DE1906665A1 - Agent for the treatment of dandruff caused by seborrhea or similar damage to the scalp - Google Patents

Description

-lSHß.Efi5.

February 10, 1969 Jd 1

Ruth G. Van Sant Palm Beach, Florida USA 434 Sea Spray Avenue

Means for the treatment of impairments caused by seborrhea or similar flaking of the scalp

The invention relates to an agent for the treatment of impairments of the scalp caused by seborrhea or the like Flaking.

Experience has shown that dandruff can be eliminated often resisting stubborn resistance and that they even after weekly shampooing and regular hair care keep coming back. Dandruff is the result of a skin disease, mainly seborrhea, in some cases also dry seborrhea (seborrhea slcca capitis) or the bran-shaped scaling of the head (pityriasis capitis). Commonly used drugs to combat Dandruff contains sulfur, resorcinol, mercury, chrysal

009834/1926

λaasess

February 10, 1969

robinum or tar. It has been shown that this is known Funds are of limited value and often too serious Have caused damage. For example, sulfur is unsightly and can cause serious skin diseases of its own. Resorcinol bleaches the hair and leads to a green tinge in blonde or red hair. Mercury is easily absorbed and is extremely poisonous. Chrysarobinum may cause kidney irritation when applied to or over large areas Conjunctivitis when used near the eyes. Tar is dirty and potentially carcinogenic.

The present invention la? Therefore, the object of the invention is to find a means for combating dandruff which is not cumbersome and expensive to use and which does not have the disadvantages which occur when using the known dandruff agents.

This object is achieved according to the invention in that, as a means for treating the dandruff caused by seborrhea or similar impairments of the scalp, 5 to 20 vol .-? I, preferably 12 vol.-56 N, N-diethyl-m-toluamide in a binding agent or solvents can be suggested. . In a particularly expedient further development of the invention it is proposed that the solvent is essentially aqueous isopropyl alcohol. According to the invention, a mixture has proven to be particularly advantageous, which consists of 12 vol. -i » Ν, Ν-diethyl-m-toluamide, 50 vciL-36 isopropyl alcohol and 38 νο1-5ί distilled water.

009834/1926

02/10/1969 year 1

/
The Ν, Ν-diethyl-m-toluamide is the active component of the dandruff agent according to the invention. Good results have been achieved with a 7 vol .- # portion of this ingredient, excellent results with a 12 vol% portion. In general, the agent is applied in small amounts daily, and the treatment is continued for 1 to 3 weeks, depending on the severity of the dandruff. In many cases it has been found that success is achieved within the first week and that it is generally not necessary to continue treatment beyond three weeks. With each treatment, the hair should be moistened or the scalp should be drunk with the treatment agent; will. It has been shown that with such a treatment a bottle with a content of 6 el is sufficient for two weeks. However, the individual dose that should be used with each treatment is not critical. It is recommended that you massage the scalp with your fingertips for about a minute with each treatment. The agent according to the invention should normally be used daily in the morning, otherwise the application should be based on the severity of the dandruff.

Clinical tests have already been carried out in a large number of cases carried out, which showed unusually successful results have without any failure. There are also three-part side effects have not yet been observed. The results of these clinical tests are shown below using two examples reported.

- 4 009834/1926

February 10, 1969 JJ V

1st example:

The agent according to the invention, which contained an active ingredient of 7 vol .- # N, N-diethyl-m-toluamide, was tested on a group of 26 patients, all of whom suffered from dandruff that is difficult to treat. Seventeen of them were men, nine women. Their mean age was 39.4 years and ranged from 21 to 54 years. In 16 cases the diagnosis was seborrhea, in 6 cases dry seborrhea and in 4 cases bran-shaped scaling of the head. The patients had suffered from their dandruff for one to nine years, on average for three to eight years. Most of these cases showed a significant decrease in dandruff in the first week and complete disappearance of dandruff by the end of the second or third week. In 5 cases the treatment had to be continued for 4 weeks before the dandruff was completely under control. Successful results were obtained from 1-4 weeks, averaging 2.6 weeks. In 18 cases or 69 # the dandruff disappeared completely without a relapse during the observation period. In 5 cases or 19 # , only slight recurrence of the dandruff was observed after 1 week. In 3 cases or 12/6 some dandruff reappeared after a week, but considerably less than before the treatment. Thus, favorable results were obtained in all 26 cases and in no case did dandruff appear even nearly as bad as originally. Irritation, itching or other side effects were not observed in any case.

