DE19933719A1 - Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung - Google Patents
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und VerwendungInfo
- Publication number
- DE19933719A1 DE19933719A1 DE19933719A DE19933719A DE19933719A1 DE 19933719 A1 DE19933719 A1 DE 19933719A1 DE 19933719 A DE19933719 A DE 19933719A DE 19933719 A DE19933719 A DE 19933719A DE 19933719 A1 DE19933719 A1 DE 19933719A1
- Authority
- DE
- Germany
- Prior art keywords
- structural protein
- protein according
- mutation
- aav
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933719A DE19933719A1 (de) | 1999-07-19 | 1999-07-19 | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
| CA2379564A CA2379564C (en) | 1999-07-19 | 2000-07-18 | Structural protein of adeno-associated virus with modified chromatographic properties, its production and use |
| EP00951400A EP1198580B1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| ES00951400T ES2263481T3 (es) | 1999-07-19 | 2000-07-18 | Proteina estructural de virus adenoasociados con propiedades cromatograficas modificadas. |
| DE50012863T DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| PCT/EP2000/006861 WO2001005991A1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften, seine herstellung und verwendung |
| US10/031,187 US7285381B1 (en) | 1999-07-19 | 2000-07-18 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
| JP2001511201A JP4938189B2 (ja) | 1999-07-19 | 2000-07-18 | 修飾されたクロマトグラフィー特性を有するアデノ随伴ウイルスの構造タンパク質と、その製造及び使用 |
| AT00951400T ATE328101T1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
| AU64354/00A AU777885B2 (en) | 1999-07-19 | 2000-07-18 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
| US11/903,662 US20100105123A2 (en) | 1999-07-19 | 2007-09-24 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same |
Applications Claiming Priority (1)
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| DE19933719A DE19933719A1 (de) | 1999-07-19 | 1999-07-19 | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
Publications (1)
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| DE19933719A1 true DE19933719A1 (de) | 2001-01-25 |
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| DE50012863T Expired - Lifetime DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
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| DE50012863T Expired - Lifetime DE50012863D1 (de) | 1999-07-19 | 2000-07-18 | Strukturprotein von adeno-assoziiertem virus mit veränderten chromatographischen eigenschaften |
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| JP (1) | JP4938189B2 (enExample) |
| AT (1) | ATE328101T1 (enExample) |
| AU (1) | AU777885B2 (enExample) |
| CA (1) | CA2379564C (enExample) |
| DE (2) | DE19933719A1 (enExample) |
| ES (1) | ES2263481T3 (enExample) |
| WO (1) | WO2001005991A1 (enExample) |
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| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| EP1135468B1 (en) | 1998-11-10 | 2010-01-06 | University Of North Carolina At Chapel Hill | Virus vectors and methods of making and administering the same |
| US8313908B2 (en) | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
| US7374916B2 (en) | 2000-02-23 | 2008-05-20 | The Trustees Of The University Of Pennsylvania | Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals |
| US7022506B2 (en) | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
| US7429471B2 (en) | 2000-02-23 | 2008-09-30 | The Trustees Of The University Of Pennsylvania | Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals |
| US7465566B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
| US7465546B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
| US7981611B2 (en) | 2000-02-23 | 2011-07-19 | The Trustees Of The University Of Pennsylvania | Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| CN1918285B (zh) | 2004-01-12 | 2013-09-25 | 宾夕法尼亚大学理事会 | 通过施加由特异性和选择性的电以及电磁信号产生的场上调骨细胞中骨形态发生蛋白(bmp)基因表达的系统以及方法 |
| US7893985B1 (en) | 2004-03-15 | 2011-02-22 | Grandeye Ltd. | Wide angle electronic camera with improved peripheral vision |
| EP1828390B1 (en) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| EP2158211B1 (en) | 2007-05-31 | 2016-08-10 | Medigene AG | Mutated structural protein of a parvovirus |
| EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| CA2754335C (en) | 2009-03-04 | 2019-12-24 | Medigene Ag | Assembly activating protein (aap) and its use for the manufacture of parvovirus particles essentially consisting of vp3 |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| DK3693025T3 (da) | 2011-04-22 | 2022-01-10 | Univ California | Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf |
| US9821043B2 (en) | 2011-09-15 | 2017-11-21 | Medigene Ag | Anti-HER2 vaccine based upon AAV derived multimeric structures |
