DE19704243A1 - Neue 2-Amino-substituierte Pyridine - Google Patents

Neue 2-Amino-substituierte Pyridine

Info

Publication number
DE19704243A1
DE19704243A1 DE19704243A DE19704243A DE19704243A1 DE 19704243 A1 DE19704243 A1 DE 19704243A1 DE 19704243 A DE19704243 A DE 19704243A DE 19704243 A DE19704243 A DE 19704243A DE 19704243 A1 DE19704243 A1 DE 19704243A1
Authority
DE
Germany
Prior art keywords
carbon atoms
chain
straight
phenyl
branched alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19704243A
Other languages
German (de)
English (en)
Inventor
Carsten Dr Schmeck
Arndt Dr Brandes
Michael Dr Loegers
Gunter Dr Schmidt
Klaus-Dieter Dr Bremm
Hilmar Dr Bischoff
Delf Dr Schmidt
Joachim Dr Schuhmacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19704243A priority Critical patent/DE19704243A1/de
Priority to PL98334899A priority patent/PL334899A1/xx
Priority to BR9807181-5A priority patent/BR9807181A/pt
Priority to IL13112798A priority patent/IL131127A0/xx
Priority to SK1040-99A priority patent/SK104099A3/sk
Priority to AU62123/98A priority patent/AU730109B2/en
Priority to CA002279636A priority patent/CA2279636A1/en
Priority to CN98803916A priority patent/CN1252057A/zh
Priority to IDW990821D priority patent/ID24208A/id
Priority to HU0001022A priority patent/HUP0001022A2/hu
Priority to NZ337011A priority patent/NZ337011A/en
Priority to KR1019997007015A priority patent/KR20000070756A/ko
Priority to TR1999/01857T priority patent/TR199901857T2/xx
Priority to EP98904126A priority patent/EP0973744A1/de
Priority to JP53369198A priority patent/JP2001510478A/ja
Priority to CZ992792A priority patent/CZ279299A3/cs
Priority to PCT/EP1998/000362 priority patent/WO1998034920A1/de
Publication of DE19704243A1 publication Critical patent/DE19704243A1/de
Priority to NO993738A priority patent/NO993738L/no
Priority to BG103631A priority patent/BG103631A/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE19704243A 1997-02-05 1997-02-05 Neue 2-Amino-substituierte Pyridine Withdrawn DE19704243A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE19704243A DE19704243A1 (de) 1997-02-05 1997-02-05 Neue 2-Amino-substituierte Pyridine
HU0001022A HUP0001022A2 (hu) 1997-02-05 1998-01-23 Arterioszklerozis és hiperlipoproteinémia kezelésére alkalmas 2-amino-szubsztituált piridinszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
NZ337011A NZ337011A (en) 1997-02-05 1998-01-23 2-amino-substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia
IL13112798A IL131127A0 (en) 1997-02-05 1998-01-23 2-Amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia
SK1040-99A SK104099A3 (en) 1997-02-05 1998-01-23 2-amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia
AU62123/98A AU730109B2 (en) 1997-02-05 1998-01-23 2-amino-substituted pyridines which can be used for the treatment of arteriosclerosis and hyperclipoproteinaemia
CA002279636A CA2279636A1 (en) 1997-02-05 1998-01-23 2-amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia
CN98803916A CN1252057A (zh) 1997-02-05 1998-01-23 用于治疗动脉粥样硬化和血脂蛋白过高的2－氨基取代的吡啶
IDW990821D ID24208A (id) 1997-02-05 1998-01-23 Piridin-piridin pensubtitusi 2-amino baru
PL98334899A PL334899A1 (en) 1997-02-05 1998-01-23 Novel 2-amino-substituted pyridines
BR9807181-5A BR9807181A (pt) 1997-02-05 1998-01-23 Piridinas 2-amino-substituìdas
KR1019997007015A KR20000070756A (ko) 1997-02-05 1998-01-23 동맥경화증 및 지단백질과잉혈증 치료에 사용되는 2-아미노 치환된 피리딘
TR1999/01857T TR199901857T2 (xx) 1997-02-05 1998-01-23 Yeni 2-amino-ikameli piridinler
EP98904126A EP0973744A1 (de) 1997-02-05 1998-01-23 2-amino-substituierte pyridine verwendbar zur behandlung von arteriosklerose und hyperlipoproteinemie
JP53369198A JP2001510478A (ja) 1997-02-05 1998-01-23 動脈硬化症および高リポタンパク質血症の治療における使用のための２−アミノ置換ピリジン類
CZ992792A CZ279299A3 (cs) 1997-02-05 1998-01-23 2-aminosubstituované peridiny, způsob jejich výroby, farmaceutické prostředky tyto látky obsahující a jejich použití
PCT/EP1998/000362 WO1998034920A1 (de) 1997-02-05 1998-01-23 2-amino-substituierte pyridine verwendbar zur behandlung von arteriosklerose und hyperlipoproteinemie
NO993738A NO993738L (no) 1997-02-05 1999-08-02 2-amino-substituerte pyridiner som kan anvendes ved behandling ved arteriosclerose og hyper-lipoproteinemi
BG103631A BG103631A (en) 1997-02-05 1999-08-03 2-aminosubstituted pyridines applied for the treatment of atherosclerosis and hyperlipoproteinaemia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19704243A DE19704243A1 (de) 1997-02-05 1997-02-05 Neue 2-Amino-substituierte Pyridine

