DE19611953A1 - Use of unsaturated monocarboxylic acids against superinfections - Google Patents

Abstract

The object of the invention is the use of one or more mono or polyunsaturated monocarboxylic acids or their derivatives or oils containing them as active ingredients against superinfections, especially superinfections of the skin.

Description

The healthy human skin is with a variety of non-pathogenic Microorganisms colonized. This so-called microflora of the skin is not only harmless, it provides an important protection to the defense opportunisti shear or pathogenic germs.

In case of primary infection, d. h., the normal germ colonization of Skin, entering new infection with high bacterial counts of one or more often physiological pathogens, such as staphylococci, but often also Unphysiological pathogen, for example Candida albicans, may be included Coincidence of unfavorable influences a "superinfection" of affected skin occur. The normal microflora of the skin (or a other body organ) becomes thereby from the secondary exciter downright overgrown.

Such superinfections may vary, depending on the particular Germ, in favorable cases in unpleasant skin conditions (Itching, unpleasant external appearance) express. In unfavorable ver In current cases, however, they can lead to extensive destruction of the skin lead to culminate in the worst case even in the death of the patient.

Superinfections of the aforementioned kind are z. B. the full screen of AIDS common secondary diseases. In itself - at least in low germ densities - innocuous, but under certain circumstances too  extremely pathogenic germs overgrow in this way the healthy skin flora. In AIDS, however, are other body organs affected by superinfections.

Likewise, such superinfections in a variety dermatological diseases, e.g. Atopic dermatitis, atopic dermatitis, Acne, seborrheic dermatitis or psoriasis is observed. Also many medical and therapeutic measures, eg. B. the radio or Chemotherapy of tumor diseases, caused as a side effect ne, drug-induced immunosuppression or systemic Antibiotic treatment, as well as external chemical or physical Influences (eg pollution, smog), promote the occurrence of Superinfections of the external and internal organs, especially the skin and mucous membranes.

Although it is in some cases readily possible, superinfections with Antibiotics, but mostly such substances have that Disadvantage of unpleasant side effects. Often there are patients For example, allergic to penicillins, which is why a corresponding Treatment would be prohibited in such a case.

Furthermore, topically administered antibiotics have the disadvantage that they Relieve skin flora not only from the secondary pathogen, but also the strongly affect physiological skin flora and the natural Healing process is slowed down in this way.

Object of the present invention was the disadvantages of the prior Technique to eliminate and substances and preparations, such Containing substances, by their use Superinfections can be cured, with the physiological Skin flora suffers no significant loss.

Moreover, it was an object of the present invention, substances and cosmetic or dermatological preparations, such substances containing to provide prophylactic against Superinfections work.  

According to the invention, the objects are achieved.

The invention relates to the use of one or more monounsaturated or polyunsaturated monocarboxylic acids or their derivatives or oils containing them, as active substances against Superinfections, especially superinfections of the skin.

Preferably, the monocarboxylic acids contain 10 to 24 carbon atoms and 1 to 5 double bonds.

The invention also cosmetic and dermatological Preparations containing these active substances. Preference is given to topical Preparations.

Preference is given to monounsaturated or polyunsaturated fatty acids and their Derivatives.

Preferred monocarboxylic acids or fatty acids contain 14 to 24, in particular 16 to 22 carbon atoms. You can have one, two, three, four or five double bonds.

Preferred derivatives are monoglycerides, diglycerides or triglycerides of Carboxylic acids according to the invention and also mixtures thereof and also Oils, in particular natural oils containing these active substances. Active ingredients according to the invention are also the natural oils which the contain listed active ingredients.

Particularly suitable

Evening primrose oil
Borage oil
sesame oil
Currant seed oil, especially blackcurrant,
Sea Buckthorn Oil
rosehip oil
Raspberry seed oil
safflower oil
olive oil
fish oil
almond oil
Macadamia nut oil and
Kiwikernöl.

Evening primrose seed oil, borage oil, Currant seed oil and other high-content oils Gamma-linolenic acid.

