DE19721700C1 - Mutierter OKT3-Antikörper - Google Patents

Mutierter OKT3-Antikörper

Info

Publication number
DE19721700C1
DE19721700C1 DE19721700A DE19721700A DE19721700C1 DE 19721700 C1 DE19721700 C1 DE 19721700C1 DE 19721700 A DE19721700 A DE 19721700A DE 19721700 A DE19721700 A DE 19721700A DE 19721700 C1 DE19721700 C1 DE 19721700C1
Authority
DE
Germany
Prior art keywords
monoclonal antibody
okt3
expression
vector
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19721700A
Other languages
German (de)
English (en)
Inventor
Sergey Dr Kipriyanov
Melvyn Prof Dr Little
Gerhard Dr Moldenhauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
German Cancer Research Center
Original Assignee
German Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by German Cancer Research Center filed Critical German Cancer Research Center
Priority to DE19721700A priority Critical patent/DE19721700C1/de
Priority to ES98934774T priority patent/ES2263212T3/es
Priority to JP54981698A priority patent/JP4276302B2/ja
Priority to EP98934774A priority patent/EP0983302B1/de
Priority to AT98934774T priority patent/ATE324381T1/de
Priority to PCT/DE1998/001409 priority patent/WO1998052975A1/de
Priority to DE59813519T priority patent/DE59813519D1/de
Application granted granted Critical
Publication of DE19721700C1 publication Critical patent/DE19721700C1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE19721700A 1997-05-23 1997-05-23 Mutierter OKT3-Antikörper Expired - Fee Related DE19721700C1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19721700A DE19721700C1 (de) 1997-05-23 1997-05-23 Mutierter OKT3-Antikörper
ES98934774T ES2263212T3 (es) 1997-05-23 1998-05-22 Anticuerpo okt3 mutado.
JP54981698A JP4276302B2 (ja) 1997-05-23 1998-05-22 突然変異させたｏｋｔ３抗体
EP98934774A EP0983302B1 (de) 1997-05-23 1998-05-22 Mutiertes ScFv-Fragment des OKT-3 Antikörpers
AT98934774T ATE324381T1 (de) 1997-05-23 1998-05-22 Mutiertes scfv-fragment des okt-3 antikörpers
PCT/DE1998/001409 WO1998052975A1 (de) 1997-05-23 1998-05-22 Mutierter okt3-antikörper
DE59813519T DE59813519D1 (de) 1997-05-23 1998-05-22 Mutiertes ScFv-Fragment des OKT-3 Antikörpers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19721700A DE19721700C1 (de) 1997-05-23 1997-05-23 Mutierter OKT3-Antikörper

Publications (1)

Publication Number Publication Date
DE19721700C1 true DE19721700C1 (de) 1998-11-19

Family

ID=7830336

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19721700A Expired - Fee Related DE19721700C1 (de) 1997-05-23 1997-05-23 Mutierter OKT3-Antikörper
DE59813519T Expired - Lifetime DE59813519D1 (de) 1997-05-23 1998-05-22 Mutiertes ScFv-Fragment des OKT-3 Antikörpers

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59813519T Expired - Lifetime DE59813519D1 (de) 1997-05-23 1998-05-22 Mutiertes ScFv-Fragment des OKT-3 Antikörpers

Country Status (6)

