WO2000015187A1 - Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers - Google Patents

Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers Download PDF

Info

Publication number
WO2000015187A1
WO2000015187A1 PCT/EP1999/006670 EP9906670W WO0015187A1 WO 2000015187 A1 WO2000015187 A1 WO 2000015187A1 EP 9906670 W EP9906670 W EP 9906670W WO 0015187 A1 WO0015187 A1 WO 0015187A1
Authority
WO
WIPO (PCT)
Prior art keywords
creatine
preparation according
preparation
moisturizers
derivatives
Prior art date
Application number
PCT/EP1999/006670
Other languages
German (de)
French (fr)
Inventor
Christian Gloxhuber
Bernd Mertschenk
Original Assignee
Skw Trostberg Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skw Trostberg Aktiengesellschaft filed Critical Skw Trostberg Aktiengesellschaft
Priority to GB0108722A priority Critical patent/GB2357970A/en
Priority to JP2000569772A priority patent/JP2002524486A/en
Publication of WO2000015187A1 publication Critical patent/WO2000015187A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the present invention relates to the use of creatine and / or creatine derivatives as moisturizers (moisturizers) in cosmetic preparations.
  • Preparations in cream, gel or liquid form which can be used topically for cosmetic purposes, but also orally and then systemically, contain in most cases moisturizers, the so-called moisturizers.
  • moisturizers the so-called moisturizers.
  • humectants also contribute to a certain sense of wellbeing due to the cooling effect that the various cream and gel preparations emit when they are used.
  • the aim of most cosmetic preparations is to have a positive influence on the condition and appearance of the skin.
  • the condition and appearance of the skin are strongly influenced by aging processes.
  • the colloidal state of the protein body for example of collagen
  • changes in such a way that the ability to bind water decreases and the tissue turgor is reduced.
  • atrophic changes which manifests itself in particular in an increased formation of wrinkles and an increased dryness in particular of the upper skin layers, such as the stratum corneum.
  • the increased symptoms associated with these changes such as Dandruff formation, overall lead to a deteriorated appearance of the skin surface.
  • the skin surface is not only changed by aging processes, but also by a number of external influences. So generally cause environmental influences and the weather, but also extreme washing and degreasing of the skin, such as. B. the frequent use of solvents, increased drying of the skin with cracking and flaking. Age-related changes in the skin caused by external influences can add up.
  • the skin In order to counteract these processes that take place on the surface of the skin, the skin naturally has mechanisms that are called natural moisturizing factors.
  • natural moisturizing factors are urea and certain amino acids such as glycine and arginine, which are found naturally on the surface of the skin.
  • moisturizers These naturally occurring substances are supported in modern skin care products - as already mentioned - by the so-called moisturizers.
  • These partially synthetic humectants such as polyols, glycerol, sorbitol, ethoxylated phenols and hydrolyzed proteins, can favorably influence age-related and / or skin roughness due to external influences in the sense that the skin obtains a smoother and smoother surface.
  • a disadvantage of numerous synthetic humectants is their lack of stability, especially over long periods, which leads to the breaking of the emulsions, particularly at extreme temperatures, which has a particularly negative effect on cream-like O / W emulsions.
  • the invention is based on the object of providing a moisturizer for cosmetic preparations which ensures stable preparations, is of natural origin or identical to nature, is also easily accessible and, on account of its composition, does not allow any adverse health effects to be expected.
  • Creatine is a natural compound known as energy storage, especially in muscle tissue, which is non-toxic, is catabolized by the kidneys to urinate creatinine, and is also very well tolerated locally, as experimental studies have shown. Creatine is also known to be able to bind 23 ml of water per gram (cf. Neumann: Creatinabol study).
  • the creatine monohydrate has proven to be particularly suitable in the sense of the present invention and is therefore preferred; but also creatine derivatives, for example in salt form, such as the preferred creatine ascorbate, are very suitable. All suitable creatine derivatives can also be used as mixtures with one another, however also together with other suitable humectants, such as the known natural "moisturizing" factors.
  • creatine derivatives
  • humectants in cosmetic preparations has also proven to be particularly advantageous because, with the suitable creatine compounds, additives can be achieved in part but also synergistically.
  • the invention provides for the creatine and / or its suitable derivatives to be used preferably in creams such as day and night creams, gel-like or liquid preparations, the latter being particularly preferably facial toners, lotions and suspensions.
  • the creatine and / or creatine derivative can also be packaged in liposomes in these and the other preparation forms. This form is preferred if reactions with other components of the preparation are to be avoided.
  • the creatine component (s) according to the invention are preferably used in amounts of 0.5 to 10% by weight, particularly preferably in an amount of 1 to 5% by weight, based in each case on the Overall preparation.
  • the invention is also suitable for oral administration of the preparations containing creatine.
  • the preferred preparation forms which have no other humectants, such as powders, dragees, tablets, troches, capsules, liposomes or liquids, should allow the creatine component to be taken up in an amount which does not exceed a daily dose of 10 g; a daily dose of approx. 4 to 6 g is recommended.
  • creatine components are used in preparations for the outer or inner Used in combination with other physiologically active ingredients.
  • Antioxidants such as ascorbic acid, vitamins such as ⁇ -tocopherol acetate, trace elements and / or sunscreens are preferred.
  • creatine and / or its derivatives according to the invention showed that when the corresponding cosmetic preparations are taken orally, water is stored within the body, but especially in the deeper layers of the skin, as a result of which particularly existing wrinkles can be smoothed and new wrinkle formation is prevented can be.
  • the creatine-containing preparations according to the invention are used locally and mostly superficially, the main phenomenon of dry skin, the skin flaking, is suppressed and the superficial formation of wrinkles is avoided.
  • the correspondingly formulated formulations containing creatine above all improve the elastic properties, in particular of stressed skin, sustainably, which makes them suitable for numerous cosmetic applications which can also go beyond the traditional fields of skin cosmetics, for example in shampoos, hair and mouth and gargling, lipsticks, make-up formulations, hand and foot baths as well as masking creams etc.
  • Skin care product based on an O / W (oil-in-water) cream.