The active compounds according to the invention can be used as free carboxylic acids or also as their salts with inorganic or organic cations be used. Suitable z. As sodium, potassium, magnesium, Calcium, aluminum, zinc or ammonium salts and the primary, secondary or tertiary alkylammonium salts, in particular the Cations with the radicals H, methyl and / or ethyl.

Preference is also given to the esters of the carboxylic acids according to the invention with saturated or single or multiple, in particular double or triunsaturated alkanols, in particular 1 to 24, preferably 1 to 12 carbon atoms, wherein the alkyls straight or branched could be. Suitable alkyls are, for. Methyl, ethyl, n- or iso-propyl, n- or iso- or tert-butyl.

Further suitable esters are glycol esters, glycerides and partial glycerides, sugar esters and the esters with diols, in particular ethyldiols of the formula HO- (CH₂-CH₂-O) _n -H where n = 1 to 20, in particular 1 to 10.

The carboxylic acids according to the invention can also be in the form of their Amides can be used which are unsubstituted or substituted can. Suitable mono- or dialkylamides with C₁- to C₁₀-, in particular C₁ to C₅-alkyl radicals.  

Further suitable acid substituents of the carboxylic acid group are Phospholipids, ceramides, cerebrosides, glycosphingolipids, lipoproteins and amino acids or their derivatives.

Preference is given to polyunsaturated fatty acids according to the invention and their derivatives, especially those with two, three or four Double bonds.

Particularly preferred are alpha-linolenic acid and gamma-linolenic acid and their derivatives. It can also be described as salt, mono-, di- or as described Triglyceride or alkyl esters are used, for. B. as ethyl ester.

The active compounds according to the invention and the thus obtained Preparations are extremely effective against superinfections, especially the skin, caused by microorganisms, parasites and Protozoa are caused. The microorganisms include, for. B. eukaryotic and prokaryotic protozoa, mycota and viruses.

The prokaryotic protozoans include bacteria. You can roughly after their shape (sphere, cylinder, curved cylinder) and after the construction their cell wall (gram positive, gram negative) can be distinguished. finer Subdivisions also take into account the physiology of the organisms. So exist aerobic, anaerobic and facultative anaerobic bacteria. Some Individuals are more medicinal in their capacity as pathogenic germs Meaning, others are completely harmless.

Against bacteria active substances have been known for some time. The Term "antibiotics" for example, not all antimicrobial effective substances can be dated to the year 1941, although the first findings on penicillin already in 1929 were found. Antibiotics in the modern sense are not for everyone medical, certainly not cosmetic applications, since often also the warm-blooded organism, for example the ill patient,  if used in any way in its metabolic functions is impaired.

An object of the present invention was therefore the prior art in enrich this direction, in particular, substances for To provide against gram-positive and / or gram-negative Bacteria are effective without the application of the substances unacceptable impairment of the health of the user would.

Gram-negative bacteria are, for example, Escherichia coli, Pseudomonas species and enterobacteriaceae, such as Citrobacter.

Gram-positive bacteria also play a role in cosmetics and dermatology. In the case of impure skin, for example, bacts are among other influences secondary secondary infections of etiologic significance. One of most important microorganisms associated with impure skin, is Propionibacterium acnes.

Mykota according to the invention are mentioned for example in the following: Fungi, also fungi [fungus = Latin fungus], Mycota [mukhζ = Greek fungus] or Mycobionts, count in contrast to the bacteria to the Euca ryonten. Eucaryotes are living things, their cells (Eucyten) in contrast to those of the so-called Procaryonten (Procyten) over a through Nuclear envelope and nuclear membrane demarcated from the remaining cytoplasm Cell nucleus. The nucleus contains the genetic information in chromosomes saved.

Examples of mycobionts include yeasts (Protoascomycetes), molds (Plectomycetes), mildew  (Pyrenomycetes), the downy mildew (Phycomycetes) and the stem fungi (Basidiomycetes).

Mushrooms, not even the Basidiomycetes, are not plant organisms, but like these have a cell wall, cellulosic vacuoles and a Microscopically visible plasma flow. They contain no photosynthe pigments and are C-heterotrophic. They grow under aerobic Conditions and gain energy through oxidation of organic substances. However, some representatives, such as yeasts, are facultative anaerobes and capable of generating energy through fermentation processes.

Dermatomycoses are diseases in which certain types of fungi, in particular Dermatophytes, penetrate the skin and hair follicles. The symptoms of Dermatomycoses are, for example, vesicles, exfoliation, rhagades and Erosion, usually associated with itching or allergic eczema.

Dermatomycoses can be divided essentially into the following four groups dermatophytics (eg epidermophytia, favus, microspor Trichophytia), yeast mycoses (eg, pityriasis and other pityrosporum-related Mycoses, Candida infections, Blastomycosis, Buschke's disease, Torulosis, Piedra alba, torulopsidosis, trichosporosis), mold mycoses (e.g. Aspergillosis, cephalosporidosis, phycomycosis and scopular isopsidosis), System mycoses (eg chromomycosis, coccidiomycosis, histoplasmosis).

The pathogenic and facultative pathogens include, for example from the group of the yeasts Candida kinds (eg Candida albicans) and such the family Pityrosporum. Pityrosporum species, in particular Pityrosporum Oval, are for skin disorders such as pityriasis versicolor, seborrhoea in the Forms Seborrhoea oleosa and Seborrhoea sicca, which are mainly as Seborrhoea capitis (= dandruff), seborrheic dermatitis and Responsible for pityrosporum folliculitis. An involvement of  Pityrosporum ovale at the emergence of psoriasis is considered by experts discussed.

All areas of human skin can be affected by dermatomycoses become. Dermatophytoses almost exclusively affect the skin, hair and nails. Yeast mycoses can also infect mucous membranes and internal organs, system mycoses regularly extend to whole organ systems.

Particularly often the areas of the body are affected by which Clothing, jewelry or footwear can dampen moisture and heat. So the athlete's foot belongs to the most well-known and most widespread Dermatomycoses. Especially unpleasant are fungal infections Finger and toenail areas (onychomycoses).

Protozoa according to the invention are mentioned for example in the following:
Protozoa are parasitically living unicellular organisms with clearly delineated nucleus that reproduce asexually (by dividing into two or four divisions and budding) or sexually (gameto-, gamonto- and autogamy). The food intake from the environment takes place by permeation and by Pino- or phagocytosis. Most protozoa can, in addition to vegetative, mostly mobile state forms (so-called trophozoites) under unfavorable circumstances also form cysts as permanent forms.

Depending on the type of locomotion and apparatus, protozoa become four divided into different groups:

• (a) Mastigophora (flagellate with flagella)
• (b) Sarcodina / Rhizopoda (amoeboid movement pattern Plasmaausstülpungen)
• (c) Sporozoa (meandering or sliding pattern of movement)
• (d) Ciliata / Ciliophora (Bewimperung or Flagellation)

Parasitic protozoa are found in subtropical and tropical Areas frequent by stinging and sucking insects, as well Dirt and smear infection and transmitted through the food chain.

Some medically and dermatologically relevant protozoonoses are:
Trichomoniasis (caused by Trichomonas vaginalis), Lamblia (caused by Lamblia intestinalis), visceral as well as cutaneous and mucosal letenhmaniosis (caused for example by Leishmania donövanii, L. tropica, L. brasiliensis, L. mexicana, L. diffusa or L. pifanoi) , Try panosmiasis (caused by various species of Trypanosoma), amanita and amebiasis (caused, for example, by various Entamoeba species, Jodamoeba butschlii or Naegleria fowieri), coccidosis (by Isospora belli) and Balantidenruhr (caused by Balantidium coli).

Protozoan-induced medical and dermatological Phenomena affect, in part, the human Well-being. Therefore, there is a considerable amount of affected persons it is necessary to remedy this situation. An object of the present invention So it was to find effective principles against protozoa.

Parasites according to the invention are mentioned below, for example:
Parasites are monocellular or multicellular plants or animals that feed on (= ectoparasites) or in (= endoparasites) other creatures at their expense, with (= pathogenic parasites) or without (apathogenic parasites) causing disease. The lifestyle is either aprophytic or purely parasitic, possibly only as a periodic, temporary or stationary parasite. The development of parasites is linked to one or more different host organisms, whereby the human can be an intermediate or end host.

Medicinal and dermatologically important parasites are for example the Helminths, which in turn are found in Trematodae, Cestodae and Nematodae untergiiedern. Helminths affecting human well-being are, for example, schistosomiasis (caused by Schistosoma species), Tapeworm infestation of the intestine and other internal organs (caused by for example, Taenia species and Echinococcus species), Ascariasis (caused by Ascaris lumbricoides), enterobiasis (caused by Enterobium vermicularis), parngonimiasis (caused by Paragonium species), filariasis (caused for example by Wucheria bancrofti) as well as others Nematode infestation (caused for example by Trichuris trichura or Trichinella spiralis).

In addition, there are a variety of parasitic on or in humans and animals living insects or arachnids, the medical and dermatological changes of the host organisms. In this Respect for the impairment of human well-being Responsible parasitoses include Accrodermatitis (caused by cereal mites, for example Pediculoides ventricosus), scabies (caused by Sarcoptes scabii), fly and / or fly larvae infestation caused by, for example, Glossina, Stomoxys, Tabanus, Chrysops, Lucilia, Chrysomya, Cochliamya, Wohlfartia, Cordylobia or Dermatobia Species), mosquito and / or mosquito larvae (caused for example by Aedes-Culex, Anopheles, Phlebotomus-Culicuides, Sumilium- or Haemagoges species), tick infestation (caused for example by Argas persicus and other species of argas, Ornithodorus erraticus and others Ornithodorus species, Orobius Rhiphocephalus, Dermacentor, Haemaphysalis, Amblyomma, Ixodes species), Porocephalose (caused by Porocephalus species), flea infestation (caused by, for example, Pulex irritans, Ctenocephalides canis, Xenopsylla cheopsis, Nosophyllus fasciatus or Sarcopsylla penetrans), lice infestation (caused, for example, by  Phthirius pubis, Pediculosus humanus or Pediculosus captits), bugs caused for example by Cimex lectularius, Cimex hemipterus, Panstrongylus megistus, Rhodnius prolixus, Triatoma dimidata, Triatoma infestans, Triatoma sordida or Triatoma brasiliensis) as well as mite infestation caused for example by Demodex folliculorum and others Demodex species and Dermamyskus species, Glyciphagus domesticus, Pyemotes species, Sarcoptes species or Trombicula species).

It is of additional importance that the on or in the human Organism living parasites in turn re-carriers of bacteria, Mycota, protozoa and viruses can be health and well-being of the host organism, for example of man, sustainable can affect. There was therefore a need to combat parasitosis to find effective principles of action that the medical or dermatological appearance are able to improve. This need breastfeeding was therefore another object of the present invention.

For example, viruses according to the invention are named below:
In contrast to the prokaryotic and eukaryotic cellular organisms, viruses are biological structures that require a host cell for biosynthesis. Extracellular viruses (also called "virions") consist of a single- or double-stranded nucleic acid sequence (DNA or RNA) and a protein coat (called capsid), optionally surrounded by an additional lipid-containing envelope (envelope). The whole of nucleic acid and capsid is also called Nucleo capsid. The classification of the viruses was classically according to clinical criteria, but nowadays mostly according to their structure, their morphology, but in particular according to the nucleic acid sequence.

Medically important viral genera are, for example, influenza viruses (Family of the Orthomyxoviridae), Lyssaviren (eg rabies, family of the Rhabdoviruses) enteroviruses (eg hepatitis A, family Picornaviridae), Hepadnaviruses (eg hepatitis B, family Hepadnaviridae).

Viruzide, so virus-killing substances in the true sense, there are not, because viruses do not have their own metabolism. It was off For this reason also discussed whether viruses are classified as living things should. Pharmacological interventions without damaging the unaffected Cells are difficult anyway. Possible mechanisms of action in the fight against the viruses are primarily the disorder whose replication, z. B. by blocking the enzymes important for replication present in the host cell present. Furthermore, the release of the viral nucleic acids in the Host cell can be prevented. In the context of the hereby submitted Offenba This term is used under terms such as "antiviral" or "effective against viruses", "virucidal" or the like understood the property of a substance, an on or multicellular organism from harmful consequences of a viral infection, be it prophylactically or therapeutically, regardless of what the actual mechanism of action of the substance in an individual case is.

The state of the art, however, lacks effective against viruses Substances which also do not or not represent the host organism barem measure.

An object of the present invention was thus, this evil situation to remedy, that is, to find substances which are effective on or off multicellular organism from harmful consequences of a viral infection, be it prophylactically or therapeutically.

By the active compounds according to the invention and the thus obtained Preparations are also solved the above objects. The  Active ingredients according to the invention are outstandingly suitable for treatment and prophylactic treatment of said superinfections.

The active compounds according to the invention are outstandingly effective against Su perinfections, in particular of the skin, and in particular against those caused by staphylococci, Pityrosporum ovale as well as Dermatophytes, yeasts or fungi.

The Haufflora of a healthy man consists essentially of apothogenic staphylococci, their presence in some areas (Armpit, genital area) is supplemented by coryneform bacteria. A Variety of diseases of the skin (eg atopic eczema, atopic Dermatitis, atopic dermatitis, psoriasis, defense weakness through Immunosuppression, etc.) is accompanied by numerical changes in the colonization by cutaneous microorganisms. Next Germ number changes on nonpathogenic germs occur pathogenic Organisms in high numbers of germs. For example, you will find it the skin of atopic people in addition to high bacterial counts of presumably harmless germs Staphylococcus epidermidis large numbers of pathogenic bacteria Staphylococcus aureus. While Staph. epidermidis adhered to cornified areas of the skin, hence in very far outward stratum corneum, binds staph. aureus via a different mechanism to cell wall components living cells, is therefore found in lower regions (Epidermis). It is believed that by presenting so-called Superantigens Staph. aureus inflammatory reactions in the epidermis stimulated, which lead to an increase in the clinical picture. Other, usually not in high numbers on the healthy skin occurring organisms are gram-negative organisms (eg. Escherichia coli, Pseudomonas aeruginosa), yeasts (in addition to P. ovale, ie z. Candida albicans) fungi and dermatophytes. Also for prevention of vaginal infections and intimate hygiene, the Agents of the invention are used.

Although it is known that topically effective antimicrobial formulations to alleviate the above-mentioned pathological changes  human skin can be used, however, all of these show Formulations together with the active ingredients known therein no selectivity against pathogenic Staphylococci, but affect the Total flora in one and the same way. Surprisingly, it is however possible that growth of pathogenic staphylococci, especially Staph. aureus, selectively by the gift of suppress the active compounds according to the invention. This finding is new and was unpredictable. By z. B. topical administration It is active ingredients according to the invention in suitable cosmetic vehicles possible, selective and selective growth of pathogenic Staphylococci on the skin to prevent and thus the emergence of Superinfections z. Atopics, psoriatics and immunosuppressed Prevent patients. In this way, by applying a suitable skin care with active ingredients of the stronger clinical manifestation of these diseases can be prevented. Suitable indications of use are also the treatment of Superinfections in atopic eczema, atopic dermatitis, Atopic dermatitis, psoriasis, immunosuppression (eg by UV, chemo- and Radiotherapy) or viral diseases (Aids, Herpesvirus-In infections, varicella virus infections) as well as all other pathological Changes in the skin, the z. B. by the presence of pathogenic Staphylococci are accompanied. Also suitable indications are Drug treatment induced changes in the skin flora, the Use as adjunctive therapy for treatment with corticosteroids or Antimycotics and the use as occupational health cosmetics for Occupational branches with high chemical or physical stress Skin (eg beauticians, hairdressers). Also in the application of Deodorants and antiperspirants can be the inventive Active ingredients are used.

The active compounds according to the invention and the resulting cosmetic and dermatological preparations are for the preservation and the Restoration of a healthy skin flora, d. H. you can be used prophylactically and for the treatment of disorders. you are especially for selectively influencing pathogenic skin germs, preferably pathogenic staphylococci with simultaneous protection of the  natural skin flora, preferably apathogenic staphylococci. So they are very good for the selective fight against staph. aureus at Simultaneous protection of Staph. epidermidis suitable.

