02 | 2001-10-18 | Jurgen Kleinschmidt | Method for purifying and concentrating AAV-2 and antigen portions thereof |
| DE19827457C1 (de) | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| AU780231B2 (en) * | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| WO2002053703A2 (en) | 2001-01-05 | 2002-07-11 | Children's Hospital, Inc. | Aav2 vectors and methods |
-
1999
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-
2000
- 2000-07-18 WO PCT/EP2000/006861 patent/WO2001005991A1/de not_active Ceased
- 2000-07-18 JP JP2001511201A patent/JP4938189B2/ja not_active Expired - Fee Related
- 2000-07-18 US US10/031,187 patent/US7285381B1/en not_active Expired - Fee Related
- 2000-07-18 AU AU64354/00A patent/AU777885B2/en not_active Ceased
- 2000-07-18 DE DE50012863T patent/DE50012863D1/de not_active Expired - Lifetime
- 2000-07-18 CA CA2379564A patent/CA2379564C/en not_active Expired - Fee Related
- 2000-07-18 ES ES00951400T patent/ES2263481T3/es not_active Expired - Lifetime
- 2000-07-18 AT AT00951400T patent/ATE328101T1/de not_active IP Right Cessation
- 2000-07-18 EP EP00951400A patent/EP1198580B1/de not_active Expired - Lifetime
-
2007
- 2007-09-24 US US11/903,662 patent/US20100105123A2/en not_active Abandoned
Non-Patent Citations (1)
| Title |
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| Hum. Gene Ther. 6, S. 1531-1541, 1995 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379564A1 (en) | 2001-01-25 |
| US20100105123A2 (en) | 2010-04-29 |
| AU777885B2 (en) | 2004-11-04 |
| US7285381B1 (en) | 2007-10-23 |
| CA2379564C (en) | 2012-03-20 |
| US20090098634A2 (en) | 2009-04-16 |
| JP4938189B2 (ja) | 2012-05-23 |
| DE50012863D1 (de) | 2006-07-06 |
| JP2003505033A (ja) | 2003-02-12 |
| EP1198580B1 (de) | 2006-05-31 |
| US20090246854A2 (en) | 2009-10-01 |
| AU6435400A (en) | 2001-02-05 |
| WO2001005991A1 (de) | 2001-01-25 |
| EP1198580A1 (de) | 2002-04-24 |
| ATE328101T1 (de) | 2006-06-15 |
| ES2263481T3 (es) | 2006-12-16 |
| US20080241906A1 (en) | 2008-10-02 |
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Inventor name: STOLLA, CHRISTOF GERHARD, DR., 80538 MUENCHEN, DE Inventor name: GIROD, ANNE, DR., 81475 MUENCHEN, DE Inventor name: HALLEK, MICHAEL, PROF. DR., 86938 SCHONDORF, DE Inventor name: RIED, MARTIN, 86697 OBERHAUSEN, DE |
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