Abstract

The invention relates to a cosmetic preparation containing creatine and/or creatine derivatives as moisturizers.

Description

Kreatin und/oder Kreatinderivate als Feuchthaltemittel enthaltende kosmetische ZubereitungenCreatine and / or creatine derivatives as cosmetic preparations containing humectants
Beschreibungdescription
Gegenstand der vorliegenden Erfindung ist die Verwendung von Kreatin und/oder Kreatinderivaten als Feuchthaltemittel (Moisturizer) in kosmetischen Zubereitungen.The present invention relates to the use of creatine and / or creatine derivatives as moisturizers (moisturizers) in cosmetic preparations.
Zubereitungen in creme-, gel- oder flüssiger Form, die zu kosmetischen Zwecken topisch, daneben aber auch oral und dann systemisch angewendet werden können, beinhalten in den meisten Fällen Feuchthaltemittel, die sogenannten Moisturizer. Mit Hilfe dieser Feuchthaltemittel wird zum einen eine anhaltend stabile Konsistenz und Anwendbarkeit der jeweiligen Kosmetika gewährleistet, was insbesondere bei den unterschiedlichsten Cremes wichtig ist. Zum anderen tragen die Feuchthaltemittel auch zu einem gewissen Wohlbefinden aufgrund des kühlenden Effektes bei, die von den diversen Creme- und Gelzubereitungen bei deren Anwendung ausgehen.Preparations in cream, gel or liquid form, which can be used topically for cosmetic purposes, but also orally and then systemically, contain in most cases moisturizers, the so-called moisturizers. With the help of these humectants, on the one hand, a lasting, stable consistency and applicability of the respective cosmetics is ensured, which is particularly important for a wide variety of creams. On the other hand, the humectants also contribute to a certain sense of wellbeing due to the cooling effect that the various cream and gel preparations emit when they are used.
Ziel der allermeisten kosmetischen Zubereitungen ist eine positive Einflussnahme auf den Zustand und das Aussehen der Haut.The aim of most cosmetic preparations is to have a positive influence on the condition and appearance of the skin.
Zustand und Aussehen der Haut werden durch Alterungsprozesse stark beeinflusst. Mit zunehmenden Alter verändert sich nämlich der kolloidale Zustand der Eiweißkörper, beispielsweise des Kollagens derart, dass die Wasserbindungsfähigkeit abnimmt und der Gewebsturgor verringert wird. Ein Folge davon sind atrophische Veränderungen, was sich insbesondere in einer vermehrten Faltenbildung und einer gesteigerten Trockenheit insbesondere der oberen Hautschichten, wie des Stratum corneum äußert. Die mit diesen Veränderungen einhergehenden vermehrten Symptome, wie Schuppenbildung, führen insgesamt zu einem verschlechterten Aussehen der Hautoberfläche.The condition and appearance of the skin are strongly influenced by aging processes. With increasing age, the colloidal state of the protein body, for example of collagen, changes in such a way that the ability to bind water decreases and the tissue turgor is reduced. One consequence of this is atrophic changes, which manifests itself in particular in an increased formation of wrinkles and an increased dryness in particular of the upper skin layers, such as the stratum corneum. The increased symptoms associated with these changes, such as Dandruff formation, overall lead to a deteriorated appearance of the skin surface.
Die Hautoberfläche wird aber nicht nur durch Alterungsprozesse verändert, sondern auch durch eine Reihe äußerer Einflüsse. So verursachen generell Umwelteinflüsse und die Witterung, aber auch extremes Waschen und Entfetten der Haut, wie z. B. der häufige Gebrauch von Lösemitteln, eine verstärkte Austrocknung der Haut mit Rissbildung und Schuppung. Dabei können sich altersbedingte und durch äußere Einflüsse verursachte Veränderungen der Haut addieren.The skin surface is not only changed by aging processes, but also by a number of external influences. So generally cause environmental influences and the weather, but also extreme washing and degreasing of the skin, such as. B. the frequent use of solvents, increased drying of the skin with cracking and flaking. Age-related changes in the skin caused by external influences can add up.