Country Link
EP (1) EP0983302B1 (enExample)
JP (1) JP4276302B2 (enExample)
AT (1) ATE324381T1 (enExample)
DE (2) DE19721700C1 (enExample)
ES (1) ES2263212T3 (enExample)
WO (1) WO1998052975A1 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6242195B1 (en) 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
AU5345901A (en) 2000-04-13 2001-10-30 Univ Rockefeller Enhancement of antibody-mediated immune responses
US8530627B2 (en) 2002-08-14 2013-09-10 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8187593B2 (en) 2002-08-14 2012-05-29 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8968730B2 (en) 2002-08-14 2015-03-03 Macrogenics Inc. FcγRIIB specific antibodies and methods of use thereof
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
US7355008B2 (en) 2003-01-09 2008-04-08 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
BRPI0514068B8 (pt) 2004-08-04 2021-05-25 Applied Molecular Evolution Inc anticorpo anti-cd20, e, composição farmacêutica
AU2005335714B2 (en) 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
JP5838021B2 (ja) 2005-04-15 2015-12-24 マクロジェニクス，インコーポレーテッド 共有結合型ダイアボディとその使用
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US11254748B2 (en) 2005-04-15 2022-02-22 Macrogenics, Inc. Covalent diabodies and uses thereof
DK2573114T3 (en) 2005-08-10 2016-07-04 Macrogenics Inc The identification and production of antibodies with variant Fc regions, and methods of using same
CA2660592C (en) 2006-05-26 2016-07-12 Macrogenics, Inc. Humanized fc.gamma.riib-specific antibodies and methods of use thereof
EP2032159B1 (en) 2006-06-26 2015-01-07 MacroGenics, Inc. Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
EP2029173B1 (en) 2006-06-26 2016-07-20 MacroGenics, Inc. Fc riib-specific antibodies and methods of use thereof
US8652466B2 (en) 2006-12-08 2014-02-18 Macrogenics, Inc. Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
WO2009117030A2 (en) 2007-12-19 2009-09-24 Macrogenics, Inc. Improved compositions for the prevention and treatment of smallpox
SG189730A1 (en) 2008-04-02 2013-05-31 Macrogenics Inc Her2/neu-specific antibodies and methods of using same
CN106349390B (zh) 2008-04-02 2019-12-10 宏观基因有限公司 Bcr-复合体-特异性抗体和其使用方法
MX2012004029A (es) 2009-10-07 2012-05-08 Macrogenics Inc Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso.
DK2542256T3 (da) 2010-03-04 2019-08-26 Macrogenics Inc Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
ES2667100T3 (es) 2010-08-02 2018-05-09 Macrogenics, Inc. Diacuerpos covalentes y sus usos
EP3974453A3 (en) 2010-11-16 2022-08-03 Amgen Inc. Agents and methods for treating diseases that correlate with bcma expression
LT2691417T (lt) 2011-03-29 2018-10-25 Roche Glycart Ag Antikūno fc variantai
US9376495B2 (en) 2011-05-21 2016-06-28 Macrogenics, Inc. Deimmunized serum-binding domains and their use in extending serum half-life
WO2013188693A1 (en) * 2012-06-15 2013-12-19 Imaginab, Inc. Antigen binding constructs to cd3
SI3495387T1 (sl) 2012-07-13 2021-12-31 Roche Glycart Ag Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
KR20150131208A (ko) 2013-03-13 2015-11-24 이미지냅 인코포레이티드 Cd８에의 항원 결합 구조체들
CA2906566C (en) 2013-03-14 2024-09-10 Macrogenics, Inc. Immunoreactive bispecific molecules at immune effector cells expressing an activation receptor
UA116479C2 (uk) 2013-08-09 2018-03-26 Макродженікс, Інк. БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
US11384149B2 (en) 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
EP2840091A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
WO2016054101A1 (en) 2014-09-29 2016-04-07 Duke University Bispecific molecules comprising an hiv-1 envelope targeting arm
AR103488A1 (es) 2015-01-23 2017-05-10 Sanofi Sa Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123
EP3091032A1 (en) 2015-05-08 2016-11-09 Miltenyi Biotec GmbH Humanized antibody or fragment thereof specific for cd3
CN108136012B (zh) 2015-08-07 2022-10-04 伊麦吉纳博公司 靶向分子的抗原结合构建体
CN109069633A (zh) 2016-04-15 2018-12-21 宏观基因有限公司 新颖的b7-h3-结合分子、其抗体药物缀合物及其使用方法
TWI790206B (zh) 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
CN111699004A (zh) 2018-02-06 2020-09-22 豪夫迈·罗氏有限公司 眼科疾病的治疗

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885573A (en) * 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hum. Antibod. Hybridomas, 1994, Vol. 5, 1 und 2, S. 41-47 *

Also Published As

Publication number Publication date
ES2263212T3 (es) 2006-12-01
DE59813519D1 (de) 2006-06-01
ATE324381T1 (de) 2006-05-15
JP2001527414A (ja) 2001-12-25
WO1998052975A1 (de) 1998-11-26
JP4276302B2 (ja) 2009-06-10
EP0983302B1 (de) 2006-04-26
EP0983302A1 (de) 2000-03-08

Similar Documents

Publication Publication Date Title
EP0983302B1 (de) Mutiertes ScFv-Fragment des OKT-3 Antikörpers
DE60127143T2 (de) Bispezifische Antikörper gegen CD19 und CD16 und deren Verwendung
DE19819846B4 (de) Multivalente Antikörper-Konstrukte
DE69434578T2 (de) Expressionsvektoren die für bispezifische Proteine kodieren, und Verfahren zur Herstellung von biologisch-aktiven bispezifischen Fusionsproteinen in Zellen von Säugetieren
DE69133179T2 (de) Katalytische antikörperkomponente
US5939531A (en) Recombinant antibodies specific for a growth factor receptor
EP1566442B1 (de) Herstellung und Verwendung von Genbanken menschlicher Antikörper("Human-Antikörper-Bibliotheken")
DE60124912T2 (de) Multimerische, einzelkettige, Tandem-Fv-Antikörper
DE60133479T2 (de) Modifizierter tpo-agonisten antikörper
DE69406423T2 (de) Methode zum überbringen von agenzien an zielzellen
DE102010039018B4 (de) Anti-La Antikörper und ihre Anwendung zum Immunotargeting
DE102011118022A1 (de) Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung
DE69634774T2 (de) Modulatoren von regulationsproteinen
CN104098698A (zh) 一种抗cd3抗体及其制法和应用
George et al. Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule.
DE60118370T2 (de) Leader-anteile zur erhöhung der sekretion von rekombinanten proteinen aus einer wirtzelle
DE60214127T2 (de) Hybridomzelllinie g250 und deren verwendung zur herstellung monoklonaler antikörper
EP0720623B1 (de) Monoklonale antikörper gegen leukozyten-spezifische g-protein-gekoppelte rezeptoren
DE69020112T2 (de) Spezifische bindende Wirkstoffe.
DE69216600T2 (de) Synthetisches CDw52(CAMPATH-1) Peptidantigen
EP1141271A1 (de) Selektion von monoklonalen antikörpern
WO2001027159A2 (de) Polypeptide zur detektion und elimination ca19-9 antigen positiver zellen
JP2020534023A (ja) ｈＥＲＧ１およびｈＥＲＧ１／インテグリンβ１に結合する単一特異性および二重特異性抗体
EP1015583B1 (de) Srcr domäne-enthaltendes protein
EP1092769B1 (de) Polypeptid-Tag's für den Nachweis und die Aufreinigung von Polypeptiden

Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20111201