DE1088193B - Process for the production of durable, high-percentage hydrogen peroxide ointments - Google Patents
Process for the production of durable, high-percentage hydrogen peroxide ointmentsInfo
- Publication number
- DE1088193B DE1088193B DEV15319A DEV0015319A DE1088193B DE 1088193 B DE1088193 B DE 1088193B DE V15319 A DEV15319 A DE V15319A DE V0015319 A DEV0015319 A DE V0015319A DE 1088193 B DE1088193 B DE 1088193B
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen peroxide
- ointments
- durable
- production
- percentage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Description
Verfahren zur Herstellung haltbarer, hochprozentiger Wasserstoffperoxydsalben Die Erfindung bezweckt die Herstellung einer haltbaren Salbe, deren medizinische Anwendung es ermöglicht, ohne den bislang üblichen apparativen Aufwand dem Organismus unter Umgehung der Lungen Sauerstoff zuzuführen.Process for the production of durable, high-percentage hydrogen peroxide ointments The invention aims to produce a durable ointment, its medicinal Application makes it possible for the organism without the hitherto customary outlay on equipment Deliver oxygen bypassing the lungs.
Es wurde festgestellt, daß hochprozentiges Wasserstoffperoxyd, auf die Haut gebracht, reichlich Sauerstoff in das Gewebe und in die Blutbahn einbringt. It was found that high percentage hydrogen peroxide, on brought up the skin, bringing abundant oxygen to the tissues and bloodstream.
Für die Verwendung in der Heilkunde ist es am zweckmäßigsten, Wasserstoffperoxyd in Form einer Salbe anzuwenden, die zugleich einen kontinuierlichen Sauerstoffeinstrom für längere Zeit gewährleistet.For use in medicine, it is most expedient to use hydrogen peroxide apply in the form of an ointment, which at the same time has a continuous influx of oxygen guaranteed for a long time.
Im Gegensatz zu den bisher gebräuchlichen unstabilen, niederprozentigen Wasserstoffperoxydsalben, die lediglich Bleichzwecken dienen, werden nach dem erfindungsgemäßen Verfahren stabile, hochprozentige Wasserstoffperoxydsalben hergestellt zum Zwecke der Sauerstoffzufuhr in erkranktes Gewebe. In contrast to the unstable, low-percentage that has been used up to now Hydrogen peroxide ointments, which are used only for bleaching purposes, are according to the invention Process stable, high-percentage hydrogen peroxide ointments produced for the purpose the supply of oxygen to diseased tissue.
Es wurde gefunden, daß man haltbare, hochprozentige, Sauerstoff ins Gewebe und Blut abgebende Wasserstoffperoxydsalben erhält, wenn man zu Salbengrundlagen aus einem Gemisch von Cetylalkohol und Octadecylalkohol, flüssigem Paraffin und einem flüssigen Estergemisch (flüssiges Wachs), das aus C10- bis C22-Fettsäuren und einwertigen C6- bis C9-Alkoholen gebildet wird, einen für wässerige Wasserstoffperoxydlösungen bekannten Stabilisator, wie Acetphenetidin oder Malonsäure, in Mengen von unter 10/o in gelöster Form zugibt, innig vermischt und dann das für die gewünschte Endkonzentration erforderliche hochprozentige Wasserstoffperoxyd zusetzt. Als wirksames Agens wird säurefreies 20- bis 400/oiges Wasserstoffperoxyd verwendet. It has been found that durable, high percentage, oxygen ins Hydrogen peroxide ointments which donate tissue and blood are obtained if one uses ointment bases from a mixture of cetyl alcohol and octadecyl alcohol, liquid paraffin and a liquid ester mixture (liquid wax) consisting of C10 to C22 fatty acids and monohydric C6 to C9 alcohols are formed, one for aqueous hydrogen peroxide solutions known stabilizers, such as acetphenetidine or malonic acid, in amounts of less than 10 / o is added in dissolved form, intimately mixed and then that for the desired final concentration required high percentage hydrogen peroxide added. As an effective agent will acid-free 20 to 400% hydrogen peroxide is used.
Die nach dem erfindungsgemäßen Verfahren hergestellten Salben entsprechen hinsichtlich Stabilität, Lagerfähigkeit und therapeutischer Wirksamkeit den Erfordernissen der praktischen Therapie. The ointments produced by the process according to the invention correspond the requirements with regard to stability, shelf life and therapeutic effectiveness practical therapy.