Um diesen sich an der Oberfläche der Haut abspielenden Prozessen entgegenzuwirken, verfügt die Haut von Natur aus über Mechanismen, die man als Natural Moisturizing Faktoren bezeichnet. Bekannte Vertreter dieser Faktoren sind Harnstoff und bestimmte Aminosäuren wie Glycin und Arginin, die natürlicherweise auf der Hautoberfläche angetroffen werden.In order to counteract these processes that take place on the surface of the skin, the skin naturally has mechanisms that are called natural moisturizing factors. Known representatives of these factors are urea and certain amino acids such as glycine and arginine, which are found naturally on the surface of the skin.
Diese natürlich vorkommenden Stoffe werden in modernen Hautpflegemitteln - wie bereits erwähnt - durch die sogenannten Moisturizer unterstützt. Diese zum Teil synthetischen Feuchthaltemittel wie Polyole, Glycerin, Sorbit, ethoxylierte Phenole und hydrolysierte Proteine können altersbedingte und/oder durch äußere Einflüsse bedingte Hautrauigkeiten in dem Sinn günstig beeinflussen, dass die Haut eine glattere und geschmeidigere Oberfläche erhält.These naturally occurring substances are supported in modern skin care products - as already mentioned - by the so-called moisturizers. These partially synthetic humectants, such as polyols, glycerol, sorbitol, ethoxylated phenols and hydrolyzed proteins, can favorably influence age-related and / or skin roughness due to external influences in the sense that the skin obtains a smoother and smoother surface.
Nachteilig bei zahlreichen synthetischen Feuchthaltemitteln ist deren vielfach vor allem über längere Zeiträume hinweg mangelnde Stabilität, was insbesondere bei extremen Temperaturen zum Brechen der Emulsionen führt, was sich besonders auf cremeartige O/W-Emulsionen negativ auswirkt. Der Erfindung liegt nun die Aufgabe zugrunde, ein Feuchthaltemittel (Moisturizer) für kosmetische Zubereitungen bereitzustellen, das stabile Zubereitungen gewährleistet, natürlichen Ursprungs oder naturidentisch ist, darüber hinaus leicht zugänglich ist und das aufgrund seiner Zusammensetzung keine gesundheitlichen Nebenwirkungen erwarten lässt.A disadvantage of numerous synthetic humectants is their lack of stability, especially over long periods, which leads to the breaking of the emulsions, particularly at extreme temperatures, which has a particularly negative effect on cream-like O / W emulsions. The invention is based on the object of providing a moisturizer for cosmetic preparations which ensures stable preparations, is of natural origin or identical to nature, is also easily accessible and, on account of its composition, does not allow any adverse health effects to be expected.
Gelöst wurde diese Aufgabe durch die Verwendung von Kreatin und/oder Kreatinderivaten als Feuchthaltemittel für kosmetische Zubereitungen.This task was solved by the use of creatine and / or creatine derivatives as humectants for cosmetic preparations.
Überraschend konnte beim praktischen Einsatz von Kreatin bzw. dessen geeigneter Derivate festgestellt werden, dass damit nicht nur die gewünschten stabilen kosmetischen Zubereitungen erhalten werden, sondern dass auch die Symptome einer trockenen Haut, wie Risse und Schuppung, nachhaltig beseitigt werden oder diesen Phänomenen sogar vorgebeugt werden kann. Außerdem kann durch die erfindungsgemäße Verwendung auch der körpereigene Energiehaushalt in dem Sinn positiv beeinflusst werden, dass auch tiefere Unterhautschichten eine andauernde Straffung erfahren, was in diesem Ausmaß so nicht vorhersehbar war.Surprisingly, when creatine or its suitable derivatives were used in practice, it was found that not only were the desired stable cosmetic preparations obtained, but also the symptoms of dry skin, such as cracks and scaling, were permanently eliminated or these phenomena were even prevented can. In addition, the use of energy according to the invention can also have a positive influence on the body's energy balance in the sense that even deeper layers of the subcutaneous tissue are continuously tightened, which was not so predictable to this extent.