009834/1926

19666-

10.2.1969 Jd 1

2nd example:

A double-encrypted test was carried out on 25 patients. One treating agent consisted of a liquid A containing 12 vol .- ^ of the active ingredient. Your exact The composition was as follows: 12 ml of N, N-diethylm-toluamide, 38 ml distilled water, 50 ml isopropyl alcohol, approx. 1.5 ml perfume.

The second treatment agent consisted of a liquid B, which was only a suggestive agent and contained no active ingredient. Neither the patients nor the doctors knew what the liquids contained. The 25 test persons were initially examined and evaluated according to the duration of their condition, the manifestations and the objective findings of their seborrhea. The subjects were instructed to continue washing their hair and heads as usual. Liquids A and B were alternately dispensed to the test subjects, who were instructed to use the liquid daily for a period of two weeks. At the end of this period, the patients were evaluated according to objective and subjective criteria. They were then given a bottle of the same liquid to use for an additional two week period. At the end of the entire 4 weeks, the subjects were interviewed and examined again. The treatment was then suspended in all patients for 3 weeks, so that the transfer of effects from the treatment with the first liquid to the time of the treatment with the second liquid could be avoided. After these three weeks the patients received the other treatment "fiu" 0lgk "it, dl · they also for a period of time

006834/1826

- 6 - ORIGINAL INSPECTED

I weeks at. Consequently • 6 - 1906665 ϊ everyone Patient's fltis Ü.M. Table 1 F. / 1SlS Race Duration of the Difficulty 1 year and the February 10, 1969 respectively 4 contiguous CD. Age gender F. C. 4 years Yy 1 Weeks with a three-week break . Age, gender, BRA. 17th F. N 2 years they turn under Race and Duration of illness of the test subjects are in B.W. 43 F. C. 4 years a treatment inter- Table 1 reproduced: M.H. 17th M. C. 2 years L _? at the end of it use « L.T. 19th F. C. 6 months Liquid B for Case no. Initials CJ. 15th F. C. 2 years 1 T.S. 26th F. N 2 months 2 M.T. 42 F. C. 26 years Had to use for 2 weeks 3 M. McM. 30th F. C. 2 years were sought. Then closed 4th S.B. 42 F. C. 6 years vall of i VJl N.O'C. 30th F. C. 4 years ity A 6th M.IC. 26th F. C. 2 months 7th V. F. 37 F. C. 6 weeks 8th P.H. 47 F. C. 2 years 9 M.A. 36 F. C. 1 month 10 BRA. 21 F. C. 3 years 11th E.W. 38 F. C. 1 year 12th S.I. 36 F. C. 15 months 13th CD. 43 F. C. 6 weeks 14th BI. 19th F. C. 1 year 15th M.G. 29 F. C. 3 months 16 M.B. 41 F. C. 3 years 17th E. M. 33 F. C. 2 years 18th H.K. 57 K C. ten years 19th The evaluation of the 46 Testes is in the C. following table 2 20th reproduced: 45 21 009334 22nd - 7 - 23 24 25th

