DE1198011B - Skin care products - Google Patents

Description

Skin Care Products The invention relates to the use of 4,5-diphenylimidazole or 4,5-di-3 ', 4'-methylenedioxyphenylimidazole as absorption-promoting substances in skin care products, Among the commercially available cosmetic preparations, such as cream, Milk lotion, face lotion, and the like, there are those that if on very sensitive Skin of allergic persons can be applied after application for cause irritation and inflammation for a short time and even with frequent use cause a rash. Of course, there aren't many people who use it of cosmetics suffer from such skin irritation. They take it for granted that irritation occurs when using cosmetic preparations. Although such Irritations and the like do not occur in normal people, it is a fact that unsuitable, Usual cosmetic preparations cause unpleasant phenomena and with them the desired skin-smoothing effect is not achieved, as is the task of a cosmetic is. Therefore, any additive used to nourish or stimulate the skin must be cosmetic Preparation is to be added, be absolutely reliable.

In order to avoid the above undesirable effects, was suggested the known cosmetic preparations some antihistamines, for example wise to add Banadryl or Adrenal Cortical Hormone, etc. But all of these means have practically no effect and are sometimes the cause of skin irritation, or, as with the use of Banadryl, a neuroparalytic effect occurs. Adding antihistamine alone will not have any effect if the preparation is applied to very sensitive skin because this agent, even if it is in the Skin penetrates, does not cause good blood circulation in the skin and consequently the metabolism cannot stimulate.

The object of the present invention is to address these disadvantages of the commercially available Eliminate skin care products. This is achieved through the use of 4,5-diphenylimidazole or 4,5-di-3 ', 4'-methylenedioxyphenylimidazole as absorption-promoting substances achieved.

4,5-Diphenylimidazole (hereinafter referred to as DI) with the structural formula and 4,5-di-3 ', 4'-methylenedioxyphenybmidazole (hereinafter referred to as PI) with the structural formula should be described in more detail below.

These two compounds show no irritating effects on the skin and can therefore be applied to the most sensitive areas. They are easily absorbed expand the capillaries and increase blood and lymph circulation.

The dilation or widening of the capillaries was tried in one attempt proven, in which the Loewen-Trendenburg method was applied to a toad. A Ringer's solution that is obtained from the abdomen aorta according to the Loewen-Trendenburg method was introduced, it was allowed to exit from the abdominal vein. The solution was something DI added.

The amount excreted was measured. The amount was compared to the number of drops of Ringer's solution produced per minute and the result is shown in the table below. DI minutes 1 2 3 4 5 6 7 8 9 Control 73 71 74 72 0.01 mg 76 75 84 81 89 88 83 78 76 Case 1 73 72 77 IT case 0.01 mg 73 72 77 77 76 76 76 75, case II 0.001 mg 70 73 72 70 80 83 77 79 76 These figures clearly show that with an addition of 0.01 mg DI the excreted drops increase steadily from the 3rd to the 7th minute and with an addition of 0.001 mg of the same substance an increase between the 5th and 8th minute he follows.

A similar effect also occurs when using PI. By The widening of the capillaries and the increase in blood circulation becomes the most functional activates the papillae under the skin. Only under such conditions does the skin take off really effective skin stimulants and other nutrients and will thus kept fresh.

DI and which have antihistamine functions can cause inflammation the skin, which significantly affects the beauty of the skin. It there is no side effect, even if the preparations are used continuously over a long period of time be applied. For the above reason z. B. a hair cream and a hair lotion with an addition of the compounds mentioned very quickly from the scalp absorbed, thereby promoting blood circulation and preventing hair loss. Dandruff is kept away and hair growth is supported. If this connection mixed into the soap will help remove dead substances and promote blood circulation.

The amounts of imidazole derivatives required for the stated purpose are between 0.1 and 0.01 percent by weight. If this limit is exceeded, if the balance is lost and the amount remains below the lower limit, the desired effect cannot be achieved.

Some experiments were carried out, which are described below will. The amounts of the individual components are expressed in weight.

Example 1 Cold-Cream beeswax ........................... 8% Solid paraffin ......................... 5% Vaseline .................... ........... 15% liquid paraffin ....................... 40% emulsifier .................... ..... 6% PI or DI ............................ 0.06% distilled water ----.---- . 24.9 0 / o perfume 1.0 01o antiseptic .................... some preparation: 1.beeswax, solid paraffin, petroleum jelly and liquid paraffin have been mixed, heated and held at 70 ° C; 2. Distilled water was also at 70 ° C heated; 3. PI or DI, perfume and the emulsifier were mixed together and so long heated until everything was melted and then added to mixture 1.

4. The distilled water was then added to mixture 1 and 3 poured, everything carefully mixed together and finally in an emulsifying mixer further mixed.

5. While stirring, the mixture 4 was cooled and transferred to a suitable one Poured vessel.

Example 2 stearic acid day cream ............................ 15.00% glycerine monostearate .................... 5.00% cetyl alcohol .................... ....... 4.00% emulsifier ......................... 5.00% PI or DI ............. .............. 0.02 01o perfume ................................ 1.00% distilled water ....... .............. 54.78% propylene glycol ......................... 15.00% potassium hydroxide solution ............... ............... 0.20% antiseptic .................... some preparation: 1. PI or DI, the emulsifier and perfume were mixed and heated until everything was even was resolved.

2. Distilled water and potassium hydroxide were mixed and up Heated to 70 ° C.

3. Stearic acid, glycerol monostearate and cetyl alcohol were after heated to mixing to dissolve everything well. The liquid was kept at 70 ° C.

4. Solution 1 was mixed well with solution 3.

5. Solution 2 was added to solution 4 and placed in an emulsifying mixer converted into a fine emulsion.

6. The mixture was then stirred until a cream was obtained.

Example 3 Face Milk Lotion Liquid Paraffin ....................... 10.00% stearic acid ............................ 2.00% emulsifier ............ ............. 4.00% distilled water ..................... 77.92% alcohol ........... ....... ... ......... 5.00 0 / o PI or DI ............................ 0.08% Perfume ................................ 1.00% Antiseptic .................... some preparation: 1. PI or DI was mixed with perfume, emulsifier stearic acid and liquid paraffin and heated to dissolve everything well and kept at 65 ° C.

2. The distilled water mixed with alcohol was brought to 65 ° C heated and added to mixture 1 with stirring and again after emulsification subjected to a fine emulsion in an emulsifying mixer.

3. The mixture was cooled to 30 ° C. while stirring.

Example 4 Carbowax face lotion ..... ...................... 5.00% propylene glycol ......................... 10.00% alcohol ............... ....... . 15.00 01o PI or DI ............ ............. 0.03% perfume ............. ................... 0.20% emulsifier ......................... 1.00% distilled water .............. ....... 68.77% dye and antiseptic something Preparation: 1. Perfume, PI or DI and the emulsifier were blended into a smooth blend.

2. All other ingredients mentioned were mixed at the same time and added to 1 and dissolved.

Ten women were made with those prepared by the above procedures Preparations, both with DI or PI addition and without this addition, treated.

The preparation was applied to one half of the face without any additive and the preparation with additive applied to the other half of the face.

The following results were obtained: Cases of skin irritation Beauty products Preparations with Preparations without Pl or DI I PI or DI Cold cream ......... 1 10 Day cream ......... 0 2 Facial milk lotion. . 0 10 Face lotion ... 0 5 Overall ........... | 1 | 27 The skin irritations include itching and burning.

Claims (1)

Claim: Use of 4,5-diphenylimidazole or 4,5-di-3 ', 4'-methylenedioxyphenylimidazole as absorption-promoting substances in skin care products.