DE10360793A1 - Spirocyclische Cyclohexan-Derivate - Google Patents

Spirocyclische Cyclohexan-Derivate Download PDF

Info

Publication number
DE10360793A1
DE10360793A1 DE10360793A DE10360793A DE10360793A1 DE 10360793 A1 DE10360793 A1 DE 10360793A1 DE 10360793 A DE10360793 A DE 10360793A DE 10360793 A DE10360793 A DE 10360793A DE 10360793 A1 DE10360793 A1 DE 10360793A1
Authority
DE
Germany
Prior art keywords
unsubstituted
polysubstituted
monosubstituted
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10360793A
Other languages
German (de)
English (en)
Inventor
Claudia Dr. Hinze
Bernd Dr. Sundermann
Hans Prof. Dr. Schick
Birgitta Dr. Henkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE10360793A priority Critical patent/DE10360793A1/de
Priority to DE502004009243T priority patent/DE502004009243D1/de
Priority to DK04804137T priority patent/DK1697379T3/da
Priority to JP2006546041A priority patent/JP4791374B2/ja
Priority to AT04804137T priority patent/ATE426604T1/de
Priority to PT04804137T priority patent/PT1697379E/pt
Priority to CA2550892A priority patent/CA2550892C/en
Priority to PCT/EP2004/014540 priority patent/WO2005063769A1/de
Priority to ES04804137T priority patent/ES2324788T3/es
Priority to EP04804137A priority patent/EP1697379B1/de
Priority to PL04804137T priority patent/PL1697379T3/pl
Priority to SI200431139T priority patent/SI1697379T1/sl
Priority to ARP040104858A priority patent/AR046794A1/es
Priority to US11/019,416 priority patent/US7288560B2/en
Priority to PE2005000021A priority patent/PE20050680A1/es
Publication of DE10360793A1 publication Critical patent/DE10360793A1/de
Priority to CY20091100629T priority patent/CY1109142T1/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE10360793A 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate Withdrawn DE10360793A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE10360793A DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate
PCT/EP2004/014540 WO2005063769A1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
PL04804137T PL1697379T3 (pl) 2003-12-23 2004-12-21 Spirocykliczne pochodne cykloheksanu
JP2006546041A JP4791374B2 (ja) 2003-12-23 2004-12-21 スピロ環状シクロヘキサン誘導体
AT04804137T ATE426604T1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
PT04804137T PT1697379E (pt) 2003-12-23 2004-12-21 Derivados de ciclo-hexano espirocíclicos
CA2550892A CA2550892C (en) 2003-12-23 2004-12-21 Spirocyclic cyclohexane derivatives
DE502004009243T DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
ES04804137T ES2324788T3 (es) 2003-12-23 2004-12-21 Derivados de ciclohexano espirociclicos.
EP04804137A EP1697379B1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
DK04804137T DK1697379T3 (da) 2003-12-23 2004-12-21 Spirocykliske cyklohexan-derivater
SI200431139T SI1697379T1 (sl) 2003-12-23 2004-12-21 Spirociklični cikloheksanski derivati
ARP040104858A AR046794A1 (es) 2003-12-23 2004-12-22 Derivados de ciclohexano espirociclicos, un metodo para su preparacion y medicamentos que los contienen como principio activo.
US11/019,416 US7288560B2 (en) 2003-12-23 2004-12-23 Spirocyclic cyclohexane derivatives
PE2005000021A PE20050680A1 (es) 2003-12-23 2005-01-03 Derivados de ciclohexano espirociclicos
CY20091100629T CY1109142T1 (el) 2003-12-23 2009-06-12 Χαρακτηρισμος: σπειροκυκλικα παραγωγα κυκλοεξανιου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10360793A DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate

Publications (1)

Publication Number Publication Date
DE10360793A1 true DE10360793A1 (de) 2005-07-28

Family

ID=34706498

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10360793A Withdrawn DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate
DE502004009243T Expired - Lifetime DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502004009243T Expired - Lifetime DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate

Country Status (15)