Publications (1)

Publication Number Publication Date
DE19704243A1 true DE19704243A1 (de) 1998-08-06

Family

ID=7819326

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19704243A Withdrawn DE19704243A1 (de) 1997-02-05 1997-02-05 Neue 2-Amino-substituierte Pyridine

Country Status (19)

Country Link
EP (1) EP0973744A1 (no)
JP (1) JP2001510478A (no)
KR (1) KR20000070756A (no)
CN (1) CN1252057A (no)
AU (1) AU730109B2 (no)
BG (1) BG103631A (no)
BR (1) BR9807181A (no)
CA (1) CA2279636A1 (no)
CZ (1) CZ279299A3 (no)
DE (1) DE19704243A1 (no)
HU (1) HUP0001022A2 (no)
ID (1) ID24208A (no)
IL (1) IL131127A0 (no)
NO (1) NO993738L (no)
NZ (1) NZ337011A (no)
PL (1) PL334899A1 (no)
SK (1) SK104099A3 (no)
TR (1) TR199901857T2 (no)
WO (1) WO1998034920A1 (no)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275091A1 (en) 2001-06-22 2011-01-19 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of an amorphous drug
EP2283822A2 (en) 2003-08-04 2011-02-16 Bend Research, Inc. Spray drying processes for forming solid amorphous dispersions of drugs and polymers
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
US9468604B2 (en) 2001-06-22 2016-10-18 Bend Research, Inc. Pharmaceutical compositions of dispersions of drug and neutral polymers

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0307344A (pt) 2002-02-01 2004-12-14 Pfizer Prod Inc Composições farmacêuticas de dispersões amorfas de fármacos e materiais formadores de microfase lipofìlica
AU2004222436A1 (en) 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
WO2005011635A2 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
WO2005030185A2 (en) 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006032987A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Indoline compounds and their use in the treatment of arteriosclerosis
US20100113473A1 (en) 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275091A1 (en) 2001-06-22 2011-01-19 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of an amorphous drug
US8389006B2 (en) 2001-06-22 2013-03-05 Bend Research, Inc. Pharmaceutical compositions of adsorbates of amorphous drug
US8703199B2 (en) 2001-06-22 2014-04-22 Bend Research, Inc. Pharmaceutical compositions of adsorbates of amorphous drug
US9468604B2 (en) 2001-06-22 2016-10-18 Bend Research, Inc. Pharmaceutical compositions of dispersions of drug and neutral polymers
EP2283822A2 (en) 2003-08-04 2011-02-16 Bend Research, Inc. Spray drying processes for forming solid amorphous dispersions of drugs and polymers
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance

Also Published As

Publication number Publication date
CN1252057A (zh) 2000-05-03
JP2001510478A (ja) 2001-07-31
BR9807181A (pt) 2000-01-25
IL131127A0 (en) 2001-01-28
CZ279299A3 (cs) 1999-11-17
NO993738D0 (no) 1999-08-02
PL334899A1 (en) 2000-03-27
BG103631A (en) 2000-11-30
AU730109B2 (en) 2001-02-22
SK104099A3 (en) 2000-01-18
HUP0001022A2 (hu) 2000-09-28
KR20000070756A (ko) 2000-11-25
NZ337011A (en) 2001-04-27
WO1998034920A1 (de) 1998-08-13
AU6212398A (en) 1998-08-26
TR199901857T2 (xx) 1999-10-21
ID24208A (id) 2000-07-13
CA2279636A1 (en) 1998-08-13
EP0973744A1 (de) 2000-01-26
NO993738L (no) 1999-09-17

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee