DE19521945A1 - Kaskadenpolymere mit Iodaromaten - Google Patents

Kaskadenpolymere mit Iodaromaten

Info

Publication number
DE19521945A1
DE19521945A1 DE1995121945 DE19521945A DE19521945A1 DE 19521945 A1 DE19521945 A1 DE 19521945A1 DE 1995121945 DE1995121945 DE 1995121945 DE 19521945 A DE19521945 A DE 19521945A DE 19521945 A1 DE19521945 A1 DE 19521945A1
Authority
DE
Germany
Prior art keywords
group
mmol
digits
stands
iodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1995121945
Other languages
German (de)
English (en)
Inventor
Werner Prof Dr Krause
Franz-Karl Dr Maier
Heribert Dr Schmitt-Willich
Johannes Dr Platzek
Wolf-Ruediger Press
Gabriele D Schuhmann-Giampieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE1995121945 priority Critical patent/DE19521945A1/de
Priority to EP96921966A priority patent/EP0832150A1/de
Priority to PCT/EP1996/002517 priority patent/WO1996041830A1/de
Publication of DE19521945A1 publication Critical patent/DE19521945A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
DE1995121945 1995-06-12 1995-06-12 Kaskadenpolymere mit Iodaromaten Withdrawn DE19521945A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE1995121945 DE19521945A1 (de) 1995-06-12 1995-06-12 Kaskadenpolymere mit Iodaromaten
EP96921966A EP0832150A1 (de) 1995-06-12 1996-06-11 Kaskadenpolymere mit iodaromaten
PCT/EP1996/002517 WO1996041830A1 (de) 1995-06-12 1996-06-11 Kaskadenpolymere mit iodaromaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1995121945 DE19521945A1 (de) 1995-06-12 1995-06-12 Kaskadenpolymere mit Iodaromaten

Publications (1)

Publication Number Publication Date
DE19521945A1 true DE19521945A1 (de) 1996-12-19

Family

ID=7764538

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995121945 Withdrawn DE19521945A1 (de) 1995-06-12 1995-06-12 Kaskadenpolymere mit Iodaromaten

Country Status (3)

Country Link
EP (1) EP0832150A1 (en26)
DE (1) DE19521945A1 (en26)
WO (1) WO1996041830A1 (en26)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001161A1 (de) * 1997-07-03 1999-01-14 Schering Aktiengesellschaft Oligomere, perfluoralkylhaltige verbindungen, verfahren zu deren herstellung und ihre verwendung in der nmr-diagnostik
DE19740403A1 (de) * 1997-09-09 1999-03-11 Schering Ag Neue Kontrastmittel
DE10214217A1 (de) * 2002-03-22 2003-10-09 Schering Ag Kaskadenpolymere mit hydrophilen lodaromaten

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02001017A (es) 1999-07-29 2002-08-12 Epix Medical Inc Agente multimerico de formacion de imagenes con especificidad hacia el blanco mediante su union a multiples regiones.
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2610935B1 (fr) * 1987-02-13 1989-09-01 Guerbet Sa Polymeres iodes, leurs procedes de preparation et leurs applications comme produits de contraste
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1993010824A1 (fr) * 1991-12-04 1993-06-10 Guerbet S.A. Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001161A1 (de) * 1997-07-03 1999-01-14 Schering Aktiengesellschaft Oligomere, perfluoralkylhaltige verbindungen, verfahren zu deren herstellung und ihre verwendung in der nmr-diagnostik
DE19740403A1 (de) * 1997-09-09 1999-03-11 Schering Ag Neue Kontrastmittel
DE19740403C2 (de) * 1997-09-09 1999-11-11 Schering Ag Neue Kontrastmittel
DE10214217A1 (de) * 2002-03-22 2003-10-09 Schering Ag Kaskadenpolymere mit hydrophilen lodaromaten

Also Published As

Publication number Publication date
EP0832150A1 (de) 1998-04-01
WO1996041830A1 (de) 1996-12-27

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Legal Events

Date Code Title Description
8130 Withdrawal