Preparations according to the invention, the active compounds according to the invention containing, are particularly advantageous in that the active compounds according to the invention in concentrations of 0.01-99.9% by weight, in particular 0.05 to 50.00 wt .-%, preferably 0.1-5.0 wt .-%, before in each case based on the total weight of the preparations.

The active compounds according to the invention can be used in the usual cosmetic and dermatological preparations. Well suited Preparations are, for example, emulsions such as O / W emulsions, W / O emulsions, each having higher or lower viscosities can, gels such as lipo-gels with different water and / or Ethanol contents, lotions, fat lotions, ointments, oils such as skin oils or Bath oils, powders, lip care preparations such as lip balms, Sunscreen preparations, z. B. with UVA and / or UVB filters, surfactant-containing Products, eg. B. for hair care or the care of the scalp, shower and Bath preparations, deodorant formulations and antiperspirants, masks, such as As facial masks and decorative cosmetics.

Cosmetic and dermatological preparations according to the invention can also in the form of aerosols, so from aerosol containers, crush bottles or preparations sprayable by a pumping device or in the form of roll-on devices can be applied liquid compositions, but also in the form of normal For bottles and containers, W / O or O / W emulsions, eg. B. Creams or lotions. Furthermore, the preparations may be advantageous in Form of tinctures, shampoos, washing, shower or bath preparations or powdering.

As usual cosmetic carriers for the production of Preparations according to the invention can, in addition to water, ethanol and Isopropanol, glycerol and propylene glycol skin care fat or fat-like substances, such as oleic acid dicylate, cetyl alcohol, cetyl stearyl  alcohol and 2-octyldodecanol, in the usual for such preparations Quantity ratios are used and slime-forming substances and Thickener, z. Hydroxyethyl or hydroxypropyl cellulose, Polyacrylic acid, polyvinylpyrrolidone, but also in small quantities cyclic silicone oils (polydimethylsiloxanes) as well as liquid polymethyl low viscosity phenylsiloxanes.

As a propellant for inventive sprayable from aerosol containers Preparations are the usual known volatile, liquefied Propellants, for example hydrocarbons (propane, butane, isobutane) suitable, which are used alone or in mixture with each other can. Also, compressed air is advantageous to use.

Of course, the person skilled in the art knows that there are nontoxic propellants per se, which would in principle be suitable for the present invention, to the but still because of harmful effects on the environment or other Accompanying circumstances should be avoided, especially fluorine chlorine hydrocarbons (CFCs).

As emulsifiers for the preparation of the preparations according to the invention, nonionic types such as polyoxyethylene fatty alcohol ethers, e.g. B. Cetylstearylalcohol polyethylene glycol ethers with 12 or 20 attached Ethylene oxide units per molecule, cetostearyl alcohol and sorbitan esters and sorbitan ester ethylene oxide compounds (e.g., sorbitan monostearate and polyoxyethylene sorbitan monostearate) and long chain higher molecular weight waxy polyglycol ethers have proven suitable.

In addition to the above ingredients he can inventive preparations whose pH preferably z. B. by customary buffer mixtures to 4.0 to 7.5, in particular 5.0 to 6.5, set is, perfume, dyes, antioxidants, suspending agents, buffer mixtures or other common cosmetic or dermatological precursors be mixed.  

According to the invention as favorable antioxidants all for cosmetic and / or dermatological applications suitable or common Antioxidants are used.

Advantageously, the antioxidants are selected from the group consisting from amino acids (eg, glycine, histidine, tyrosine, tryptophan) and theirs Derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (eg anserine), Carotenoids, carotenes (eg, α-carotene, β-carotene, lycopene) and their de derivatives, lipoic acid and its derivatives (eg dihydrolipoic acid), Aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, Glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, Methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilaurylthio dipropionate, distearyl thiodipropionate, thiodipropionic acid and their Derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (eg, buthionine sulfoximines, homocysts insulfoximine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine) in very low tolerated dosages (eg pmol to μmol / kg), furthermore (Metal) chelators (eg, α-hydroxy fatty acids, palmitic acid, phytic acid, Lactoferrin), α-hydroxy acids (eg citric acid, lactic acid, malic acid), Humic acid, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and its derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, Ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg. Ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg, vitamin E acetate), vitamin A and derivatives (vitamin A-pal mitat) as well as Konyferylbenzoat of Benzoeharzes, Rutinsäure and their Derivatives, ferulic acid and its derivatives, butylhydroxytoluene, Butylhydroxanisole, nordihydroguaiakolic acid, nordihydroguiaretic acid, Trihydroxybutyrophenone, uric acid and its derivatives, mannose and their derivatives, zinc and its derivatives (eg ZnO, ZnSO₄) selenium and its derivatives (eg selenomethionine), stilbenes and their derivatives (eg Stilbene oxide, trans-stilbene oxide) and the present invention suitable Derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and Lipids) of these drugs.  

