DE921282C - Process for the production of skin creams with a blood circulation stimulating effect - Google Patents

Process for the production of skin creams with a blood circulation stimulating effect

Info

Publication number
DE921282C
DE921282C DESCH9496A DESC009496A DE921282C DE 921282 C DE921282 C DE 921282C DE SCH9496 A DESCH9496 A DE SCH9496A DE SC009496 A DESC009496 A DE SC009496A DE 921282 C DE921282 C DE 921282C
Authority
DE
Germany
Prior art keywords
nicotinic acid
production
blood circulation
skin creams
stimulating effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH9496A
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KARL HANS SCHUSTER DR MED
Original Assignee
KARL HANS SCHUSTER DR MED
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KARL HANS SCHUSTER DR MED filed Critical KARL HANS SCHUSTER DR MED
Priority to DESCH9496A priority Critical patent/DE921282C/en
Application granted granted Critical
Publication of DE921282C publication Critical patent/DE921282C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung von Hautcremes mit durchblutungsfördemder Wirkung Bei der Herstellung von Hautcremes mit durchblutungsfördernder Wirkung wurden bisher Campher, ätherische Öle ud verschiedene Ester der Nikotinsäure verwendet. Bei allen diesen Wirkstoffen hat es sich gezeigt, daB die durch sie bewirkte Durchblutungssteigerung sehr rasch beginnt, daß sie einen unerwünscht hohen Grad erreicht und wieder zu rasch abklingt. Nach vorliegender Erfindung ist es überraschenderweise gelungen, eine tagelang anhaltende milde durchblutungssteigernde Wirkung dadurch zu erzielen, daß Nikotinsäure und bzw. oder ihre Salze in sehr geringer Konzentration angewendet werden. Dabei hat es sich als notwendig erwiesen, der wäßrigen Phase der betreffenden Cremezubereitung einen pH-Wert von 5 bis 6,8 zu erteilen. Weiter wurde gefunden, daß diese Wirkung in vollem Umfang vor allem dann eintritt, wenn die wäßrige Lösung der Nikotinsäure und bzw. oder ihrer Salze die äußere Phase der als Hautcreme dienenden Emulsion bildet. Die so hergestellten Zubereitungen weisen gegenüber den bisher üblichen Präparaten eine außerordentlich milde, der Haut sehr zuträgliche und nachhaltige Wirkung auf. Eine weitere Unterstützung dieser Wirkung läßt sich dadurch erreichen, daß den erfindungsgemäßen Zubereitungen ungesättigte Fettsäuren, z. B. Vitamin F und Vitamin E enthaltende Öle, z. B. Weizenkeimöl, zugesetzt werden.Process for the production of skin creams with blood circulation promoting effect In the manufacture of skin creams with a blood circulation-stimulating effect So far, camphor, essential oils and various esters of nicotinic acid have been used. With all these active ingredients it has been shown that the increase in blood flow caused by them very quickly begins to reach an undesirably high level and then to increase again quickly subsides. According to the present invention, it has surprisingly succeeded to achieve a mild blood circulation-increasing effect that lasts for days, that nicotinic acid and / or its salts are used in very low concentrations will. It has proven to be necessary, the aqueous phase of the relevant To give cream preparation a pH of 5 to 6.8. Further it was found that this effect occurs to its full extent especially when the aqueous solution nicotinic acid and / or its salts form the outer phase of the skin cream used Forms emulsion. The preparations produced in this way have compared to the previous usual preparations an extraordinarily mild, very beneficial and sustainable for the skin Effect on. A further support of this effect can be achieved by that the preparations according to the invention unsaturated fatty acids, for. B. Vitamin F and oils containing vitamin E, e.g. B. wheat germ oil can be added.