| US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| EP3564379A1 (en) | 2013-09-13 | 2019-11-06 | California Institute of Technology | Selective recovery |
| ES2822551T3 (es) | 2014-03-17 | 2021-05-04 | Adverum Biotechnologies Inc | Composiciones y métodos para la expresión génica mejorada en células de los conos |
| FI3265178T3 (fi) | 2015-03-02 | 2026-08-03 | Adverum Biotechnologies Inc | Koostumuksia ja menetelmiä polynukleotidien viemiseksi intravitreaalisesti retinaalisiin tappisoluihin |
| JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | アデノ随伴ウイルス変異体及びその使用方法 |
| AU2016366549B2 (en) | 2015-12-11 | 2022-11-10 | California Institute Of Technology | Targeting peptides for directing adeno-associated viruses (AAVs) |
| CN109640949B (zh) | 2016-07-29 | 2022-11-25 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体和其使用方法 |
| AU2017345470B2 (en) | 2016-10-19 | 2023-08-03 | Adverum Biotechnologies, Inc. | Modified AAV capsids and uses thereof |
| SI3645551T1 (sl) * | 2017-06-27 | 2024-06-28 | Regeneron Pharmaceuticals, Inc. | S tropizmi spremenjeni rekombinantni virusni vektorji in njihova uporaba za tarčni vnos genetskega materiala v človeške celice |
| KR20250023600A (ko) | 2017-06-30 | 2025-02-18 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 보유한 아데노-부속 바이러스 비리온 및 이의 사용 방법 |
| MX2020001997A (es) | 2017-08-28 | 2020-07-20 | Univ California | Variantes de capside de virus adenoasociado y metodos de uso de estas. |
| US11149256B2 (en) | 2018-09-26 | 2021-10-19 | California Institute Of Technology | Adeno-associated virus compositions for targeted gene therapy |
| JP2022551986A (ja) | 2019-10-16 | 2022-12-14 | ザ・ブロード・インスティテュート・インコーポレイテッド | 修飾筋肉標的化組成物 |
| US12668814B2 (en) | 2020-07-22 | 2026-06-30 | The Broad Institute, Inc. | Engineered muscle targeting compositions |
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| JPH06507383A (ja) * | 1991-01-25 | 1994-08-25 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ラミニンのａ鎖のドメイン６のポリペプチド |
| FR2716893B1 (fr) | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US5837520A (en) * | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| JPH11511326A (ja) | 1995-08-30 | 1999-10-05 | ジエンザイム コーポレイション | アデノウィルスおよびａａｖの精製 |
| WO1997038723A1 (en) * | 1996-04-16 | 1997-10-23 | Immusol Incorporated | Targeted viral vectors |
| US20010031463A1 (en) | 1997-09-02 | 2001-10-18 | Jurgen Kleinschmidt | Method for purifying and concentrating AAV-2 and antigen portions thereof |
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| EP1135468B1 (en) * | 1998-11-10 | 2010-01-06 | University Of North Carolina At Chapel Hill | Virus vectors and methods of making and administering the same |
| WO2002053703A2 (en) | 2001-01-05 | 2002-07-11 | Children's Hospital, Inc. | Aav2 vectors and methods |
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-
2000
- 2000-07-18 JP JP2001511201A patent/JP4938189B2/ja not_active Expired - Fee Related
- 2000-07-18 ES ES00951400T patent/ES2263481T3/es not_active Expired - Lifetime
- 2000-07-18 US US10/031,187 patent/US7285381B1/en not_active Expired - Fee Related
- 2000-07-18 AT AT00951400T patent/ATE328101T1/de not_active IP Right Cessation
- 2000-07-18 EP EP00951400A patent/EP1198580B1/de not_active Expired - Lifetime
- 2000-07-18 CA CA2379564A patent/CA2379564C/en not_active Expired - Fee Related
- 2000-07-18 WO PCT/EP2000/006861 patent/WO2001005991A1/de not_active Ceased
- 2000-07-18 DE DE50012863T patent/DE50012863D1/de not_active Expired - Lifetime
- 2000-07-18 AU AU64354/00A patent/AU777885B2/en not_active Ceased
-
2007
- 2007-09-24 US US11/903,662 patent/US20100105123A2/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| Hum. Gene Ther. 6, S. 1531-1541, 1995 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379564A1 (en) | 2001-01-25 |
| US20080241906A1 (en) | 2008-10-02 |
| EP1198580B1 (de) | 2006-05-31 |
| WO2001005991A1 (de) | 2001-01-25 |
| CA2379564C (en) | 2012-03-20 |
| EP1198580A1 (de) | 2002-04-24 |
| ES2263481T3 (es) | 2006-12-16 |
| JP4938189B2 (ja) | 2012-05-23 |
| US20100105123A2 (en) | 2010-04-29 |
| JP2003505033A (ja) | 2003-02-12 |
| US7285381B1 (en) | 2007-10-23 |
| DE50012863D1 (de) | 2006-07-06 |
| US20090098634A2 (en) | 2009-04-16 |
| AU777885B2 (en) | 2004-11-04 |
| AU6435400A (en) | 2001-02-05 |
| ATE328101T1 (de) | 2006-06-15 |
| US20090246854A2 (en) | 2009-10-01 |
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Inventor name: STOLLA, CHRISTOF GERHARD, DR., 80538 MUENCHEN, DE Inventor name: GIROD, ANNE, DR., 81475 MUENCHEN, DE Inventor name: HALLEK, MICHAEL, PROF. DR., 86938 SCHONDORF, DE Inventor name: RIED, MARTIN, 86697 OBERHAUSEN, DE |
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