The amount of antioxidants (one or more compounds) in the Preparations is preferably 0.001 to 30 wt .-%, especially preferably 0.05-20 wt .-%, in particular 1-10 wt .-%, based on the total weight of the preparation.

If vitamin E and / or its derivatives, the antioxidant (s) is advantageous, their respective concentrations from the field from 0.001 to 10% by weight, based on the total weight of the formulation, to choose.

If vitamin A, or vitamin A derivatives, or carotenes or their Derivatives which are or are antioxidants, is advantageous whose respective concentrations in the range of 0.001-10% by weight, based on the total weight of the formulation to choose.

It is advantageous for the present invention that the pH of the dermatological preparations according to the invention is less than 8. pH Who te, which are slightly higher than 7, but smaller than 7.5 can do so in the be tolerated in general. Anyway, for a given fatty acid Mix in an individual case by simple trial and error, without inventive Dazutun, easy to determine which exact upper pH limit to observe is.

Advantageously, the pH of the formulations according to the invention in acidic to very weak alkaline range less than 8, preferably from 4.0-7.5, more preferably from 5.0-6.5.

The quantities of auxiliary auxiliaries and carriers to be used in each case and possibly perfume may vary depending on the type of respective product by the expert by simple trial and error be determined.

The preparation of the preparations according to the invention is carried out, except of special preparations, each separately in the examples are noted, in the usual way, mostly by simple mixing  with stirring, if necessary with gentle heating. It offers none Trouble. Emulsions become fat phase and the water phase z; B. separately, optionally with heating and then emulsified.

Otherwise, the usual measures for putting together galenic formulations, which are familiar to the expert are.

If the combinations according to the invention are to be incorporated into powder, then the suspension bases can advantageously be selected from the group
Silica gels (eg those available under the tradename Aerosil®), diatomaceous earth, talc, modified starch, titanium dioxide, silk powder, nylon powder, polyethylene powder and related materials.

The quantities always refer to% by weight, if nothing another is specified and relate z. B. on the total weight the preparation.

The following examples serve to illustrate the invention.

example 1 W / O cream Wt .-% paraffin oil 10 ozocerites 4 vaseline 4 Evening primrose oil 12.5 Lanolin alcohol 2 Aluminum stearate 0.4 antioxidant 0.02   Water and preservatives ad 100

Example 2 W / O lotion Wt .-% paraffin oil 25 silicone oil 2 ceresin 1.5 Lanolin alcohol 0.5 Glucosesesquistearat 2.5 palmitoleic 5 antioxidant 0.02 butylene 3 Water and preservatives ad 100

Example 3 O / W lotion Wt .-% paraffin oil 5 Isopropylpalmitate 5 Cetyl alcohol 2 beeswax 2 Currant seed oil 10 Ceteareth-20 2 PEG-20 glyceryl stearate 1.5 glycerin 3 antioxidant 0.01 Water and preservatives ad 100

Example 4 O / W cream Wt .-% margaroleic 10 Cetyl alcohol 2 Glycerol monostearate 1.5 PEG-30 glyceryl stearate 2 ethylhexyl 5 Myristyl myristate 2 Carbopol 980 (neutralized) 0.3 glycerin 3 antioxidant 0.02 Water and preservatives ad 100

Example 5 ointment Wt .-% vaseline 36 ceresin 10 zinc oxide 4 Evening primrose oil 20 antioxidant 0.02 Paraffin oil ad 100

Example 6 skin oil Wt .-% cetyl palmitate 3 Evening primrose oil 20 myristate 2 antioxidant 0.02 Paraffin oil ad 100