Country Link
US (1) US7288560B2 (https=)
EP (1) EP1697379B1 (https=)
JP (1) JP4791374B2 (https=)
AR (1) AR046794A1 (https=)
AT (1) ATE426604T1 (https=)
CA (1) CA2550892C (https=)
CY (1) CY1109142T1 (https=)
DE (2) DE10360793A1 (https=)
DK (1) DK1697379T3 (https=)
ES (1) ES2324788T3 (https=)
PE (1) PE20050680A1 (https=)
PL (1) PL1697379T3 (https=)
PT (1) PT1697379E (https=)
SI (1) SI1697379T1 (https=)
WO (1) WO2005063769A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
CA2719735A1 (en) 2008-03-27 2009-10-01 Gruenenthal Gmbh Substituted 4-aminocyclohexane derivatives
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
WO2009118174A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Substituierte cyclohexyldiamine
ATE537143T1 (de) 2008-03-27 2011-12-15 Gruenenthal Gmbh Spiro(5.5)undecan derivate
AU2009228637B2 (en) 2008-03-27 2013-12-19 Grunenthal Gmbh (Hetero-)aryl cyclohexane derivatives
JP5599774B2 (ja) 2008-03-27 2014-10-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヒドロキシメチルシクロヘキシルアミン類
KR101333660B1 (ko) 2008-07-21 2013-11-27 시오노기세이야쿠가부시키가이샤 치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도
SG10201510665WA (en) 2009-12-04 2016-01-28 Sunovion Pharmaceuticals Inc Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders
TWI582092B (zh) * 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
KR20130097173A (ko) 2010-08-04 2013-09-02 그뤼넨탈 게엠베하 신경병증성 통증을 치료하기 위한 ６’­플루오로­（Ｎ­메틸­ 또는 Ｎ，Ｎ­디메틸­）­４­페닐­４’，９’­디하이드로­３’Ｈ­스피로[사이클로헥산­１，１’­피라노[３，４，ｂ]인돌]­４­아민을 포함하는 약제학적 투여형
MX2013011589A (es) * 2011-04-07 2013-12-16 Ariad Pharma Inc Metodos y composiciones para tratar enfermedad de parkinson.
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
HUE040133T2 (hu) 2014-07-15 2019-02-28 Gruenenthal Gmbh Szubsztituált azaspiro(4.5)dekán származékok
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
PT3494119T (pt) 2016-07-29 2024-12-10 Pgi Drug Discovery Llc Compostos e composições e seus usos
MX390141B (es) 2017-02-16 2025-03-20 Sunovion Pharmaceuticals Inc Metodos para tratar esquizofrenia
CA3070993C (en) 2017-08-02 2025-05-20 Sunovion Pharmaceuticals Inc. ISOCHROMANE COMPOUNDS AND THEIR USES
UA130249C2 (uk) 2018-02-16 2025-12-31 Сумітомо Фарма Америка, Інк. Солі, кристалічні форми і способи їх отримання
EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
CN119241381A (zh) 2019-12-26 2025-01-03 吉尔伽美什制药公司 芳基环己基胺衍生物及其在精神障碍的治疗中的用途
KR20260008838A (ko) 2020-02-18 2026-01-16 길가메쉬 파마슈티컬스, 인코포레이티드 기분 장애 치료에 사용되기 위한 특이적 트립타민
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12180158B1 (en) 2023-08-03 2024-12-31 Gilgamesh Pharmaceuticals, Inc. Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10044649A1 (de) * 2000-09-08 2002-07-04 Gruenenthal Gmbh Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
WO2002090330A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
HUP0302962A2 (hu) * 1998-06-12 2003-12-29 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
WO2000038720A1 (en) * 1998-12-24 2000-07-06 Meiji Seika Kaisha, Ltd. Remedies for pain
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10044649A1 (de) * 2000-09-08 2002-07-04 Gruenenthal Gmbh Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
WO2002090330A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate

Also Published As

Publication number Publication date
EP1697379A1 (de) 2006-09-06
US7288560B2 (en) 2007-10-30
SI1697379T1 (sl) 2009-08-31
DK1697379T3 (da) 2009-07-20
PE20050680A1 (es) 2005-09-27
ATE426604T1 (de) 2009-04-15
CY1109142T1 (el) 2014-07-02
WO2005063769A1 (de) 2005-07-14
JP4791374B2 (ja) 2011-10-12
AR046794A1 (es) 2005-12-21
CA2550892A1 (en) 2005-07-14
CA2550892C (en) 2012-03-06
PT1697379E (pt) 2009-06-08
EP1697379B1 (de) 2009-03-25
ES2324788T3 (es) 2009-08-14
JP2007515447A (ja) 2007-06-14
DE502004009243D1 (en) 2009-05-07
US20050187281A1 (en) 2005-08-25
PL1697379T3 (pl) 2009-08-31

Similar Documents

Publication Publication Date Title
EP1697379B1 (de) Spirocyclische cyclohexan-derivate
EP1725567B1 (de) Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor
EP2121691B1 (de) Spirocyclische cyclohexan-derivate
EP2233487B1 (de) Spirocyclische Cyclohexan-Derivate
EP2121689B1 (de) Spirocyclische cyclohexan-derivate
EP2271613B1 (de) Hydroxymethylcyclohexylamine
EP1778680B1 (de) Spirocyclische cyclohexan-derivate
DE102006033109A1 (de) Substituierte Heteroaryl-Derivate
EP1745009B1 (de) Heteroarylsubstituierte cyclohexyl-1,4-diamin-derivate
DE102006033114A1 (de) Spirocyclische Azaindol-Derivate
EP1751090B1 (de) Säurederivate substituierter cyclohexyl-1,4-diamine
EP1751088B1 (de) Oxosubstituierte cyclohexyl-1,4-diamin-derivate
EP1751095B1 (de) Substituierte cyclohexylcarbonsäure-derivate
WO2016008583A1 (de) Substituierte aza-spiro(4.5)decan-derivate

Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8139 Disposal/non-payment of the annual fee