Kreatin ist eine natürliche, als bekannter Energiespeicher vor allem im Muskelgewebe vorkommende Verbindung, die nicht toxisch ist, von den Nieren zum harngängigen Kreatinin katabolisiert wird, und darüber hinaus lokal eine sehr gute Verträglichkeit aufweist, wie experimentelle Untersuchungen gezeigt haben. Von Kreatin ist ebenfalls bekannt, dass es pro Gramm 23 ml Wasser zu binden vermag (vgl. Neumann: Creatinabol- Studie).Creatine is a natural compound known as energy storage, especially in muscle tissue, which is non-toxic, is catabolized by the kidneys to urinate creatinine, and is also very well tolerated locally, as experimental studies have shown. Creatine is also known to be able to bind 23 ml of water per gram (cf. Neumann: Creatinabol study).
Als besonders geeignet im Sinne der vorliegenden Erfindung hat sich das Kreatinmonohydrat erwiesen und wird daher bevorzugt; aber auch Kreatinderivate beispielsweise in Salzform, wie das bevorzugte Kreatinascorbat, sind sehr gut geeignet. Dabei können alle geeigneten Kreatinderivate auch als Mischungen untereinander verwendet werden, aber auch gemeinsam mit weiteren geeigneten Feuchthaltemitteln, wie beispielsweise den bekannten natürlichen "moisturizing" Faktoren.The creatine monohydrate has proven to be particularly suitable in the sense of the present invention and is therefore preferred; but also creatine derivatives, for example in salt form, such as the preferred creatine ascorbate, are very suitable. All suitable creatine derivatives can also be used as mixtures with one another, however also together with other suitable humectants, such as the known natural "moisturizing" factors.
Als besonders vorteilhaft hat sich die Verwendung von Kreatin(-derivaten) als Feuchthaltemittel in kosmetischen Zubereitungen auch deshalb erwiesen, da mit den geeigneten Kreatinverbindungen additive zum Teil aber auch synergistische Wirkungen erreicht werden können.The use of creatine (derivatives) as humectants in cosmetic preparations has also proven to be particularly advantageous because, with the suitable creatine compounds, additives can be achieved in part but also synergistically.
Für diese speziellen Anwendungsfälle sieht die Erfindung vor, das Kreatin und/oder dessen geeignete Derivate vorzugsweise in Cremes, wie Tagesund Nachtcremes, gelartigen oder flüssigen Zubereitungen zu verwenden, wobei sich bei letzteren besonders bevorzugt um Gesichtswässer, Lotionen und Suspensionen handelt. Das Kreatin oder/und Kreatinderivat kann in diesen und den anderen Zubereitungsformen auch in Liposomen verpackt vorliegen. Diese Form wird bevorzugt, wenn Reaktionen mit anderen Komponenten der Zubereitung vermieden werden sollen.For these special applications, the invention provides for the creatine and / or its suitable derivatives to be used preferably in creams such as day and night creams, gel-like or liquid preparations, the latter being particularly preferably facial toners, lotions and suspensions. The creatine and / or creatine derivative can also be packaged in liposomes in these and the other preparation forms. This form is preferred if reactions with other components of the preparation are to be avoided.
In Fällen einer rein äußerlichen Anwendung erfolgt die erfindungsgemäße Verwendung der Kreatin-Komponente(n) vorzugsweise in Mengen von 0,5 bis 1 0 Gew.-%, besonders bevorzugt in einer Menge von 1 bis 5 Gew.-%, jeweils bezogen auf die Gesamtzubereitung.In cases of purely external use, the creatine component (s) according to the invention are preferably used in amounts of 0.5 to 10% by weight, particularly preferably in an amount of 1 to 5% by weight, based in each case on the Overall preparation.
Die Erfindung eignet sich auch für eine orale Verabreichung der Kreatin- enthaltenden Zubereitungen. Die bevorzugten Zubereitungsformen, die keine weiteren Feuchthaltemittel aufweisen wie Pulver, Dragees, Tabletten, Pastillen, Kapseln, Liposomen oder Flüssigkeiten, sollten dabei die Aufnahme der Kreatin-Komponente in einer Menge erlauben, die eine Tagesdosis von 10 g nicht überschreitet; empfohlen wird eine Tagesdosis von ca. 4 bis 6 g.The invention is also suitable for oral administration of the preparations containing creatine. The preferred preparation forms which have no other humectants, such as powders, dragees, tablets, troches, capsules, liposomes or liquids, should allow the creatine component to be taken up in an amount which does not exceed a daily dose of 10 g; a daily dose of approx. 4 to 6 g is recommended.
Gemäß einer weiteren Ausführungsform der Erfindung werden geeignete Kreatinkomponenten in Zubereitungen für die äußere oder innere Anwendung in Kombination mit weiteren physiologisch aktiven Bestandteilen verwendet. Bevorzugt werden hierzu Antioxidantien wie beispielsweise Ascorbinsäure, Vitamine wie σ-Tocopherol-acetat, Spurenelemente oder/und Sonnenschutzmittel.According to a further embodiment of the invention, suitable creatine components are used in preparations for the outer or inner Used in combination with other physiologically active ingredients. Antioxidants such as ascorbic acid, vitamins such as σ-tocopherol acetate, trace elements and / or sunscreens are preferred.
Die erfindungsgemäße Verwendung von Kreatin und/oder dessen Derivaten ergab, dass bei oraler Aufnahme der entsprechenden kosmetischen Zubereitungen innerhalb des Körpers, vor allem aber in den tieferen Schichten der Haut, Wasser gespeichert wird, wodurch besonders bestehende Falten geglättet werden können und einer neuerlichen Faltenbildung vorgebeugt werden kann. Bei lokaler und meist oberflächlicher Anwendung der Kreatin-haltigen Zubereitungen gemäß der Erfindung wird insbesondere das Hauptphänomen der trockenen Haut, die Hautschuppung, zurückgedrängt und die oberflächliche Faltenbildung vermieden.The use of creatine and / or its derivatives according to the invention showed that when the corresponding cosmetic preparations are taken orally, water is stored within the body, but especially in the deeper layers of the skin, as a result of which particularly existing wrinkles can be smoothed and new wrinkle formation is prevented can be. When the creatine-containing preparations according to the invention are used locally and mostly superficially, the main phenomenon of dry skin, the skin flaking, is suppressed and the superficial formation of wrinkles is avoided.
Die entsprechend formulierten Kreatin-haltigen Zubereitungen verbessern vor allem die elastischen Eigenschaften, insbesondere der strapazierten Haut, nachhaltig, was sie für zahlreiche kosmetische Anwendungen geeignet macht, die auch über die traditionellen Felder der Hautkosmetik hinausgehen können, beispielsweise in Shampoos, Haar-, Mund- und Gurgelwässern, Lippenstiften, Make-up-Formulierungen, Hand- und Fußbädern sowie Abdeckcremes usw. The correspondingly formulated formulations containing creatine above all improve the elastic properties, in particular of stressed skin, sustainably, which makes them suitable for numerous cosmetic applications which can also go beyond the traditional fields of skin cosmetics, for example in shampoos, hair and mouth and gargling, lipsticks, make-up formulations, hand and foot baths as well as masking creams etc.
BeispieleExamples
Hautpflegemittel auf Basis einer O/W (Öl-in-Wasser-) Creme.Skin care product based on an O / W (oil-in-water) cream.
Inhaltsstoffe: Gew.-%Ingredients:% by weight
15,015.0
Paraffmöl, subliquidumParaffmöl, subliquidum
Kreatin-Monohydrat 4,0Creatine monohydrate 4.0
Caprylcaprinsäure-Triglycerid 4,0Caprylic capric acid triglyceride 4.0
Cetylalkohol 3,0Cetyl alcohol 3.0
Vaseline 3,0Vaseline 3.0
Glycerin 3,0Glycerin 3.0
Glycerin-Monostearat 2,0Glycerol monostearate 2.0
Octyldodecanol 2,0 hydriertes Kokosfett 2,0Octyldodecanol 2.0 hydrogenated coconut fat 2.0
Cetylphosphat 0,4Cetyl phosphate 0.4
Natriumhydroxid q.s.Sodium hydroxide q.s.
Par ümöl q.s.Par ümöl q.s.
Konservierungsmittel q.s.Preservatives q.s.
Wasser, demineralisiert ad 100,0Water, demineralized to 100.0
q.s. = quantum satis q.s. = quantum satis

Claims

Ansprüche Expectations
1. Kreatin oder/und Kreatinderivate als Feuchthaltemittel (Moisturizer) enthaltende kosmetische Zubereitung.1. Creatine and / or creatine derivatives as a cosmetic preparation containing moisturizers (moisturizers).
2. Zubereitung nach Anspruch 1, d ad u rch g e ke n nzeic h net, dass sie als Kreatin-(Derivate) Kreatin-Monohydrat und Kreatin- Ascorbat enthält.2. Preparation according to claim 1, d ad u rch g e ke n nzeic h net that it contains creatine monohydrate and creatine ascorbate as creatine (derivatives).
3. Zubereitung nach den Ansprüchen 1 oder 2, d ad u rch g e ken nzei c h net, dass sie ein oder mehrere weitere Feuchthaltemittel enthält.3. Preparation according to claims 1 or 2, d ad u rch g e ken nzei c h net that it contains one or more other humectants.
4. Zubereitung nach einem der Ansprüche 1 bis 3 als Creme, gelartige oder flüssige Formulierung.4. Preparation according to one of claims 1 to 3 as a cream, gel-like or liquid formulation.
5. Zubereitung nach Anspruch 4 als flüssige Formulierung in Form von Gesichtswasser, Lotion oder Suspension, jeweils mit oder ohne5. Preparation according to claim 4 as a liquid formulation in the form of facial toner, lotion or suspension, in each case with or without
Gehalt an Liposomen.Liposome content.
6. Zubereitung nach einem der Ansprüche 1 bis 5, d a d u rc h g e ke n n ze i c h n et, dass die Kreatinkomponente in einer Menge von 0,5 bis 10 Gew.-%, bezogen auf die Gesamtzubereitung vorliegt.6. Preparation according to one of claims 1 to 5, so that the creatine component is present in an amount of 0.5 to 10% by weight, based on the total preparation.
7. Zubereitung nach Anspruch 6, d a d u rc h g e ke n n ze i c hn et , dass sie 1 bis 5 Gew.-% Kreatinkomponente enthält. 7. Preparation according to claim 6, so that it contains 1 to 5% by weight of creatine component.
8. Zubereitung nach Anspruch 1 oder 2 als oral zu verabreichende Formulierung.8. Preparation according to claim 1 or 2 as an orally administered formulation.
9. Zubereitung nach Anspruch 8, d a d u rc h g e ke n n z e i c h n et, dass sie Kreatinkomponente in solcher Menge enthält, dass 10 g pro Tagesdosis nicht überschritten werden.9. Preparation according to claim 8, d a d u rc h g e ke n n z e i c h n et that it contains creatine component in such an amount that 10 g per daily dose is not exceeded.
10. Zubereitung nach einem der Ansprüche 8 und 9 in Form von Pulver, Dragee, Tablette, Pastille, Kapsel oder flüssiger Formulierung.10. Preparation according to one of claims 8 and 9 in the form of powder, dragee, tablet, lozenge, capsule or liquid formulation.
11. Zubereitung nach einem der vorhergehenden Ansprüche, d a d u rc h g e ke n n ze i c h n et , dass sie das Kreatin oder/und Kreatinderivat in Liposomen verpackt enthält.11. Preparation according to one of the preceding claims, that it contains the creatine and / or creatine derivative packaged in liposomes.
12. Zubereitung nach einem der vorhergehenden Ansprüche, d a d u rc h g e ke n n ze i c h n et , dass sie weitere physiologisch aktive Bestandteile, insbesondere Antioxidantien, Vitamine, Spurenelemente und Sonnenschutzmittel enthält.12. Preparation according to one of the preceding claims, d a d u rc h g e ke n n ze i c h n et that it contains other physiologically active ingredients, in particular antioxidants, vitamins, trace elements and sunscreen.
13. Verwendung von Kreatin oder/und mindestens einem Kreatinderivat als Feuchthaltemittel für eine kosmetische Zubereitung. 13. Use of creatine and / or at least one creatine derivative as a humectant for a cosmetic preparation.
PCT/EP1999/006670 1998-09-10 1999-09-09 Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers WO2000015187A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0108722A GB2357970A (en) 1998-09-10 1999-09-09 Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers
JP2000569772A JP2002524486A (en) 1998-09-10 1999-09-09 Cosmetic composition containing creatine and / or creatine derivative as humectant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19841385.8 1998-09-10
DE1998141385 DE19841385A1 (en) 1998-09-10 1998-09-10 Use of creatine and/or creatine derivatives as moisturizers in cosmetic compositions

Publications (1)

Publication Number Publication Date
WO2000015187A1 true WO2000015187A1 (en) 2000-03-23

Family

ID=7880498

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/006670 WO2000015187A1 (en) 1998-09-10 1999-09-09 Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers

Country Status (4)