Example 7 Bath oil Wt .-% linoleic acid 5 paraffin oil 10 PEG-40 Hydrogenated Castor Oil 5 Soybean oil ad 100

Example 8 Lip Balm Wt .-% ceresin 8th beeswax 4 carnauba 2 vaseline 40 Borage oil 10 antioxidant 0.01 Paraffin oil ad 100

Example 9 care mask Wt .-% PEG-50 lanolin 0.5 Glyceryl stearate 2 oleic acid 3 antioxidant 0.02 bentonite 8th kaolin 35 zinc oxide 5 Water and preservatives ad 100

Example 10 Liposome-containing gel Wt .-% lecithin 6 Evening primrose oil 12.5 antioxidant 0.02 Xanthan gum 1.4 Butylene glycol 3 Water and preservatives ad 100

Example 11 Shower preparation with moisturizer Wt .-% Cocamidodiacetate 10 sodium lauryl sulfate 25 Potassium Cocoyl Hydrolized Collagen 5 NaCl 0.6 alpha-linolenic acid 10 retinyl palmitate 0.02 Water and preservatives ad 100

Example 12 Hair care products Wt .-% TEA-Cocoyl Hydrolized Collagen 30 monoethanolamine 25 almond oil 5 NaCl 1 Water and preservatives ad 100

Example 13 aerosol spray Wt .-% a) liquid phase octyldodecanol 0.5 Gammalinolensäureethylester 1 Perfume q.s. Ethanol ad 100

b) the liquid phase obtained under a) is used together with a Propane-butane-2,7-mixture in the ratio 39: 61 filled in aerosol container.

Example 14 pump spray Wt .-% a) ethanol 60 glycerin 1.0 PEG-40-hydr. castor oil 2.0 Gamma-linolenic acid sodium salt 1 Perfume q.s. b) water ad 100

The ingredients mentioned under a) become a homogeneous solution processed and filled with the water phase b). The finished solution is in Pump atomizer bottled.

Example 15 Roll-on emulsion Wt .-% a) 1,3-Butylene glycol 2   hydroxyethyl 0.5 b) water ad 100 c) ethanol 60 PEG-40-hydr. castor oil 2 palmitoleic 0.3 Perfume q.s.

Disperse the ingredients under a), b) and at room temperature swell. Then a solution of the ingredients indicated under c) to admit. The mixture is homogenized and bottled.

Example 16 Crayon Wt .-% Hydrogenated castor oil 5 beeswax 6 Ceresin (hard ozokeratite) 30 C _12-15 alcohol benzoate 17 oleic acid 1 Perfume q.s. Octyldodecanol ad 100

Melt ingredients at 75 ° C, mix well and place in suitable Pour molds.

Example 17 Roll-on emulsion Wt .-% a)   Tricetearethphosphat 0.3 octyldodecanol 2.0 C _12-15 alcohol benzoate 2.0 Evening primrose oil 5 C _10-30 alkyl acrylate 0.15 b) @ Water ad 100 NaOH 0.05 c) @ ethanol 10 Perfume q.s.

The substances mentioned under a) and b) each with stirring to 75 ° C. heat. Then add a) to b) and cool to 350. From c) a 35 ° C prepare warm solution and add to the mixture of a) and b).

Claims (7)

1. Use of one or more monounsaturated or polyunsaturated monocarboxylic acids or their derivatives or Oils containing them as agents against superinfections, especially superinfections of the skin. 2. Use according to claim 1, characterized in that the Monocarboxylic acid is a fatty acid. 3. Use according to claim 1, characterized in that the Monocarboxylic acid, alpha-linolenic acid or gamma-linolenic acid or a Derivative thereof. 4. Use according to claim 1, characterized in that Evening primrose seed oil, borage oil or currant seed oil used becomes. 5. Cosmetic or dermatological preparations containing Active substances according to claim 1. 6. Use of the active ingredients according to claim 1 for the preparation of cosmetic or dermatological preparations for the treatment or prophylactic treatment of superinfections, in particular the Skin. 7. Use according to claim 1, characterized in that the Superinfection by microorganisms, protozoa or parasites be caused.