665

02/10/1969 year 1

No / redness
' d. skin Table 2 speed Dry scab Itch Burn 11th A. Abschup- greasy B. Ness education delightful A. pen B. no A. A. no 1 A. A ' B. as well no A. no 2 A. A. B. no no as well no 3 A. A. B. no A. A. no 4th A. A. no no no as well no VJI A. A. B. A. A. A. no 6th A. A. B. A. B. A. A. 7th as well A. no no no A. no 8th A. A. as well A. A. A. A. 9 A. A. no A. no A. no 10 A. A. B. A. A. A. no 11th A. A. B. no no A. A. 12th A. A. B. A. no A. no 13th A. A. B. A. A. A. no H B. A. no no no A. no 15th A. A. no B ■ no A. no 16 A. A. no B. A. A. no 17th as well A. B. A. A. A. no 18th A. A. A. A. A. A. no 19th A. A. no as well A. B. no 20th A. A. no A. A. A ' no 21 A. A. B. A. A. A. no 22nd A. A. A. A. no A. no 23 A. A. B. A. A. A. no 24 A. no A. A. no 25th A.

For the individual symptoms, Table 2 shows which of the two liquids A or B has improved to a greater extent. "No ™ means that the individual symptom did not occur. • Likewise ¹ · means that both liquids A and B had the same effect.

The result of the clinical test is summarized as follows:

The reddening of the skin diminished in 22 cases, or 88 % of all cases, or disappeared entirely during the use of liquid A, which contained 12 vol .- ^ N, N-diethyl-m-toluamide

009834/1926

ORIGINAL INSPSCTHD

02/10/1969 year 1

by using the liquid B, which is only a suggestion contained medium, only 1 case was / was improved. The flaking completely disappeared and went away in 18 cases in 7 cases it was reduced by using liquid A, while when using liquid B it only decreased in 8 cases, remained unchanged in 10 cases and got worse in 7 cases. Thus, 100 $ of the time, the flake became whole or partial cured by applying liquid A. The itchy skin went noticeably in 22 cases, or $ 88 of all cases back or disappeared completely with the application of the liquid A, while only one case improved with the application of the liquid B. became.

Some of the patients observed an increase in scalp oiliness when using liquid A.

Dermatologists have shown that head seborrhea and associated skin inflammation are important contributing causes of hair loss. The seborrhea in its various forms is regarded as the most important local cause of premature hair loss, in 75 to 90? Ί as a causative factor, the dermatologists have also found that the seborrhea and its consequences can be permanent and untreatable chronic when they recur in later years. It was therefore extremely surprising and unexpected that it was possible to achieve such satisfactory results by using the agent according to the invention. The invention was also not suggested by the fact that the H, N-DiSthyl ~ m ~ T © luamld itself was previously known. Although it was known as an excellent insect repellant, it was not for the purposes indicated by the present invention. DiMthjl-Ei-Toluamid is commercially available and has the cheap Sunanenformel G ^ H ₁₇ NO and a molecular weight τοη 191 »26. It is freely soluble in alcohol and is known for the sweets

009834/1926 " ⁹ "

February 10, 1969

Jd 1

present invention in any suitable Bind © - or Solvent-bound or loosened- It nfurdss, however found that the most suitable and therefore preferred solvent The mixture described in Example 2 is “If a different proportion of the active ingredient is used, E.g. 7 vol .- # of Ν, Ν-dietbyl-m-toluamide is the Ifenge des Water and alcohol to be adjusted proportionally accordingly »The present invention is o © but not based on that Solution τοπ NiN-diethyl-ni-toluamide in aqueous isopropyl alcohol limited; rather, the active ingredient can be matched with any suitable liquid or semi-liquid binders or solvents are combined, as s.B. the well-known hair-washing "hair rinse" and hair toning agents.

- 10 -

008834/1826

ORIGINAL INSPECTED

Claims (3)

- ίο - 02/10/1969 claims 1. Agent for the treatment of dandruff caused by Seborrho © or similar impairments of the scalp, characterized by 5 Ms 20 vol. - ^ ₉ preferably 12 vol .- $ N, N-diethyl »ia ~ TQluamid. In a binder or solvent. 2. Composition according to claim 1, characterized in that the solvent is essentially aqueous isopropyl alcohol is. 3. Means according to claim 2, characterized by 12 vol.-Ji Ν, Ν-diethyl-m-toluamide, 50 vol .- ^ isopropyl alcohol and 38 vol.-56 distilled water. OJlJL ORIGINAL INSPECTED