Country Link
JP (1) JP2002524486A (en)
DE (1) DE19841385A1 (en)
GB (1) GB2357970A (en)
WO (1) WO2000015187A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054676A2 (en) * 2000-01-28 2001-08-02 Degussa Ag Formulations for states of dehydration
DE10119608A1 (en) * 2001-04-21 2002-10-24 Goldschmidt Ag Th Hair treatment or post-treatment compositions for preventing or repairing damage caused by chemical treatment, e.g. perming or bleaching, containing creatine or its derivative as hair strengthening agent
EP1338269A1 (en) * 2002-02-15 2003-08-27 Goldschmidt AG Composition for whitening the skin and alleviating of pigmentation disorders containing creatinine and/or a creatinine derivative as active ingredient
EP1535604A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Combination of creatine and/or creatinine, phenoxyethanol and eventually glycerine
EP1535605A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Cosmetic preparations containing creatine, creatinine and/or the derivatives thereof combined with an organic thickener.
US7186754B2 (en) 1999-06-25 2007-03-06 Avicena Group, Inc. Use of creatine or creatine compounds for skin preservation
EP1328242B2 (en) † 2001-03-24 2015-07-22 Wella Aktiengesellschaft Non-therapeutic use of creatine, creatinine and/or cyclocreatine for strengthening and improving the structure of hair

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032964B4 (en) * 2000-07-06 2017-10-12 Beiersdorf Ag Use of creatine in cosmetic or dermatological preparations
DE10106288A1 (en) * 2001-02-02 2002-09-05 Coty Bv Revitalizing active complex for the skin
DE10133198A1 (en) * 2001-07-07 2003-01-23 Beiersdorf Ag Use of topical compositions containing creatine and its precursors and derivatives e.g. to improve skin condition and to treat or prevent skin disorders
DE10136077A1 (en) * 2001-07-25 2003-02-13 Beiersdorf Ag Cosmetic or dermatological preparations containing creatinine and creatine, useful e.g. for combating skin aging symptoms or treating inflammatory conditions such as eczema or psoriasis
DE10136076A1 (en) * 2001-07-25 2003-02-13 Beiersdorf Ag Cosmetic or dermatological preparations containing creatinine or its derivative, useful e.g. for combating skin aging symptoms or treating inflammatory conditions such as eczema or psoriasis
DE10301632A1 (en) * 2003-01-17 2004-07-29 Beiersdorf Ag Cosmetic and dermatological composition, useful e.g. for restructuring and rejuvenating the skin, contains soya bean germ extract, creatinine and creatine
DE102004009962A1 (en) * 2004-03-01 2005-09-22 Degussa Ag Use of guanidine compounds as physiological restorative in the form of nutritional supplements, feed additives, in cosmetic preparations and as plant strengthening agents
JP5756614B2 (en) * 2010-11-02 2015-07-29 花王株式会社 Autoinducer-2 inhibitor and preventive and / or therapeutic agent for caries disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091171A (en) * 1986-12-23 1992-02-25 Yu Ruey J Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
FR2725896A1 (en) * 1994-10-19 1996-04-26 Sederma Sa Topical compsns. contg. microbial filtrates rich in glycine, arginine and creatine
JPH09202710A (en) * 1995-11-20 1997-08-05 Kao Corp Wrinkles improver
US5939078A (en) * 1995-11-20 1999-08-17 Kao Corporation Wrinkle-care product

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091171A (en) * 1986-12-23 1992-02-25 Yu Ruey J Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
US5091171B1 (en) * 1986-12-23 1995-09-26 Ruey J Yu Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
FR2725896A1 (en) * 1994-10-19 1996-04-26 Sederma Sa Topical compsns. contg. microbial filtrates rich in glycine, arginine and creatine
JPH09202710A (en) * 1995-11-20 1997-08-05 Kao Corp Wrinkles improver
US5939078A (en) * 1995-11-20 1999-08-17 Kao Corporation Wrinkle-care product

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K. SAKAMOTO: "The development of two new moisturizing ingredients", COSMETICS & TOILETRIES, vol. 99, no. 3, 1984, pages 109 - 117, XP000571951 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 12 25 December 1997 (1997-12-25) *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186754B2 (en) 1999-06-25 2007-03-06 Avicena Group, Inc. Use of creatine or creatine compounds for skin preservation
WO2001054676A2 (en) * 2000-01-28 2001-08-02 Degussa Ag Formulations for states of dehydration
WO2001054676A3 (en) * 2000-01-28 2002-05-16 Sueddeutsche Kalkstickstoff Formulations for states of dehydration
EP1328242B2 (en) † 2001-03-24 2015-07-22 Wella Aktiengesellschaft Non-therapeutic use of creatine, creatinine and/or cyclocreatine for strengthening and improving the structure of hair
DE10119608A1 (en) * 2001-04-21 2002-10-24 Goldschmidt Ag Th Hair treatment or post-treatment compositions for preventing or repairing damage caused by chemical treatment, e.g. perming or bleaching, containing creatine or its derivative as hair strengthening agent
EP1338269A1 (en) * 2002-02-15 2003-08-27 Goldschmidt AG Composition for whitening the skin and alleviating of pigmentation disorders containing creatinine and/or a creatinine derivative as active ingredient
AU2003200465B2 (en) * 2002-02-15 2007-09-06 Evonik Goldschmidt Gmbh Compositions for Skin Lightening and Toning Down Pigment Disorders, Comprising Creatinine and/or Creatinine Derivatives as Active Substances
EP1535604A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Combination of creatine and/or creatinine, phenoxyethanol and eventually glycerine
EP1535605A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Cosmetic preparations containing creatine, creatinine and/or the derivatives thereof combined with an organic thickener.
EP2796136A1 (en) * 2003-11-26 2014-10-29 Beiersdorf AG Cosmetic preparations containing creatine and/or creatine derivatives and organic thickeners
US10682534B2 (en) 2003-11-26 2020-06-16 Beiersdorf, Ag Cosmetic preparations containing creatine and/or creatinine and organic thickeners
US10888719B2 (en) 2003-11-26 2021-01-12 Beiersdorf Ag Active substance combination of creatine and/or creatinine and phenoxyethanol

Also Published As

Publication number Publication date
JP2002524486A (en) 2002-08-06
GB2357970A (en) 2001-07-11
GB0108722D0 (en) 2001-05-30
DE19841385A1 (en) 2000-03-16

Similar Documents

Publication Publication Date Title
DE69918775T2 (en) A bearberry extract and a reducing agent-containing skin depigmenting composition
EP0802783B1 (en) Topical preparations containing l-arginine
DE19927229B4 (en) Cosmetic enzyme and its use
DE10228837B4 (en) Skin cosmetic composition and use of the composition as a skin tanning agent
DE19654508C1 (en) Cosmetic cleaning and care preparation
EP0731686A1 (en) Use of l-arginine, l-ornithine or l-citrulline and topical preparations with these substances
WO1994014412A1 (en) Synergistic combinations of active substance for the cosmetic or dermatological care of the skin, hair and nails
WO2000015187A1 (en) Creatine and/or creatine derivatives used as cosmetic preparations containing moisturizers
DE102010017151A1 (en) Use of a polyphenol rich plant extract as an antioxidant in combination with a moisturizer or moisturizer
EP2029089B1 (en) O/w emulsion for caring for hands
EP0687467A2 (en) Cosmetic and dermatological combinations containing glycerylalkylethers as active ingredients
EP0734246B1 (en) Cosmetic or dermatological oil-in-water emulsions containing amino acids and inorganic pigments
DE19533330A1 (en) Anti-skin cancer topical preparations
EP0836848B1 (en) Cosmetic tanning and sunscreen composition
DE102005030864A1 (en) Cosmetic formulation for moisturizing skin, improving elasticity of skin, hair and nails, reducing cellulite and care of sensitive skin contains lotus blossom extract
EP1885328B1 (en) Active ingredient combinations of glucosyl glycerides and creatine and/or creatinine
EP2560666B1 (en) Agent combinationen of magnolia bark extract and surfactace active agents (polyglaceryl(3)-methylglucosedistearate)
DE60105617T2 (en) Composition and in particular cosmetic composition containing DHEA and / or a precursor or a derivative of DHEA in combination with at least one active against glycation
EP1889597A1 (en) Active agent combinations of an ascorbyl compound and hydrogenated lecithin
EP0570405B1 (en) Stable cosmetic preparations
DE60212474T2 (en) Use of alkyl 3- (N-alkylacetamino) propionate derivatives as humectants
DE10145008A1 (en) Cosmetic composition e.g. useful for skin treatment, comprises a ubiquinone or plastoquinone, beta-glucan, Dead Sea water and a solubilizing agent
CH693981A5 (en) Cosmetic and/or therapeutic skin-care compositions useful for e.g. treating acne, comprising retinoid in moisture-free environment and separate conditioning cream formulation
DE10241541A1 (en) Urea is used in cosmetics, including fat-free and greasy cosmetics, used for treating scalp disorders accompanied by dandruff and/or itching, especially in shampoo
DE2926267A1 (en) COSMETIC CARE AND USE THEREOF

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): GB JP US

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 569772

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09786733

Country of ref document: US

ENP Entry into the national phase

Ref country code: GB

Ref document number: 200108722

Kind code of ref document: A

Format of ref document f/p: F