Beispiel 1 Es wird eine Salbengrundlage hergestellt, die 5 Teile flüssiges Wachs, 7,5 Teile fliissiges Paraffin, 20 Teile eines Gemisches aus Cetylalkohol und Octadecylalkohol und 22,5 Teile Wasser enthält. Von dieser Salbengrundlage werden zur Herstellung einer 200/oigen Wasserstoffperoxydsalbe 35,0 g genommen. Example 1 An ointment base is prepared which has 5 parts liquid wax, 7.5 parts of liquid paraffin, 20 parts of a mixture of cetyl alcohol and octadecyl alcohol and 22.5 parts water. Be from this ointment base 35.0 g were taken to produce a 200% hydrogen peroxide ointment.
Zu ihr gibt man 15 ml einer 0;75 g enthaltenden alkoholischen Lösung von Acetphenetidin und anschließend vorsichtig unter Verrühren 100,0 g 300/oiges Wasserstoffperoxyd in kleinen Anteilen allmählich hinzu. Beispiel 2 Es wird eine Salbengrundlage hergestellt, die 5 Teile flüssiges Wachs, 7,5 Teile flüssiges Paraffin, 20Teile eines Gemisches aus Cetylalkohol und Octadecylalkohol und 30 Teile Wasser enthält. Von dieser Salbengrundlage werden zur Herstellung einer 200/oigen Wasserstoffperoxydsalbe 70,0 g genommen.15 ml of an alcoholic solution containing 0.75 g are added to it of acetphenetidine and then carefully, while stirring, 100.0 g of 300% Gradually add hydrogen peroxide in small portions. Example 2 It becomes a Ointment base prepared, the 5 parts of liquid wax, 7.5 parts of liquid paraffin, 20 parts of a mixture of cetyl alcohol and octadecyl alcohol and 30 parts of water contains. This ointment base is used to produce a 200% hydrogen peroxide ointment 70.0 g taken.
Zu ihr gibt man 5 ml einer 1,0 g enthaltenden wässerigen Lösung von Malonsäure und anschließend vorsichtig unter Verrühren 75,0 g 400/oiges Wasserstoffperoxyd in kleinen Anteilen allmählich hinzu.To it is added 5 ml of an aqueous solution containing 1.0 g of Malonic acid and then carefully, with stirring, 75.0 g of 400% hydrogen peroxide gradually added in small portions.
PATENTANSPRUCR: Verfahren zur Herstellung haltbarer, hochprozentiger, Sauerstoff ins Gewebe und Blut abgebender Wasserstoffperoxydsalben, dadurch gekennzeichnet, daß man zu einer Salbengrundlage aus einem Gemisch von Cetylalkohol und Octadecylalkohol, flüssigem Paraffin und einem aus C16- bis C22-Fettsäuren und einwertigen C6- bis Cg-Alkoholen gebildeten flüssigen Estergemisch einen für wässerige Wasserstoffperoxydlösungen bekannten Stabilisator, wie Acetphenetidin oder Malonsäure, in Mengen von unter 1 0/o in gelöster Form zugibt und mit hochprozentiger Wasserstoffperoxydlösung emulgiert. PATENT CLAIM: Process for the production of durable, high-percentage, Hydrogen peroxide ointments releasing oxygen into tissue and blood, characterized in that that one becomes an ointment base from a mixture of cetyl alcohol and octadecyl alcohol, liquid paraffin and one of C16 to C22 fatty acids and monovalent C6 bis Liquid ester mixture formed from Cg alcohols, one for aqueous hydrogen peroxide solutions known stabilizers, such as acetphenetidine or malonic acid, in amounts of less than 1 0 / o is added in dissolved form and emulsified with a high-percentage hydrogen peroxide solution.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV15319A DE1088193B (en) | 1958-10-31 | 1958-10-31 | Process for the production of durable, high-percentage hydrogen peroxide ointments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV15319A DE1088193B (en) | 1958-10-31 | 1958-10-31 | Process for the production of durable, high-percentage hydrogen peroxide ointments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1088193B true DE1088193B (en) | 1960-09-01 |
Family
ID=7574965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEV15319A Pending DE1088193B (en) | 1958-10-31 | 1958-10-31 | Process for the production of durable, high-percentage hydrogen peroxide ointments |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE1088193B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2347052A1 (en) * | 1976-04-06 | 1977-11-04 | Bayer Ag | NEW ANTHELMINTHIC FORMULATIONS FOR EXTERNAL APPLICATION |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB190616151A (en) * | 1906-07-17 | 1907-02-21 | Francis Alfred Manly | An Improved Continuing or Loud Pedal for Pianofortes. |
-
1958
- 1958-10-31 DE DEV15319A patent/DE1088193B/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB190616151A (en) * | 1906-07-17 | 1907-02-21 | Francis Alfred Manly | An Improved Continuing or Loud Pedal for Pianofortes. |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2347052A1 (en) * | 1976-04-06 | 1977-11-04 | Bayer Ag | NEW ANTHELMINTHIC FORMULATIONS FOR EXTERNAL APPLICATION |
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