Beispiel 2,5 g eines Gemisches höherer gesättigter Fettalkohole und 8 g Weichwachs, 6 g Vaselinöl, I,5 g Weizenkeimöl, I,5 g Linolensäure werden auf etwa 700 erwärmt und unter intensivem Rühren 70 ccm einer wäßrigen Lösung zugesetzt, die 5 bis IO mg Nikotinsäure enthält sowie 0,1 g p-Oxybenzoesäure-methylester und IO ccm eines Puffergemisches, welches der wäßrigen Lösung einen pH-Wert von 6 erteilt. Example 2.5 g of a mixture of higher saturated fatty alcohols and 8 g of soft wax, 6 g of vaseline oil, I, 5 g of wheat germ oil, I, 5 g of linolenic acid are applied about 700 heated and with vigorous stirring 70 ccm an aqueous one Solution added containing 5 to 10 mg nicotinic acid and 0.1 g p-oxybenzoic acid methyl ester and IO ccm of a buffer mixture, which the aqueous solution has a pH of 6 granted.

Claims (3)

PATENTANsPRÜcHE: I. Verfahren zur Herstellung von Hautcremes mit durchblutungsfördernder Wirkung, dadurch gekennzeichnet, daß diesen Nikotinsäure und bzw. oder nikotinsaure Salze zugesetzt werden. PATENTAL CLAIMS: I. Process for the production of skin creams with circulation-promoting effect, characterized in that these nicotinic acid and / or nicotinic acid salts are added. 2. Verfahren nach Anspruch I, dadurch gekennzeichnet, daß der Nikotinsäure und bzw. oder deren Salze enthaltenden Lösung ein p Wert von 5 bis 6,8 erteilt wird. 2. The method according to claim I, characterized in that the nicotinic acid and / or their salt-containing solution is given a p value of 5 to 6.8. 3. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß die Nikotinsäure bzw. deren Salze enthaltende Lösung in der Weise emulgiert wird, daß sie die äußere Phase der Hautcremeemulsion bildet. 3. The method according to claim 1, characterized in that the nicotinic acid or their salt-containing solution is emulsified in such a way that they the outer Phase of the skin cream emulsion forms. Angezogene Druckschriften: Deutsche Patentschrift Nr. 835 o3S; »Salben, Puder, Externa«, Ig50, von Czetsch-Lindenwald und S chmidt-La B aume, S. I9I, Absatz 7, ferner die S. III, 33 und 45; »Hagers Handbuch der pharmazeutischen Praxis«, Berlin I938, S. 248. Cited publications: German patent specification No. 835 03S; "Anoint, Powder, Externa ", Ig50, by Czetsch-Lindenwald and S chmidt-La Baum, p. 19I, paragraph 7, also pp. III, 33 and 45; "Hager's Handbook of Pharmaceutical Practice", Berlin I938, p. 248.
DESCH9496A 1952-05-10 1952-05-10 Process for the production of skin creams with a blood circulation stimulating effect Expired DE921282C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH9496A DE921282C (en) 1952-05-10 1952-05-10 Process for the production of skin creams with a blood circulation stimulating effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH9496A DE921282C (en) 1952-05-10 1952-05-10 Process for the production of skin creams with a blood circulation stimulating effect

Publications (1)

Publication Number Publication Date
DE921282C true DE921282C (en) 1954-12-13

Family

ID=7426057

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH9496A Expired DE921282C (en) 1952-05-10 1952-05-10 Process for the production of skin creams with a blood circulation stimulating effect

Country Status (1)

Country Link
DE (1) DE921282C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1046055B (en) * 1956-06-18 1958-12-11 Ernst Schneider Dipl Chem Dr Process for the production of an ester of multiply unsaturated higher molecular fatty acids
DE1104120B (en) * 1958-11-14 1961-04-06 Wella Ag Skin care products
DE1201951B (en) * 1959-07-14 1965-09-30 Colgate Palmolive Co Stable acidic main care emulsion

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE835038C (en) * 1951-01-16 1952-03-27 Nordmark Werke Gmbh Hair care products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE835038C (en) * 1951-01-16 1952-03-27 Nordmark Werke Gmbh Hair care products

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1046055B (en) * 1956-06-18 1958-12-11 Ernst Schneider Dipl Chem Dr Process for the production of an ester of multiply unsaturated higher molecular fatty acids
DE1104120B (en) * 1958-11-14 1961-04-06 Wella Ag Skin care products
DE1201951B (en) * 1959-07-14 1965-09-30 Colgate Palmolive Co Stable acidic main care emulsion

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